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Details

Stereochemistry ACHIRAL
Molecular Formula C31H26F2N4O6
Molecular Weight 588.5581
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CEP-40783

SMILES

COC1=CC2=C(C=C1OC)C(OC3=C(F)C=C(NC(=O)C4=CN(C(C)C)C(=O)N(C4=O)C5=CC=C(F)C=C5)C=C3)=CC=N2

InChI

InChIKey=FKCWHHYUMFGOPY-UHFFFAOYSA-N
InChI=1S/C31H26F2N4O6/c1-17(2)36-16-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)13-19)43-25-11-12-34-24-15-28(42-4)27(41-3)14-21(24)25/h5-17H,1-4H3,(H,35,38)

HIDE SMILES / InChI
Molecular Formula C31H26F2N4O6
Molecular Weight 588.5581
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Tyrosine-protein kinase receptor UFO
14
Target ID: P30530
Gene ID: 558.0
Gene Symbol: AXL
Target Organism: Homo sapiens (Human)
Inhibitor
8297
 7.0 nM [IC50]
Hepatocyte growth factor receptor
54
Target ID: P08581
Gene ID: 4233.0
Gene Symbol: MET
Target Organism: Homo sapiens (Human)
Inhibitor
8297
 12.0 nM [IC50]
Tyrosine-protein kinase Mer
3
Target ID: Q12866
Gene ID: 10461.0
Gene Symbol: MERTK
Target Organism: Homo sapiens (Human)
Inhibitor
8297
 29.0 nM [IC50]
Tyrosine-protein kinase receptor TYRO3
2
Target ID: Q06418
Gene ID: 7301.0
Gene Symbol: TYRO3
Target Organism: Homo sapiens (Human)
Inhibitor
8297
 19.0 nM [IC50]
Substance Class Chemical
Created
by admin
on Sat Dec 16 14:09:08 GMT 2023
Edited
by admin
on Sat Dec 16 14:09:08 GMT 2023
Record UNII
1969ZJE05Q
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CEP-40783
Code English
RXDX-106
Code English
5-PYRIMIDINECARBOXAMIDE, N-(4-((6,7-DIMETHOXY-4-QUINOLINYL)OXY)-3-FLUOROPHENYL)-3-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2,4-DIOXO-
Systematic Name English
N-(4-((6,7-DIMETHOXY-4-QUINOLINYL)OXY)-3-FLUOROPHENYL)-3-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2,4-DIOXO-5-PYRIMIDINECARBOXAMIDE
Systematic Name English
Code System Code Type Description
PUBCHEM
71576419
Created by admin on Sat Dec 16 14:09:08 GMT 2023 , Edited by admin on Sat Dec 16 14:09:08 GMT 2023
PRIMARY
FDA UNII
1969ZJE05Q
Created by admin on Sat Dec 16 14:09:08 GMT 2023 , Edited by admin on Sat Dec 16 14:09:08 GMT 2023
PRIMARY
CAS
1437321-24-8
Created by admin on Sat Dec 16 14:09:08 GMT 2023 , Edited by admin on Sat Dec 16 14:09:08 GMT 2023
PRIMARY
NCI_THESAURUS
C150585
Created by admin on Sat Dec 16 14:09:08 GMT 2023 , Edited by admin on Sat Dec 16 14:09:08 GMT 2023
PRIMARY
Related Record Type Details
HEPATOCYTE GROWTH FACTOR RECEPTOR
TARGET -> INHIBITOR
BIOCHEMICAL SLOW OFF RATE
IC50
TYROSINE-PROTEIN KINASE RECEPTOR TYRO3
TARGET -> INHIBITOR
BIOCHEMICAL SLOW OFF RATE
IC50
TYROSINE-PROTEIN KINASE MER
TARGET -> INHIBITOR
CELLULAR ASSAY pseudo-irreversible
IC50
HEPATOCYTE GROWTH FACTOR RECEPTOR
TARGET -> INHIBITOR
CELLULAR ASSAY pseudo-irreversible
IC50
TYROSINE-PROTEIN KINASE RECEPTOR UFO
TARGET -> INHIBITOR
CELLULAR ASSAY pseudo-irreversible
IC50
TYROSINE-PROTEIN KINASE RECEPTOR TYRO3
TARGET -> INHIBITOR
CELLULAR ASSAY pseudo-irreversible
IC50
TYROSINE-PROTEIN KINASE MER
TARGET -> INHIBITOR
BIOCHEMICAL ASSAY
IC50
TYROSINE-PROTEIN KINASE RECEPTOR UFO
TARGET -> INHIBITOR
BIOCHEMICAL SLOW OFF RATE
IC50
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2
OFF TARGET->NON-INHIBITOR
Related Record Type Details
Structure of CEP-40783
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