SERINE/THREONINE-PROTEIN KINASE PIM-1

Approval Year

Substance Class	Protein
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	5NJ22TAB5Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PIM1

Preferred Name

English

SERINE/THREONINE-PROTEIN KINASE PIM-1

Common Name

English

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Code System

Code

Type

Description

PHAROS

P11309

PRIMARY

FDA UNII

5NJ22TAB5Y

PRIMARY

CHEBI

87673

PRIMARY

UNIPROT

P11309

PRIMARY

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Subunit 0

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Related Record

Type

Details


					0237X8153Q

UZANSERTIB

INHIBITOR -> TARGET


					FAJ9F9K7LH

AZD-1897

INHIBITOR -> TARGET


					C6RWP0N0L2

SILMITASERTIB

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

46 NANOMOLAR (average)


					947VD76D3L

PERFLUOROOCTANOIC ACID

INHIBITOR -> TARGET

Qualification:

Ki

Amount:

40000 NANOMOLAR (average)


					72AUA0603W

SGI-1776

INHIBITOR -> TARGET

Interaction Type:

COMPETITIVE INHIBITOR

Qualification:

IC50

Amount:

7 NANOMOLAR (average)

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_99] [1_189] [1_352]				DEXFOSFOSERINE	VI4F0K069V
AMINO ACID SUBSTITUTION	[1_114]				THREONINE PHOSPHATE	3L4WX7B1EI

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL

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