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Approval Year

Unknown
127998
Substance Class Protein
Created
by admin
on Sun Dec 18 06:17:58 UTC 2022
Edited
by admin
on Sun Dec 18 06:17:58 UTC 2022
Protein Type ENZYME
Protein Sub Type CYTOCHROME P450
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
0UY97CSG1T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYTOCHROME P450 2B6
Common Name English
1,4-CINEOLE 2-EXO-MONOOXYGENASE
Common Name English
CYP2B6
Common Name English
CYTOCHROME P 450 2B6
Common Name English
HUMAN CYTOCHROME P450 2B6
Common Name English
Code System Code Type Description
FDA UNII
0UY97CSG1T
Created by admin on Sun Dec 18 06:18:08 UTC 2022 , Edited by admin on Sun Dec 18 06:18:08 UTC 2022
PRIMARY
CAS
330207-11-9
Created by admin on Sun Dec 18 06:18:08 UTC 2022 , Edited by admin on Sun Dec 18 06:18:08 UTC 2022
PRIMARY
UNIPROT
P20813
Created by admin on Sun Dec 18 06:18:08 UTC 2022 , Edited by admin on Sun Dec 18 06:18:08 UTC 2022
PRIMARY
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Structure of CENOBAMATE
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Structure of CYCLOPHOSPHAMIDE ANHYDROUS
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Structure of CHLORPYRIFOS
SUBSTRATE -> METABOLIC ENZYME
Structure of MALATHION
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Screening of potential CYP2B6 inhibitions illustrates that CYP2B6 activity was extensively inhibited by all tested organophosphate pesticides. Malathion and phenthoate resulted in 91% inhibition.
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SUBSTRATE -> METABOLIC ENZYME
Structure of COBICISTAT
INHIBITOR -> METABOLIC ENZYME
Structure of MIDAZOLAM
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Structure of PEXIDARTINIB
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Structure of VILOXAZINE
INHIBITOR -> METABOLIC ENZYME
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Structure of VILOXAZINE
INDUCER -> METABOLIC ENZYME
Structure of TILIDINE
SUBSTRATE -> METABOLIC ENZYME
Structure of PERHEXILINE
SUBSTRATE -> METABOLIC ENZYME
Structure of DPC-963
SUBSTRATE -> METABOLIC ENZYME
Structure of PROADIFEN
INHIBITOR -> METABOLIC ENZYME
SELECTIVE
Structure of RELUGOLIX
INDUCER -> METABOLIC ENZYME
Structure of DIMPYLATE
SUBSTRATE -> METABOLIC ENZYME
Structure of MDE
MDE
SUBSTRATE -> METABOLIC ENZYME
Structure of MEPERIDINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of OTESECONAZOLE
INHIBITOR -> METABOLIC ENZYME
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IC50
Structure of Desloratadine
INHIBITOR -> METABOLIC ENZYME
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Structure of ZANUBRUTINIB
INDUCER -> METABOLIC ENZYME
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Structure of PROPOFOL
SUBSTRATE -> METABOLIC ENZYME
Structure of EPINASTINE
SUBSTRATE -> METABOLIC ENZYME
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Structure of OSPEMIFENE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of IFOSFAMIDE
SUBSTRATE -> METABOLIC ENZYME
Structure of CENOBAMATE
SUBSTRATE -> METABOLIC ENZYME
Structure of SELEGILINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of NELONICLINE
SUBSTRATE -> METABOLIC ENZYME
3.2% conversion to M1
Structure of TAFAMIDIS
INDUCER -> METABOLIC ENZYME
tafamidis induced CYP2B6 in vitro with an EC50 of 25 ?M.
