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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Mon Mar 31 21:24:29 GMT 2025
Edited
by admin
on Mon Mar 31 21:24:29 GMT 2025
Protein Type ENZYME
Protein Sub Type CYTOCHROME P450
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
8E4LAA4357
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYP2D6
Preferred Name English
CYTOCHROME P450 2D6
Common Name English
CYTOCHROME P450, FAMILY 2, SUBFAMILY D, POLYPEPTIDE 6
Common Name English
CYTOCHROME P 450 2D6
Common Name English
HUMAN CYTOCHROME P450 2D6
Common Name English
Code System Code Type Description
CAS
330597-62-1
Created by admin on Mon Mar 31 21:24:30 GMT 2025 , Edited by admin on Mon Mar 31 21:24:30 GMT 2025
PRIMARY
FDA UNII
8E4LAA4357
Created by admin on Mon Mar 31 21:24:30 GMT 2025 , Edited by admin on Mon Mar 31 21:24:30 GMT 2025
PRIMARY
UNIPROT
P10635
Created by admin on Mon Mar 31 21:24:30 GMT 2025 , Edited by admin on Mon Mar 31 21:24:30 GMT 2025
PRIMARY
Related Record Type Details
Structure of Vortioxetine
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of PROADIFEN
INHIBITOR -> METABOLIC ENZYME
SELECTIVE
Structure of IXAZOMIB
SUBSTRATE -> METABOLIC ENZYME
At higher than clinical concentrations, ixazomib was metabolized by multiple CYP isoforms with estimated relative contributions of 3A4 (42%), 1A2 (26%), 2B6 (16%), 2C8 (6%), 2D6 (5%), 2C19 (5%) and 2C9 (< 1%).
Structure of PF-06835919
NON-INHIBITOR -> METABOLIC ENZYME
IC50
Structure of Dronedarone
INHIBITOR -> METABOLIC ENZYME
LOW
Ki
Structure of VERUBECESTAT
NON-INHIBITOR -> METABOLIC ENZYME
Structure of RIPRETINIB
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of Duloxetine
INHIBITOR -> METABOLIC ENZYME
Structure of LOFEXIDINE
SUBSTRATE -> METABOLIC ENZYME
Lofexidine exposures were approximately 30% greater with co-administration of paroxetine a strong inhibitor of CYP2D6.
MAJOR
Structure of CIFENLINE
SUBSTRATE -> METABOLIC ENZYME
Structure of PAROXETINE
SUBSTRATE -> METABOLIC ENZYME
Structure of DEFERASIROX
SUBSTRATE -> METABOLIC ENZYME
Structure of BUPIVACAINE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of TRIPELENNAMINE
SUBSTRATE -> METABOLIC ENZYME
Structure of Miridesap
NON-INHIBITOR -> METABOLIC ENZYME
Structure of DACOMITINIB ANHYDROUS
SUBSTRATE -> METABOLIC ENZYME
Structure of IMIPRAMINE
SUBSTRATE -> METABOLIC ENZYME
Structure of ENCORAFENIB
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of TAFENOQUINE
INHIBITOR -> METABOLIC ENZYME
Ki
Structure of PALONOSETRON
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of FORMOTEROL
SUBSTRATE -> METABOLIC ENZYME
Structure of DPA-714 F-18
SUBSTRATE -> METABOLIC ENZYME
Structure of INDACATEROL
SUBSTRATE -> METABOLIC ENZYME
Structure of FLUVOXAMINE
INHIBITOR -> METABOLIC ENZYME
WEAK INHIBITOR
Structure of IMATINIB
INHIBITOR -> METABOLIC ENZYME
Structure of QUINIDINE
INHIBITOR -> METABOLIC ENZYME
POTENT
Structure of GLECAPREVIR
SUBSTRATE -> METABOLIC ENZYME
Structure of ASENAPINE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of CICLESONIDE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of Berotralstat
