PF-06821497

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H24Cl2N2O5
Molecular Weight	467.342
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CO[C@H](C1COC1)C2=C(Cl)C3=C(CCN(CC4=C(OC)C=C(C)NC4=O)C3=O)C(Cl)=C2

InChI

InChIKey=RXCVUHMIWHRLDF-HXUWFJFHSA-N

InChI=1S/C22H24Cl2N2O5/c1-11-6-17(29-2)15(21(27)25-11)8-26-5-4-13-16(23)7-14(19(24)18(13)22(26)28)20(30-3)12-9-31-10-12/h6-7,12,20H,4-5,8-10H2,1-3H3,(H,25,27)/t20-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H24Cl2N2O5
Molecular Weight	467.342
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histone-lysine N-methyltransferase EZH2 10 Target ID: Q15910\|\|\|Q96FI6 Gene ID: 2146.0 Gene Symbol: EZH2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/29211475	Inhibitor 8297

Substance Class	Chemical Created by `admin` on `Sat Dec 16 14:20:58 GMT 2023` Edited by `admin` on `Sat Dec 16 14:20:58 GMT 2023`
Record UNII	S4L4MM20B6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PF-06821497

Code

English

1(2H)-ISOQUINOLINONE, 5,8-DICHLORO-2-((1,2-DIHYDRO-4-METHOXY-6-METHYL-2-OXO-3-PYRIDINYL)METHYL)-3,4-DIHYDRO-7-((R)-METHOXY-3-OXETANYLMETHYL)-

Common Name

English

Code System Code Type Description

FDA UNII

S4L4MM20B6