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Details

Stereochemistry ACHIRAL
Molecular Formula C23H25I2NO3
Molecular Weight 617.2584
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DESETHYLAMIODARONE

SMILES

CCCCC1=C(C(=O)C2=CC(I)=C(OCCNCC)C(I)=C2)C3=CC=CC=C3O1

InChI

InChIKey=VXOKDLACQICQFA-UHFFFAOYSA-N
InChI=1S/C23H25I2NO3/c1-3-5-9-20-21(16-8-6-7-10-19(16)29-20)22(27)15-13-17(24)23(18(25)14-15)28-12-11-26-4-2/h6-8,10,13-14,26H,3-5,9,11-12H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C23H25I2NO3
Molecular Weight 617.2584
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Amiodarone N-deethylation in human liver microsomes: involvement of cytochrome P450 3A enzymes (first report).
1993
Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone beta 1-receptor protein.
1994 Apr
Effects of triiodothyronine and amiodarone on the promoter of the human LDL receptor gene.
1998 Aug 19
Desethylamiodarone interferes with the binding of co-activator GRIP-1 to the beta 1-thyroid hormone receptor.
2000 Sep 22
Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport.
2001 Feb
Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence.
2003 Feb
Amiodarone induces angiotensinogen gene expression in lung alveolar epithelial cells through activation protein-1.
2007 Jan
The effect of beta-naphthoflavone on the metabolism of amiodarone by hepatic and extra-hepatic microsomes.
2010 Jun 2
Mechanisms of amiodarone and desethylamiodarone cytotoxicity in nontransformed human peripheral lung epithelial cells.
2011 Feb
Substance Class Chemical
Created
by admin
on Sat Dec 16 18:57:04 UTC 2023
Edited
by admin
on Sat Dec 16 18:57:04 UTC 2023
Record UNII
M31FU99E3Y
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DESETHYLAMIODARONE
Common Name English
AMIODARONE RELATED COMPOUND D [USP-RS]
Common Name English
Desethylaminodarone [WHO-DD]
Common Name English
N-DEETHYLAMIODARONE
Common Name English
(2-BUTYLBENZOFURAN-3-YL)(4-(2-(ETHYLAMINO)ETHOXY)-3,5-DIIODOPHENYL)METHANONE
Systematic Name English
AMIODARONE RELATED COMPOUND D
Common Name English
LB 33020
Code English
DEETHYLAMIODARONE
Common Name English
AMIODARONE METABOLITE M7
Common Name English
N-MONODESETHYLAMIODARONE
Common Name English
DESETHYLAMINODARONE
WHO-DD  
Common Name English
LB-33020
Code English
N-DESETHYLAMIODARONE
Common Name English
METHANONE, (2-BUTYL-3-BENZOFURANYL)(4-(2-(ETHYLAMINO)ETHOXY)-3,5-DIIODOPHENYL)-
Systematic Name English
AMIODARONE HYDROCHLORIDE IMPURITY B [EP IMPURITY]
Common Name English
DAMI
Common Name English
Code System Code Type Description
MESH
C036116
Created by admin on Sat Dec 16 18:57:04 UTC 2023 , Edited by admin on Sat Dec 16 18:57:04 UTC 2023
PRIMARY
EPA CompTox
DTXSID00232344
Created by admin on Sat Dec 16 18:57:04 UTC 2023 , Edited by admin on Sat Dec 16 18:57:04 UTC 2023
PRIMARY
CAS
83409-32-9
Created by admin on Sat Dec 16 18:57:04 UTC 2023 , Edited by admin on Sat Dec 16 18:57:04 UTC 2023
PRIMARY
RS_ITEM_NUM
1027346
Created by admin on Sat Dec 16 18:57:04 UTC 2023 , Edited by admin on Sat Dec 16 18:57:04 UTC 2023
PRIMARY
FDA UNII
M31FU99E3Y
Created by admin on Sat Dec 16 18:57:04 UTC 2023 , Edited by admin on Sat Dec 16 18:57:04 UTC 2023
PRIMARY
PUBCHEM
104774
Created by admin on Sat Dec 16 18:57:04 UTC 2023 , Edited by admin on Sat Dec 16 18:57:04 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> METABOLITE ACTIVE
MAJOR
Related Record Type Details
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP