Details
Stereochemistry | RACEMIC |
Molecular Formula | C27H38N2O4 |
Molecular Weight | 454.6016 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(OC)C=C(CCN(C)CCCC(C#N)(C(C)C)C2=CC(OC)=C(OC)C=C2)C=C1
InChI
InChIKey=SGTNSNPWRIOYBX-UHFFFAOYSA-N
InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3
Molecular Formula | C27H38N2O4 |
Molecular Weight | 454.6016 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
DescriptionCurator's Comment: Description was created based on several sources, including https://www.drugbank.ca/drugs/DB00661
Curator's Comment: Description was created based on several sources, including https://www.drugbank.ca/drugs/DB00661
Verapamil is a FDA approved drug used to treat high blood pressure and to control chest pain. Verapamil is an L-type calcium channel blocker that also has antiarrythmic activity. The R-enantiomer is more effective at reducing blood pressure compared to the S-enantiomer. However, the S-enantiomer is 20 times more potent than the R-enantiomer at prolonging the PR interval in treating arrhythmias. Verapamil inhibits voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thuis reducing heart rate and blood pressure. Verapamil's mechanism of effect in cluster headache is thought to be linked to its calcium-channel blocker effect, but which channel subtypes are involved is presently not known.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19125880
Curator's Comment: As a lipophilic substance, verapamil easily crosses
the blood–brain barrier. Verapamil is, however, a
substrate for the efflux transporter P-glycoprotein
(P-gp) in the blood–brain barrier. The P-pg restricts
net brain uptake of verapamil by immediately transporting
it out of the brain.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
3.4 µM [IC50] | |||
Target ID: CHEMBL1940 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | CALAN Approved UseCALAN tablets are indicated for the treatment of the following:
Angina
1. Angina at rest including:
— Vasospastic (Prinzmetal’s variant) angina
— Unstable (crescendo, pre-infarction) angina
2. Chronic stable angina (classic effort-associated angina)
Arrhythmias
1. In association with digitalis for the control of ventricular rate at rest and during
stress in patients with chronic atrial flutter and/or atrial fibrillation (see
WARNINGS: Accessory bypass tract)
2. Prophylaxis of repetitive paroxysmal supraventricular tachycardia
Essential hypertension
CALAN is indicated for the treatment of hypertension, to lower blood pressure. Lowering
blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily
strokes and myocardial infarctions. These benefits have been seen in controlled trials of
antihypertensive drugs from a wide variety of pharmacologic classes including this drug. Launch Date1981 |
|||
Primary | CALAN Approved UseCALAN tablets are indicated for the treatment of the following:
Angina
1. Angina at rest including:
— Vasospastic (Prinzmetal’s variant) angina
— Unstable (crescendo, pre-infarction) angina
2. Chronic stable angina (classic effort-associated angina)
Arrhythmias
1. In association with digitalis for the control of ventricular rate at rest and during
stress in patients with chronic atrial flutter and/or atrial fibrillation (see
WARNINGS: Accessory bypass tract)
2. Prophylaxis of repetitive paroxysmal supraventricular tachycardia
Essential hypertension
CALAN is indicated for the treatment of hypertension, to lower blood pressure. Lowering
blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily
strokes and myocardial infarctions. These benefits have been seen in controlled trials of
antihypertensive drugs from a wide variety of pharmacologic classes including this drug. Launch Date1981 |
|||
Primary | CALAN Approved UseCALAN tablets are indicated for the treatment of the following:
Angina
1. Angina at rest including:
— Vasospastic (Prinzmetal’s variant) angina
— Unstable (crescendo, pre-infarction) angina
2. Chronic stable angina (classic effort-associated angina)
Arrhythmias
1. In association with digitalis for the control of ventricular rate at rest and during
stress in patients with chronic atrial flutter and/or atrial fibrillation (see
WARNINGS: Accessory bypass tract)
2. Prophylaxis of repetitive paroxysmal supraventricular tachycardia
