U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

1958
117
Substance Class Mixture
Created
by admin
on Thu Jul 06 08:07:10 UTC 2023
Edited
by admin
on Thu Jul 06 08:07:10 UTC 2023
Record UNII
6D53G0FD0Z
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
ALTERNATIVE DEFINITION for [PLASMA PROTEIN FRACTION (HUMAN)]
Alternative Definition
Name Type Language
PLASMA PROTEIN FRACTION (HUMAN)
WHO-DD  
Common Name English
PLASMA PROTEIN FRACTION HUMAN
Common Name English
Plasma protein fraction (human) [WHO-DD]
Common Name English
PLASMA PROTEIN FRACTION,HUMAN [VANDF]
Common Name English
PLASMA, PROTEIN
Common Name English
PLASMA, PROTEIN FRACTION (HUMAN)
Common Name English
PLASMA PROTEIN
Common Name English
Classification Tree Code System Code
CFR 21 CFR 640.93
Created by admin on Thu Jul 06 08:07:52 UTC 2023 , Edited by admin on Thu Jul 06 08:07:52 UTC 2023
CFR 21 CFR 640.92
Created by admin on Thu Jul 06 08:07:52 UTC 2023 , Edited by admin on Thu Jul 06 08:07:52 UTC 2023
CFR 21 CFR 640.91
Created by admin on Thu Jul 06 08:07:52 UTC 2023 , Edited by admin on Thu Jul 06 08:07:52 UTC 2023
CFR 21 CFR 640.90
Created by admin on Thu Jul 06 08:07:52 UTC 2023 , Edited by admin on Thu Jul 06 08:07:52 UTC 2023
CFR 21 CFR 640.94
Created by admin on Thu Jul 06 08:07:52 UTC 2023 , Edited by admin on Thu Jul 06 08:07:52 UTC 2023
Code System Code Type Description
FDA UNII
6D53G0FD0Z
Created by admin on Thu Jul 06 08:07:52 UTC 2023 , Edited by admin on Thu Jul 06 08:07:52 UTC 2023
PRIMARY
DRUG BANK
DB13968
Created by admin on Thu Jul 06 08:07:52 UTC 2023 , Edited by admin on Thu Jul 06 08:07:52 UTC 2023
PRIMARY
RXCUI
33835
Created by admin on Thu Jul 06 08:07:52 UTC 2023 , Edited by admin on Thu Jul 06 08:07:52 UTC 2023
PRIMARY RxNorm
DAILYMED
6D53G0FD0Z
Created by admin on Thu Jul 06 08:07:52 UTC 2023 , Edited by admin on Thu Jul 06 08:07:52 UTC 2023
PRIMARY
EVMPD
SUB127871
Created by admin on Thu Jul 06 08:07:52 UTC 2023 , Edited by admin on Thu Jul 06 08:07:52 UTC 2023
PRIMARY
HUMAN PLASMA
All of the following components must be present:
ALPHA-1-ACID GLYCOPROTEIN
Unknown Structure
UNSPECIFIED SUBSTANCE
(not present in database)
ALBUMIN HUMAN
HUMAN COAGULATION FACTORS
Related Record Type Details
Structure of TENAPANOR
LIGAND->BINDER
BINDING
Structure of RABEPRAZOLE
LIGAND->BINDER
Structure of KETAMINE
LIGAND->BINDER
Structure of SIBUTRAMINE
LIGAND->BINDER
Structure of TRICLABENDAZOLE
LIGAND->BINDER
BINDING
Structure of AZELASTINE
LIGAND->BINDER
Structure of THIORIDAZINE
LIGAND->BINDER
Structure of GOSERELIN
LIGAND->BINDER
Structure of BMS-986120
LIGAND->BINDER
BINDING
Structure of DROPERIDOL
LIGAND->BINDER
Structure of BOSENTAN ANHYDROUS
LIGAND->BINDER
BINDING
Structure of DESIPRAMINE
LIGAND->BINDER
Structure of NAFCILLIN
LIGAND->BINDER
Structure of ACECAINIDE
LIGAND->BINDER
Structure of ELEXACAFTOR
LIGAND->BINDER
Structure of SUFENTANIL
LIGAND->BINDER
Structure of FORMOTEROL
LIGAND->BINDER
Structure of APRACLONIDINE
LIGAND->BINDER
Structure of DESVENLAFAXINE
LIGAND->BINDER
Structure of GLECAPREVIR
LIGAND->BINDER
GLE is approximately 97.5% bound to human plasma proteins independent of concentration from 0.1 to 30 μM (800 to 25,200 ng/mL).
Structure of MINOCYCLINE
LIGAND->BINDER
Structure of ROFLUMILAST N-OXIDE
LIGAND->BINDER
Structure of CEPHALOTHIN
LIGAND->BINDER
Structure of VALDECOXIB
LIGAND->BINDER
Plasma protein binding for valdecoxib is about 98% over the concentration range (21-2384 ng/mL).
BINDING
Structure of LANSOPRAZOLE
LIGAND->BINDER
Structure of APOMORPHINE
LIGAND->BINDER
Structure of RELUGOLIX
LIGAND->BINDER
Plasma protein binding of relugolix is 68 to 71%, primarily to albumin and to a lesser extent to α1-acid glycoprotein.
Structure of SOLRIAMFETOL
LIGAND->BINDER
BINDING
Structure of CEFIDEROCOL
LIGAND->BINDER
Primarily to albumin
BINDING
Structure of CABOZANTINIB
LIGAND->BINDER
Structure of 3-HYDROXY-APATINIB, TRANS-
LIGAND->BINDER
BINDING
Structure of HYDROXYFLUTAMIDE
LIGAND->BINDER
Structure of VABORBACTAM
LIGAND->BINDER
BINDING
Structure of BUMETANIDE
LIGAND->BINDER
Structure of FAMCICLOVIR
LIGAND->BINDER
Structure of CONIVAPTAN
LIGAND->BINDER
Structure of PRAMIPEXOLE
LIGAND->BINDER
Structure of DEOXYCHOLIC ACID
LIGAND->BINDER
BINDING
Structure of HYDROXYITRACONAZOLE
LIGAND->BINDER
BINDING
Structure of RUFINAMIDE
LIGAND->BINDER
BINDING
Structure of BREMELANOTIDE
LIGAND->BINDER
BINDING
Structure of BREXPIPRAZOLE
LIGAND->BINDER
Structure of DASATINIB ANHYDROUS
LIGAND->BINDER
with no concentration dependence over the range of 100–500 ng/mL
BINDING
Structure of TRIMETREXATE
LIGAND->BINDER
Structure of FLUCYTOSINE
LIGAND->BINDER
Structure of ITRACONAZOLE
LIGAND->BINDER
BINDING
Structure of PERAMIVIR ANHYDROUS
LIGAND->BINDER
In vitro, human plasma protein binding was determined to be low (<18%) across a range of peramivir concentrations (10-1000 ng/mL) with no partitioning into red blood cells (Study DM99362).
