NX-5948 free base

Approval Year

Substance Class	Concept
Record UNII	HVD6HGW6JD
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

NX-5948 free base

Code

English

3-[[4-[1-[[1-[6-[[[(3S)-2,6-Dioxo-3-piperidinyl]amino]carbonyl]-3-pyridinyl]-4-piperidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-[(3R)-3-(3-methyl-2-oxo-1-imidazolidinyl)-1-piperidinyl]-2-pyrazinecarboxamide

Systematic Name

English

BTK-IN-24

Code

English

2-Pyrazinecarboxamide, 3-[[4-[1-[[1-[6-[[[(3S)-2,6-dioxo-3-piperidinyl]amino]carbonyl]-3-pyridinyl]-4-piperidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-[(3R)-3-(3-methyl-2-oxo-1-imidazolidinyl)-1-piperidinyl]-

Systematic Name

English

Code System Code Type Description

FDA UNII

HVD6HGW6JD

Created by admin on Sat Dec 16 19:12:40 UTC 2023 , Edited by admin on Sat Dec 16 19:12:40 UTC 2023

PRIMARY

PUBCHEM

156464216

Created by admin on Sat Dec 16 19:12:40 UTC 2023 , Edited by admin on Sat Dec 16 19:12:40 UTC 2023

PRIMARY

CAS

2649400-34-8

Created by admin on Sat Dec 16 19:12:40 UTC 2023 , Edited by admin on Sat Dec 16 19:12:40 UTC 2023

PRIMARY

This is a non-substance concept

Related Record Type Details


					SBH6S6T2J2

TYROSINE-PROTEIN KINASE BTK

TARGET->DEGRADER

Comments:

NX-5948 is a chimeric targeting molecule (CTM) that induces the degradation of BTK in cells through recruitment of cereblon (CRBN), an adaptor protein of the E3 ubiquitin ligase complex, and promotes the formation of a ternary complex of CRBN, NX-5948, and BTK. Within this complex, ubiquitin is transferred to BTK directing it for degradation by the proteasome

Interaction Type:

PRECLINICAL

Amount:

Related Record Type Details


					HVD6HGW6JD

NX-5948 free base

ACTIVE MOIETY

Amount: