POSELTINIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H26N6O3
Molecular Weight	470.523
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of POSELTINIB

Structure Search

SMILES

CN1CCN(CC1)C2=CC=C(NC3=NC(OC4=CC=CC(NC(=O)C=C)=C4)=C5OC=CC5=N3)C=C2

InChI

InChIKey=LZMJNVRJMFMYQS-UHFFFAOYSA-N

InChI=1S/C26H26N6O3/c1-3-23(33)27-19-5-4-6-21(17-19)35-25-24-22(11-16-34-24)29-26(30-25)28-18-7-9-20(10-8-18)32-14-12-31(2)13-15-32/h3-11,16-17H,1,12-15H2,2H3,(H,27,33)(H,28,29,30)

HIDE SMILES / InChI

Molecular Formula	C26H26N6O3
Molecular Weight	470.523
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:17:04 UTC 2023` Edited by `admin` on `Sat Dec 16 10:17:04 UTC 2023`
Record UNII	D01E4B1U35
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

POSELTINIB

Official Name

English

HM71224

Code

English

Poseltinib [WHO-DD]

Common Name

English

N-(3-((2-(4-(4-METHYLPIPERAZIN-1-YL)ANILINO)FURO(3,2-D)PYRIMIDIN-4-YL)OXY)PHENYL)PROP-2-ENAMIDE

Systematic Name

English

LY3337641

Code

English

2-PROPENAMIDE, N-(3-((2-((4-(4-METHYL-1-PIPERAZINYL)PHENYL)AMINO)FURO(3,2-D)PYRIMIDIN-4-YL)OXY)PHENYL)-

Systematic Name

English

poseltinib [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C124801

Created by admin on Sat Dec 16 10:17:05 UTC 2023 , Edited by admin on Sat Dec 16 10:17:05 UTC 2023

Code System Code Type Description

CAS

1353552-97-2

Created by admin on Sat Dec 16 10:17:05 UTC 2023 , Edited by admin on Sat Dec 16 10:17:05 UTC 2023

PRIMARY

EPA CompTox

DTXSID501112972

Created by admin on Sat Dec 16 10:17:05 UTC 2023 , Edited by admin on Sat Dec 16 10:17:05 UTC 2023

PRIMARY

INN

10235

Created by admin on Sat Dec 16 10:17:05 UTC 2023 , Edited by admin on Sat Dec 16 10:17:05 UTC 2023

PRIMARY

WIKIPEDIA

Poseltinib

Created by admin on Sat Dec 16 10:17:05 UTC 2023 , Edited by admin on Sat Dec 16 10:17:05 UTC 2023

PRIMARY

NCI_THESAURUS

C141273

Created by admin on Sat Dec 16 10:17:05 UTC 2023 , Edited by admin on Sat Dec 16 10:17:05 UTC 2023

PRIMARY

SMS_ID

100000174648

Created by admin on Sat Dec 16 10:17:05 UTC 2023 , Edited by admin on Sat Dec 16 10:17:05 UTC 2023

PRIMARY

PUBCHEM

56644522

Created by admin on Sat Dec 16 10:17:05 UTC 2023 , Edited by admin on Sat Dec 16 10:17:05 UTC 2023

PRIMARY

FDA UNII

D01E4B1U35

Created by admin on Sat Dec 16 10:17:05 UTC 2023 , Edited by admin on Sat Dec 16 10:17:05 UTC 2023

PRIMARY

Related Record Type Details


					ODH2D6OFW2

TYROSINE-PROTEIN KINASE TXK

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					RGHTSAKWXW

CYTOPLASMIC TYROSINE-PROTEIN KINASE BMX

TARGET -> INHIBITOR

Interaction Type:

IRREVERSIBLE INHIBITOR

Qualification:

IC50

Amount:


					SBH6S6T2J2

TYROSINE-PROTEIN KINASE BTK

TARGET -> INHIBITOR

Interaction Type:

IRREVERSIBLE INHIBITOR

Qualification:

IC50

Amount:


					Q8CNI6U44N

TYROSINE-PROTEIN KINASE TEC

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					SEV29N8JND

POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2

OFF-TARGET->INHIBITOR

Qualification:

IC50

Amount:

Related Record Type Details


					D01E4B1U35

ACTIVE MOIETY