OCT-2

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 08:07:49 GMT 2023` Edited by `admin` on `Sat Dec 16 08:07:49 GMT 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	482M00274D
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

OCT-2

Common Name

English

ORGANIC CATION TRANSPORTER 2

Common Name

English

SLC22A2

Common Name

English

SOLUTE CARRIER FAMILY 22 MEMBER 2

Common Name

English

OCT2

Common Name

English

Classification Tree Code System Code

UCSF-FDA TRANSPORTAL

SLC22A2

Created by admin on Sat Dec 16 08:07:51 GMT 2023 , Edited by admin on Sat Dec 16 08:07:51 GMT 2023

Code System Code Type Description

FDA UNII

482M00274D

Created by admin on Sat Dec 16 08:07:51 GMT 2023 , Edited by admin on Sat Dec 16 08:07:51 GMT 2023

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_72

Related Record Type Details


					BKJ8M8G5HI

IMATINIB

SUBSTRATE -> TRANSPORTER


					TK8ERE8P56

RIBOCICLIB

INHIBITOR -> TRANSPORTER


					IHP475989U

FLURAZEPAM

INHIBITOR -> TRANSPORTER


					7H5Q4J1CM5

SEPANTRONIUM BROMIDE

INHIBITOR -> TRANSPORTER


					FVF865388R

Desloratadine

INHIBITOR -> TRANSPORTER


					9647FM7Y3Z

PANOBINOSTAT

INHIBITOR -> TRANSPORTER

Amount:


					RBZ1571X5H

DASATINIB

INHIBITOR -> TRANSPORTER


					V99T50803M

SUNITINIB

INHIBITOR -> TRANSPORTER


					WOH1JD9AR8

Olaparib

INHIBITOR -> TRANSPORTER


					8GTS82S83M

DIPHENHYDRAMINE

INHIBITOR -> TRANSPORTER


					1U511HHV4Z

MEXILETINE

INHIBITOR -> TRANSPORTER


					9IKH79PSWL

TETRAPENTYLAMMONIUM

INHIBITOR -> TRANSPORTER


					7C0697DR9I

ATROPINE

INHIBITOR -> TRANSPORTER


					0K47UL67F2

CARVEDILOL

INHIBITOR -> TRANSPORTER


					OGG85SX4E4

IMIPRAMINE

INHIBITOR -> TRANSPORTER


					5AV7G7EIEE

TETRAETHYLAMMONIUM

INHIBITOR -> TRANSPORTER


					S65743JHBS

GEFITINIB

SUBSTRATE -> TRANSPORTER


					094ZI81Y45

TAMOXIFEN

INHIBITOR -> TRANSPORTER


					7LBRZUYSHU

BRANEBRUTINIB

INHIBITOR -> TRANSPORTER


					690G0D6V8H

KETAMINE

INHIBITOR -> TRANSPORTER


					2DS058H2CF

FENFLURAMINE

INHIBITOR -> TRANSPORTER


					BF4C9Z1J53

AMANTADINE

SUBSTRATE -> TRANSPORTER


					MN3L5RMN02

CLONIDINE

INHIBITOR -> TRANSPORTER


					YO460OQ37K

VANDETANIB

INHIBITOR -> TRANSPORTER


					J4T82NDH7E

ERLOTINIB

SUBSTRATE -> TRANSPORTER


					44RAL3456C

METHAMPHETAMINE

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					80061L1WGD

CIMETIDINE

SUBSTRATE -> TRANSPORTER


					262P8GS9L9

TAFENOQUINE

INHIBITOR -> TRANSPORTER

Comments:

corrected for non-specific binding

Qualification:

IC50

Amount:


					AYI8EX34EU

CREATININE

SUBSTRATE -> TRANSPORTER


					4340891KFS

PONATINIB

NON-SUBSTRATE -> TRANSPORTER

Amount:


					939U7C91AI

Solriamfetol

INHIBITOR -> TRANSPORTER

Interaction Type:

