U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
28299
Substance Class Protein
Created
by admin
on Sat Jun 26 18:05:53 UTC 2021
Edited
by admin
on Sat Jun 26 18:05:53 UTC 2021
Protein Sub Type
Sequence Type COMPLETE
Record UNII
ONY583280Z
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OCT-1
Common Name English
OCT1
Common Name English
SLC22A1
Common Name English
HUMAN ORGANIC CATION TRANSPORTER 1
Common Name English
SOLUTE CARRIER FAMILY 22 MEMBER 1
Common Name English
ORGANIC CATION TRANSPORTER 1
Common Name English
HOCT1
Common Name English
Classification Tree Code System Code
UCSF-FDA TRANSPORTAL SLC22A1
Created by admin on Sat Jun 26 18:05:56 UTC 2021 , Edited by admin on Sat Jun 26 18:05:56 UTC 2021
Code System Code Type Description
FDA UNII
ONY583280Z
Created by admin on Sat Jun 26 18:05:56 UTC 2021 , Edited by admin on Sat Jun 26 18:05:56 UTC 2021
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_71
Related Record Type Details
Structure of RANITIDINE
INHIBITOR -> TRANSPORTER
Structure of LORLATINIB
INHIBITOR -> TRANSPORTER
Structure of AMISULPRIDE
SUBSTRATE -> TRANSPORTER
Structure of MEMANTINE
INHIBITOR -> TRANSPORTER
Structure of DESIPRAMINE
SUBSTRATE -> TRANSPORTER
Structure of PENTAMIDINE
INHIBITOR -> TRANSPORTER
Structure of AMANTADINE
INHIBITOR -> TRANSPORTER
Structure of BUTYLSCOPOLAMINE
INHIBITOR -> TRANSPORTER
Structure of COCAINE
INHIBITOR -> TRANSPORTER
Structure of PONATINIB
NON-SUBSTRATE -> TRANSPORTER
Structure of REPAGLINIDE
INHIBITOR -> TRANSPORTER
Structure of TETRAETHYLAMMONIUM
INHIBITOR -> TRANSPORTER
Structure of RUCAPARIB
INHIBITOR -> TRANSPORTER
MODERATE
Structure of PIOGLITAZONE
INHIBITOR -> TRANSPORTER
Structure of OXALIPLATIN
SUBSTRATE -> TRANSPORTER
MAY BE RESPONSIBLE FOR THE ACTIVITY OF OXALIPLATIN AGAINST against colorectal tumors
MAJOR
Structure of METHAMPHETAMINE
INHIBITOR -> TRANSPORTER
IC50
Structure of KETAMINE
INHIBITOR -> TRANSPORTER
Structure of TUBOCURARINE
INHIBITOR -> TRANSPORTER
Structure of LURBINECTEDIN
INHIBITOR -> TRANSPORTER
Structure of FURAMIDINE
INHIBITOR -> TRANSPORTER
Structure of QUINIDINE
SUBSTRATE -> TRANSPORTER
Structure of SAQUINAVIR
INHIBITOR -> TRANSPORTER
Structure of CIMETIDINE
SUBSTRATE -> TRANSPORTER
Structure of PHENFORMIN
INHIBITOR -> TRANSPORTER
Structure of PONATINIB
SUBSTRATE -> TRANSPORTER
Structure of BRANEBRUTINIB
INHIBITOR -> TRANSPORTER
Structure of TIRBANIBULIN
INHIBITOR -> TRANSPORTER
The results suggest that KLISYRI has no clinically meaningful effect on the PK of drugs mediated by OCT1
IC50
Structure of CLONIDINE
INHIBITOR -> TRANSPORTER
Structure of ETILEFRINE
INHIBITOR -> TRANSPORTER
Structure of PHENCYCLIDINE
INHIBITOR -> TRANSPORTER
Structure of QUINIDINE
INHIBITOR -> TRANSPORTER
Structure of AMANTADINE
SUBSTRATE -> TRANSPORTER
Structure of MIDOMAFETAMINE
INHIBITOR -> TRANSPORTER
Structure of OLAPARIB
INHIBITOR -> TRANSPORTER
INHIBITOR
IC50
Structure of PROCAINAMIDE
INHIBITOR -> TRANSPORTER
Structure of THIAMINE
SUBSTRATE -> TRANSPORTER
Structure of METFORMIN
INHIBITOR -> TRANSPORTER
Structure of INDINAVIR
INHIBITOR -> TRANSPORTER
Structure of CIMETIDINE
INHIBITOR -> TRANSPORTER
Structure of AMITRIPTYLINE
INHIBITOR -> TRANSPORTER
Structure of GLYBURIDE
INHIBITOR -> TRANSPORTER
Structure of QUININE
INHIBITOR -> TRANSPORTER
Structure of GANCICLOVIR
SUBSTRATE -> TRANSPORTER
Structure of ACYCLOVIR
SUBSTRATE -> TRANSPORTER
Structure of CORTICOSTERONE
INHIBITOR -> TRANSPORTER
Structure of ACYCLOVIR
SUBSTRATE -> TRANSPORTER
Structure of GANCICLOVIR
SUBSTRATE -> TRANSPORTER
Structure of FAMOTIDINE
SUBSTRATE -> TRANSPORTER
Structure of ERLOTINIB
SUBSTRATE -> TRANSPORTER
Structure of HISTAMINE
SUBSTRATE -> TRANSPORTER
Structure of VERAPAMIL
INHIBITOR -> TRANSPORTER
Structure of DIZOCILPINE
INHIBITOR -> TRANSPORTER
Structure of LESINURAD
INHIBITOR -> TRANSPORTER
Based on in vitro studies, lesinurad is a weak inhibitor of OATP1B1, OCT1, OAT1, and OAT3.
WEAK
Structure of DUVELISIB
INHIBITOR -> TRANSPORTER
Structure of SEROTONIN
SUBSTRATE -> TRANSPORTER
Structure of DISOPYRAMIDE
INHIBITOR -> TRANSPORTER
Structure of ROSIGLITAZONE
INHIBITOR -> TRANSPORTER
Structure of MIDAZOLAM
INHIBITOR -> TRANSPORTER
Structure of NELFINAVIR
INHIBITOR -> TRANSPORTER
Structure of RITONAVIR
INHIBITOR -> TRANSPORTER
Structure of GILTERITINIB
INHIBITOR -> TRANSPORTER
IC50
Structure of SEPANTRONIUM BROMIDE
INHIBITOR -> TRANSPORTER
Structure of DASATINIB
SUBSTRATE -> TRANSPORTER
HUMAN LIVER
TISSUE EXPRESSION->TRANSPORTER
INFLUX
Structure of PHENOXYBENZAMINE
INHIBITOR -> TRANSPORTER
Structure of RANITIDINE
SUBSTRATE -> TRANSPORTER
Structure of METFORMIN
SUBSTRATE -> TRANSPORTER
Structure of FAMOTIDINE
INHIBITOR -> TRANSPORTER
Structure of DIPHENHYDRAMINE
INHIBITOR -> TRANSPORTER
Structure of IMEGLIMIN
INHIBITOR -> TRANSPORTER
Structure of IMEGLIMIN
SUBSTRATE -> TRANSPORTER
Structure of SORAFENIB
SUBSTRATE -> TRANSPORTER
Structure of DEXTROAMPHETAMINE
INHIBITOR -> TRANSPORTER
Structure of PANOBINOSTAT
INHIBITOR -> TRANSPORTER
Structure of SIMVASTATIN
INHIBITOR -> TRANSPORTER
Structure of NILOTINIB
SUBSTRATE -> TRANSPORTER
Structure of CHOLINE
SUBSTRATE -> TRANSPORTER
Structure of SUNITINIB
SUBSTRATE -> TRANSPORTER
Structure of DOPAMINE
SUBSTRATE -> TRANSPORTER
Structure of QUININE
SUBSTRATE -> TRANSPORTER
Structure of ATROPINE
INHIBITOR -> TRANSPORTER
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966