Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H19F3N4O2 |
| Molecular Weight | 356.3429 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@H]1CCN1C2=NC(=CC(=N2)N3C[C@H]4[C@H](CC(O)=O)[C@H]4C3)C(F)(F)F
InChI
InChIKey=MDUYWDNWFXSMJJ-XWLWVQCSSA-N
InChI=1S/C16H19F3N4O2/c1-8-2-3-23(8)15-20-12(16(17,18)19)5-13(21-15)22-6-10-9(4-14(24)25)11(10)7-22/h5,8-11H,2-4,6-7H2,1H3,(H,24,25)/t8-,9-,10-,11+/m0/s1
| Molecular Formula | C16H19F3N4O2 |
| Molecular Weight | 356.3429 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
23.39 μg/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT04427917 |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
PF-06835919 plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
30.49 μg/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT04427917 |
300 mg 1 times / day multiple, oral dose: 300 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
PF-06835919 plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
169.3 μg × h/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT04427917 |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
PF-06835919 plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
169.3 μg × h/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT04427917 |
300 mg 1 times / day multiple, oral dose: 300 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
PF-06835919 plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
14.62 h CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT04427917 |
300 mg 1 times / day multiple, oral dose: 300 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
PF-06835919 plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Apr 01 20:52:33 GMT 2025
by
admin
on
Tue Apr 01 20:52:33 GMT 2025
|
| Record UNII |
EC2P9H3A8S
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| Record Status |
Validated (UNII)
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| Record Version |
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129278694
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EC2P9H3A8S
Created by
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2102501-84-6
Created by
admin on Tue Apr 01 20:52:33 GMT 2025 , Edited by admin on Tue Apr 01 20:52:33 GMT 2025
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300000008140
Created by
admin on Tue Apr 01 20:52:33 GMT 2025 , Edited by admin on Tue Apr 01 20:52:33 GMT 2025
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