Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Thu Jul 06 17:48:53 UTC 2023
by
admin
on
Thu Jul 06 17:48:53 UTC 2023
|
| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
SBH6S6T2J2
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
EU-Orphan Drug |
EU/3/17/1951
Created by
admin on Thu Jul 06 17:48:54 UTC 2023 , Edited by admin on Thu Jul 06 17:48:54 UTC 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
Q06187
Created by
admin on Thu Jul 06 17:48:54 UTC 2023 , Edited by admin on Thu Jul 06 17:48:54 UTC 2023
|
PRIMARY | |||
|
Q06187
Created by
admin on Thu Jul 06 17:48:54 UTC 2023 , Edited by admin on Thu Jul 06 17:48:54 UTC 2023
|
PRIMARY | |||
|
SBH6S6T2J2
Created by
admin on Thu Jul 06 17:48:54 UTC 2023 , Edited by admin on Thu Jul 06 17:48:54 UTC 2023
|
PRIMARY |
| Linkage Type | Residue Index | |||
|---|---|---|---|---|
| COORDINATION COMPOUND | 1_142 | 1_153 | 1_154 | 1_164 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
INHIBITOR -> TARGET |
k(inactivation)
|
||
|
INHIBITOR -> TARGET |
INHIBITOR
IC50
|
||
|
INHIBITOR -> TARGET |
IRREVERSIBLE INHIBITOR
|
||
|
INHIBITOR -> TARGET |
|
||
|
INHIBITOR -> TARGET |
IRREVERSIBLE INHIBITOR
IC50
|
||
|
INHIBITOR -> TARGET |
|
||
|
INHIBITOR -> TARGET |
IRREVERSIBLE INHIBITOR
IC50
|
||
|
INHIBITOR -> TARGET |
Binds to a cysteine residue (Cys-481) in the BTK active site
IRREVERSIBLE INHIBITOR
IC50
|
||
|
INHIBITOR -> TARGET |
IRREVERSIBLE INHIBITOR
|
||
|
|
INHIBITOR -> TARGET |
IN-VITRO
IC50
|
||
|
INHIBITOR -> TARGET |
human whole
blood assay (hWB) measuring BCR stimulated CD69
expression on B cells
COMPETITIVE INHIBITOR
IC50
|
||
|
INHIBITOR -> TARGET |
IRREVERSIBLE INHIBITOR
|
||
|
INHIBITOR -> TARGET |
Acalabrutinib forms a covalent bond with Cys481 in the BTK adenosine triphosphate (ATP).
IRREVERSIBLE INHIBITOR
IC50
|
||
|
|
INHIBITOR -> TARGET |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
|