U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Fri Jun 25 21:41:46 UTC 2021
Edited
by admin
on Fri Jun 25 21:41:46 UTC 2021
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
SEV29N8JND
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2
Common Name English
H-ERG
Common Name English
ETHER-A-GO-GO-RELATED GENE POTASSIUM CHANNEL 1
Common Name English
HERG
Common Name English
HERG-1
Common Name English
Code System Code Type Description
FDA UNII
SEV29N8JND
Created by admin on Fri Jun 25 21:41:46 UTC 2021 , Edited by admin on Fri Jun 25 21:41:46 UTC 2021
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_598
Related Record Type Details
INHIBITOR->OFF-TARGET
INHIBITOR->OFF-TARGET
INHIBITOR->OFF-TARGET
IC50
INHIBITOR->OFF-TARGET
NON-INHIBITOR->OFF TARGET
INHIBITOR->OFF-TARGET
INHIBITOR->OFF-TARGET
IC50
INHIBITOR->OFF-TARGET
INHIBITOR->OFF-TARGET
Avanafil inhibited hERG current in a concentration-dependent manner with IC50 of 15.8 ?M, which corresponded to exposures approximately 290-fold above the unbound Cmax (~26 ng/mL, 0.054 ?M) in human subjects after the maximum recommended single oral dose at 200 mg.
IC50
INHIBITOR->OFF-TARGET
INHIBITOR->OFF-TARGET
INHIBITOR -> TARGET
INHIBITOR->OFF-TARGET
NON-INHIBITOR->OFF TARGET
did not predict QTc prolongation, by inhibition of the hERG channel at clinically relevant concentrations
NON-INHIBITOR->OFF TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR->OFF-TARGET
NON-INHIBITOR->OFF TARGET
INHIBITOR->OFF-TARGET
INHIBITOR->OFF-TARGET
INHIBITOR->OFF-TARGET
IC50
NON-INHIBITOR->OFF TARGET
INHIBITOR -> TARGET
INHIBITOR->OFF-TARGET
TRANSPORTER -> NON-INHIBITOR
INHIBITOR -> TARGET
INHIBITOR->OFF-TARGET
NON-INHIBITOR->OFF TARGET
IC50
INHIBITOR->OFF-TARGET
IC50
NON-INHIBITOR->OFF TARGET
INHIBITOR -> TRANSPORTER
INHIBITOR->OFF-TARGET
MAY BE RESPONSIBLE FOR QT PROLONGATION
IC50
NON-INHIBITOR->OFF TARGET
9% inhibition at 3 MICROMOLAR
IC50
INHIBITOR -> TARGET
INHIBITOR->OFF-TARGET
INHIBITOR->OFF-TARGET
NON-INHIBITOR->OFF TARGET
IC50
NON-INHIBITOR->OFF TARGET
INHIBITOR->OFF-TARGET
INHIBITOR -> TARGET
IC50
NON-INHIBITOR -> TRANSPORTER
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL