U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C10H12N2O
Molecular Weight 176.2151
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SEROTONIN

SMILES

NCCC1=CNC2=C1C=C(O)C=C2

InChI

InChIKey=QZAYGJVTTNCVMB-UHFFFAOYSA-N
InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2

HIDE SMILES / InChI

Molecular Formula C10H12N2O
Molecular Weight 176.2151
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter produced by serotonergic neurons in the CNS and enterochromaffin cells in the gastrointestinal tract. Pharmacologic action of serotonin is mediated by a large and diverse range of 5-HT receptors. Serotonin plays an important part in the biochemistry of depression, migraine, bipolar disorder, and anxiety. It is also believed to be influential on sexuality and appetite. Creatinine is a product of the metabolic breakdown of creatine phosphate in muscle. Creatinine is filtered by healthy kidneys. Serotonin creatinine sulfate complex was the first isolated salt form of serotonin.

Approval Year

PubMed

PubMed

TitleDatePubMed
Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors.
1999 Jun
Effect of the 5-hydroxytryptamine3 (5-HT3)-receptor antagonist KB-R6933 on experimental diarrhea models.
1999 May
Serotonin in human allergic contact dermatitis. An immunohistochemical and high-performance liquid chromatographic study.
1999 May
Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.
2000 Dec 5
Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.
2000 Feb
Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA ('ecstasy') on the 5-HT and dopamine concentrations in mouse brain.
2001
Modulation of 5-HT(1A) receptor activation by its interaction with wild-type and mutant g(alphai3) proteins.
2001
Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1.
2001 Apr 20
Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily.
2001 Apr 6
Identification of the aromatic L-amino acid decarboxylase (AADC) gene and its expression in the attachment and metamorphosis of the barnacle, Balanus amphitrite.
2001 Feb
Cisapride and dexamethasone in the prevention of delayed emesis after cisplatin administration.
2001 Jan
Trimethoprim-sulfamethoxazole and clozapine.
2001 Jan
Misdiagnosis of schizophrenia for a patient with epilepsy.
2001 Jan
Levels of serotonin receptor 2A higher in suicide victims?
2001 Jan
A novel augmentation strategy for treating resistant major depression.
2001 Jan
Ondansetron hydrochloride for the treatment of delirium after coronary artery surgery.
2001 Jan
Ondansetron is no more effective than supplemental intraoperative oxygen for prevention of postoperative nausea and vomiting.
2001 Jan
A single serotonergic modulatory cell can mediate reinforcement in the withdrawal network of the terrestrial snail.
2001 Jan
Melatonin potentiates contractile responses to serotonin in isolated porcine coronary arteries.
2001 Jan
Pharmacological agents for the treatment of urinary incontinence due to overactive bladder.
2001 Jan
Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin.
2001 Jan
Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study.
2001 Jan
Necessity of thromboxane A2 for initiation of platelet-mediated contact sensitivity: dual activation of platelets and vascular endothelial cells.
2001 Jan 1
Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134).
2001 Jan 8
Alcohol-induced euphoria: exclusion of serotonin.
2001 Jan-Feb
Pharmacological characterization of the rat paw edema induced by Bothrops lanceolatus (Fer de lance) venom.
2001 Jun
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:16:50 GMT 2023
Edited
by admin
on Fri Dec 15 15:16:50 GMT 2023
Record UNII
333DO1RDJY
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SEROTONIN
MART.   MI   WHO-DD  
Common Name English
THROMBOTONIN
Common Name English
SEROTONIN [MI]
Common Name English
3-(2-AMINOETHYL)-1H-INDOL-5-OL
Systematic Name English
5-HYDROXYTRYPTAMINE
Systematic Name English
Serotonin [WHO-DD]
Common Name English
ENTERAMINE
Common Name English
SEROTONIN [MART.]
Common Name English
3-(.BETA.-AMINOETHYL)-5-HYDROXYINDOLE
Systematic Name English
Classification Tree Code System Code
LOINC 14910-4
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
NCI_THESAURUS C687
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 2939-7
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DSLD 4216 (Number of products:1)
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 42671-8
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LOINC 32339-4
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LOINC 25524-0
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LOINC 34373-1
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LOINC 34374-9
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LOINC 25981-2
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LOINC 17003-5
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LOINC 2940-5
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LOINC 18375-6
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LOINC 2941-3
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LOINC 71804-9
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LOINC 18253-5
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LOINC 56978-0
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LOINC 26035-6
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LOINC 27057-9
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Code System Code Type Description
PUBCHEM
5202
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
WIKIPEDIA
SEROTONIN
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
SMS_ID
100000078432
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
CHEBI
350546
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
NCI_THESAURUS
C828
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
MERCK INDEX
m9871
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
200-058-9
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
MESH
D012701
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
CHEBI
28790
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
CAS
50-67-9
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
RXCUI
1311214
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID8075330
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
DRUG BANK
DB08839
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
FDA UNII
333DO1RDJY
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
DAILYMED
333DO1RDJY
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
EVMPD
SUB15230MIG
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
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SALT/SOLVATE -> PARENT
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