U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C25H29I2NO3
Molecular Weight 645.3116
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMIODARONE

SMILES

CCCCC1=C(C(=O)C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)C3=C(O1)C=CC=C3

InChI

InChIKey=IYIKLHRQXLHMJQ-UHFFFAOYSA-N
InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C25H29I2NO3
Molecular Weight 645.3116
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/pro/amiodarone.html | DOI: 10.1007/978-1-4613-2827-8_26

Amiodarone is an antiarrhythmic with mainly class III properties, but it possesses electrophysiologic characteristics of all four Vaughan Williams classes. Like class I drugs, amiodarone blocks sodium channels at rapid pacing frequencies, and like class II drugs, amiodarone exerts a noncompetitive antisympathetic action. In addition to blocking sodium channels, amiodarone blocks myocardial potassium channels, which contributes to slowing of conduction and prolongation of refractoriness. It is indicated for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. The most common adverse reactions (1-2%) leading to discontinuation of intravenous amiodarone therapy are hypotension, asystole/cardiac arrest/pulseless electrical activity, VT, and cardiogenic shock. Other important adverse reactions are, torsade de pointes (TdP), congestive heart failure, and liver function test abnormalities. Fluoroquinolones, macrolide antibiotics, and azoles are known to cause QTc prolongation. There have been reports of QTc prolongation, with or without TdP, in patients taking amiodarone when fluoroquinolones, macrolide antibiotics, or azoles were administered concomitantly. Since amiodarone is a substrate for CYP3A and CYP2C8, drugs/substances that inhibit these isoenzymes may decrease the metabolism and increase serum concentration of amiodarone.

CNS Activity

Curator's Comment: The penetration of amiodarone into brain is poor.

Originator

Sources: DOI; 10.1007/978-1-4613-2827-8_26

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PACERONE

Approved Use

Amiodarone injection is indicated for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation (VF) and hemodynamically unstable ventricular tachycardia (VT) in patients refractory to other therapy. Amiodarone also can be used to treat patients with VT/VF for whom oral amiodarone is indicated, but who are unable to take oral medication. During or after treatment with amiodarone, patients may be transferred to oral amiodarone therapy.

Launch Date

8.9389439E11
Primary
PACERONE

Approved Use

Amiodarone injection is indicated for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation (VF) and hemodynamically unstable ventricular tachycardia (VT) in patients refractory to other therapy. Amiodarone also can be used to treat patients with VT/VF for whom oral amiodarone is indicated, but who are unable to take oral medication. During or after treatment with amiodarone, patients may be transferred to oral amiodarone therapy [ see Dosage and Administration (2)

Launch Date

8.9389439E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
23.8 ng/mL
2.5 mg/kg single, intravenous
dose: 2.5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DESETHYLAMIODARONE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
13660 ng/mL
5 mg/kg single, intravenous
dose: 5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
AMIODARONE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
2920 ng/mL
1.25 mg/kg single, intravenous
dose: 1.25 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
AMIODARONE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
7140 ng/mL
2.5 mg/kg single, intravenous
dose: 2.5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
AMIODARONE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
41.2 ng/mL
5 mg/kg single, intravenous
dose: 5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DESETHYLAMIODARONE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
9 ng/mL
1.25 mg/kg single, intravenous
dose: 1.25 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DESETHYLAMIODARONE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
1.7 mg/L
800 mg single, oral
dose: 800 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
AMIODARONE serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
16600 ng × h/mL
5 mg/kg single, intravenous
dose: 5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
AMIODARONE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
3600 ng × h/mL
1.25 mg/kg single, intravenous
dose: 1.25 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
AMIODARONE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
8100 ng × h/mL
2.5 mg/kg single, intravenous
dose: 2.5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
AMIODARONE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
16900 ng × h/mL
5 mg/kg single, intravenous
dose: 5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DESETHYLAMIODARONE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
14.6 day
5 mg/kg single, intravenous
dose: 5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
AMIODARONE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
14.2 day
5 mg/kg single, intravenous
dose: 5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
DESETHYLAMIODARONE serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
4.62 h
800 mg single, oral
dose: 800 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
AMIODARONE serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
0.023%
200 mg 1 times / day multiple, oral
dose: 200 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
AMIODARONE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Overview

