U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H24Cl2N2O5
Molecular Weight 467.342
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Mevrometostat

SMILES

CO[C@H](C1COC1)C2=C(Cl)C3=C(CCN(CC4=C(OC)C=C(C)NC4=O)C3=O)C(Cl)=C2

InChI

InChIKey=RXCVUHMIWHRLDF-HXUWFJFHSA-N
InChI=1S/C22H24Cl2N2O5/c1-11-6-17(29-2)15(21(27)25-11)8-26-5-4-13-16(23)7-14(19(24)18(13)22(26)28)20(30-3)12-9-31-10-12/h6-7,12,20H,4-5,8-10H2,1-3H3,(H,25,27)/t20-/m1/s1

HIDE SMILES / InChI

Molecular Formula C22H24Cl2N2O5
Molecular Weight 467.342
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Q15910|||Q96FI6
Gene ID: 2146.0
Gene Symbol: EZH2
Target Organism: Homo sapiens (Human)
Substance Class Chemical
Created
by admin
on Tue Apr 01 23:13:33 GMT 2025
Edited
by admin
on Tue Apr 01 23:13:33 GMT 2025
Record UNII
S4L4MM20B6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PF-06821497
Preferred Name English
Mevrometostat
USAN   INN  
Official Name English
MEVROMETOSTAT [USAN]
Common Name English
1(2H)-Isoquinolinone, 5,8-dichloro-2-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-3,4-dihydro-7-[(R)-methoxy-3-oxetanylmethyl]-
Systematic Name English
5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoqinolin-1(2H)-one
Systematic Name English
mevrometostat [INN]
Common Name English
5,8-dichloro-7-[(R)-methoxy(oxetan-3-yl)methyl]-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one
Systematic Name English
Code System Code Type Description
INN
13206
Created by admin on Tue Apr 01 23:13:33 GMT 2025 , Edited by admin on Tue Apr 01 23:13:33 GMT 2025
PRIMARY
FDA UNII
S4L4MM20B6
Created by admin on Tue Apr 01 23:13:33 GMT 2025 , Edited by admin on Tue Apr 01 23:13:33 GMT 2025
PRIMARY
PUBCHEM
118572065
Created by admin on Tue Apr 01 23:13:33 GMT 2025 , Edited by admin on Tue Apr 01 23:13:33 GMT 2025
PRIMARY
USAN
LM-228
Created by admin on Tue Apr 01 23:13:33 GMT 2025 , Edited by admin on Tue Apr 01 23:13:33 GMT 2025
PRIMARY
CAS
1844849-10-0
Created by admin on Tue Apr 01 23:13:33 GMT 2025 , Edited by admin on Tue Apr 01 23:13:33 GMT 2025
PRIMARY
NCI_THESAURUS
C156743
Created by admin on Tue Apr 01 23:13:33 GMT 2025 , Edited by admin on Tue Apr 01 23:13:33 GMT 2025
PRIMARY
SMS_ID
300000041366
Created by admin on Tue Apr 01 23:13:33 GMT 2025 , Edited by admin on Tue Apr 01 23:13:33 GMT 2025
PRIMARY
DRUG BANK
DB14799
Created by admin on Tue Apr 01 23:13:33 GMT 2025 , Edited by admin on Tue Apr 01 23:13:33 GMT 2025
PRIMARY
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