WEAK

Qualification:

IC50

Amount:


					W8O17SJF3T

MEMANTINE

SUBSTRATE -> TRANSPORTER


					66D92MGC8M

GILTERITINIB

INHIBITOR -> TRANSPORTER

Interaction Type:

WEAK

Qualification:

IC50

Amount:


					F41401512X

NILOTINIB

SUBSTRATE -> TRANSPORTER


					8GB79LOJ07

BICTEGRAVIR

INHIBITOR -> TRANSPORTER

Comments:

Co‐administration of BIKTARVY with dofetilide may increase dofetilide plasma concentrations which can lead to serious and/or life threatening events.

Qualification:

IC50

Amount:


					AN164J8Y0X

TRIMETHOPRIM

INHIBITOR -> TRANSPORTER


					J4T82NDH7E

ERLOTINIB

INHIBITOR -> TRANSPORTER


					KE1SEN21RM

MIDOMAFETAMINE

INHIBITOR -> TRANSPORTER


					1806D8D52K

AMITRIPTYLINE

INHIBITOR -> TRANSPORTER


					A7V27PHC7A

QUININE

INHIBITOR -> TRANSPORTER


					J697UZ2A9J

IPRATROPIUM BROMIDE

INHIBITOR -> TRANSPORTER


					I5Y540LHVR

COCAINE

INHIBITOR -> TRANSPORTER


					LW2E03M5PG

COBICISTAT

INHIBITOR -> TRANSPORTER


					886U3H6UFF

CHLOROQUINE

INHIBITOR -> TRANSPORTER


					04ZR38536J

OXALIPLATIN

SUBSTRATE -> TRANSPORTER

Comments:

MAY BE RESPONSIBLE FOR THE ACTIVITY OF OXALIPLATIN AGAINST against colorectal tumors

Interaction Type:

MAJOR


					UU226QGU97

IMEGLIMIN

INHIBITOR -> TRANSPORTER


					TG537D343B

DESIPRAMINE

INHIBITOR -> TRANSPORTER


					NH9L3PP67S

PYRIDINE

INHIBITOR -> TRANSPORTER


					80061L1WGD

CIMETIDINE

INHIBITOR -> TRANSPORTER


					S65743JHBS

GEFITINIB

INHIBITOR -> TRANSPORTER


					XF7XD5P9KG

1-Hexylpyridinium chloride

INHIBITOR -> TRANSPORTER


					W980KJ009P

CORTICOSTERONE

INHIBITOR -> TRANSPORTER


					6UO390AMFB

ABAMETAPIR

INHIBITOR -> TRANSPORTER

Comments:

but the ratio of the unbound Cmax to the IC50 is less than 0.1

Qualification:

IC50

Amount:


					884KT10YB7

RANITIDINE

INHIBITOR -> TRANSPORTER


					UU226QGU97

IMEGLIMIN

SUBSTRATE -> TRANSPORTER


					BF4C9Z1J53

AMANTADINE

INHIBITOR -> TRANSPORTER


					XHV1ZJL59R

1-BUTYL-1-METHYLPYRROLIDINIUM CHLORIDE

INHIBITOR -> TRANSPORTER


					TML814419R

MEFLOQUINE

INHIBITOR -> TRANSPORTER


					7PY8KH681I

DIZOCILPINE

INHIBITOR -> TRANSPORTER


					J1DOI7UV76

PHENCYCLIDINE

INHIBITOR -> TRANSPORTER


					K94FTS1806

FLECAINIDE

INHIBITOR -> TRANSPORTER


					L1M1U2HC31

GREPAFLOXACIN

INHIBITOR -> TRANSPORTER


					XM03YJ541D

PRAZOSIN

INHIBITOR -> TRANSPORTER


					RBZ1571X5H

DASATINIB

SUBSTRATE -> TRANSPORTER


					DD5K7529CE

PHENFORMIN

INHIBITOR -> TRANSPORTER


					181R97MR71

Binimetinib

INHIBITOR -> TRANSPORTER

Interaction Type:

MINOR

Qualification:

IC50

Amount:


					38BQL5563G

1-ETHYLPYRIDINIUM CHLORIDE

INHIBITOR -> TRANSPORTER


					BKJ8M8G5HI

IMATINIB

INHIBITOR -> TRANSPORTER


					0TTZ664R7Z

PHENOXYBENZAMINE

INHIBITOR -> TRANSPORTER


					08GH1YF0RA

FURAMIDINE

INHIBITOR -> TRANSPORTER


					673LC5J4LQ

PENTAMIDINE

INHIBITOR -> TRANSPORTER


					VS58MO4P47

BMS-986299

INHIBITOR -> TRANSPORTER


					53DTP6U9Q2

ABAMETAPIR CARBOXYL

INHIBITOR -> TRANSPORTER


					GFO928U8MQ

DISOPYRAMIDE

INHIBITOR -> TRANSPORTER


					BRU7LG9LNL

PSEUDOISOCYANINE IODIDE

INHIBITOR -> TRANSPORTER


					WV5EC51866

SIBUTRAMINE

INHIBITOR -> TRANSPORTER


					CJ0O37KU29

VERAPAMIL

INHIBITOR -> TRANSPORTER


					68IQX3T69U

PROPAFENONE

INHIBITOR -> TRANSPORTER


					9Y8NXQ24VQ

PROPRANOLOL

INHIBITOR -> TRANSPORTER


					8I07J24F45

MEPIPERPHENIDOL

INHIBITOR -> TRANSPORTER


					9100L32L2N

METFORMIN

SUBSTRATE -> TRANSPORTER


					YO7261ME24

CETIRIZINE

INHIBITOR -> TRANSPORTER


					6Y75Z4E8NS

LEVOMETHADONE

INHIBITOR -> TRANSPORTER


					6L1XP550I6

FEDRATINIB

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					AV0X7V6CSE

PILSICAINIDE

INHIBITOR -> TRANSPORTER


					TZ47U051FI

DEXTROAMPHETAMINE

INHIBITOR -> TRANSPORTER


					ITX08688JL

QUINIDINE

INHIBITOR -> TRANSPORTER


					8L7891MRB6

ENCORAFENIB

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					2Z3E1OF81V

BUTYLSCOPOLAMINE

INHIBITOR -> TRANSPORTER


					1C058IKG3B

TERIFLUNOMIDE

INHIBITOR -> TRANSPORTER

Comments:

Terifluniomide is an inhibitor of BCRP, OAT3, OATP1B1, OCT2 in vitro


					41PS77334A

BUTYLMETHYLIMIDAZOLIUM CHLORIDE

INHIBITOR -> TRANSPORTER


					F8M63J351A

N-BUTYLPYRIDINIUM CHLORIDE

INHIBITOR -> TRANSPORTER


					5QZO15J2Z8

FAMOTIDINE

INHIBITOR -> TRANSPORTER


					5ASJ6HUZ7D

DOXEPIN

INHIBITOR -> TRANSPORTER


					44RAL3456C

METHAMPHETAMINE

SUBSTRATE -> TRANSPORTER

Amount:


					W8O17SJF3T

MEMANTINE

INHIBITOR -> TRANSPORTER


					U42B7VYA4P

CHLORPROMAZINE

INHIBITOR -> TRANSPORTER


					CK833KGX7E

AMPHETAMINE

SUBSTRATE -> TRANSPORTER

Amount:


					3XMK78S47O

TESTOSTERONE

INHIBITOR -> TRANSPORTER


					4V9848RS5G

TIRBANIBULIN

INHIBITOR -> TRANSPORTER

Comments:

The results suggest that KLISYRI has no clinically meaningful effect on the PK of drugs mediated by OCT2

Qualification:

IC50

Amount:


					H012AL9PN0

DX-619

INHIBITOR -> TRANSPORTER

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL