U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 19:52:27 GMT 2025
Edited
by admin
on Tue Apr 01 19:52:27 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
J2234208AE
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ENHANCER OF ZESTE 2 (HUMAN CELL LINE BJA-B GENE EZH2)
Preferred Name English
HISTONE-LYSINE N-METHYLTRANSFERASE EZH2
Common Name English
LYSINE N-METHYLTRANSFERASE 6
Common Name English
ENHANCER OF ZESTE HOMOLOG 2
Common Name English
ENX-1
Common Name English
KMT6
Common Name English
Code System Code Type Description
WIKIPEDIA
EZH2
Created by admin on Tue Apr 01 19:52:27 GMT 2025 , Edited by admin on Tue Apr 01 19:52:27 GMT 2025
PRIMARY
CAS
459578-94-0
Created by admin on Tue Apr 01 19:52:27 GMT 2025 , Edited by admin on Tue Apr 01 19:52:27 GMT 2025
PRIMARY
UNIPROT
Q15910
Created by admin on Tue Apr 01 19:52:27 GMT 2025 , Edited by admin on Tue Apr 01 19:52:27 GMT 2025
PRIMARY
FDA UNII
J2234208AE
Created by admin on Tue Apr 01 19:52:27 GMT 2025 , Edited by admin on Tue Apr 01 19:52:27 GMT 2025
PRIMARY
PHAROS
Q15910
Created by admin on Tue Apr 01 19:52:27 GMT 2025 , Edited by admin on Tue Apr 01 19:52:27 GMT 2025
PRIMARY
CAS
487555-47-5
Created by admin on Tue Apr 01 19:52:27 GMT 2025 , Edited by admin on Tue Apr 01 19:52:27 GMT 2025
ALTERNATIVE
EC (ENZYME CLASS)
EC 2.1.1.43
Created by admin on Tue Apr 01 19:52:27 GMT 2025 , Edited by admin on Tue Apr 01 19:52:27 GMT 2025
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
O 1_75
Related Record Type Details
INHIBITOR -> TARGET
biochemical assay
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
The maximal dose and schedule attained with GSK2816126 has shown insufficient evidence of clinical activity, and does not justify further clinical investigation.

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_345] THREONINE THREONINE PHOSPHATE 3L4WX7B1EI
AMINO ACID SUBSTITUTION [1_339] [1_367] [1_487] THREONINE THREONINE PHOSPHATE 3L4WX7B1EI
AMINO ACID SUBSTITUTION [1_76] [1_363] [1_366] SERINE DEXFOSFOSERINE VI4F0K069V
AMINO ACID SUBSTITUTION [1_21] SERINE DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL