U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
134361
Substance Class Protein
Created
by admin
on Thu Jul 06 16:30:39 UTC 2023
Edited
by admin
on Thu Jul 06 16:30:39 UTC 2023
Protein Type ENZYME
Protein Sub Type CYTOCHROME P450
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
0UY97CSG1T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYTOCHROME P450 2B6
Common Name English
1,4-CINEOLE 2-EXO-MONOOXYGENASE
Common Name English
CYP2B6
Common Name English
CYTOCHROME P 450 2B6
Common Name English
HUMAN CYTOCHROME P450 2B6
Common Name English
Code System Code Type Description
FDA UNII
0UY97CSG1T
Created by admin on Thu Jul 06 16:30:47 UTC 2023 , Edited by admin on Thu Jul 06 16:30:47 UTC 2023
PRIMARY
CAS
330207-11-9
Created by admin on Thu Jul 06 16:30:47 UTC 2023 , Edited by admin on Thu Jul 06 16:30:47 UTC 2023
PRIMARY
UNIPROT
P20813
Created by admin on Thu Jul 06 16:30:47 UTC 2023 , Edited by admin on Thu Jul 06 16:30:47 UTC 2023
PRIMARY
Related Record Type Details
Structure of LUSUTROMBOPAG
INHIBITOR -> TARGET
MINOR
Structure of TRAMADOL
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of PARATHION
SUBSTRATE -> METABOLIC ENZYME
Structure of CENOBAMATE
INDUCER -> METABOLIC ENZYME
Structure of OTESECONAZOLE
INDUCER -> METABOLIC ENZYME
mRNA levels in at least 2 hepatocyte cultures. Up 10 micromolar OTESECONAZOLE
Structure of CYCLOPHOSPHAMIDE ANHYDROUS
SUBSTRATE -> METABOLIC ENZYME
Structure of CHLORPYRIFOS
SUBSTRATE -> METABOLIC ENZYME
Structure of OXYMETAZOLINE
NON-SUBSTRATE -> METABOLIC ENZYME
Structure of PF-06835919
NON-INHIBITOR -> METABOLIC ENZYME
IC50
Structure of MALATHION
INHIBITOR -> METABOLIC ENZYME
Screening of potential CYP2B6 inhibitions illustrates that CYP2B6 activity was extensively inhibited by all tested organophosphate pesticides. Malathion and phenthoate resulted in 91% inhibition.
Structure of RIFAMYCIN
INDUCER -> METABOLIC ENZYME
Rifamycin is an inducer of CYP3A4 and CYP2B6 but not CYP1A2 in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose, clinically relevant induction of these enzymes in vivo is unlikely.
Structure of AZILSARTAN
SUBSTRATE -> METABOLIC ENZYME
Structure of COBICISTAT
INHIBITOR -> METABOLIC ENZYME
Structure of MIDAZOLAM
SUBSTRATE -> METABOLIC ENZYME
Structure of PEXIDARTINIB
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of ZIMLOVISERTIB
NON-INHIBITOR -> METABOLIC ENZYME
Structure of VILOXAZINE
INHIBITOR -> METABOLIC ENZYME
REVERSIBLE
Structure of UAB-30
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of VILOXAZINE
INDUCER -> METABOLIC ENZYME
Structure of TILIDINE
SUBSTRATE -> METABOLIC ENZYME
Structure of PERHEXILINE
SUBSTRATE -> METABOLIC ENZYME
Structure of DPC-963
SUBSTRATE -> METABOLIC ENZYME
Structure of PROADIFEN
INHIBITOR -> METABOLIC ENZYME
SELECTIVE
Structure of RELUGOLIX
INDUCER -> METABOLIC ENZYME
Structure of DIMPYLATE
SUBSTRATE -> METABOLIC ENZYME
Structure of MDE
MDE
SUBSTRATE -> METABOLIC ENZYME
Structure of MEPERIDINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of OTESECONAZOLE
INHIBITOR -> METABOLIC ENZYME
REVERSIBLE
IC50
Structure of Desloratadine
INHIBITOR -> METABOLIC ENZYME
WEAK
Structure of ZANUBRUTINIB
INDUCER -> METABOLIC ENZYME
Zanubrutinib induces CYP2B6 in vitro.
Structure of PROPOFOL
SUBSTRATE -> METABOLIC ENZYME
Structure of EPINASTINE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of OSPEMIFENE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of IFOSFAMIDE
SUBSTRATE -> METABOLIC ENZYME
Structure of CENOBAMATE
SUBSTRATE -> METABOLIC ENZYME
Structure of SELEGILINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of NELONICLINE
SUBSTRATE -> METABOLIC ENZYME
3.2% conversion to M1
Structure of TAFAMIDIS
INDUCER -> METABOLIC ENZYME
tafamidis induced CYP2B6 in vitro with an EC50 of 25 μM.
EC50
Structure of N-(3-METHOXYPROPYL)-1-PHENYLCYCLOHEXANAMINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of ABAMETAPIR
SUBSTRATE -> METABOLIC ENZYME
Structure of PHENOBARBITAL
INDUCER -> METABOLIC ENZYME
Structure of ALDUMASTAT
NON-SUBSTRATE -> METABOLIC ENZYME
Structure of MDMC
SUBSTRATE -> METABOLIC ENZYME
Structure of ENDOSULFAN I
SUBSTRATE -> METABOLIC ENZYME
Structure of PHENTHOATE
INHIBITOR -> METABOLIC ENZYME
Screening of potential CYP2B6 inhibitions illustrates that CYP2B6 activity was extensively inhibited by all tested organophosphate pesticides. Phenthoate resulted in 91% inhibition.
Structure of SONIDEGIB
INHIBITOR -> METABOLIC ENZYME
Ki
Structure of LEMBOREXANT
INDUCER -> METABOLIC ENZYME
Structure of 3-ISOXAZOLECARBOXAMIDE, N-(2,4-DICHLOROPHENYL)-5-METHYL-
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of FLIBANSERIN
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of TICLOPIDINE
INHIBITOR -> METABOLIC ENZYME
Structure of RIFAMYCIN
INHIBITOR -> METABOLIC ENZYME
Rifamycin is an inhibitor of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4/5 in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose clinically relevant inhibition of these enzymes in vivo is unlikely.
Structure of BUPROPION
SUBSTRATE -> METABOLIC ENZYME
Structure of PROFENOFOS
PARENT->INNOVATOR
Screening of potential CYP2B6 inhibitions illustrates that CYP2B6 activity was extensively inhibited by all tested organophosphate pesticides. Inhibition percentages were 100% with profenofos.
Structure of ARTEMOTIL
SUBSTRATE -> METABOLIC ENZYME
Structure of DIETHYLTOLUAMIDE
SUBSTRATE -> METABOLIC ENZYME
Structure of METHADONE
SUBSTRATE -> METABOLIC ENZYME
CYP2B6 preferentially metabolized (S)-methadone,
Structure of EXEMESTANE
SUBSTRATE -> METABOLIC ENZYME
Structure of ENASIDENIB
SUBSTRATE -> METABOLIC ENZYME
Structure of PHENYTOIN
INDUCER -> METABOLIC ENZYME
Structure of ARTEMETHER
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of EFAVIRENZ
SUBSTRATE -> METABOLIC ENZYME
Structure of LETERMOVIR
INDUCER -> METABOLIC ENZYME
Structure of BRANEBRUTINIB
INHIBITOR -> METABOLIC ENZYME
HUMAN LIVER
TISSUE EXPRESSION -> PARENT
Structure of NOMIFENSINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of TERIFLUNOMIDE
NON-SUBSTRATE -> METABOLIC ENZYME
Structure of CYCLOHEXANAMINE, N-(3-ETHOXYPROPYL)-1-PHENYL-
SUBSTRATE -> METABOLIC ENZYME
HUMAN TYPE I COLLAGEN (LUNG)
TISSUE EXPRESSION -> PARENT
Structure of GNE-0877
INDUCER -> METABOLIC ENZYME
Structure of LORLATINIB
INDUCER -> METABOLIC ENZYME
ACTIVATOR
Structure of VOXELOTOR
SUBSTRATE -> METABOLIC ENZYME
In vitro metabolism studies involving recombinant enzymes indicated that CYP3A4, CYP1A1, CYP3A5, CYP2C9, CYP2C19 and CYP2B6 were responsible for the oxidative metabolism of voxelotor.
Structure of CENOBAMATE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of SKF-26754A
INHIBITOR -> METABOLIC ENZYME
Structure of TRICLABENDAZOLE SULFOXIDE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of LOMITAPIDE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of 4-(N-NITROSOMETHYLAMINO)-1-(3-PYRIDYL)-1-BUTANONE
SUBSTRATE -> METABOLIC ENZYME
Structure of ELAGOLIX
INDUCER -> TARGET
Structure of SEBETRALSTAT
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of PEXIDARTINIB
INDUCER -> METABOLIC ENZYME
Structure of LORCASERIN
SUBSTRATE -> METABOLIC ENZYME
Structure of MEPHENYTOIN, (+)-
SUBSTRATE -> METABOLIC ENZYME
Structure of TICLOPIDINE
SUBSTRATE -> METABOLIC ENZYME
Structure of SKF-8742
INHIBITOR -> METABOLIC ENZYME
Structure of ALECTINIB
SUBSTRATE -> METABOLIC ENZYME
Structure of LOPERAMIDE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of LURASIDONE
INHIBITOR -> METABOLIC ENZYME
MODERATE
Structure of VELPATASVIR
SUBSTRATE -> METABOLIC ENZYME
Structure of ENCORAFENIB
INDUCER -> METABOLIC ENZYME
IC50
Structure of SERATRODAST
SUBSTRATE -> METABOLIC ENZYME
Structure of VALPROIC ACID
SUBSTRATE -> METABOLIC ENZYME
Structure of MIDOMAFETAMINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of PARATHION-METHYL
SUBSTRATE -> METABOLIC ENZYME
Structure of CHLORPYRIFOS
INHIBITOR -> METABOLIC ENZYME
Screening of potential CYP2B6 inhibitions illustrates that CYP2B6 activity was extensively inhibited by all tested organophosphate pesticides. Inhibition percentages were 100% with chlorpyrifos.
Structure of N-(2-METHOXYETHYL)-1-PHENYLCYCLOHEXANAMINE
INDUCER -> METABOLIC ENZYME
MAJOR
Structure of CYCLOHEXANAMINE, N-(2-ETHOXYETHYL)-1-PHENYL-
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of IXAZOMIB
SUBSTRATE -> METABOLIC ENZYME
Structure of PALBOCICLIB
NON-INDUCER -> METABOLIC ENZYME
Structure of ISAVUCONAZOLE
INDUCER -> METABOLIC ENZYME
Structure of ENZALUTAMIDE
INHIBITOR -> METABOLIC ENZYME
Structure of MITAPIVAT
INDUCER -> METABOLIC ENZYME
Structure of FLUVOXAMINE
INHIBITOR -> METABOLIC ENZYME
WEAK INHIBITOR
Structure of .ALPHA.-PYRROLIDINOPENTIOPHENONE
SUBSTRATE -> METABOLIC ENZYME
Structure of CLOBAZAM
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of TRICLABENDAZOLE
SUBSTRATE -> METABOLIC ENZYME
Structure of OSILODROSTAT
SUBSTRATE -> METABOLIC ENZYME
Structure of FENITROTHION
INHIBITOR -> METABOLIC ENZYME
Screening of potential CYP2B6 inhibitions illustrates that CYP2B6 activity was extensively inhibited by all tested organophosphate pesticides. Inhibition percentages were 100% with fenitrothion.
Structure of 2,4-DICHLOROANILINE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of REGORAFENIB ANHYDROUS
INHIBITOR -> METABOLIC ENZYME
Ki
Structure of TRICLABENDAZOLE SULFONE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of SELICICLIB
SUBSTRATE -> METABOLIC ENZYME
Structure of ENCORAFENIB
INHIBITOR -> METABOLIC ENZYME
IC50
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966