Approval Year
Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 09:56:49 GMT 2023
by
admin
on
Sat Dec 16 09:56:49 GMT 2023
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Protein Sub Type | |
Sequence Type | COMPLETE |
Record UNII |
ONY583280Z
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Record Status |
Validated (UNII)
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Record Version |
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-
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Common Name | English |
Classification Tree | Code System | Code | ||
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UCSF-FDA TRANSPORTAL |
SLC22A1
Created by
admin on Sat Dec 16 09:56:51 GMT 2023 , Edited by admin on Sat Dec 16 09:56:51 GMT 2023
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Code System | Code | Type | Description | ||
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ONY583280Z
Created by
admin on Sat Dec 16 09:56:51 GMT 2023 , Edited by admin on Sat Dec 16 09:56:51 GMT 2023
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PRIMARY |
Glycosylation Type | HUMAN |
Glycosylation Link Type | Site |
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N | 1_71 |
Related Record | Type | Details | ||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER |
MODERATE
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER |
IC50
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER |
IC50
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER |
MAY BE RESPONSIBLE FOR THE ACTIVITY OF OXALIPLATIN AGAINST against colorectal tumors
MAJOR
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INHIBITOR -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER |
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INHIBITOR -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER |
The results suggest that KLISYRI has no clinically meaningful effect on the PK of drugs mediated by OCT1
IC50
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER |
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER |
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SUBSTRATE -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER |
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER |
Thus, the unbound Cmax is about 0.09 μM, much lower than 8.5 μM. Therefore, E2007 is unlikely to inhibit OAT1, OAT3, OCT1 and OCT3 in vivo.
Ki
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INHIBITOR -> TRANSPORTER |
Based on in vitro studies, lesinurad is a weak inhibitor of OATP1B1, OCT1, OAT1, and OAT3.
WEAK
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INHIBITOR -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER |
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER |
IC50
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INHIBITOR -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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TISSUE EXPRESSION->TRANSPORTER |
INFLUX
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INHIBITOR -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER |
INHIBITOR
IC50
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SUBSTRATE -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER |
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INHIBITOR -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER | |||
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SUBSTRATE -> TRANSPORTER |
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SUBSTRATE -> TRANSPORTER | |||
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INHIBITOR -> TRANSPORTER | |||
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NON-SUBSTRATE -> TRANSPORTER |
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Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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