Essential hypertension
CALAN is indicated for the treatment of hypertension, to lower blood pressure. Lowering
blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily
strokes and myocardial infarctions. These benefits have been seen in controlled trials of
antihypertensive drugs from a wide variety of pharmacologic classes including this drug. Launch Date1981 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
139.28 ng/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/16892180 |
80 mg single, oral dose: 80 mg route of administration: Oral experiment type: SINGLE co-administered: |
VERAPAMIL plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
367.05 ng × h/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/16892180 |
80 mg single, oral dose: 80 mg route of administration: Oral experiment type: SINGLE co-administered: |
VERAPAMIL plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
7.15 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/16892180 |
80 mg single, oral dose: 80 mg route of administration: Oral experiment type: SINGLE co-administered: |
VERAPAMIL plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
9.9% EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/6209501 |
VERAPAMIL plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Drug as perpetrator
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/11996015/ Page: 146.0 |
likely | |||
moderate [IC50 23 uM] | ||||
Sources: https://pubmed.ncbi.nlm.nih.gov/11996015/ Page: 99.0 |
weak | |||
yes [IC50 1.23 uM] |
Drug as victim
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Page: 7.0 |
yes | |||
Page: 7.0 |
yes | |||
Page: 7.0 |
yes | |||
Page: 7.0 |
yes | |||
Page: 7.0 |
yes | yes (co-administration study) Comment: Co-administration of multiple doses of 10 mg of verapamil with 80 mg simvastatin resulted in exposure to simvastatin 2.5-fold that following simvastatin alone; Clinically significant interactions have been reported with inhibitors of CYP3A4 (e.g., erythromycin, ritonavir) causing elevation of plasma levels of verapamil while inducers of CYP3A4 (e.g., rifampin) have caused a lowering of plasma levels of verapamil Page: 7.0 |
Tox targets
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
PubMed
Title | Date | PubMed |
---|---|---|
[Demonstration of a major preexcitation syndrome during treatment of auricular flutter using intravenous injection of verapamil]. | 1975 |
|
[Mapping electrocardiographic fields in heart hypertrophy]. | 1998 |
|
[The importance of the ion-transport systems of the sarcolemma and sarcoplasmic reticulum in changing rat cardiac contractile function under a hypersodium medium]. | 1999 Apr |
|
Neurological recovery after prolonged verapamil-induced cardiac arrest. | 1999 Dec |
|
Successful resuscitation of a verapamil-intoxicated patient with percutaneous cardiopulmonary bypass. | 1999 Dec |
|
Increase in doxorubicin cytotoxicity by carvedilol inhibition of P-glycoprotein activity. | 1999 Dec 1 |
|
Comparison of intravenous metoprolol, verapamil and diltiazem on the attenuation of haemodynamic changes associated with tracheal extubation. | 1999 Jul |
|
Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil. | 1999 Sep |
|
Affinities at the verapamil binding site of MDR1-encoded P-glycoprotein: drugs and analogs, stereoisomers and metabolites. | 2000 Apr |
|
Sleep attacks and Parkinson's disease treatment. | 2000 Apr 15 |
|
KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. | 2000 Jun |
|
Acute onset of auditory hallucinations after initiation of celecoxib therapy. | 2000 Jun |
|
Early administration of verapamil after thrombolysis in acute anterior myocardial infarction. Effect on left ventricular remodeling and clinical outcome. VAMI Study Group. Verapamil Acute Myocardial Infarction. | 2000 May |
|
Increased incidence of infection in verapamil-treated kidney transplant recipients. | 2000 May |
|
Effect of metoprolol and verapamil administered separately and concurrently after single doses on liver blood flow and drug disposition. | 2000 May |
|
Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats. | 2000 Nov 10 |
|
Monitoring of cellular resistance to cancer chemotherapy: drug retention and efflux. | 2001 |
|
