Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C31H26F2N4O6 |
| Molecular Weight | 588.5581 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=C(C=C1OC)C(OC3=C(F)C=C(NC(=O)C4=CN(C(C)C)C(=O)N(C4=O)C5=CC=C(F)C=C5)C=C3)=CC=N2
InChI
InChIKey=FKCWHHYUMFGOPY-UHFFFAOYSA-N
InChI=1S/C31H26F2N4O6/c1-17(2)36-16-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)13-19)43-25-11-12-34-24-15-28(42-4)27(41-3)14-21(24)25/h5-17H,1-4H3,(H,35,38)
| Molecular Formula | C31H26F2N4O6 |
| Molecular Weight | 588.5581 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P30530 Gene ID: 558.0 Gene Symbol: AXL Target Organism: Homo sapiens (Human) |
7.0 nM [IC50] | ||
Target ID: P08581 Gene ID: 4233.0 Gene Symbol: MET Target Organism: Homo sapiens (Human) |
12.0 nM [IC50] | ||
Target ID: Q12866 Gene ID: 10461.0 Gene Symbol: MERTK Target Organism: Homo sapiens (Human) |
29.0 nM [IC50] | ||
Target ID: Q06418 Gene ID: 7301.0 Gene Symbol: TYRO3 Target Organism: Homo sapiens (Human) |
19.0 nM [IC50] |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 14:09:08 UTC 2023
by
admin
on
Sat Dec 16 14:09:08 UTC 2023
|
| Record UNII |
1969ZJE05Q
|
| Record Status |
Validated (UNII)
|
| Record Version |
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-
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71576419
Created by
admin on Sat Dec 16 14:09:08 UTC 2023 , Edited by admin on Sat Dec 16 14:09:08 UTC 2023
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1969ZJE05Q
Created by
admin on Sat Dec 16 14:09:08 UTC 2023 , Edited by admin on Sat Dec 16 14:09:08 UTC 2023
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1437321-24-8
Created by
admin on Sat Dec 16 14:09:08 UTC 2023 , Edited by admin on Sat Dec 16 14:09:08 UTC 2023
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C150585
Created by
admin on Sat Dec 16 14:09:08 UTC 2023 , Edited by admin on Sat Dec 16 14:09:08 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
TARGET -> INHIBITOR |
BIOCHEMICAL SLOW OFF RATE
IC50
|
||
|
TARGET -> INHIBITOR |
BIOCHEMICAL SLOW OFF RATE
IC50
|
||
|
TARGET -> INHIBITOR |
CELLULAR ASSAY pseudo-irreversible
IC50
|
||
|
TARGET -> INHIBITOR |
CELLULAR ASSAY pseudo-irreversible
IC50
|
||
|
TARGET -> INHIBITOR |
CELLULAR ASSAY pseudo-irreversible
IC50
|
||
|
TARGET -> INHIBITOR |
CELLULAR ASSAY pseudo-irreversible
IC50
|
||
|
TARGET -> INHIBITOR |
BIOCHEMICAL ASSAY
IC50
|
||
|
TARGET -> INHIBITOR |
BIOCHEMICAL SLOW OFF RATE
IC50
|
||
|
|
OFF TARGET->NON-INHIBITOR |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ACTIVE MOIETY |