SUBSTRATE -> METABOLIC ENZYME
Structure of BUPROPION
INHIBITOR -> METABOLIC ENZYME
Strong Inhibitors(2) 5-fold increase in AUC or > 80% decrease in CL
MAJOR
Structure of Dronedarone
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of SKF-8742
INHIBITOR -> METABOLIC ENZYME
Structure of ARIPIPRAZOLE
SUBSTRATE -> METABOLIC ENZYME
Structure of CHLORPROMAZINE
SUBSTRATE -> METABOLIC ENZYME
Structure of CIMETIDINE
INHIBITOR -> METABOLIC ENZYME
POTENT
Structure of ALVESPIMYCIN
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of Febuxostat
INHIBITOR -> METABOLIC ENZYME
Ki
Structure of CYCLOHEXANAMINE, N-(3-ETHOXYPROPYL)-1-PHENYL-
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of ENCORAFENIB
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of TERBINAFINE
SUBSTRATE -> METABOLIC ENZYME
Structure of TAMOXIFEN
SUBSTRATE -> METABOLIC ENZYME
Structure of Valbenazine
SUBSTRATE -> METABOLIC ENZYME
Structure of LEVOMETHADONE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of TRICLABENDAZOLE
SUBSTRATE -> METABOLIC ENZYME
Structure of ALDUMASTAT
SUBSTRATE -> METABOLIC ENZYME
Structure of VILAZODONE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of DIPHENHYDRAMINE
SUBSTRATE -> METABOLIC ENZYME
N-demethylation of diphenhydramine is mainly catalyzed by CYP2D6 as a high-affinity P450 isozyme at a clinically relevant concentration.
MAJOR
Structure of COBICISTAT
INHIBITOR -> METABOLIC ENZYME
Structure of BETRIXABAN
SUBSTRATE -> METABOLIC ENZYME
Structure of DRONABINOL
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of ZOLPIDEM
SUBSTRATE -> METABOLIC ENZYME
Structure of CARBENDAZIM
INHIBITOR -> METABOLIC ENZYME
Structure of ATOMOXETINE
INHIBITOR -> METABOLIC ENZYME
POTENT
Structure of Tofacitinib
NON-INHIBITOR -> METABOLIC ENZYME
Structure of Vortioxetine
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of GSK-1070916
INHIBITOR -> METABOLIC ENZYME
bufuralol substrate
IC50
Structure of MEPHEDRONE
SUBSTRATE -> METABOLIC ENZYME
In vitro studies suggest that mephedrone metabolic disposition is regulated by the highly polymorphic isoenzyme of CYP2D6 (Pedersen et al., 2013).
Structure of ALMOTRIPTAN
SUBSTRATE -> METABOLIC ENZYME
Structure of MOTESANIB
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of RIVOGLITAZONE
SUBSTRATE -> METABOLIC ENZYME
Structure of HYDROXYZINE
INHIBITOR -> METABOLIC ENZYME
Inhibition of bufuralol 1?-hydroxylation. Could be clinically relevant concentration in liver is within these values.
COMPETITIVE INHIBITOR
Ki
Structure of CJ-12458
SUBSTRATE -> METABOLIC ENZYME
Structure of TRICLABENDAZOLE SULFOXIDE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of BPR-1K871
SUBSTRATE -> METABOLIC ENZYME
Structure of LICOFELONE
SUBSTRATE -> METABOLIC ENZYME
Structure of FLUPERLAPINE
SUBSTRATE -> METABOLIC ENZYME
Structure of ABIRATERONE
INHIBITOR -> METABOLIC ENZYME
Abiraterone is an inhibitor of CYP2D6, in vivo. In vitro studies with human hepatic microsomes showed that abiraterone has the potential to inhibit CYP1A2, CYP2D6, CYP2C8 and to a lesser extent CYP2C9, CYP2C19 and CYP3A4/5.
Structure of SKF-26754A
INHIBITOR -> METABOLIC ENZYME
Structure of METOCLOPRAMIDE
SUBSTRATE -> METABOLIC ENZYME
Structure of OSILODROSTAT
INHIBITOR -> METABOLIC ENZYME
WEAK INHIBITION
Structure of HALOPERIDOL
SUBSTRATE -> METABOLIC ENZYME
Structure of MDE
MDE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of OTESECONAZOLE
INHIBITOR -> METABOLIC ENZYME
REVERSIBLE
IC50
Structure of Belumosudil
SUBSTRATE -> METABOLIC ENZYME
Based on in vitro assessment, CYP3A4 (41.9%) was the predominant cytochrome P450 (CYP) isoform responsible for the metabolism of belumosudil although CYP2D6 (21.7%), CYP2C8 (14.2%), CYP1A2 (<5%), CYP2C19 (<5%), and UGT1A9 may also contribute to a lesser extent
Structure of VILOXAZINE
INHIBITOR -> METABOLIC ENZYME
REVERSIBLE
Structure of ESCITALOPRAM
SUBSTRATE -> METABOLIC ENZYME
Structure of RUCAPARIB
SUBSTRATE -> METABOLIC ENZYME
Structure of ISTRADEFYLLINE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of TIOTROPIUM
SUBSTRATE -> METABOLIC ENZYME
Structure of Belumosudil
INHIBITOR -> METABOLIC ENZYME
Inhibits at clinically relevant concentrations.
Structure of PITAVASTATIN
SUBSTRATE -> METABOLIC ENZYME
Structure of PALIPERIDONE
SUBSTRATE -> METABOLIC ENZYME
Structure of OXYMETAZOLINE
NON-SUBSTRATE -> METABOLIC ENZYME
Structure of FLIBANSERIN
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of OSILODROSTAT
SUBSTRATE -> METABOLIC ENZYME
Structure of CHLORAMPHENICOL
WEAK INHIBITOR->METABOLIC ENZYME
COMPETITIVE INHIBITOR
Ki
Structure of ROLAPITANT
INHIBITOR -> METABOLIC ENZYME
Structure of Desloratadine
SUBSTRATE -> METABOLIC ENZYME
Structure of ZUCLOPENTHIXOL
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of LOFEXIDINE
INHIBITOR -> METABOLIC ENZYME
Interaction with CYP2D6 substrates is not expected to be clinically significant.
MINOR
IC50
Structure of BUFURALOL
SUBSTRATE -> METABOLIC ENZYME
Structure of MECLIZINE
SUBSTRATE -> METABOLIC ENZYME
Structure of DIPHENHYDRAMINE
INHIBITOR -> METABOLIC ENZYME
POTENT
Structure of NEBIVOLOL
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of TERFENADINE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of M-CHLOROPHENYLPIPERAZINE
SUBSTRATE -> METABOLIC ENZYME
Structure of PANOBINOSTAT
INHIBITOR -> METABOLIC ENZYME
Structure of BICIFADINE
SUBSTRATE -> METABOLIC ENZYME
Structure of TRAXOPRODIL
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of TEGILERIDINE
SUBSTRATE -> METABOLIC ENZYME
Structure of CLOMIPRAMINE
SUBSTRATE -> METABOLIC ENZYME
Structure of ZIMLOVISERTIB
NON-INHIBITOR -> METABOLIC ENZYME
Structure of TAMSULOSIN
SUBSTRATE -> METABOLIC ENZYME
Structure of PITOLISANT
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of UPADACITINIB
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of PERHEXILINE
SUBSTRATE -> METABOLIC ENZYME
Structure of OLICERIDINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of ALECTINIB
SUBSTRATE -> METABOLIC ENZYME
Structure of MKC-963
SUBSTRATE -> METABOLIC ENZYME
Structure of 1-(DIMETHYLAMINO)-3-(2-(2-(3-METHOXYPHENYL)ETHYL)PHENOXY)-2-PROPANOL
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of LYS-006
NON-INHIBITOR -> METABOLIC ENZYME
IC50
Structure of TERFENADINE
SUBSTRATE -> METABOLIC ENZYME
Structure of ANANDAMIDE
SUBSTRATE -> METABOLIC ENZYME
Structure of TAFENOQUINE
SUBSTRATE -> METABOLIC ENZYME
Structure of RANOLAZINE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of METHAMPHETAMINE
SUBSTRATE -> METABOLIC ENZYME
Structure of ILOPERIDONE
SUBSTRATE -> METABOLIC ENZYME
Structure of TEGILERIDINE
INHIBITOR -> METABOLIC ENZYME
Structure of TEGASEROD
INHIBITOR -> METABOLIC ENZYME
Ki
Structure of ACT-777991
NON-SUBSTRATE -> METABOLIC ENZYME
Intentionally designed to limit CYP2D6 based metabolism
Structure of DONEPEZIL
SUBSTRATE -> METABOLIC ENZYME
Structure of METHADONE
SUBSTRATE -> METABOLIC ENZYME
Structure of TIMOLOL ANHYDROUS
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of TOLTERODINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of ELETRIPTAN
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of ALOGLIPTIN
SUBSTRATE -> METABOLIC ENZYME
Structure of CARVEDILOL
SUBSTRATE -> METABOLIC ENZYME
Structure of DELAVIRDINE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of LUSUTROMBOPAG
INHIBITOR -> TARGET
Structure of ELAGOLIX
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of PACTIMIBE
SUBSTRATE -> METABOLIC ENZYME
Structure of CEVIMELINE
SUBSTRATE -> METABOLIC ENZYME
Structure of Duloxetine
SUBSTRATE -> METABOLIC ENZYME
Structure of Amitriptyline
SUBSTRATE -> METABOLIC ENZYME
Structure of CARVEDILOL, (+)-
SUBSTRATE -> METABOLIC ENZYME
Structure of DPA-714
SUBSTRATE -> METABOLIC ENZYME
Structure of CLOZAPINE
SUBSTRATE -> METABOLIC ENZYME
Structure of NELONICLINE
SUBSTRATE -> METABOLIC ENZYME
2.1% conversion to M1
Structure of Galantamine
SUBSTRATE -> METABOLIC ENZYME
O-demethylation, mediated by CYP2D6 was greater in extensive metabolizers of CYP2D6 than in poor metabolizers
MAJOR
Structure of GEPIRONE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of VILAZODONE
INHIBITOR -> METABOLIC ENZYME
In vitro studies have shown that vilazodone is a moderate inhibitor of CYP2C19 and CYP2D6
Structure of TRICLABENDAZOLE SULFONE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of AZELASTINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of Darbinurad
SUBSTRATE -> METABOLIC ENZYME
Structure of PROMETHAZINE
INHIBITOR -> METABOLIC ENZYME
Ki
Structure of Isavuconazole
INHIBITOR -> METABOLIC ENZYME
Structure of CITALOPRAM
SUBSTRATE -> METABOLIC ENZYME
IN VITRO
Structure of TASIMELTEON
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of PHA-543613
SUBSTRATE -> METABOLIC ENZYME
Structure of MAVOGLURANT
SUBSTRATE -> METABOLIC ENZYME
Structure of PIMAVANSERIN
SUBSTRATE -> METABOLIC ENZYME
Structure of methyl-MA
SUBSTRATE -> METABOLIC ENZYME
Structure of CI-1007
SUBSTRATE -> METABOLIC ENZYME
Structure of IMRECOXIB
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of NALOXEGOL
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of TETRABENAZINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of TICLOPIDINE
INHIBITOR -> METABOLIC ENZYME
Structure of SUNEPITRON
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of BRANEBRUTINIB
INHIBITOR -> METABOLIC ENZYME
Structure of TROPISETRON
SUBSTRATE -> METABOLIC ENZYME
Structure of PF-05212377
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of MIDOMAFETAMINE
SUBSTRATE -> METABOLIC ENZYME
IN-VIVO
Structure of RISPERIDONE
SUBSTRATE -> METABOLIC ENZYME
Structure of ONDANSETRON
SUBSTRATE -> METABOLIC ENZYME
Structure of FLUOXETINE
INHIBITOR -> METABOLIC ENZYME
POTENT
Structure of PAROXETINE
INHIBITOR -> METABOLIC ENZYME
POTENT
Structure of ETORICOXIB
SUBSTRATE -> METABOLIC ENZYME
Structure of KRO-105714
SUBSTRATE -> METABOLIC ENZYME
Structure of NICOTINE
SUBSTRATE -> METABOLIC ENZYME
Structure of Berotralstat
INHIBITOR -> METABOLIC ENZYME
MODERATE
Structure of ELIGLUSTAT
INHIBITOR -> METABOLIC ENZYME
Eliglustat also exhibited time-dependent inhibition (TDI) of CYP2D6.
