Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C27H31F5N4O |
Molecular Weight | 522.5543 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@]1([H])Cc2c3ccccc3[nH]c2[C@@]([H])(c4c(cc(cc4F)NC5CN(CCCF)C5)F)N1CC(CO)(F)F
InChI
InChIKey=GQCXHIKRWBIQMD-AKJBCIBTSA-N
InChI=1S/C27H31F5N4O/c1-16-9-20-19-5-2-3-6-23(19)34-25(20)26(36(16)14-27(31,32)15-37)24-21(29)10-17(11-22(24)30)33-18-12-35(13-18)8-4-7-28/h2-3,5-6,10-11,16,18,26,33-34,37H,4,7-9,12-15H2,1H3/t16-,26-/m1/s1
Molecular Formula | C27H31F5N4O |
Molecular Weight | 522.5543 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 12:32:21 UTC 2021
by
admin
on
Sat Jun 26 12:32:21 UTC 2021
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Record UNII |
28P3DU6DB3
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Record Status |
Validated (UNII)
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Record Version |
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-
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Code | English |
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121410806
Created by
admin on Sat Jun 26 12:32:21 UTC 2021 , Edited by admin on Sat Jun 26 12:32:21 UTC 2021
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PRIMARY | |||
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28P3DU6DB3
Created by
admin on Sat Jun 26 12:32:21 UTC 2021 , Edited by admin on Sat Jun 26 12:32:21 UTC 2021
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C147030
Created by
admin on Sat Jun 26 12:32:21 UTC 2021 , Edited by admin on Sat Jun 26 12:32:21 UTC 2021
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11226
Created by
admin on Sat Jun 26 12:32:21 UTC 2021 , Edited by admin on Sat Jun 26 12:32:21 UTC 2021
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1953133-47-5
Created by
admin on Sat Jun 26 12:32:21 UTC 2021 , Edited by admin on Sat Jun 26 12:32:21 UTC 2021
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PRIMARY |
Related Record | Type | Details | ||
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TARGET -> INHIBITOR |
IC50
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OFF-TARGET->INHIBITOR |
IC50
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TARGET -> INHIBITOR |
induction of an inactive conformation of the ER ligand-binding domain (LBD) and 2) induces ER? (WT and mutant) degradation
IC50
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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log D | CHEMICAL |
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