Activating transcription factor 2-derived peptides alter resistance of human tumor cell lines to ultraviolet irradiation and chemical treatment. | 2001 Feb |
|
[Treatment of cluster headache]. | 2001 Feb |
|
Pharmacologic management of atrial fibrillation: current therapeutic strategies. | 2001 Feb |
|
Dysfunction of polymorphonuclear leukocytes in uremia: role of parathyroid hormone. | 2001 Feb |
|
Intra- and intercellular Ca(2+)-transient propagation in normal and high glucose solutions in ROS cells during mechanical stimulation. | 2001 Feb |
|
L-type calcium channel blockers and EGTA enhance superoxide production in cardiac fibroblasts. | 2001 Feb |
|
Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia. | 2001 Feb |
|
Signaling mechanisms for the selective vasoconstrictor effect of norbormide on the rat small arteries. | 2001 Feb |
|
Characterization of a novel cationic drug transporter in human retinal pigment epithelial cells. | 2001 Feb |
|
Pre- or post-ischemic treatment with a novel Na+/Ca2+ exchange inhibitor, KB-R7943, shows renal protective effects in rats with ischemic acute renal failure. | 2001 Feb |
|
Ivermectin excretion by isolated functionally intact brain endothelial capillaries. | 2001 Feb |
|
Multidrug resistance protein (MRP) activity in normal mature leukocytes and CD34-positive hematopoietic cells from peripheral blood. | 2001 Feb 2 |
|
Mechanisms of hydrogen peroxide-induced relaxation in rabbit mesenteric small artery. | 2001 Feb 2 |
|
Volume-weighted mean nuclear volume and numerical nuclear density in the cardiomyocyte following enalapril and verapamil treatment. | 2001 Jan |
|
Identification of an organic anion transport system in the human colon carcinoma cell line HT29 clone 19A. | 2001 Jan |
|
The effects of vasopressin in isolated rat hearts. | 2001 Jan |
|
Verapamil prevents stretch-induced shortening of atrial effective refractory period in langendorff-perfused rabbit heart. | 2001 Jan |
|
Effects of simultaneous atrioventricular pacing on atrial refractoriness and atrial fibrillation inducibility: role of atrial mechanoelectrical feedback. | 2001 Jan |
|
Transport of [3H]MPP+ in an immortalized rat brain microvessel endothelial cell line (RBE 4). | 2001 Jan |
|
Sarcoglycan, the heart, and skeletal muscles: new treatment, old drug? | 2001 Jan |
|
Modulator activity of PSC 833 and cyclosporin-A in vincristine and doxorubicin-selected multidrug resistant murine leukemic cells. | 2001 Jan |
|
P-glycoprotein-mediated drug secretion in mouse proximal tubule perfused in vitro. | 2001 Jan |
|
Prognostic implications of intima-media thickness and plaques in the carotid and femoral arteries in patients with stable angina pectoris. | 2001 Jan |
|
Calcium channel antagonists enhance retention of passive avoidance and maze learning in mice. | 2001 Jan |
|
Hepatic uptake of synthetic chlorogenic acid derivatives by the organic anion transport proteins. | 2001 Jan |
|
In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576. | 2001 Jan 15 |
|
Effect of intraovarian factors on porcine follicular cells: cumulus expansion, granulosa and cumulus cell progesterone production. | 2001 Jan 31 |
|
The effects of LY393613, nimodipine and verapamil, in focal cerebral ischaemia. | 2001 Jan 5 |
|
Cardiogenic shock following a single therapeutic oral dose of verapamil. | 2001 Jan-Feb |
|
How to manage atrial fibrillation: an update on recent clinical trials. | 2001 Mar-Apr |
Sample Use Guides
Angina: Clinical trials show that the usual dose is 80 mg to 120 mg three times a day.
However, 40 mg three times a day may be warranted in patients who may have an
increased response to verapamil (eg, decreased hepatic function, elderly, etc). Upward
titration should be based on therapeutic efficacy and safety evaluated approximately eight
hours after dosing. Dosage may be increased at daily (eg, patients with unstable angina)
or weekly intervals until optimum clinical response is obtained.
Arrhythmias: The dosage in digitalized patients with chronic atrial fibrillation (see
PRECAUTIONS) ranges from 240 to 320 mg/day in divided (t.i.d. or q.i.d.) doses. The
dosage for prophylaxis of PSVT (non-digitalized patients) ranges from 240 to
480 mg/day in divided (t.i.d. or q.i.d.) doses. In general, maximum effects for any given
dosage will be apparent during the first 48 hours of therapy.
Essential hypertension: Dose should be individualized by titration. The usual initial
monotherapy dose in clinical trials was 80 mg three times a day (240 mg/day). Daily
dosages of 360 and 480 mg have been used but there is no evidence that dosages beyond
360 mg provided added effect. Consideration should be given to beginning titration at
40 mg three times per day in patients who might respond to lower doses, such as the
elderly or people of small stature. The antihypertensive effects of CALAN are evident
within the first week of therapy. Upward titration should be based on therapeutic
efficacy, assessed at the end of the dosing interval.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27763693
Blockade of L-type calcium channels by verapamil (50 um) prevented a Norgestrel-induced calcium influx in stressed 661W photoreceptor-like cells.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 17:42:15 GMT 2023
by
admin
on
Sat Dec 16 17:42:15 GMT 2023
|
Record UNII |
CJ0O37KU29
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NDF-RT |
N0000175566
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
||
|
WHO-VATC |
QC09BB10
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
||
|
WHO-VATC |
QC08DA01
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
||
|
WHO-ATC |
C08DA51
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
||
|
NCI_THESAURUS |
C333
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
||
|
WHO-ESSENTIAL MEDICINES LIST |
12.2
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
||
|
WHO-ESSENTIAL MEDICINES LIST |
12.1
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
||
|
WHO-VATC |
QC08DA51
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
||
|
NDF-RT |
N0000000069
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
||
|
WHO-ATC |
C09BB10
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
||
|
LIVERTOX |
NBK548362
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
||
|
WHO-ATC |
C08DA01
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
200-145-1
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
9948
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
2520
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
2406
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
CJ0O37KU29
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
2122
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
N0000182141
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | Cytochrome P450 3A4 Inhibitors [MoA] | ||
|
11170
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | RxNorm | ||
|
100000079099
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
52-53-9
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
VERAPAMIL
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
Verapamil
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
DB00661
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
D014700
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
2815
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
N0000185503
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | P-Glycoprotein Inhibitors [MoA] | ||
|
C928
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
CJ0O37KU29
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
m11414
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | Merck Index | ||
|
DTXSID9041152
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
SUB00038MIG
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
CHEMBL6966
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | |||
|
N0000190114
Created by
admin on Sat Dec 16 17:42:17 GMT 2023 , Edited by admin on Sat Dec 16 17:42:17 GMT 2023
|
PRIMARY | Cytochrome P450 3A Inhibitors [MoA] |
Related Record | Type | Details | ||
---|---|---|---|---|
|
TRANSPORTER -> INHIBITOR | |||
|
BINDER->LIGAND |
|
||
|
METABOLIC ENZYME -> SUBSTRATE | |||
|
METABOLIC ENZYME -> INHIBITOR |
IC50
|
||
|
TRANSPORTER -> INHIBITOR | |||
|
TRANSPORTER -> INHIBITOR | |||
|
TRANSPORTER -> INHIBITOR | |||
|
TRANSPORTER -> INHIBITOR | |||
|
TRANSPORTER -> INHIBITOR | |||
|
TRANSPORTER -> SUBSTRATE | |||
|
TRANSPORTER -> SUBSTRATE | |||
|
SALT/SOLVATE -> PARENT | |||
|
TRANSPORTER -> INHIBITOR | |||
|
METABOLIC ENZYME -> SUBSTRATE | |||
|
METABOLIC ENZYME -> INHIBITOR | |||
|
TRANSPORTER -> INHIBITOR |
|
||
|
TRANSPORTER -> SUBSTRATE |
Related Record | Type | Details | ||
---|---|---|---|---|
|
METABOLITE -> PARENT |
22% 0f dose
MAJOR
URINE
|
||
|
METABOLITE ACTIVE -> PARENT | |||
|
METABOLITE ACTIVE -> PARENT |
MAJOR
PLASMA
|
||
|
METABOLITE -> PARENT |
3-4% of dose
MINOR
URINE
|
||
|
METABOLITE -> PARENT |
3-4% of dose
MINOR
URINE
|
||
|
METABOLITE -> PARENT |
7% of dose
URINE
|
||
|
METABOLITE -> PARENT |
6% of dose
MINOR
URINE
|
||
|
METABOLITE ACTIVE -> PARENT |
6% of dose
MINOR
URINE
|
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |
Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
---|---|---|---|---|---|---|
Volume of Distribution | PHARMACOKINETIC |
|
Populations PHARMACOKINETIC |
|
||
Duration of Action | PHARMACOKINETIC |
|
|
|||
Volume of Distribution | PHARMACOKINETIC |
|
Populations PHARMACOKINETIC |
|
||
Duration of Action | PHARMACOKINETIC |
|
|
|||