BINDING
Structure of BROMOCRIPTINE
LIGAND->BINDER
Structure of CEFDITOREN
LIGAND->BINDER
Structure of ACALABRUTINIB
LIGAND->BINDER
Structure of ABROCITINIB METABOLITE M1
LIGAND->BINDER
Structure of LOXAPINE
LIGAND->BINDER
Structure of AMPRENAVIR
LIGAND->BINDER
The high affinity binding protein for amprenavir is alpha1-acid glycoprotein (AAG).
BINDING
Structure of VILAZODONE
LIGAND->BINDER
Structure of TAFENOQUINE
LIGAND->BINDER
BINDING
Structure of FULVESTRANT
LIGAND->BINDER
Structure of FAVIPIRAVIR
LIGAND->BINDER
BINDING
Structure of PARECOXIB
LIGAND->BINDER
BINDING
Structure of LAPATINIB
LIGAND->BINDER
Structure of LOSARTAN
LIGAND->BINDER
Structure of CARBIDOPA
LIGAND->BINDER
Structure of CHLOROQUINE
LIGAND->BINDER
Structure of LICARBAZEPINE
LIGAND->BINDER
Structure of CARBAMAZEPINE-10,11-EPOXIDE
LIGAND->BINDER
Structure of Amphotericin B
LIGAND->BINDER
Structure of PIROXICAM
LIGAND->BINDER
Structure of TEPOTINIB
LIGAND->BINDER
Protein binding of tepotinib is 98% and is independent of drug concentration at clinically relevant exposures.
Structure of AMOXICILLIN
LIGAND->BINDER
Structure of ALDUMASTAT
LIGAND->BINDER
Structure of SPIRONOLACTONE
LIGAND->BINDER
Structure of DEFERIPRONE
LIGAND->BINDER
Structure of ILOPERIDONE
LIGAND->BINDER
BINDING
Structure of LONAFARNIB
LIGAND->BINDER
In vitro plasma protein binding of lonafarnib was greater than or equal to 99% over the concentration range between 0.5 to 40.0 μg/mL.
Structure of PAPAVERINE
LIGAND->BINDER
Structure of MEBENDAZOLE
LIGAND->BINDER
Structure of DORAVIRINE
LIGAND->BINDER
BINDING
Structure of LUTETIUM OXODOTREOTIDE LU-177
LIGAND->BINDER
Structure of AMANTADINE
LIGAND->BINDER
Structure of IVACAFTOR
LIGAND->BINDER
Ivacaftor is approximately 99% bound to plasma proteins, primarily to albumin, and also to alpha 1-acid glycoprotein and human gamma-globulin.
BINDING
Structure of GLASDEGIB
LIGAND->BINDER
Glasdegib is 91% bound to human plasma proteins in vitro
Structure of METHADONE
LIGAND->BINDER
BINDING
Structure of ALBENDAZOLE OXIDE
LIGAND->BINDER
Structure of LORCASERIN
LIGAND->BINDER
Structure of FUROSEMIDE
LIGAND->BINDER
Structure of NITISINONE
LIGAND->BINDER
Structure of LENVATINIB
LIGAND->BINDER
Structure of IXABEPILONE
LIGAND->BINDER
The percentages ixabepilone bound to proteins at concentrations of 50, 500 and 5000 ng/mL were 76.6%, 72.0% and 67.1%, respectively. The protein binding of ixabepilone was not concentration dependent from 50 ng/mL to 5000 ng/mL.
BINDING
Structure of EPIRUBICIN
LIGAND->BINDER
Structure of VISMODEGIB
LIGAND->BINDER
Structure of THRX-195518
LIGAND->BINDER
Structure of DACLATASVIR
LIGAND->BINDER
BINDING
Structure of TRICLABENDAZOLE SULFONE
LIGAND->BINDER
BINDING
Structure of CEFOXITIN
LIGAND->BINDER
Structure of CLONAZEPAM
LIGAND->BINDER
Structure of AZTREONAM
LIGAND->BINDER
Structure of 2-(4-(2-CARBOXYPROPOXY)-3-CYANOPHENYL)-4-METHYL-5-THIAZOLECARBOXYLIC ACID
LIGAND->BINDER
BINDING
Structure of BIMATOPROST
LIGAND->BINDER
Structure of ERDAFITINIB
LIGAND->BINDER
primarily to alpha-1-acid glycoprotein.
BINDING
Structure of ENTECAVIR ANHYDROUS
LIGAND->BINDER
BINDING
Structure of LINEZOLID
LIGAND->BINDER
Structure of CI-1007
LIGAND->BINDER
BINDING
Structure of Desloratadine
LIGAND->BINDER
BINDING
DALBAVANCIN
LIGAND->BINDER
Structure of DESFESOTERODINE
LIGAND->BINDER
Structure of PITOLISANT
LIGAND->BINDER
BINDING
Structure of Roflumilast
LIGAND->BINDER
Structure of MEPROBAMATE
LIGAND->BINDER
Structure of NALOXEGOL
LIGAND->BINDER
Structure of TELBIVUDINE
LIGAND->BINDER
BINDING
Structure of INCB-3284
LIGAND->BINDER
BINDING
Structure of MORPHINE
LIGAND->BINDER
Structure of BMS-986142
LIGAND->BINDER
Structure of IBANDRONIC ACID
LIGAND->BINDER
In vitro protein binding in human serum was 99.5% to 90.9% over an ibandronate concentration range of 2 to 10 ng/mL in one study and approximately 85.7% over a concentration range of 0.5 to 10 ng/mL in another study.
BINDING
Structure of TAPINAROF
LIGAND->BINDER
BINDING
Structure of PRETOMANID
LIGAND->BINDER
Human plasma protein binding of pretomanid is approximately 86.4% and is independent of drug concentration.
BINDING
Structure of MOMETASONE
LIGAND->BINDER
Structure of RITONAVIR
LIGAND->BINDER
Structure of GLIPIZIDE
LIGAND->BINDER
Structure of PYRIMETHAMINE
LIGAND->BINDER
Structure of BEMPEDOIC ACID
LIGAND->BINDER
BINDING
Structure of IVABRADINE
LIGAND->BINDER
BINDING
Structure of MOLINDONE
LIGAND->BINDER
Structure of ZONISAMIDE
LIGAND->BINDER
Structure of EXEMESTANE
LIGAND->BINDER
BINDING
Structure of DORZOLAMIDE
LIGAND->BINDER
Structure of RIFAMPIN
LIGAND->BINDER
Structure of PAROXETINE
LIGAND->BINDER
Structure of TRICLABENDAZOLE SULFOXIDE
LIGAND->BINDER
BINDING
Structure of ATORVASTATIN
LIGAND->BINDER
Structure of AXITINIB
LIGAND->BINDER
Structure of SACUBITRIL
LIGAND->BINDER
BINDING
Structure of UBROGEPANT
LIGAND->BINDER
BINDING
Structure of BPR-1K871
LIGAND->BINDER
Structure of BUDESONIDE
LIGAND->BINDER
Plasma protein binding is estimated to be 85 to 90% in the concentration range 1 to 230 nmol/L, independent of gender.
BINDING
Structure of GABAPENTIN
LIGAND->BINDER
Structure of GUANABENZ
LIGAND->BINDER
Structure of CEFPODOXIME
LIGAND->BINDER
Structure of ELIGLUSTAT
LIGAND->BINDER
BINDING
Structure of EZOGABINE
LIGAND->BINDER
BINDING
Structure of SOLIFENACIN
LIGAND->BINDER
in vivo
BINDING
Structure of Apinocaltamide
LIGAND->BINDER
Teicoplanin
LIGAND->BINDER
BINDING
Structure of OLACAFTOR
LIGAND->BINDER
Structure of LENALIDOMIDE
LIGAND->BINDER
Structure of QUININE
LIGAND->BINDER
Structure of TEZACAFTOR
LIGAND->BINDER
tezacaftor are approximately 99% bound to plasma proteins, primarily to albumin.
BINDING
Structure of SUVOREXANT
LIGAND->BINDER
Structure of TUCATINIB
LIGAND->BINDER
BINDING
Structure of 10-HYDROXYNORTRIPTYLINE, (E)-
BINDER->LIGAND
Structure of VANDETANIB
LIGAND->BINDER
Structure of DABIGATRAN
LIGAND->BINDER
Structure of FLUMAZENIL
LIGAND->BINDER
Structure of MONOETHYL CHLOROQUINE
LIGAND->BINDER
Structure of NELARABINE
LIGAND->BINDER
Plasma protein binding is independent on nelarabine concentrations.
BINDING
Structure of ESZOPICLONE
LIGAND->BINDER
Structure of CEFTRIAXONE
LIGAND->BINDER
Structure of CLADRIBINE
LIGAND->BINDER
Structure of DULOXETINE
LIGAND->BINDER
Structure of OSPEMIFENE
LIGAND->BINDER
Structure of RIFAPENTINE
LIGAND->BINDER
The bound concentration increased slightly (,2%) as the concentration of 14C-rifapentine increased from 0.5 to 10 mg/ml. At concentrations above 10 mg/ml, protein binding did not appear to vary with increasing concentration.
BINDING
Structure of BENZNIDAZOLE
LIGAND->BINDER
Structure of GS-563117
LIGAND->BINDER
BINDING
Structure of 4-((4-((3-CHLORO-4-METHOXYBENZYL)AMINO)-5-((PYRIMIDIN-2-YLMETHYL)CARBAMOYL)PYRIMIDIN-2-YL)AMINO)-5-HYDROXYPENTANOIC ACID
LIGAND->BINDER
For M16, protein binding was moderate and ranged from 82.6 to 85.7% 0.5 hr after avanafil administration.
BINDING
Structure of PROPAFENONE
LIGAND->BINDER
Structure of BREXANOLONE
LIGAND->BINDER
Plasma protein binding was greater than 99% and is independent of plasma concentrations.
BINDING
Structure of FOSPROPOFOL
LIGAND->BINDER
Structure of CLOBAZAM
LIGAND->BINDER
BINDING
Structure of DIAMORPHINE
LIGAND->BINDER
Reported not to bind to serum proteins
BINDING
Structure of Tafluprost acid
LIGAND->BINDER
BINDING
Structure of ENASIDENIB
LIGAND->BINDER
Structure of DILTIAZEM
LIGAND->BINDER
Structure of ERIBULIN
BINDER->LIGAND
BINDING
Structure of VOCLOSPORIN
LIGAND->BINDER
Structure of PERGOLIDE
LIGAND->BINDER
Structure of LEDIPASVIR
LIGAND->BINDER
LDV is >99.8% bound to human plasma proteins when determined in vitro with equilibrium dialysis. In agreement with in vitro data, LDV protein binding was ≥ 98% in healthy subjects and in subjects with renal or hepatic impairment.
BINDING
Structure of HYOSCYAMINE
LIGAND->BINDER
Structure of BOSUTINIB
LIGAND->BINDER
Structure of DOXORUBICIN
LIGAND->BINDER
Structure of DEFLAZACORT
LIGAND->BINDER
BINDING
Structure of ABROCITINIB METABOLITE M2
LIGAND->BINDER
BINDING
Structure of REMDESIVIR
LIGAND->BINDER
BINDING
Structure of VORTIOXETINE
LIGAND->BINDER
Structure of FELBAMATE
LIGAND->BINDER
Structure of OXCARBAZEPINE
LIGAND->BINDER
BINDING
Structure of DESOGESTREL
LIGAND->BINDER
Structure of DAROLUTAMIDE
LIGAND->BINDER
BINDING
Structure of OSIMERTINIB
LIGAND->BINDER
Structure of SILODOSIN
LIGAND->BINDER
Structure of BROMPHENIRAMINE
LIGAND->BINDER
Structure of CHLORAMPHENICOL
LIGAND->BINDER
Structure of CGP-74588
LIGAND->BINDER
Structure of CETRORELIX
LIGAND->BINDER
Structure of CANGRELOR
LIGAND->BINDER
Structure of TAMSULOSIN
LIGAND->BINDER
Structure of CABAZITAXEL
LIGAND->BINDER
Structure of VERINURAD
LIGAND->BINDER
BINDING
Structure of ENCORAFENIB
LIGAND->BINDER
Encorafenib is 86% bound to human plasma proteins and binding is not concentrationdependent
Structure of CHLORPHENIRAMINE
LIGAND->BINDER
Structure of BALSALAZIDE
LIGAND->BINDER
Structure of DIDESMETHYLCITALOPRAM
LIGAND->BINDER
Structure of EAPB-0203
LIGAND->BINDER
BINDING
Structure of RP-6306
LIGAND->BINDER
BINDING
Structure of ULIPRISTAL ACETATE
LIGAND->BINDER
BINDING
Structure of PHENYLEPHRINE
LIGAND->BINDER
Structure of MEPERIDINE
LIGAND->BINDER
Structure of CEFADROXIL
LIGAND->BINDER
Structure of INDOXYL SULFATE
LIGAND->BINDER
Unable to clear indoxyl sulfate in hemodialysis.
Structure of MILCICLIB
LIGAND->BINDER
BINDING
Structure of CALCITRIOL
LIGAND->BINDER
Structure of ABAMETAPIR
LIGAND->BINDER
Abametapir plasm protein binding ranged from 91.3 – 92.3% and was concentration independent within the tested concentration range of 50 – 800 ng/mL.
BINDING
Structure of ENFLURANE
LIGAND->BINDER
Structure of MIGLUSTAT
LIGAND->BINDER
Miglustat does not bind to plasma proteins.
Structure of OSILODROSTAT
LIGAND->BINDER
BINDING
Structure of Valbenazine
LIGAND->BINDER
Structure of VIBEGRON
LIGAND->BINDER
BINDING
Structure of RUZINURAD
LIGAND->BINDER
BINDING
Structure of MEROPENEM
LIGAND->BINDER
BINDING
Structure of BAZEDOXIFENE
LIGAND->BINDER
Structure of ZOLEDRONIC ACID ANHYDROUS
LIGAND->BINDER
Binding to human plasma proteins was low (approximately 22 %) and independent of the concentration of zoledronic acid.
BINDING
Structure of VORICONAZOLE
LIGAND->BINDER
Plasma protein binding is estimated to be 58% and was shown to be independent of plasma concentrations achieved following single and multiple oral doses of 200 mg or 300 mg (approximate range: 0.9-15 mg/ml).
BINDING
Structure of NORCLOZAPINE
LIGAND->BINDER
Structure of HYDROXYZINE
LIGAND->BINDER
Structure of FOSPHENYTOIN
LIGAND->BINDER
Structure of DIMETHADIONE
LIGAND->BINDER
Structure of FELODIPINE
LIGAND->BINDER
Structure of DICHLORPHENAMIDE
LIGAND->BINDER
Structure of DEXMETHYLPHENIDATE
LIGAND->BINDER
Structure of BUPIVACAINE
LIGAND->BINDER
Structure of NICOTINE
LIGAND->BINDER
Structure of ROSUVASTATIN
LIGAND->BINDER
Structure of DM-3411
LIGAND->BINDER
Structure of DEMOXEPAM
LIGAND->BINDER
Structure of PIMECROLIMUS
LIGAND->BINDER
Structure of TRIAZOLAM
LIGAND->BINDER
Structure of LURBINECTEDIN
LIGAND->BINDER
BINDING
Structure of PIRFENIDONE
LIGAND->BINDER
Structure of LEMBOREXANT
LIGAND->BINDER
Protein binding of lemborexant is approximately 93.2% to 94.0% between 29 ng/mL and 71 ng/mL.
BINDING
Structure of PANTOPRAZOLE
LIGAND->BINDER
Structure of NELFINAVIR
LIGAND->BINDER
Structure of ABIRATERONE
LIGAND->BINDER
Structure of Nirmatrelvir
LIGAND->BINDER
Structure of DESMETHYLSIBUTRAMINE
LIGAND->BINDER
Structure of RISPERIDONE
LIGAND->BINDER
Structure of Erythromycin
LIGAND->BINDER
Structure of NORGESTREL
LIGAND->BINDER
Structure of PIPERACILLIN ANHYDROUS
LIGAND->BINDER
The protein binding of either piperacillin or tazobactam is unaffected by the presence of the other compound.
BINDING
Structure of NORDAZEPAM
LIGAND->BINDER
Structure of VILOXAZINE
LIGAND->BINDER
Viloxazine is 76-82% bound to human plasma proteins over the blood concentration range of 0.5 mcg/mL to 10 mcg/mL.
BINDING
Structure of .ALPHA.-DIHYDROARTEMISININ
LIGAND->BINDER
Structure of QUETIAPINE
LIGAND->BINDER
BINDING
Structure of JNJ-64264681
LIGAND->BINDER
BINDING
Structure of NALMEFENE
LIGAND->BINDER
Structure of CANNABIDIOL
LIGAND->BINDER
Structure of EFAVIRENZ
LIGAND->BINDER
BINDING
Structure of CARVEDILOL
LIGAND->BINDER
Structure of ELBASVIR
LIGAND->BINDER
BINDING
Structure of LURASIDONE
LIGAND->BINDER
Structure of TIPIRACIL
LIGAND->BINDER
The in vitro protein binding in human plasma is below 8% for tipiracil.
BINDING
Structure of Arformoterol
LIGAND->BINDER
Structure of EDARAVONE
LIGAND->BINDER
BINDING
Structure of SULFORIDAZINE
LIGAND->BINDER
Structure of DEFERASIROX
LIGAND->BINDER
Structure of ACEBUTOLOL
LIGAND->BINDER
Structure of FENOPROFEN
LIGAND->BINDER
Structure of LEVOFLOXACIN
LIGAND->BINDER
SEMAGLUTIDE
LIGAND->BINDER
BINDING
Structure of NINTEDANIB
LIGAND->BINDER
Structure of TEGASEROD
LIGAND->BINDER
Structure of FEDRATINIB
LIGAND->BINDER
BINDING
Structure of MOXIFLOXACIN
LIGAND->BINDER
Structure of N-DESETHYLOXYBUTYNIN
LIGAND->BINDER
Structure of GILTERITINIB
LIGAND->BINDER
~90% Gilteritinib bound to plasma proteins, mainly albumin
BINDING
Structure of SULFADOXINE
LIGAND->BINDER
Structure of NORLIDOCAINE
LIGAND->BINDER
PLASMA PROTEIN FRACTION
SUB_CONCEPT->SUBSTANCE
Structure of QUINIDINE
LIGAND->BINDER
Structure of CEFIXIME ANHYDROUS
LIGAND->BINDER
BINDING
Structure of FLUPHENAZINE
LIGAND->BINDER
Structure of QUAZEPAM
LIGAND->BINDER
Structure of CASPOFUNGIN
LIGAND->BINDER
Structure of ETHOXZOLAMIDE
LIGAND->BINDER
Structure of APATINIB-25-N-OXIDE
LIGAND->BINDER
BINDING
Structure of AZILSARTAN
LIGAND->BINDER
Structure of BUPRENORPHINE
LIGAND->BINDER
Structure of Binimetinib
LIGAND->BINDER
Structure of ACETYLCYSTEINE
LIGAND->BINDER
Structure of AVAPRITINIB
LIGAND->BINDER
Structure of (+)-α-Dihydrotetrabenazine
LIGAND->BINDER
Structure of RAMELTEON
LIGAND->BINDER
independent of concentration
BINDING
Structure of FLUOXYMESTERONE
LIGAND->BINDER
Structure of NAFARELIN
LIGAND->BINDER
Structure of FOSAMPRENAVIR
LIGAND->BINDER
Structure of RIMEGEPANT
LIGAND->BINDER
BINDING
Structure of AMITRIPTYLINE
LIGAND->BINDER
BINDING
Structure of CITALOPRAM
LIGAND->BINDER
Structure of TACRINE
LIGAND->BINDER
Structure of LORLATINIB
LIGAND->BINDER
In vitro, protein binding of lorlatinib to human plasma proteins, including serum albumin and α1-acid glycoprotein, was 66% at a concentration of 2.4 μM.
