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Approval Year

Unknown
116683
Substance Class Protein
Created
by admin
on Sat Jun 26 18:05:53 UTC 2021
Edited
by admin
on Sat Jun 26 18:05:53 UTC 2021
Protein Sub Type
Sequence Type COMPLETE
Record UNII
ONY583280Z
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OCT-1
Common Name English
OCT1
Common Name English
SLC22A1
Common Name English
HUMAN ORGANIC CATION TRANSPORTER 1
Common Name English
SOLUTE CARRIER FAMILY 22 MEMBER 1
Common Name English
ORGANIC CATION TRANSPORTER 1
Common Name English
HOCT1
Common Name English
Classification Tree Code System Code
UCSF-FDA TRANSPORTAL SLC22A1
Created by admin on Sat Jun 26 18:05:56 UTC 2021 , Edited by admin on Sat Jun 26 18:05:56 UTC 2021
Code System Code Type Description
FDA UNII
ONY583280Z
Created by admin on Sat Jun 26 18:05:56 UTC 2021 , Edited by admin on Sat Jun 26 18:05:56 UTC 2021
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_71
Related Record Type Details
Structure of RANITIDINE
INHIBITOR -> TRANSPORTER
Structure of LORLATINIB
INHIBITOR -> TRANSPORTER
Structure of AMISULPRIDE
SUBSTRATE -> TRANSPORTER
Structure of MEMANTINE
INHIBITOR -> TRANSPORTER
Structure of DESIPRAMINE
SUBSTRATE -> TRANSPORTER
Structure of PENTAMIDINE
INHIBITOR -> TRANSPORTER
Structure of AMANTADINE
INHIBITOR -> TRANSPORTER
Structure of BUTYLSCOPOLAMINE
INHIBITOR -> TRANSPORTER
Structure of COCAINE
INHIBITOR -> TRANSPORTER
Structure of PONATINIB
NON-SUBSTRATE -> TRANSPORTER
Structure of REPAGLINIDE
INHIBITOR -> TRANSPORTER
Structure of TETRAETHYLAMMONIUM
INHIBITOR -> TRANSPORTER
Structure of RUCAPARIB
INHIBITOR -> TRANSPORTER
MODERATE
Structure of PIOGLITAZONE
INHIBITOR -> TRANSPORTER
Structure of OXALIPLATIN
SUBSTRATE -> TRANSPORTER
MAY BE RESPONSIBLE FOR THE ACTIVITY OF OXALIPLATIN AGAINST against colorectal tumors
MAJOR
Structure of METHAMPHETAMINE
INHIBITOR -> TRANSPORTER
IC50
Structure of KETAMINE
INHIBITOR -> TRANSPORTER
Structure of TUBOCURARINE
INHIBITOR -> TRANSPORTER
Structure of LURBINECTEDIN
INHIBITOR -> TRANSPORTER
Structure of FURAMIDINE
INHIBITOR -> TRANSPORTER
Structure of QUINIDINE
SUBSTRATE -> TRANSPORTER
Structure of SAQUINAVIR
INHIBITOR -> TRANSPORTER
Structure of CIMETIDINE
SUBSTRATE -> TRANSPORTER
Structure of PHENFORMIN
INHIBITOR -> TRANSPORTER
Structure of PONATINIB
SUBSTRATE -> TRANSPORTER
Structure of BRANEBRUTINIB
INHIBITOR -> TRANSPORTER
Structure of TIRBANIBULIN
INHIBITOR -> TRANSPORTER
The results suggest that KLISYRI has no clinically meaningful effect on the PK of drugs mediated by OCT1
IC50
Structure of CLONIDINE
INHIBITOR -> TRANSPORTER
Structure of ETILEFRINE
INHIBITOR -> TRANSPORTER
Structure of PHENCYCLIDINE
INHIBITOR -> TRANSPORTER
Structure of QUINIDINE
INHIBITOR -> TRANSPORTER
Structure of AMANTADINE
SUBSTRATE -> TRANSPORTER
Structure of MIDOMAFETAMINE
INHIBITOR -> TRANSPORTER
Structure of OLAPARIB
INHIBITOR -> TRANSPORTER
INHIBITOR
IC50
Structure of PROCAINAMIDE
INHIBITOR -> TRANSPORTER
Structure of THIAMINE
SUBSTRATE -> TRANSPORTER
Structure of METFORMIN
INHIBITOR -> TRANSPORTER
Structure of INDINAVIR
INHIBITOR -> TRANSPORTER
Structure of CIMETIDINE
INHIBITOR -> TRANSPORTER
Structure of AMITRIPTYLINE
INHIBITOR -> TRANSPORTER
Structure of GLYBURIDE
INHIBITOR -> TRANSPORTER
Structure of QUININE
INHIBITOR -> TRANSPORTER
Structure of GANCICLOVIR
SUBSTRATE -> TRANSPORTER
Structure of ACYCLOVIR
SUBSTRATE -> TRANSPORTER
Structure of CORTICOSTERONE
INHIBITOR -> TRANSPORTER
Structure of ACYCLOVIR
SUBSTRATE -> TRANSPORTER
Structure of GANCICLOVIR
SUBSTRATE -> TRANSPORTER
Structure of FAMOTIDINE
SUBSTRATE -> TRANSPORTER
Structure of ERLOTINIB
SUBSTRATE -> TRANSPORTER
Structure of HISTAMINE
SUBSTRATE -> TRANSPORTER
Structure of VERAPAMIL
INHIBITOR -> TRANSPORTER
Structure of DIZOCILPINE
INHIBITOR -> TRANSPORTER
Structure of LESINURAD
INHIBITOR -> TRANSPORTER
Based on in vitro studies, lesinurad is a weak inhibitor of OATP1B1, OCT1, OAT1, and OAT3.
WEAK
Structure of DUVELISIB
INHIBITOR -> TRANSPORTER
Structure of SEROTONIN
SUBSTRATE -> TRANSPORTER
Structure of DISOPYRAMIDE
INHIBITOR -> TRANSPORTER
Structure of ROSIGLITAZONE
INHIBITOR -> TRANSPORTER
Structure of MIDAZOLAM
INHIBITOR -> TRANSPORTER
Structure of NELFINAVIR
INHIBITOR -> TRANSPORTER
Structure of RITONAVIR
INHIBITOR -> TRANSPORTER
Structure of GILTERITINIB
INHIBITOR -> TRANSPORTER
IC50
Structure of SEPANTRONIUM BROMIDE
INHIBITOR -> TRANSPORTER
Structure of DASATINIB
SUBSTRATE -> TRANSPORTER
HUMAN LIVER
TISSUE EXPRESSION->TRANSPORTER
INFLUX
Structure of PHENOXYBENZAMINE
INHIBITOR -> TRANSPORTER
Structure of RANITIDINE
SUBSTRATE -> TRANSPORTER
Structure of METFORMIN
SUBSTRATE -> TRANSPORTER
Structure of FAMOTIDINE
INHIBITOR -> TRANSPORTER
Structure of DIPHENHYDRAMINE
INHIBITOR -> TRANSPORTER
Structure of IMEGLIMIN
INHIBITOR -> TRANSPORTER
Structure of IMEGLIMIN
SUBSTRATE -> TRANSPORTER
Structure of SORAFENIB
SUBSTRATE -> TRANSPORTER
Structure of DEXTROAMPHETAMINE
INHIBITOR -> TRANSPORTER
Structure of PANOBINOSTAT
INHIBITOR -> TRANSPORTER
Structure of SIMVASTATIN
INHIBITOR -> TRANSPORTER
Structure of NILOTINIB
SUBSTRATE -> TRANSPORTER
Structure of CHOLINE
SUBSTRATE -> TRANSPORTER
Structure of SUNITINIB
SUBSTRATE -> TRANSPORTER
Structure of DOPAMINE
SUBSTRATE -> TRANSPORTER
Structure of QUININE
SUBSTRATE -> TRANSPORTER
Structure of ATROPINE
INHIBITOR -> TRANSPORTER
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
NCATS
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