Details
Stereochemistry | ACHIRAL |
Molecular Formula | C12H12N2 |
Molecular Weight | 184.2371 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC=C(N=C1)C2=NC=C(C)C=C2
InChI
InChIKey=PTRATZCAGVBFIQ-UHFFFAOYSA-N
InChI=1S/C12H12N2/c1-9-3-5-11(13-7-9)12-6-4-10(2)8-14-12/h3-8H,1-2H3
Molecular Formula | C12H12N2 |
Molecular Weight | 184.2371 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Hatchtech is developing abametapir, an organic heterocyclic small-molecule, for the treatment of pediculosis (head lice). Abametapir is an inhibitor of metalloproteinases critical for louse survival and egg development. Abametapir lotion, 0.74%, demonstrated significant ovicidal activity against head lice eggs with a single application.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL4596 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22957890 |
7943.28 nM [EC50] | ||
Target ID: CHEMBL2413 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22957890 |
17000.0 nM [EC50] | ||
Target ID: CHEMBL274 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22957890 |
2300.0 nM [EC50] |
PubMed
Title | Date | PubMed |
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Synthesis of heteroleptic bis(diimine)carbonylchlororuthenium(II) complexes from photodecarbonylated precursors. | 2004 May 3 |
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Intramolecular metal...sulfur interactions of platinum(II) 1,4,7-trithiacyclononane complexes with bipyridyl ligands: the relationship between molecular and electronic structures. | 2005 Mar 21 |
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Variability in the structures of [4-(aminomethyl)pyridine]silver(I) complexes through effects of ligand ratio, anion, hydrogen bonding, and pi-stacking. | 2006 Jan 23 |
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New members of the [Ru(diimine)(CN)(4)](2-) family: structural, electrochemical and photophysical properties. | 2006 Jan 7 |
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New synthetic path to 2,2'-bipyridine-5,5'-dicarbaldehyde and its use in the [3+3] cyclocondensation with trans-1,2-diaminocyclohexane. | 2007 Dec 20 |
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Dichlorido(5,5'-dimethyl-2,2'-bipyridine-κN,N')zinc(II). | 2008 Aug 30 |
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Di-μ-hydroxido-κO:O-μ-trifluoro-methane-sulfonato-κO:O'-bis-[(5,5'-dimethyl-2,2-bipyridine-κN,N')(η-penta-methyl-cyclo-penta-dien-yl)ytterbium(III)] tetra-phenyl-borate 5,5'-dimethyl-2,2-bipyridine. | 2008 Jan 30 |
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5,5'-Bis[(trimethyl-silyl)meth-yl]-2,2'-bipyridine. | 2008 Jan 4 |
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(5,5'-Dimethyl-2,2'-bipyridine-κN,N')diiodidomercury(II). | 2008 Sep 20 |
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Diazido-bis(5,5'-dimethyl-2,2'-bipyridyl-κN,N')nickel(II) monohydrate. | 2009 Aug 8 |
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(2,2'-Biquinoline-κN,N')dichlorido-iron(II). | 2009 Oct 17 |
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Aqua-bis(benzoato-κO)(5,5'-dimethyl-2,2'-bipyridine-κN,N')copper(II). | 2009 Oct 3 |
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Synchrotron study of poly[[di-μ-aqua-(μ-2,2'-bipyridyl-5,5'-dicarboxyl-ato)di-potassium] dihydrate]. | 2009 Sep 30 |
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catena-Poly[[(5,5'-dimethyl-2,2'-bi-pyridine-κN,N')cadmium(II)]-di-μ-iodido]. | 2010 Apr 24 |
Patents
Substance Class |
Chemical
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admin
on
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Sat Dec 16 10:55:32 UTC 2023
by
admin
on
Sat Dec 16 10:55:32 UTC 2023
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Record UNII |
6UO390AMFB
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Validated (UNII)
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C166964
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Abametapir
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admin on Sat Dec 16 10:55:33 UTC 2023 , Edited by admin on Sat Dec 16 10:55:33 UTC 2023
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Related Record | Type | Details | ||
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METABOLIC ENZYME -> SUBSTRATE | |||
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BINDER->LIGAND |
Abametapir plasm protein binding ranged from 91.3 – 92.3% and was concentration independent within the tested concentration range of 50 – 800 ng/mL.
BINDING
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METABOLIC ENZYME -> SUBSTRATE |
MAJOR
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TRANSPORTER -> INHIBITOR |
but the ratio of the unbound Cmax to the IC50 is less than 0.1
IC50
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TRANSPORTER -> INHIBITOR |
but the ratio of the unbound Cmax to the IC50 is less than 0.1
IC50
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Related Record | Type | Details | ||
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METABOLITE -> PARENT | |||
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METABOLITE -> PARENT |
MAJOR
PLASMA
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ACTIVE MOIETY |
Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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Biological Half-life | PHARMACOKINETIC |
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Tmax | PHARMACOKINETIC |
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