EC50
Structure of N-(3-METHOXYPROPYL)-1-PHENYLCYCLOHEXANAMINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of ABAMETAPIR
SUBSTRATE -> METABOLIC ENZYME
Structure of PHENOBARBITAL
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Structure of ALDUMASTAT
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Structure of MDMC
SUBSTRATE -> METABOLIC ENZYME
Structure of ENDOSULFAN I
SUBSTRATE -> METABOLIC ENZYME
Structure of PHENTHOATE
INHIBITOR -> METABOLIC ENZYME
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Structure of SONIDEGIB
INHIBITOR -> METABOLIC ENZYME
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Structure of LEMBOREXANT
INDUCER -> METABOLIC ENZYME
Structure of 3-ISOXAZOLECARBOXAMIDE, N-(2,4-DICHLOROPHENYL)-5-METHYL-
INHIBITOR -> METABOLIC ENZYME
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Structure of FLIBANSERIN
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of TICLOPIDINE
INHIBITOR -> METABOLIC ENZYME
Structure of OXYMETAZOLINE
NON-SUBSTRATE -> METABOLIC ENZYME
Structure of RIFAMYCIN
INHIBITOR -> METABOLIC ENZYME
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Structure of BUPROPION
SUBSTRATE -> METABOLIC ENZYME
Structure of PROFENOFOS
PARENT->INNOVATOR
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Structure of ARTEMOTIL
SUBSTRATE -> METABOLIC ENZYME
Structure of DIETHYLTOLUAMIDE
SUBSTRATE -> METABOLIC ENZYME
Structure of METHADONE
SUBSTRATE -> METABOLIC ENZYME
CYP2B6 preferentially metabolized (S)-methadone,
Structure of EXEMESTANE
SUBSTRATE -> METABOLIC ENZYME
Structure of ENASIDENIB
SUBSTRATE -> METABOLIC ENZYME
Structure of PHENYTOIN
INDUCER -> METABOLIC ENZYME
Structure of ARTEMETHER
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of EFAVIRENZ
SUBSTRATE -> METABOLIC ENZYME
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INDUCER -> METABOLIC ENZYME
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INHIBITOR -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of TERIFLUNOMIDE
NON-SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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INDUCER -> METABOLIC ENZYME
Structure of LORLATINIB
INDUCER -> METABOLIC ENZYME
ACTIVATOR
Structure of VOXELOTOR
SUBSTRATE -> METABOLIC ENZYME
In vitro metabolism studies involving recombinant enzymes indicated that CYP3A4, CYP1A1, CYP3A5, CYP2C9, CYP2C19 and CYP2B6 were responsible for the oxidative metabolism of voxelotor.
Structure of CENOBAMATE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of SKF-26754A
INHIBITOR -> METABOLIC ENZYME
Structure of TRICLABENDAZOLE SULFOXIDE
INHIBITOR -> METABOLIC ENZYME
IC50
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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INDUCER -> TARGET
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SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of PEXIDARTINIB
INDUCER -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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INHIBITOR -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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INHIBITOR -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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INDUCER -> METABOLIC ENZYME
IC50
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
MAJOR
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SUBSTRATE -> METABOLIC ENZYME
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INHIBITOR -> METABOLIC ENZYME
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INDUCER -> METABOLIC ENZYME
MAJOR
Structure of CYCLOHEXANAMINE, N-(2-ETHOXYETHYL)-1-PHENYL-
SUBSTRATE -> METABOLIC ENZYME
MAJOR
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SUBSTRATE -> METABOLIC ENZYME
Structure of ISAVUCONAZOLE
INDUCER -> METABOLIC ENZYME
Structure of ENZALUTAMIDE
INHIBITOR -> METABOLIC ENZYME
Structure of FLUVOXAMINE
INHIBITOR -> METABOLIC ENZYME
WEAK INHIBITOR
Structure of .ALPHA.-PYRROLIDINOPENTIOPHENONE
SUBSTRATE -> METABOLIC ENZYME
Structure of CLOBAZAM
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of TRICLABENDAZOLE
SUBSTRATE -> METABOLIC ENZYME
Structure of OSILODROSTAT
SUBSTRATE -> METABOLIC ENZYME
Structure of FENITROTHION
INHIBITOR -> METABOLIC ENZYME
Screening of potential CYP2B6 inhibitions illustrates that CYP2B6 activity was extensively inhibited by all tested organophosphate pesticides. Inhibition percentages were 100% with fenitrothion.
Structure of 2,4-DICHLOROANILINE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of REGORAFENIB ANHYDROUS
INHIBITOR -> METABOLIC ENZYME
Ki
Structure of TRICLABENDAZOLE SULFONE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of SELICICLIB
SUBSTRATE -> METABOLIC ENZYME
Structure of ENCORAFENIB
INHIBITOR -> METABOLIC ENZYME
IC50
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
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