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Approval Year

Unknown
116683
Substance Class Protein
Created
by admin
on Fri Jun 25 21:41:46 UTC 2021
Edited
by admin
on Fri Jun 25 21:41:46 UTC 2021
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
SEV29N8JND
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2
Common Name English
H-ERG
Common Name English
ETHER-A-GO-GO-RELATED GENE POTASSIUM CHANNEL 1
Common Name English
HERG
Common Name English
HERG-1
Common Name English
Code System Code Type Description
FDA UNII
SEV29N8JND
Created by admin on Fri Jun 25 21:41:46 UTC 2021 , Edited by admin on Fri Jun 25 21:41:46 UTC 2021
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_598
Related Record Type Details
Structure of N-DESMETHYLAPALUTAMIDE
INHIBITOR->OFF-TARGET
Structure of BMS-986142
INHIBITOR->OFF-TARGET
Structure of LUXEPTINIB
INHIBITOR->OFF-TARGET
IC50
Structure of DESMETHYLASTEMIZOLE
INHIBITOR->OFF-TARGET
MIK-665
NON-INHIBITOR->OFF TARGET
Structure of AVAPRITINIB
INHIBITOR->OFF-TARGET
Structure of BEDAQUILINE
INHIBITOR->OFF-TARGET
IC50
Structure of APOMORPHINE
INHIBITOR->OFF-TARGET
Structure of AVANAFIL
INHIBITOR->OFF-TARGET
Avanafil inhibited hERG current in a concentration-dependent manner with IC50 of 15.8 ?M, which corresponded to exposures approximately 290-fold above the unbound Cmax (~26 ng/mL, 0.054 ?M) in human subjects after the maximum recommended single oral dose at 200 mg.
IC50
Structure of ASTEMIZOLE
INHIBITOR->OFF-TARGET
Structure of APALUTAMIDE
INHIBITOR->OFF-TARGET
Structure of AMIODARONE
INHIBITOR -> TARGET
Structure of POSELTINIB
INHIBITOR->OFF-TARGET
Structure of LORLATINIB
NON-INHIBITOR->OFF TARGET
did not predict QTc prolongation, by inhibition of the hERG channel at clinically relevant concentrations
Structure of ACALABRUTINIB
NON-INHIBITOR->OFF TARGET
Structure of TAFENOQUINE
INHIBITOR -> TARGET
IC50
Structure of TECASTEMIZOLE
INHIBITOR->OFF-TARGET
Structure of CEP-40783
NON-INHIBITOR->OFF TARGET
Structure of SSR-181507
INHIBITOR->OFF-TARGET
Structure of NETARSUDIL
INHIBITOR->OFF-TARGET
Structure of MORPHOTHIADINE
INHIBITOR->OFF-TARGET
IC50
ERVOGASTAT
NON-INHIBITOR->OFF TARGET
Structure of E-4031
INHIBITOR -> TARGET
Structure of BETRIXABAN
INHIBITOR->OFF-TARGET
MIK-665
TRANSPORTER -> NON-INHIBITOR
Structure of W-18
INHIBITOR -> TARGET
HM-43239
INHIBITOR->OFF-TARGET
Structure of TP-3654
NON-INHIBITOR->OFF TARGET
IC50
Structure of AZD-1390
INHIBITOR->OFF-TARGET
IC50
Structure of RISDIPLAM
NON-INHIBITOR->OFF TARGET
VEBRELTINIB
INHIBITOR -> TRANSPORTER
Structure of N-MONODESMETHYL BEDAQUILINE
INHIBITOR->OFF-TARGET
MAY BE RESPONSIBLE FOR QT PROLONGATION
IC50
Structure of TD-2749
NON-INHIBITOR->OFF TARGET
9% inhibition at 3 MICROMOLAR
IC50
Structure of IBUTILIDE
INHIBITOR -> TARGET
Structure of GIREDESTRANT
INHIBITOR->OFF-TARGET
Structure of BOSUTINIB
INHIBITOR->OFF-TARGET
SUN-1334
NON-INHIBITOR->OFF TARGET
IC50
Structure of PF-06821497
NON-INHIBITOR->OFF TARGET
Structure of VERUBECESTAT
INHIBITOR->OFF-TARGET
Structure of CIFENLINE
INHIBITOR -> TARGET
IC50
ERVOGASTAT
NON-INHIBITOR -> TRANSPORTER
Structure of SOTALOL
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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