DESETHYLAMIODARONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H25I2NO3
Molecular Weight	617.2584
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC1=C(C(=O)C2=CC(I)=C(OCCNCC)C(I)=C2)C3=CC=CC=C3O1

InChI

InChIKey=VXOKDLACQICQFA-UHFFFAOYSA-N

InChI=1S/C23H25I2NO3/c1-3-5-9-20-21(16-8-6-7-10-19(16)29-20)22(27)15-13-17(24)23(18(25)14-15)28-12-11-26-4-2/h6-8,10,13-14,26H,3-5,9,11-12H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C23H25I2NO3
Molecular Weight	617.2584
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Amiodarone N-deethylation in human liver microsomes: involvement of cytochrome P450 3A enzymes (first report).	1993	8445979
Desethylamiodarone is a competitive inhibitor of the binding of thyroid hormone to the thyroid hormone alpha 1-receptor protein.	1995 Jul	7589780
Desethylamiodarone interferes with the binding of co-activator GRIP-1 to the beta 1-thyroid hormone receptor.	2000 Sep 22	11007966
Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport.	2001 Feb	11231118
Amiodarone and N-desethylamiodarone enhance endothelial nitric oxide production in human endothelial cells.	2006 Jan	16479044
Amiodarone analog-dependent effects on CYP2C9-mediated metabolism and kinetic profiles.	2006 Oct	16815961

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:57:04 GMT 2023` Edited by `admin` on `Sat Dec 16 18:57:04 GMT 2023`
Record UNII	M31FU99E3Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DESETHYLAMIODARONE

Common Name

English

AMIODARONE RELATED COMPOUND D [USP-RS]

Common Name

English

Desethylaminodarone [WHO-DD]

Common Name

English

N-DEETHYLAMIODARONE

Common Name

English

(2-BUTYLBENZOFURAN-3-YL)(4-(2-(ETHYLAMINO)ETHOXY)-3,5-DIIODOPHENYL)METHANONE

Systematic Name

English

AMIODARONE RELATED COMPOUND D

Common Name

English

LB 33020

Code

English

DEETHYLAMIODARONE

Common Name

English

AMIODARONE METABOLITE M7

Common Name

English

N-MONODESETHYLAMIODARONE

Common Name

English

DESETHYLAMINODARONE

Common Name

English

LB-33020

Code

English

N-DESETHYLAMIODARONE

Common Name

English

METHANONE, (2-BUTYL-3-BENZOFURANYL)(4-(2-(ETHYLAMINO)ETHOXY)-3,5-DIIODOPHENYL)-

Systematic Name

English

AMIODARONE HYDROCHLORIDE IMPURITY B [EP IMPURITY]

Common Name

English

DAMI

Common Name

English

Code System Code Type Description

MESH

C036116