LIRAMETOSTAT

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H33F3N4O3
Molecular Weight	518.5711
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=C(CNC(=O)C2=C(C)N([C@H](C)C3CCN(CC(F)(F)F)CC3)C4=CC=CC=C24)C(=O)NC(C)=C1

InChI

InChIKey=HPODOLXTMDHLLC-QGZVFWFLSA-N

InChI=1S/C27H33F3N4O3/c1-16-13-23(37-4)21(25(35)32-16)14-31-26(36)24-18(3)34(22-8-6-5-7-20(22)24)17(2)19-9-11-33(12-10-19)15-27(28,29)30/h5-8,13,17,19H,9-12,14-15H2,1-4H3,(H,31,36)(H,32,35)/t17-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C27H33F3N4O3
Molecular Weight	518.5711
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histone-lysine N-methyltransferase EZH2 10 Target ID: Q15910\|\|\|Q96FI6 Gene ID: 2146.0 Gene Symbol: EZH2 Target Organism: Homo sapiens (Human) Sources: https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20171214&CC=WO&NR=2017214373A1&KC=A1	Inhibitor 8297

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:47:16 UTC 2023` Edited by `admin` on `Sat Dec 16 10:47:16 UTC 2023`
Record UNII	455J2479FY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LIRAMETOSTAT

Official Name

English

(R)-N-((4-METHOXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-2-METHYL-1-(1-(1-(2,2,2-TRIFLUOROETHYL)PIPERIDIN-4-YL)ETHYL)-1H-INDOLE-3-CARBOXAMIDE

Systematic Name

English

CPI-1205

Code

English

lirametostat [INN]

Common Name

English

EZH2 INHIBITOR CPI-1205

Common Name

English

Lirametostat [WHO-DD]

Common Name

English

1H-INDOLE-3-CARBOXAMIDE, N-((1,2-DIHYDRO-4-METHOXY-6-METHYL-2-OXO-3-PYRIDINYL)METHYL)-2-METHYL-1-((1R)-1-(1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL)ETHYL)-

Systematic Name

English

Code System Code Type Description

DRUG BANK

DB14581