TP-3654

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H25F3N4O
Molecular Weight	418.4553
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(O)[C@H]1CC[C@@H](CC1)NC2=NN3C(C=C2)=NC=C3C4=CC(=CC=C4)C(F)(F)F

InChI

InChIKey=XRNVABDYQLHODA-JCNLHEQBSA-N

InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)/t15-,17-

HIDE SMILES / InChI

Molecular Formula	C22H25F3N4O
Molecular Weight	418.4553
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serine/threonine-protein kinase PIM1 13 Target ID: CHEMBL2147 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24953177	Inhibitor 8297		5.0 nM [Ki]
Serine/threonine-protein kinase PIM3 9 Target ID: CHEMBL5407 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24953177	Inhibitor 8297		42.0 nM [Ki]

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:53:14 UTC 2023` Edited by `admin` on `Sat Dec 16 11:53:14 UTC 2023`
Record UNII	EOB0N7BOY4
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TP-3654

Code

English

4-((3-(3-(TRIFLUOROMETHYL)PHENYL)IMIDAZO(1,2-B)PYRIDAZIN-6-YL)AMINO) -TRANS-CYCLOHEXYL)PROPAN-2-OL

Systematic Name

English

2-(4-((3-(3-(TRIFLUOROMETHYL)PHENYL)IMIDAZO(1,2-B)PYRIDAZIN-6-YL)AMINO)CYCLOHEXYL)PROPAN-2-OL

Systematic Name

English

SGI-9481

Code

English

Code System Code Type Description

FDA UNII

EOB0N7BOY4

Created by admin on Sat Dec 16 11:53:14 UTC 2023 , Edited by admin on Sat Dec 16 11:53:14 UTC 2023

PRIMARY

NCI_THESAURUS

C160203

Created by admin on Sat Dec 16 11:53:14 UTC 2023 , Edited by admin on Sat Dec 16 11:53:14 UTC 2023

PRIMARY

CAS

1361951-15-6

Created by admin on Sat Dec 16 11:53:14 UTC 2023 , Edited by admin on Sat Dec 16 11:53:14 UTC 2023

PRIMARY

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Qualification:

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Amount:


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POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2

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					5NJ22TAB5Y

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					2CI3BLM1YG

SERINE/THREONINE-PROTEIN KINASE PIM-3

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					D7A0W431TR

TP-3654 HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					EOB0N7BOY4

TP-3654

ACTIVE MOIETY

Comments:

Originator: Tolero Pharmaceuticals; Mechanism of Action: 1 Phosphatidylinositol 3 kinase inhibitor, Proto oncogene protein c pim 1 inhibito