BMS-986142

Investigational

Details

Stereochemistry
Molecular Formula	C32H30F2N4O4
Molecular Weight	572.6018
Optical Activity	UNSPECIFIED
Additional Stereochemistry	Yes
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0
Stereo Comments	ATROPISOMERISM AT TWO SITES

SHOW SMILES / InChI

Structure Search

SMILES

CN1C(=O)N(C(=O)C2=C1C(F)=CC=C2)C3=C(C)C(=CC=C3)C4=C5C6=C(C[C@H](CC6)C(C)(C)O)NC5=C(C=C4F)C(N)=O

InChI

InChIKey=ZRYMMWAJAFUANM-INIZCTEOSA-N

InChI=1S/C32H30F2N4O4/c1-15-17(7-6-10-24(15)38-30(40)19-8-5-9-21(33)28(19)37(4)31(38)41)25-22(34)14-20(29(35)39)27-26(25)18-12-11-16(32(2,3)42)13-23(18)36-27/h5-10,14,16,36,42H,11-13H2,1-4H3,(H2,35,39)/t16-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C32H30F2N4O4
Molecular Weight	572.6018
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

C_max

Value	Dose	Analyte	Population
9.03 ng/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
36.9 ng/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
185 ng/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	50 mg single, oral dose: 50 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
311 ng/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
1081 ng/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
1878 ng/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	900 mg single, oral dose: 900 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
56 ng/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	25 mg 1 times / day steady-state, oral dose: 25 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
281 ng/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	75 mg 1 times / day steady-state, oral dose: 75 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
592 ng/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	200 mg 1 times / day steady-state, oral dose: 200 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
1024 ng/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	350 mg 1 times / day steady-state, oral dose: 350 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

AUC

Value	Dose	Analyte	Population
102 ng × h/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
388 ng × h/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
1586 ng × h/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	50 mg single, oral dose: 50 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
3019 ng × h/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
11390 ng × h/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
28063 ng × h/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	900 mg single, oral dose: 900 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
539 ng × h/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	25 mg 1 times / day steady-state, oral dose: 25 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
2471 ng × h/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	75 mg 1 times / day steady-state, oral dose: 75 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
5527 ng × h/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	200 mg 1 times / day steady-state, oral dose: 200 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
10715 ng × h/mL CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	350 mg 1 times / day steady-state, oral dose: 350 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

T_1/2

Value	Dose	Analyte	Population
6.87 h CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
8.02 h CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
9.7 h CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	50 mg single, oral dose: 50 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
10.3 h CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
10.6 h CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
10.7 h CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	900 mg single, oral dose: 900 mg route of administration: Oral experiment type: SINGLE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
10.9 h CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	25 mg 1 times / day steady-state, oral dose: 25 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
10.7 h CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	75 mg 1 times / day steady-state, oral dose: 75 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
11 h CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	200 mg 1 times / day steady-state, oral dose: 200 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
10.2 h CLINICAL TRIAL https://link.springer.com/article/10.1007/s00228-017-2226-2	350 mg 1 times / day steady-state, oral dose: 350 mg route of administration: Oral experiment type: STEADY-STATE co-administered:	BMS-986142 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:59:20 GMT 2025` Edited by `admin` on `Mon Mar 31 21:59:20 GMT 2025`
Record UNII	PJX9GH268R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BMS-986142

Preferred Name

English

Code System Code Type Description

PUBCHEM

86582336