Inxight Drugs

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Development Status

Investigational

10,302

Other

116,270

Possibly Marketed Outside US

10,589

US Approved Rx

1,800

US Previously Marketed

1,479

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Primary Target

Vascular endothelial growth factor receptor 2

31

DNA

28

Dopamine D2 receptor

26

Peroxisome proliferator-activated receptor gamma

26

Serotonin 1a (5-HT1a) receptor

26

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Highest Phase

Phase II

512

Phase III

218

Phase I

215

Not Provided

82

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Approval Year

Unknown

10,302

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Condition

Unknown

129

Cancer

91

Breast cancer

87

Non-small cell lung cancer

74

Solid tumors

74

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Treatment Modality

Primary

1,071

Palliative

60

Curative

57

Preventing

50

Diagnostic

26

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CNS Activity

CNS Active

430

CNS Penetrant

200

CNS Non-penetrant

38

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Originator

Pfizer

93

GlaxoSmithKline

64

Eli Lilly

48

AstraZeneca

47

Novartis

44

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Substance Class

Chemical

7,260

Protein

1,879

Structurally Diverse

533

Nucleic Acid

227

Concept

205

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INN Stem

Monoclonal antibodies(-mab)

191

Tyrosine-kinase inhibitors(-tinib)

103

Peptides and glycopeptides(-tide)

92

Chemical substance(-ine)

91

Gene Therapy vectors(-vec)

80

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GInAS Tag

KEW

41

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Code System

FDA UNII

10,302

CAS

9,514

SMS_ID

8,022

NCI_THESAURUS

8,000

PUBCHEM

7,239

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Protein Type

MONOCLONAL ANTIBODY

847

PEPTIDE

137

MONOCLONAL ANTIBODY CONJUGATE

129

BISPECIFIC ANTIBODY

120

FUSION PROTEIN

50

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Substance Form

Principal Form

10,302

Salts, Hydrates, Esters, etc.

3,199

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Showing 1 - 10 of 10,302 results

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rel-(3R,5S,6E)-7-[2-(4-Fluoro-3-methylphenyl)-4,4,6,6-tetramethyl-1-cyclohexen-1-yl]-3,5-dihydroxy-6-heptenoic acid

XW8UFD4YLA

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Status:

Investigational

Class (Stereo):

CHEMICAL (RACEMIC)

Dalvastatin is a synthetic HMG-CoA reductase inhibitor developed by Rhône-Poulenc Rorer. Dalvastatin is a prodrug and is itself an inactive lactone. After oral ingestion, the drug is hydrolyzed in vivo to the corresponding beta-hydroxy acid, which is...

the pharmacologically active form. HMG-CoA reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway. An active form of dalvastatin inhibits HMG-CoA reductase with IC50 of 3.4 nM. In ex vivo assay, orally administered dalvastatin inhibited cholesterol biosynthesis in rat liver slices with an ED50 value of 0.9. The efficacy of dalvastatin to lower cholesterol was investigated in the clinical trials in the 1990s, but no results were reported.

Teprosulvose

WV7377RGM8

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Status:

Investigational

Class (Stereo):

CHEMICAL (ABSOLUTE)

Ratutrelvir

VR2S5588W2

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Status:

Investigational

Class (Stereo):

CHEMICAL (EPIMERIC)

Zeprumetostat

XLJ9D8HE8Y

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Gadosircoclamide

7V6P6PCM4U

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

AZAPENTACENE DISULFONIC ACID

SE786BV9SY

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Filricianine

CI4MD9KLX8

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Status:

Investigational

Class (Stereo):

CHEMICAL (RACEMIC)

Segatroxaban

53FM6EUY9U

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Status:

Investigational

Class (Stereo):

CHEMICAL (ABSOLUTE)

Pudafensine

L9NG7US8GE

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Cambritaxestat

LYY3P2KA27

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Status:

Investigational

Class (Stereo):

CHEMICAL (ABSOLUTE)

Showing 1 - 10 of 10,302 results

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