Ki
Structure of OSU-6162
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of MDMC
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of CARVEDILOL, (-)-
SUBSTRATE -> METABOLIC ENZYME
Structure of ORANTINIB
SUBSTRATE -> METABOLIC ENZYME
Structure of Teriflunomide
NON-SUBSTRATE -> METABOLIC ENZYME
Structure of TZB-30878
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of FLUVOXAMINE
SUBSTRATE -> METABOLIC ENZYME
Structure of DEUTETRABENAZINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of SIMEPREVIR
INHIBITOR -> METABOLIC ENZYME
CYP2C8
IC50
Structure of TRAMADOL
SUBSTRATE -> METABOLIC ENZYME
Structure of ENASIDENIB
SUBSTRATE -> METABOLIC ENZYME
Structure of VENLAFAXINE
SUBSTRATE -> METABOLIC ENZYME
Structure of .ALPHA.-PYRROLIDINOPENTIOPHENONE
SUBSTRATE -> METABOLIC ENZYME
Structure of EPINASTINE
SUBSTRATE -> METABOLIC ENZYME
Structure of PANOBINOSTAT
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of LORCASERIN
SUBSTRATE -> METABOLIC ENZYME
Structure of SARPOGRELATE
INHIBITOR -> METABOLIC ENZYME
COMPETITIVE INHIBITOR
IC50
Structure of NE-100 FREE BASE
SUBSTRATE -> METABOLIC ENZYME
Structure of SELICICLIB
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of CAPSAICIN
SUBSTRATE -> METABOLIC ENZYME
WEAK
Structure of ELIGLUSTAT
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of 4'-METHYL-.ALPHA.-PYRROLIDINOBUTIOPHENONE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of DESIPRAMINE
SUBSTRATE -> METABOLIC ENZYME
Structure of VELIPARIB
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of NAPHTHALENE
SUBSTRATE -> METABOLIC ENZYME
Structure of Bortezomib
SUBSTRATE -> METABOLIC ENZYME
Structure of 5-METHOXY-N,N-DIISOPROPYLTRYPTAMINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of REVEFENACIN
SUBSTRATE -> METABOLIC ENZYME
Structure of Dextromethorphan
SUBSTRATE -> METABOLIC ENZYME
Structure of APIXABAN
NON-INHIBITOR -> METABOLIC ENZYME
Structure of ENZALUTAMIDE
INHIBITOR -> METABOLIC ENZYME
Structure of Orbitazine
SUBSTRATE -> METABOLIC ENZYME
Structure of OMEPRAZOLE
SUBSTRATE -> METABOLIC ENZYME
Structure of Rifamycin
INHIBITOR -> METABOLIC ENZYME
Rifamycin is an inhibitor of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4/5 in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose clinically relevant inhibition of these enzymes in vivo is unlikely.
Structure of N-(3-METHOXYPROPYL)-1-PHENYLCYCLOHEXANAMINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of ALVAMELINE
SUBSTRATE -> METABOLIC ENZYME
Structure of LAFADOFENSINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of EZLOPITANT
SUBSTRATE -> METABOLIC ENZYME
Structure of Brilaroxazine
SUBSTRATE -> METABOLIC ENZYME
HUMAN LIVER
TISSUE EXPRESSION -> PARENT
Structure of AMIODARONE
INHIBITOR -> METABOLIC ENZYME
POTENT
Structure of DEBRISOQUIN
SUBSTRATE -> METABOLIC ENZYME
Structure of CHLOROQUINE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of Desfesoterodine
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of RIVOCERANIB
SUBSTRATE -> METABOLIC ENZYME
Structure of Desloratadine
INHIBITOR -> METABOLIC ENZYME
WEAK
Structure of TEMSIROLIMUS
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of APOMORPHINE
SUBSTRATE -> METABOLIC ENZYME
Structure of VECABRUTINIB
SUBSTRATE -> METABOLIC ENZYME
Structure of COBIMETINIB
INHIBITOR -> METABOLIC ENZYME
Cobimetinib is a reversible inhibitor of CYP3A4 and CYP2D6 in vitro.
REVERSIBLE
Structure of 2-AMINOTHIAZOLOBENZAZEPINE
SUBSTRATE -> METABOLIC ENZYME
Structure of Pralsetinib
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of Norquetiapine
SUBSTRATE -> METABOLIC ENZYME
Structure of LUMEFANTRINE
INHIBITOR -> METABOLIC ENZYME
In vitro, lumefantrine significantly inhibits the activity of CYP2D6 at therapeutic plasma concentrations
Structure of LETERMOVIR
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of REBOXETINE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of Gabapentin enacarbil
NON-SUBSTRATE -> METABOLIC ENZYME
Structure of BMS-690514
SUBSTRATE -> METABOLIC ENZYME
Structure of UMECLIDINIUM
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of MEQUITAZINE
SUBSTRATE -> METABOLIC ENZYME
Structure of MIANSERIN
SUBSTRATE -> METABOLIC ENZYME
Structure of GDC-0425
SUBSTRATE -> METABOLIC ENZYME
Structure of CODEINE ANHYDROUS
SUBSTRATE -> METABOLIC ENZYME
Structure of DELAVIRDINE
INDUCER -> METABOLIC ENZYME
Structure of METHOXYCHLOR
SUBSTRATE -> METABOLIC ENZYME
Structure of Mebufotenin
SUBSTRATE -> METABOLIC ENZYME
Structure of RITONAVIR
INHIBITOR -> METABOLIC ENZYME
POTENT
Structure of TRAZODONE
SUBSTRATE -> METABOLIC ENZYME
Structure of TERBINAFINE
INHIBITOR -> METABOLIC ENZYME
POTENT
Structure of ETHYLMORPHINE
SUBSTRATE -> METABOLIC ENZYME
Structure of GOSOGLIPTIN
SUBSTRATE -> METABOLIC ENZYME
Structure of NORTRIPTYLINE
SUBSTRATE -> METABOLIC ENZYME
Structure of (+)-?-Dihydrotetrabenazine
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of TELITHROMYCIN
INHIBITOR -> METABOLIC ENZYME
Ki
Structure of CINACALCET
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of VILOXAZINE
SUBSTRATE -> METABOLIC ENZYME
Structure of Olanzapine
SUBSTRATE -> METABOLIC ENZYME
Structure of ATOMOXETINE
SUBSTRATE -> METABOLIC ENZYME
Structure of Istisociclib
NON-INHIBITOR -> METABOLIC ENZYME
IC50
Structure of RETAPAMULIN
SUBSTRATE -> METABOLIC ENZYME
MINOR

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
Heme binding [1_443] CYS HEME-CYSTEINE (OXIDIZED) G0HAF1JK3T
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
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