OverviewOther

Other InhibitorOther SubstrateOther Inducer







Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes [IC50 15 uM]
yes (co-administration study)
Comment: reversible inhibition; The area under the plasma concentration-time curve (AUC) of metoprolol increased from 767 before to 1,387 ug * hours/L after the amiodarone loading dose
yes [IC50 5.48 uM]
yes [IC50 >50 uM]
yes (co-administration study)
Comment: reversible inhibition; After treatment with 3 g amiodarone (phase I), this parameter (AUC of lidocaine) increased to 135.3 ± 34.6 (p = 0.016), whereas the AUC of MEGEX decreased from 19.2 ± 6.5 to 15.8 ± 8.3 μg/min/ml (p = 0.04).
yes [IC50 >50 uM]
yes (co-administration study)
Comment: reversible inhibition; The mean warfarin AUC during the amiodarone regimen increased to 200% of the control value of anticoagulant alone, from 624 ± 59 Rg/ml-hr to 1249 ± 115 p,g/ml-hr, a significant difference
yes [IC50 >50 uM]
yes (co-administration study)
Comment: reversible inhibition; The mean warfarin AUC during the amiodarone regimen increased to 200% of the control value of anticoagulant alone, from 624 ± 59 Rg/ml-hr to 1249 ± 115 p,g/ml-hr, a significant difference
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
yes
likely (co-administration study)
Comment: CYP450 inhibitors: grapefruit juice, certain fluoroquinolone and macrolide antibiotics, azole antifungals, cimetidine, certain protease inhibitors: increased exposure of amiodarone. Avoid concomitant use. CYP450 inducers (St. John's Wort): reduced amiodarone serum levels
yes
likely (co-administration study)
Comment: CYP450 inhibitors: grapefruit juice, certain fluoroquinolone and macrolide antibiotics, azole antifungals, cimetidine, certain protease inhibitors: increased exposure of amiodarone. Avoid concomitant use. CYP450 inducers (St. John's Wort): reduced amiodarone serum levels
yes
likely (co-administration study)
Comment: CYP450 inhibitors: grapefruit juice, certain fluoroquinolone and macrolide antibiotics, azole antifungals, cimetidine, certain protease inhibitors: increased exposure of amiodarone. Avoid concomitant use. CYP450 inducers (St. John's Wort): reduced amiodarone serum levels
yes
likely (co-administration study)
Comment: CYP450 inhibitors: grapefruit juice, certain fluoroquinolone and macrolide antibiotics, azole antifungals, cimetidine, certain protease inhibitors: increased exposure of amiodarone. Avoid concomitant use. CYP450 inducers (St. John's Wort): reduced amiodarone serum levels
Page: 9.0
yes
likely (co-administration study)
Comment: CYP450 inhibitors: grapefruit juice, certain fluoroquinolone and macrolide antibiotics, azole antifungals, cimetidine, certain protease inhibitors: increased exposure of amiodarone. Avoid concomitant use. CYP450 inducers (St. John's Wort): reduced amiodarone serum levels
yes
likely (co-administration study)
Comment: CYP450 inhibitors: grapefruit juice, certain fluoroquinolone and macrolide antibiotics, azole antifungals, cimetidine, certain protease inhibitors: increased exposure of amiodarone. Avoid concomitant use. CYP450 inducers (St. John's Wort): reduced amiodarone serum levels
Page: 9.0
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
Acute fatal vasoplegia and asystole induced by intravenous amiodarone after cardiopulmonary bypass in a patient with preoperative cardiogenic shock.
1999 Dec
[Amiodarone induced retrobulbar neuritis. Clinical case].
1999 Jul
Efficacy and safety of intravenous amiodarone in recent-onset atrial fibrillation: experience in patients admitted to a general internal medicine department.
1999 May
Effects of chronic treatment by amiodarone on transmural heterogeneity of canine ventricular repolarization in vivo: interactions with acute sotalol.
1999 Nov
[Medication-induced vocal cord paralysis as an uncommon cause of cord paralysis].
1999 Sep
Meglumine antimoniate, amiodarone and torsades de pointes: a case report.
1999 Sep
Catheter ablation of atrial flutter due to amiodarone therapy for paroxysmal atrial fibrillation.
2000 Apr
Depressed heart rate variability identifies postinfarction patients who might benefit from prophylactic treatment with amiodarone: a substudy of EMIAT (The European Myocardial Infarct Amiodarone Trial).
2000 Apr
[Toxic hepatitis caused by intravenous amiodarone].
2000 Dec 9