BINDING
Structure of ATROPINE
LIGAND->BINDER
Structure of GDC-0425
LIGAND->BINDER
BINDING
Structure of ABARELIX
LIGAND->BINDER
Structure of MONOMETHYL FUMARATE
LIGAND->BINDER
BINDING
Structure of OZENOXACIN
LIGAND->BINDER
Structure of REMIMAZOLAM
LIGAND->BINDER
BINDING
Structure of CYCLOPHOSPHAMIDE
LIGAND->BINDER
Structure of PALONOSETRON
LIGAND->BINDER
Structure of RETAPAMULIN
LIGAND->BINDER
BINDING
Structure of REVEFENACIN
LIGAND->BINDER
BINDING
Structure of OLICERIDINE
LIGAND->BINDER
BINDING
Structure of LASMIDITAN
LIGAND->BINDER
The human plasma protein binding of lasmiditan is approximately 55% to 60% and independent of concentration between 15 and 500 ng/mL.
BINDING
Structure of AMIKACIN
LIGAND->BINDER
Structure of ARMODAFINIL
LIGAND->BINDER
Structure of ALVIMOPAN ANHYDROUS
LIGAND->BINDER
Plasma protein binding of alvimopan was independent of concentration over ranges observed clinically and averaged 80% .
BINDING
Structure of AURANOFIN
LIGAND->BINDER
Structure of ZAFIRLUKAST
LIGAND->BINDER
Structure of DESMETHYLCITALOPRAM
LIGAND->BINDER
Structure of CEPHALEXIN
LIGAND->BINDER
Structure of CINOXACIN
LIGAND->BINDER
Structure of LEVONEBIVOLOL
LIGAND->BINDER
BINDING
Structure of PARITAPREVIR
LIGAND->BINDER
BINDING
Structure of ATULIFLAPON
LIGAND->BINDER
Structure of TENOFOVIR ALAFENAMIDE
LIGAND->BINDER
BINDING
Structure of MODAFINIL
LIGAND->BINDER
Structure of MUPIROCIN
LIGAND->BINDER
Structure of IBUPROFEN
LIGAND->BINDER
Structure of RP-112273
LIGAND->BINDER
BINDING
Structure of PENICILLAMINE
LIGAND->BINDER
Structure of VIMSELTINIB
LIGAND->BINDER
Structure of MEROPENEM ANHYDROUS
LIGAND->BINDER
Structure of SAQUINAVIR
LIGAND->BINDER
ETEPLIRSEN
LIGAND->BINDER
BINDING
Structure of DABRAFENIB
LIGAND->BINDER
Structure of VECURONIUM
LIGAND->BINDER
Structure of VALACYCLOVIR
LIGAND->BINDER
Structure of AMISULPRIDE
LIGAND->BINDER
Plasma protein binding is 25% to 30% in the concentration range from 37 to 1850 ng/mL.
BINDING
Structure of CICLESONIDE
LIGAND->BINDER
BINDING
Structure of SELPERCATINIB
LIGAND->BINDER
Protein binding of selpercatinib is 97% in vitro and is independent of concentration.
BINDING
Structure of BISMUTH SUBSALICYLATE
LIGAND->BINDER
Structure of GALANTAMINE
LIGAND->BINDER
BINDING
Structure of REGORAFENIB ANHYDROUS
LIGAND->BINDER
BINDING
Structure of Zagociguat
LIGAND->BINDER
BINDING
Structure of ASENAPINE
LIGAND->BINDER
BINDING
Structure of NORPROPOXYPHENE
LIGAND->BINDER
Structure of TEDIZOLID
LIGAND->BINDER
Structure of GEFITINIB
LIGAND->BINDER
In vitro binding of gefitinib to human plasma proteins (serum albumin and α1-acid glycoprotein) is 90% and is independent of drug concentrations.
BINDING
Structure of RIBOCICLIB
LIGAND->BINDER
Structure of BROMHEXINE
LIGAND->BINDER
Structure of CABERGOLINE
LIGAND->BINDER
IVERMECTIN
LIGAND->BINDER
BINDING
Structure of TIVOZANIB
LIGAND->BINDER
Protein binding of tivozanib is ≥ 99%, primarily to albumin in vitro and is independent of concentration.
Structure of NIZATIDINE
LIGAND->BINDER
Structure of QUINAPRIL
LIGAND->BINDER
Structure of 4-ISOPROPYLAMINO-2-PHENYL-2-(2-PYRIDYL)BUTYRAMIDE
LIGAND->BINDER
Structure of CISPLATIN
LIGAND->BINDER
Structure of TRIFLUOPERAZINE
LIGAND->BINDER
Structure of AZD-0156
LIGAND->BINDER
Structure of Ertugliflozin
LIGAND->BINDER
BINDING
Structure of DIDESMETHYLSIBUTRAMINE
LIGAND->BINDER
Structure of AVANAFIL
LIGAND->BINDER
Structure of BIPERIDEN
LIGAND->BINDER
Structure of PIMAVANSERIN
LIGAND->BINDER
BINDING
Structure of NALDEMEDINE
LIGAND->BINDER
Structure of 5H-BENZO(B)CARBAZOLE-3-CARBONITRILE, 9-ETHYL-6,11-DIHYDRO-8-(4-((2-HYDROXYETHYL)AMINO)-1-PIPERIDINYL)-6,6-DIMETHYL-11-OXO-
LIGAND->BINDER
BINDING
Structure of SOTORASIB
LIGAND->BINDER
Structure of DYPHYLLINE
BINDER->LIGAND
Structure of DAPTOMYCIN
LIGAND->BINDER
Structure of OXAPROZIN
LIGAND->BINDER
Structure of CAPTOPRIL
LIGAND->BINDER
Structure of ALPROSTADIL
LIGAND->BINDER
Structure of DES-CICLESONIDE
LIGAND->BINDER
BINDING
Structure of CLARITHROMYCIN
LIGAND->BINDER
Structure of COBIMETINIB
LIGAND->BINDER
Structure of DUVELISIB
LIGAND->BINDER
BINDING
Structure of TROSPIUM
LIGAND->BINDER
Structure of CIMETIDINE
LIGAND->BINDER
BINDING
Structure of NELOCIGUAT
LIGAND->BINDER
The protein binding of M1 is ~97% and is concentration independent.
