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Approval Year

Substance Class Protein
Created
by admin
on Fri Jun 25 21:35:31 UTC 2021
Edited
by admin
on Fri Jun 25 21:35:31 UTC 2021
Protein Sub Type
Sequence Type COMPLETE
Record UNII
SBH6S6T2J2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TYROSINE-PROTEIN KINASE BTK
Common Name English
BRUTON TYROSINE KINASE
Common Name English
BPK
Common Name English
AGMX1
Common Name English
BRUTON'S TYROSINE KINASE
Common Name English
B-CELL PROGENITOR KINASE
Common Name English
AGAMMAGLOBULINEMIA TYROSINE KINASE
Common Name English
ATK
Common Name English
Classification Tree Code System Code
EU-Orphan Drug EU/3/17/1951
Created by admin on Fri Jun 25 21:35:31 UTC 2021 , Edited by admin on Fri Jun 25 21:35:31 UTC 2021
Code System Code Type Description
UNIPROT
Q06187
Created by admin on Fri Jun 25 21:35:31 UTC 2021 , Edited by admin on Fri Jun 25 21:35:31 UTC 2021
PRIMARY
PHAROS
Q06187
Created by admin on Fri Jun 25 21:35:31 UTC 2021 , Edited by admin on Fri Jun 25 21:35:31 UTC 2021
PRIMARY
FDA UNII
SBH6S6T2J2
Created by admin on Fri Jun 25 21:35:31 UTC 2021 , Edited by admin on Fri Jun 25 21:35:31 UTC 2021
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR
IC50
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
IC50
INHIBITOR -> TARGET
human whole blood assay (hWB) measuring BCR stimulated CD69 expression on B cells
COMPETITIVE INHIBITOR
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INHIBITOR -> TARGET
Binds to a cysteine residue (Cys-481) in the BTK active site
IRREVERSIBLE INHIBITOR
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INHIBITOR -> TARGET
Acalabrutinib forms a covalent bond with Cys481 in the BTK adenosine triphosphate (ATP).
IRREVERSIBLE INHIBITOR
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INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
IC50
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL