U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C10H12N2O
Molecular Weight 176.2151
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SEROTONIN

SMILES

NCCC1=CNC2=C1C=C(O)C=C2

InChI

InChIKey=QZAYGJVTTNCVMB-UHFFFAOYSA-N
InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2

HIDE SMILES / InChI

Molecular Formula C10H12N2O
Molecular Weight 176.2151
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter produced by serotonergic neurons in the CNS and enterochromaffin cells in the gastrointestinal tract. Pharmacologic action of serotonin is mediated by a large and diverse range of 5-HT receptors. Serotonin plays an important part in the biochemistry of depression, migraine, bipolar disorder, and anxiety. It is also believed to be influential on sexuality and appetite. Creatinine is a product of the metabolic breakdown of creatine phosphate in muscle. Creatinine is filtered by healthy kidneys. Serotonin creatinine sulfate complex was the first isolated salt form of serotonin.

Approval Year

PubMed

PubMed

TitleDatePubMed
Association between monoamine oxidase A activity in human male skin fibroblasts and genotype of the MAOA promoter-associated variable number tandem repeat.
1999 Dec
Effects of local application of 5-hydroxytryptamine into the dorsal or median raphe nuclei on haloperidol-induced catalepsy in the rat.
1999 Jan
High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action.
1999 May
[Anorectics and pulmonary hypertension].
2000 Feb 16
New abortive agents for the treatment of migraine.
2001
Constitutive activity at serotonin 5-HT(1D) receptors: detection by homologous GTPgammaS versus [(35)S]-GTPgammaS binding isotherms.
2001
Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily.
2001 Apr 6
Transcriptional mechanisms for induction of 5-HT1A receptor mRNA and protein in activated B and T lymphocytes.
2001 Feb 9
Atrial arrhythmia in a woman treated with fluoxetine: is there a causal relationship?
2001 Jan
Changes of biogenic amine levels in haemolymph during diapausing and non-diapausing status in Pieris brassicae L.
2001 Jan
Paroxetine in breast milk.
2001 Jan
Ondansetron hydrochloride for the treatment of delirium after coronary artery surgery.
2001 Jan
Prevention of galanin upregulation following neonatal infraorbital nerve transection or attenuation of axoplasmic transport does not rescue central vibrissae-related patterns in the rat.
2001 Jan
Ondansetron is no more effective than supplemental intraoperative oxygen for prevention of postoperative nausea and vomiting.
2001 Jan
The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholamines.
2001 Jan
Effect of inhibition of MAO and COMT on intrarenal dopamine and serotonin and on renal function.
2001 Jan
Chromaffin-adrenocortical cell interactions: effects of chromaffin cell activation in adrenal cell cocultures.
2001 Jan
The extraneuronal monoamine transporter Slc22a3/Orct3 co-localizes with the Maoa metabolizing enzyme in mouse placenta.
2001 Jan
Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin.
2001 Jan
Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study.
2001 Jan
Necessity of thromboxane A2 for initiation of platelet-mediated contact sensitivity: dual activation of platelets and vascular endothelial cells.
2001 Jan 1
Serum pancreastatin levels predict response to hepatic artery chemoembolization and somatostatin analogue therapy in metastatic neuroendocrine tumors.
2001 Jan 12
Pharmacological characterization of the rat paw edema induced by Bothrops lanceolatus (Fer de lance) venom.
2001 Jun
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:16:50 GMT 2023
Edited
by admin
on Fri Dec 15 15:16:50 GMT 2023
Record UNII
333DO1RDJY
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SEROTONIN
MART.   MI   WHO-DD  
Common Name English
THROMBOTONIN
Common Name English
SEROTONIN [MI]
Common Name English
3-(2-AMINOETHYL)-1H-INDOL-5-OL
Systematic Name English
5-HYDROXYTRYPTAMINE
Systematic Name English
Serotonin [WHO-DD]
Common Name English
ENTERAMINE
Common Name English
SEROTONIN [MART.]
Common Name English
3-(.BETA.-AMINOETHYL)-5-HYDROXYINDOLE
Systematic Name English
Classification Tree Code System Code
LOINC 14910-4
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
NCI_THESAURUS C687
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 2939-7
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
DSLD 4216 (Number of products:1)
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 42671-8
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 32339-4
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 25524-0
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 34373-1
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 34374-9
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 25981-2
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 17003-5
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 2940-5
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 18375-6
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 2941-3
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 71804-9
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 18253-5
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 56978-0
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 26035-6
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
LOINC 27057-9
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
Code System Code Type Description
PUBCHEM
5202
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
WIKIPEDIA
SEROTONIN
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
SMS_ID
100000078432
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
CHEBI
350546
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
NCI_THESAURUS
C828
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
MERCK INDEX
m9871
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
200-058-9
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
MESH
D012701
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
CHEBI
28790
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
CAS
50-67-9
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
RXCUI
1311214
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID8075330
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
DRUG BANK
DB08839
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
FDA UNII
333DO1RDJY
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
DAILYMED
333DO1RDJY
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
EVMPD
SUB15230MIG
Created by admin on Fri Dec 15 15:16:50 GMT 2023 , Edited by admin on Fri Dec 15 15:16:50 GMT 2023
PRIMARY
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