Structure of FILGOTINIB
LIGAND->BINDER
BINDING
Structure of PROPOXYPHENE
LIGAND->BINDER
Structure of SULFAMETHOXAZOLE
LIGAND->BINDER
Structure of EAPB-0503
LIGAND->BINDER
BINDING
Structure of LEVODOPA
LIGAND->BINDER
BINDING
Structure of GLYCINEXYLIDIDE
LIGAND->BINDER
Structure of OXYMORPHONE
LIGAND->BINDER
Structure of ISTRADEFYLLINE
LIGAND->BINDER
BINDING
Structure of PREGABALIN
LIGAND->BINDER
BINDING
Structure of ZOLMITRIPTAN
LIGAND->BINDER
Structure of VALPROIC ACID
LIGAND->BINDER
Structure of ARIPIPRAZOLE
LIGAND->BINDER
Structure of CEVIMELINE
LIGAND->BINDER
Structure of BRIGATINIB
LIGAND->BINDER
Structure of MILNACIPRAN
LIGAND->BINDER
The plasma protein binding of milnacipran is approximately 13% and is independent of the concentration (Study# M013).
BINDING
Structure of 2-HYDROXYFEBUXOSTAT
LIGAND->BINDER
BINDING
Structure of PLAZOMICIN
LIGAND->BINDER
BINDING
Structure of LAMOTRIGINE
LIGAND->BINDER
Structure of ZOLPIDEM
LIGAND->BINDER
Structure of LOMITAPIDE
LIGAND->BINDER
BINDING
Structure of BUSPIRONE
LIGAND->BINDER
Structure of PIOGLITAZONE
LIGAND->BINDER
Structure of DAPAGLIFLOZIN
LIGAND->BINDER
Structure of APREMILAST
LIGAND->BINDER
Structure of CHLORAMBUCIL
LIGAND->BINDER
Structure of OXAZEPAM
LIGAND->BINDER
Structure of DOXYCYCLINE
LIGAND->BINDER
Structure of CARBENICILLIN
LIGAND->BINDER
Structure of NORKETAMINE
LIGAND->BINDER
Structure of DISOPYRAMIDE
LIGAND->BINDER
Structure of BUSULFAN
LIGAND->BINDER
Structure of TELAPREVIR
LIGAND->BINDER
The protein binding is concentration dependent and decreases with increasing telaprevir concentrations at all concentrations of human serum albumin (HSA) and α-1-acid glycoprotein (AAG). In addition, protein binding of telaprevir is affected by the concentration of HSA and AAG.
BINDING
Structure of CHLORCYCLIZINE
LIGAND->BINDER
Structure of DECITABINE
LIGAND->BINDER
Structure of ELETRIPTAN
LIGAND->BINDER
Structure of SELEXIPAG
LIGAND->BINDER
Structure of NARONAPRIDE
LIGAND->BINDER
BINDING
Structure of MIZOLASTINE
LIGAND->BINDER
Structure of IRINOTECAN
LIGAND->BINDER
BINDING
Structure of EDOXABAN
LIGAND->BINDER
Structure of TOBRAMYCIN
LIGAND->BINDER
TROGLITAZONE
LIGAND->BINDER
Structure of PHENYLPROPANOLAMINE
LIGAND->BINDER
Structure of IDELALISIB
LIGAND->BINDER
BINDING
Structure of Olaparib
LIGAND->BINDER
Structure of RILPIVIRINE
LIGAND->BINDER
BINDING
Structure of CELECOXIB
LIGAND->BINDER
ATRACURIUM
LIGAND->BINDER
Structure of CENOBAMATE
LIGAND->BINDER
Cenobamate mainly binds with human albumin protein and not with α1-acid glycoprotein.
BINDING
Structure of BECLOMETHASONE
LIGAND->BINDER
Structure of ACETOHEXAMIDE
LIGAND->BINDER
Structure of TECOVIRIMAT
LIGAND->BINDER
BINDING
Structure of CEFDINIR
LIGAND->BINDER
Structure of CHLORDIAZEPOXIDE
LIGAND->BINDER
Structure of TEMSAVIR
LIGAND->BINDER
BINDING
Structure of VERAPAMIL
LIGAND->BINDER
Structure of 21-DESACETYLDEFLAZACORT
LIGAND->BINDER
BINDING
Structure of SITAGLIPTIN
LIGAND->BINDER
BINDING
Structure of Guretolimod
LIGAND->BINDER
Structure of ODANACATIB
LIGAND->BINDER
BINDING
Structure of SELUMETINIB
LIGAND->BINDER
IN VITRO
BINDING
Structure of PITAVASTATIN
LIGAND->BINDER
BINDING
Structure of IXAZOMIB
LIGAND->BINDER
Structure of 2-HYDROXYPIOGLITAZONE
LIGAND->BINDER
Structure of OXACILLIN
LIGAND->BINDER
Structure of MOEXIPRIL
LIGAND->BINDER
Structure of PRAZOSIN
LIGAND->BINDER
Structure of NETARSUDIL
LIGAND->BINDER
Structure of BMS-986251
LIGAND->BINDER
Structure of TIGECYCLINE
LIGAND->BINDER
The in vitro plasma protein binding of tigecycline ranges from approximately 71% to 89% at concentrations observed in clinical studies (0.1 to 1.0 μg/mL).
Structure of ALBUTEROL
LIGAND->BINDER
Structure of CEFIXIME
LIGAND->BINDER
Structure of ATOMOXETINE
LIGAND->BINDER
Structure of RIOCIGUAT
LIGAND->BINDER
BINDING
Structure of CLOFARABINE
LIGAND->BINDER
Structure of TOLTERODINE
LIGAND->BINDER
Structure of ANIDULAFUNGIN
LIGAND->BINDER
BINDING
Structure of PACLITAXEL
LIGAND->BINDER
Structure of P-HYDROXYTRIAMTERENE SULFATE
LIGAND->BINDER
Structure of DEXLANSOPRAZOLE
LIGAND->BINDER
Structure of BUTORPHANOL
LIGAND->BINDER
Structure of MILTEFOSINE
LIGAND->BINDER
BINDING
Structure of Colchicine
LIGAND->BINDER
Structure of VERICIGUAT
LIGAND->BINDER
Protein binding (primarily to serum albumin) of vericiguat is about 98%.
BINDING
Structure of CERIVASTATIN
LIGAND->BINDER
Structure of DARUNAVIR
LIGAND->BINDER
BLEOMYCIN
LIGAND->BINDER
ANCROD
LIGAND->BINDER
Structure of CARISOPRODOL
LIGAND->BINDER
Structure of OZANIMOD
LIGAND->BINDER
BINDING
Structure of OSELTAMIVIR
LIGAND->BINDER
Structure of 3-HYDROXYDESLORATADINE
LIGAND->BINDER
Structure of PRUCALOPRIDE
LIGAND->BINDER
In human plasma, the binding of R093877 increased at higher pH values. In the pH-range 7.1 to 7.7, the percentage bound increased from 23.3% to 35.5%
BINDING
Structure of RIVOCERANIB
LIGAND->BINDER
BINDING
Structure of ETRAVIRINE
LIGAND->BINDER
BINDING
Structure of ASTEMIZOLE
PARENT -> BIOSIMILAR
Structure of CIPROFLOXACIN
LIGAND->BINDER
Structure of LAROTRECTINIB
LIGAND->BINDER
Structure of SECOBARBITAL
LIGAND->BINDER
Structure of ARTESUNATE
LIGAND->BINDER
BINDING
Structure of EXP-3174
LIGAND->BINDER
Structure of ABEMACICLIB
LIGAND->BINDER
BINDING
Structure of PONATINIB
LIGAND->BINDER
BINDING
Structure of BMS-986224
LIGAND->BINDER
Structure of SULINDAC
LIGAND->BINDER
Structure of LULICONAZOLE
LIGAND->BINDER
Structure of LIFITEGRAST
LIGAND->BINDER
BINDING
Structure of Maraviroc
LIGAND->BINDER
Structure of Oxybutynin
LIGAND->BINDER
Structure of OMECAMTIV MECARBIL
LIGAND->BINDER
BINDING
Structure of NADOLOL
LIGAND->BINDER
BINDING
Structure of OPICAPONE
LIGAND->BINDER
independent of concentration
BINDING
Structure of RIVAROXABAN
LIGAND->BINDER
Structure of FENOLDOPAM
LIGAND->BINDER
Structure of CISAPRIDE
LIGAND->BINDER
Structure of VARDENAFIL
LIGAND->BINDER
Structure of MILVEXIAN
LIGAND->BINDER
BINDING
Structure of EMPAGLIFLOZIN
LIGAND->BINDER
BINDING
Structure of GUANFACINE
LIGAND->BINDER
Structure of REMIFENTANIL
LIGAND->BINDER
BINDING
Structure of TOPIRAMATE
LIGAND->BINDER
decreases as concentration increases
BINDING
Structure of TIPRANAVIR
LIGAND->BINDER
BINDING
Structure of ALFENTANIL
LIGAND->BINDER
Structure of ROFECOXIB
LIGAND->BINDER
Structure of TAZEMETOSTAT
LIGAND->BINDER
In vitro, tazemetostat is 87.7 to 91.1% bound to human plasma proteins over the concentration range of 1 to 30 M.
BINDING
Structure of LENACAPAVIR
LIGAND->BINDER
Structure of VENLAFAXINE
LIGAND->BINDER
Structure of N-DESMETHYLAPALUTAMIDE
LIGAND->BINDER
Structure of NITAZOXANIDE
LIGAND->BINDER
Structure of 1'-HYDROXYMIDAZOLAM GLUCURONIDE
LIGAND->BINDER
Structure of DEXFENFLURAMINE
LIGAND->BINDER
BINDING
Structure of FLORBETABEN F-18
LIGAND->BINDER
BINDING
Structure of PRIMIDONE
LIGAND->BINDER
Structure of TOLVAPTAN
LIGAND->BINDER
Structure of CEFTIBUTEN
LIGAND->BINDER
Structure of CAFFEINE
LIGAND->BINDER
BINDING
Structure of AZD-1390
LIGAND->BINDER
BINDING
Structure of DROXIDOPA
LIGAND->BINDER
Structure of ZILEUTON
LIGAND->BINDER
Structure of MACITENTAN
LIGAND->BINDER
Structure of MIRICORILANT
LIGAND->BINDER
Structure of GREPAFLOXACIN
LIGAND->BINDER
Structure of MORICIZINE
LIGAND->BINDER
Structure of DELAVIRDINE
LIGAND->BINDER
BINDING
Structure of BEXAROTENE
LIGAND->BINDER
Structure of AMPICILLIN
LIGAND->BINDER
Structure of TERFENADINE
LIGAND->BINDER
Structure of MAPROTILINE
LIGAND->BINDER
Structure of OMACETAXINE
LIGAND->BINDER
Structure of CYSTEAMINE
LIGAND->BINDER
Structure of CEFUROXIME
LIGAND->BINDER
Structure of MEMANTINE
LIGAND->BINDER
BINDING
Structure of ESOMEPRAZOLE
LIGAND->BINDER
Structure of VANOXERINE
LIGAND->BINDER
BINDING
Structure of Lacosamide
LIGAND->BINDER
BINDING
Structure of IMATINIB
LIGAND->BINDER
Structure of INDINAVIR ANHYDROUS
LIGAND->BINDER
BINDING
Structure of ANASTROZOLE
LIGAND->BINDER
Structure of ALBENDAZOLE
LIGAND->BINDER
Structure of CLINDAMYCIN
LIGAND->BINDER
Structure of AMPHETAMINE
LIGAND->BINDER
Structure of NORFLOXACIN
LIGAND->BINDER
Structure of TALAZOPARIB
LIGAND->BINDER
In vitro, protein binding of talazoparib is 74% and is independent of talazoparib concentration.
BINDING
Structure of DIENOGEST
LIGAND->BINDER
Structure of MIFEPRISTONE
LIGAND->BINDER
Binding to the latter protein is saturable, and the drug displays nonlinear kinetics with respect to plasma concentration and clearance.
BINDING
Structure of TINIDAZOLE
LIGAND->BINDER
BINDING
Structure of MK-0686
LIGAND->BINDER
BINDING
Structure of DEXNEBIVOLOL
LIGAND->BINDER
BINDING
Structure of KETOPROFEN
LIGAND->BINDER
Structure of ALPRAZOLAM
LIGAND->BINDER
Structure of BALOXAVIR
LIGAND->BINDER
BINDING
Structure of CYTARABINE
LIGAND->BINDER
Structure of TRIMETAZIDINE
LIGAND->BINDER
BINDING
Structure of OMBITASVIR
LIGAND->BINDER
BINDING
Structure of ORITAVANCIN
LIGAND->BINDER
Structure of FENOFIBRATE
LIGAND->BINDER
Structure of RP-100798
LIGAND->BINDER
BINDING
Structure of ATOVAQUONE
LIGAND->BINDER
Structure of AVATROMBOPAG
LIGAND->BINDER
BINDING
Structure of CARTEOLOL
LIGAND->BINDER
Structure of DRONEDARONE
LIGAND->BINDER
Structure of BENAZEPRIL
LIGAND->BINDER
Structure of CEFTIZOXIME
LIGAND->BINDER
Structure of PARICALCITOL
LIGAND->BINDER
Structure of KETOCONAZOLE
LIGAND->BINDER
Structure of VENETOCLAX
LIGAND->BINDER
Structure of MITAPIVAT
LIGAND->BINDER
Structure of RELEBACTAM ANHYDROUS
LIGAND->BINDER
The binding of Relebactam to human plasma proteins is approxi mately22% and is independent ofconcentration at a range of 5 to 50 μM.
BINDING
Structure of DASB C-11
LIGAND->BINDER
Structure of AMOXAPINE
LIGAND->BINDER
Structure of 7-ETHYL-10-HYDROXYCAMPTOTHECIN
LIGAND->BINDER
The plasma protein to whichSN-38 predominantly binds is albumin.
BINDING
Structure of CRISABOROLE
LIGAND->BINDER
Structure of N-DEMETHYLDILTIAZEM
LIGAND->BINDER
Structure of ROTIGOTINE
LIGAND->BINDER
Structure of BELINOSTAT
LIGAND->BINDER
Structure of FLURAZEPAM
LIGAND->BINDER
Structure of BARICITINIB
LIGAND->BINDER
Structure of BLU-945
LIGAND->BINDER
BINDING
Structure of TESAGLITAZAR
LIGAND->BINDER
BINDING
Structure of TRIMETHADIONE
LIGAND->BINDER
Structure of ZOPICLONE
LIGAND->BINDER
Structure of BISOPROLOL
LIGAND->BINDER
Structure of ULIPRISTAL
LIGAND->BINDER
Structure of NERATINIB
LIGAND->BINDER
In vitro, neratinib was highly bound (N 99 %) to human plasma proteins at clinical exposures. click to edit
BINDING
Structure of Vildagliptin
LIGAND->BINDER
The mean plasma protein binding of vildagliptin in humans was low (9.3%) and also independent of concentration.
BINDING
Structure of SSR-181507
LIGAND->BINDER
Structure of AR-13503
LIGAND->BINDER
Structure of DEACETYLDILTIAZEM
LIGAND->BINDER
Structure of TELITHROMYCIN
LIGAND->BINDER
Total in vitro protein binding is approximately 60% to 70% and is primarily due to human serum albumin. Protein binding is not modified in elderly subjects and in patients with hepatic impairment.
BINDING
Structure of GS-829845
LIGAND->BINDER
BINDING
Structure of CHLORZOXAZONE
LIGAND->BINDER
Structure of ALTRETAMINE
LIGAND->BINDER
Structure of BENZTHIAZIDE
LIGAND->BINDER
Structure of CHLORPROPAMIDE
LIGAND->BINDER
Structure of 4-HYDROXYATOMOXETINE
LIGAND->BINDER
BINDING
Structure of CHLORPROMAZINE
LIGAND->BINDER
Structure of SUMATRIPTAN
LIGAND->BINDER
Structure of PHENTERMINE
LIGAND->BINDER
Structure of CYCLOPHOSPHAMIDE ANHYDROUS
LIGAND->BINDER
BINDING
Structure of ARSENIC TRIOXIDE
LIGAND->BINDER
Structure of NABUMETONE
LIGAND->BINDER
Structure of CARBAMAZEPINE
LIGAND->BINDER
MK-8189
LIGAND->BINDER
BINDING
Structure of VEMURAFENIB
LIGAND->BINDER
Structure of ISAVUCONAZOLE
LIGAND->BINDER
BINDING
Structure of TETRACYCLINE
LIGAND->BINDER
Structure of AMSACRINE
LIGAND->BINDER
Structure of MIDAZOLAM
LIGAND->BINDER
Structure of FEXOFENADINE
LIGAND->BINDER
Structure of NEBIVOLOL
LIGAND->BINDER
Structure of ZANUBRUTINIB
LIGAND->BINDER
Zanubrutinib is approximately 94.2% bound to human plasma proteins in vitro, independent of concentration.
BINDING
Structure of BRINZOLAMIDE
LIGAND->BINDER
Structure of CEFTAZIDIME
LIGAND->BINDER
Structure of INGENOL MEBUTATE
LIGAND->BINDER
BINDING
Structure of SERDEXMETHYLPHENIDATE
LIGAND->BINDER
Structure of OLANZAPINE
LIGAND->BINDER
BINDING
Structure of CEFEPIME
LIGAND->BINDER
Structure of PHENOBARBITAL
LIGAND->BINDER
Structure of GLPG-0974
LIGAND->BINDER
Structure of LETERMOVIR
LIGAND->BINDER
Structure of TAPENTADOL
LIGAND->BINDER
Structure of CAPMATINIB
LIGAND->BINDER
independent of capmatinib concentration
BINDING
Structure of VOXELOTOR
LIGAND->BINDER
BINDING
Structure of AVIBACTAM
LIGAND->BINDER
BINDING
Structure of ALCAFTADINE CARBOXYLIC ACID
LIGAND->BINDER
BINDING
Structure of OXYCODONE
LIGAND->BINDER
Structure of ROMIDEPSIN
LIGAND->BINDER
Structure of FLUOROESTRADIOL F-18
LIGAND->BINDER
BINDING
Structure of TREPROSTINIL
LIGAND->BINDER
BINDING
Structure of N-DESMETHYL ENTRECTINIB
LIGAND->BINDER
BINDING
Structure of CINACALCET
LIGAND->BINDER
Structure of ONDANSETRON
LIGAND->BINDER
Structure of SONIDEGIB
LIGAND->BINDER
Structure of LY-2623091
LIGAND->BINDER
Structure of NEFAZODONE
LIGAND->BINDER
Structure of 3-HYDROXY-APATINIB, CIS-
LIGAND->BINDER
BINDING
Structure of ALMOTRIPTAN
LIGAND->BINDER
Structure of TIOTROPIUM
LIGAND->BINDER
BINDING
Structure of VOXILAPREVIR
LIGAND->BINDER
BINDING
Structure of Sudapyridine
LIGAND->BINDER
BINDING
Structure of CRIZOTINIB
LIGAND->BINDER
Binding of crizotinib to human plasma proteins in vitro is 91% and is independent of drug concentration.
Structure of Plogosertib
LIGAND->BINDER
Structure of AZATHIOPRINE
LIGAND->BINDER
Structure of Faznolutamide
LIGAND->BINDER
Structure of METHAZOLAMIDE
LIGAND->BINDER
Structure of OLSALAZINE
LIGAND->BINDER
Structure of FROVATRIPTAN
LIGAND->BINDER
DOXEPIN
LIGAND->BINDER
Structure of CALCIUM CARBONATE
LIGAND->BINDER
Structure of IMIPENEM ANHYDROUS
LIGAND->BINDER
BINDING
Structure of ROCURONIUM
LIGAND->BINDER
Structure of ELUXADOLINE