Ocular toxicity of systemic medications: a case series.
2000 Jan
Oral amiodarone increases the efficacy of direct-current cardioversion in restoration of sinus rhythm in patients with chronic atrial fibrillation.
2000 Jan
Positive Coombs' test results in two dogs treated with amiodarone.
2000 Jun 15
Cardiovascular studies on different classes of soft drugs.
2000 Mar
Amiodarone pulmonary, neuromuscular and ophthalmological toxicity.
2000 Mar-Apr
Polymorphic ventricular tachycardia after use of intravenous amiodarone for postoperative junctional ectopic tachycardia.
2000 Nov-Dec
Hemodynamic and antiadrenergic effects of dronedarone and amiodarone in animals with a healed myocardial infarction.
2000 Sep
Protection against drug- and chemical-induced multiorgan toxicity by a novel IH636 grape seed proanthocyanidin extract.
2001
The effects of amiodarone on the thyroid.
2001 Apr
[Radiofrequency catheter ablation in children with Wolff-Parkinson-White syndrome and sudden cardiac death who had been resuscitated].
2001 Apr
Structure-activity relationships and electrophysiological effects of short-acting amiodarone homologs in guinea pig isolated heart.
2001 Apr
Amiodarone stimulates interleukin-6 production in cultured human thyrocytes, exerting cytotoxic effects on thyroid follicles in suspension culture.
2001 Feb
Oral anticoagulants. Pharmacologic issues for use in the elderly.
2001 Feb
Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport.
2001 Feb
Differential effects of dofetilide, amiodarone, and class lc drugs on left and right atrial refractoriness and left atrial vulnerability in pigs.
2001 Feb
Single oral loading dose of propafenone for pharmacological cardioversion of recent-onset atrial fibrillation.
2001 Feb
Coronary artery revascularization in patients with sustained ventricular arrhythmias in the chronic phase of a myocardial infarction: effects on the electrophysiologic substrate and outcome.
2001 Feb
Pharmacologic management of atrial fibrillation: current therapeutic strategies.
2001 Feb
Metabolism of amiodarone (part I): identification of a new hydroxylated metabolite of amiodarone.
2001 Feb
Impressive amelioration of clinical (NYHA class) and echocardiographic parameters in heart failure patients treated with amiodarone and carvedilol.
2001 Jan
Predictors of failure of transoesophageal cardioversion of common atrial flutter.
2001 Jan
[How I treat...persistent atrial fibrillation, by internal cardioversion, in a patient with exreme obesity].
2001 Jan
[Incidence and timing of thyroid dysfunction with long-term amiodarone therapy].
2001 Jan
Amiodarone-induced thyrotoxicosis.
2001 Jan
Development of heart failure in bradycardic sick sinus syndrome.
2001 Jan
Thyroidectomy for selected patients with thyrotoxicosis.
2001 Jan
The frequency analysis of signal-averaged ECG of P wave as predictor of efficacy of class III antiarrhythmic drugs to maintain sinus rhythm in recurrent idiopathic atrial fibrillation.
2001 Jan
The effect of amiodarone and/or antioxidant treatment on splenocyte blast transformation.
2001 Jan
Heart rate variability and early recurrence of atrial fibrillation after electrical cardioversion.
2001 Jan
Arrhythmogenic right ventricular dysplasia.
2001 Jan
Amiodarone is safe and highly effective therapy for supraventricular tachycardia in infants.
2001 Jan
Antiarrhythmic drugs in pregnancy.
2001 Jan
"Stable" ventricular tachycardia is not a benign rhythm : insights from the antiarrhythmics versus implantable defibrillators (AVID) registry.
2001 Jan 16
Amiodarone-induced hyperthyroidism.
2001 Jan 22
[Diagnostic quiz. Increasing dyspnea after bypass operation. Interstitial lung disease].
2001 Jan 25
Risk of torsades de pointes with non-cardiac drugs. Prolongation of QT interval is probably a class effect of fluoroquinolones.
2001 Jan 6
Moxifloxacin: clinical efficacy and safety.
2001 Mar 1
[Hyperthyroidism and heart].
2001 Mar 15
Visual compatibility of amiodarone hydrochloride injection with various intravenous drugs.
2001 Mar 15
Oral amiodarone for prevention of atrial fibrillation after open heart surgery, the Atrial Fibrillation Suppression Trial (AFIST): a randomised placebo-controlled trial.
2001 Mar 17
Short- and long-term effects of amiodarone on the two components of cardiac delayed rectifier K(+) current.
2001 Mar 6
Patents

Sample Use Guides

Intravenous: Initial dose: 1000 mg over the first 24 hours of therapy, delivered by the following infusion regimen: -Loading infusions: 150 mg over the first 10 minutes (15 mg/min), followed by 360 mg over the next 6 hours (1 mg/min) -Maintenance infusion: 540 mg over the remaining 18 hours (0.5 mg/min) Maintenance dose: After the first 24 hours, continue the maintenance infusion rate of 0.5 mg/min; may increase infusion rate to achieve effective arrhythmia suppression. -Supplemental infusions: 150 mg over 10 minutes (15 mg/min) for breakthrough episodes of ventricular fibrillation (VF) or hemodynamically unstable ventricular tachycardia(VT) Maximum dose: Initial infusion rate: 30 mg/min Oral: Loading dose: 800 to 1600 mg orally per day for 1 to 3 weeks (occasionally longer) until adequate arrhythmia control is achieved or if side effects become prominent, then switch to adjustment dose Adjustment dose: 600 to 800 mg orally per day for 1 month, then switch to maintenance dose Maintenance dose: 400 mg orally per day
Route of Administration: Other
In Vitro Use Guide
At concentrations ranging from 75-200 uM, amiodarone induced a significant and dose-dependent release of 51Cr in FRTL-5 cells. In the same molar concentrations, amiodarone was also cytotoxic in CHO cells. In hTF, the release of 51Cr produced by amiodarone occurred at a lower concentration (37.5 vs. 75 uM) and was significantly greater than that in FRTL-5 cells.
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:55:18 UTC 2023
Edited
by admin
on Wed Jul 05 22:55:18 UTC 2023
Record UNII
N3RQ532IUT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMIODARONE
INN   MART.   MI   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
AMIODARONE [MI]
Common Name English
AMIODARONE [VANDF]
Common Name English
AMIODARONE [USAN]
Common Name English
AMIODARONE [MART.]
Common Name English
2-Butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone
Systematic Name English
Amiodarone [WHO-DD]
Common Name English
amiodarone [INN]
Common Name English
METHANONE, (2-BUTYL-3-BENZOFURANYL)(4-(2-(DIETHYLAMINO)ETHOXY)-3,5-DIIODOPHENYL)-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C47793
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
UCSF-FDA TRANSPORTAL AMIODARONE
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
WHO-VATC QC01BD01
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
FDA ORPHAN DRUG 70292
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
NDF-RT N0000175426
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
WHO-ESSENTIAL MEDICINES LIST 12.2
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
NCI_THESAURUS C93038
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
LIVERTOX NBK548109
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
WHO-ATC C01BD01
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
Code System Code Type Description
SMS_ID
100000089825
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
EPA CompTox
DTXSID7022592
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
IUPHAR
2566
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
NDF-RT
N0000182141
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY Cytochrome P450 3A4 Inhibitors [MoA]
MESH
D000638
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
DRUG BANK
DB01118
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
FDA UNII
N3RQ532IUT
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
RXCUI
703
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY RxNorm
ECHA (EC/EINECS)
217-772-1
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
WIKIPEDIA
AMIODARONE
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
DRUG CENTRAL
176
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
NDF-RT
N0000182138
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY Cytochrome P450 1A2 Inhibitors [MoA]
CAS
1951-25-3
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
EVMPD
SUB05451MIG
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
PUBCHEM
2157
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
NCI_THESAURUS
C62002
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
NDF-RT
N0000185503
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY P-Glycoprotein Inhibitors [MoA]
DAILYMED
N3RQ532IUT
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
CHEBI
2663
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
ChEMBL
CHEMBL633
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
NDF-RT
N0000185504
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY Cytochrome P450 2C9 Inhibitors [MoA]
MERCK INDEX
M1748
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY Merck Index
NDF-RT
N0000182137
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY Cytochrome P450 2D6 Inhibitors [MoA]
LACTMED
Amiodarone
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
INN
2012
Created by admin on Wed Jul 05 22:55:18 UTC 2023 , Edited by admin on Wed Jul 05 22:55:18 UTC 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
TRANSPORTER -> INHIBITOR
TARGET -> INHIBITOR
METABOLIC ENZYME -> INHIBITOR
POTENT
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
ACTIVE AT HIGH CONCENTRATIONS; AMIODARONE CONCENTRATES IN THE LIVER
MAJOR
METABOLIC ENZYME -> INHIBITOR
POTENT
TARGET -> INHIBITOR
BINDER->LIGAND
BINDING
METABOLIC ENZYME -> INHIBITOR
POTENT
Related Record Type Details
METABOLITE -> PARENT
BILE
METABOLITE ACTIVE -> PARENT
MAJOR
METABOLITE -> PARENT
BILE
METABOLITE -> PARENT
BILE
METABOLITE -> PARENT
BILE
METABOLITE -> PARENT
BILE
METABOLITE ACTIVE -> PARENT
MAJOR
METABOLITE -> PARENT
BILE
METABOLITE -> PARENT
BILE
METABOLITE -> PARENT
MAJOR
BILE
METABOLITE -> PARENT
BILE
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC