ORELABRUTINIB

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H25N3O3
Molecular Weight	427.495
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=O)C1=C(N=C(C=C1)C2CCN(CC2)C(=O)C=C)C3=CC=C(OC4=CC=CC=C4)C=C3

InChI

InChIKey=MZPVEMOYADUARK-UHFFFAOYSA-N

InChI=1S/C26H25N3O3/c1-2-24(30)29-16-14-18(15-17-29)23-13-12-22(26(27)31)25(28-23)19-8-10-21(11-9-19)32-20-6-4-3-5-7-20/h2-13,18H,1,14-17H2,(H2,27,31)

HIDE SMILES / InChI

Molecular Formula	C26H25N3O3
Molecular Weight	427.495
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

C_max

Value	Dose	Analyte	Population
805 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/37078706/	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ORELABRUTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1250 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/37078706/	150 mg single, oral dose: 150 mg route of administration: Oral experiment type: SINGLE co-administered:	ORELABRUTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1330 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/37078706/	150 mg 1 times / day multiple, oral dose: 150 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ORELABRUTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1040 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/37078706/	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ORELABRUTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
4760 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/37078706/	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ORELABRUTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
7230 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/37078706/	150 mg single, oral dose: 150 mg route of administration: Oral experiment type: SINGLE co-administered:	ORELABRUTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
8170 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/37078706/	150 mg 1 times / day multiple, oral dose: 150 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ORELABRUTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
5360 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/37078706/	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ORELABRUTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
2.47 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/37078706/	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ORELABRUTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4.12 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/37078706/	150 mg single, oral dose: 150 mg route of administration: Oral experiment type: SINGLE co-administered:	ORELABRUTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4.41 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/37078706/	150 mg 1 times / day multiple, oral dose: 150 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ORELABRUTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/37078706/	100 mg 2 times / day multiple, oral dose: 100 mg route of administration: Oral experiment type: MULTIPLE co-administered:	ORELABRUTINIB plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Substance Class	Chemical Created by `admin` on `Wed Apr 02 01:14:46 GMT 2025` Edited by `admin` on `Wed Apr 02 01:14:46 GMT 2025`
Record UNII	WJA5UO9E10
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ORELABRUTINIB

Official Name

English

orelabrutinib [INN]

Preferred Name

English

Orelabrutinib [WHO-DD]

Common Name

English

INNOBRUKA

Brand Name

English

ICP-022

Code

English

ORELABRUTINIB [USAN]

Common Name

English

3-PYRIDINECARBOXAMIDE, 6-(1-(1-OXO-2-PROPEN-1-YL)-4-PIPERIDINYL)-2-(4-PHENOXYPHENYL)-

Systematic Name

English

6-(1-(1-OXO-2-PROPEN-1-YL)-4-PIPERIDINYL)-2-(4-PHENOXYPHENYL)-3-PYRIDINECARBOXAMIDE

Systematic Name

English

ICP022

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

788920