SEROTONIN

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H12N2O
Molecular Weight	176.2151
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NCCC1=CNC2=C1C=C(O)C=C2

InChI

InChIKey=QZAYGJVTTNCVMB-UHFFFAOYSA-N

InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2

HIDE SMILES / InChI

Molecular Formula	C10H12N2O
Molecular Weight	176.2151
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://onlinelibrary.wiley.com/doi/pdf/10.1107/S0365110X65004267 | https://www.novusbio.com/products/serotonin-antibody_nb100-2052 | https://pubs.acs.org/doi/abs/10.1021/ja01155a580

Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter produced by serotonergic neurons in the CNS and enterochromaffin cells in the gastrointestinal tract. Pharmacologic action of serotonin is mediated by a large and diverse range of 5-HT receptors. Serotonin plays an important part in the biochemistry of depression, migraine, bipolar disorder, and anxiety. It is also believed to be influential on sexuality and appetite. Creatinine is a product of the metabolic breakdown of creatine phosphate in muscle. Creatinine is filtered by healthy kidneys. Serotonin creatinine sulfate complex was the first isolated salt form of serotonin.

Approval Year

Targets

Primary Target	Pharmacology	Potency
Serotonin 5a (5-HT5a) receptor 11 Target ID: CHEMBL3426 Sources: Roth, B.L. (2008) The Serotonin Receptors, page 133, retrieved from: https://books.google.ru/books?id=J6i6YpvCQfIC	Agonist 2678	170.0 nM [Ki]
Serotonin 3 (5-HT3) receptor 59 Target ID: CHEMBL2094116 Sources: B. Olivier, I. van Wijngaarden, W. Soudijn (1997) Serotonin Receptors and their Ligands, page 230, retrieved from: https://books.google.ru/books?id=lfo0hGqIex0C	Agonist 2678	692.0 nM [Ki]
Serotonin (5-HT) receptor 34 Target ID: CHEMBL2094123 Sources: Sanders-Bush, E. (2012) The Serotonin Receptors, page 32, retrieved from: https://books.google.ru/books?id=GZ4ACAAAQBAJ	Agonist 2678

PubMed

Title	Date	PubMed
New abortive agents for the treatment of migraine.	2001	11147249
A clinical trial on a plate? The potential of 384-well format solid phase extraction for high-throughput bioanalysis using liquid chromatography/tandem mass spectrometry.	2001	11135422
Peripheral interleukin-6 administration increases extracellular concentrations of serotonin and the evoked release of serotonin in the rat striatum.	2001 Apr	11137624
Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1.	2001 Apr 20	11150294
Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily.	2001 Apr 6	11139582
Identification of the aromatic L-amino acid decarboxylase (AADC) gene and its expression in the attachment and metamorphosis of the barnacle, Balanus amphitrite.	2001 Feb	11148450
New avenues in treatment of paediatric migraine: a review of the literature.	2001 Feb	11145638
Evidence for a serotonin transporter deficit in experimental acute liver failure.	2001 Feb	11137885
Human platelet calcium mobilisation in response to beta-amyloid (25-35): buffer dependency and unchanged response in Alzheimer's disease.	2001 Feb	11137883
Presynaptic neuronal antigens expressed by a small cell lung carcinoma cell line.	2001 Feb 1	11137587
Cisapride and dexamethasone in the prevention of delayed emesis after cisplatin administration.	2001 Jan	11147145
Atrial arrhythmia in a woman treated with fluoxetine: is there a causal relationship?	2001 Jan	11145788
Radiosynthesis of [123I]betaCIT, a selective ligand for the study of the dopaminergic and serotoninergic systems in human brain.	2001 Jan	11144258
Trimethoprim-sulfamethoxazole and clozapine.	2001 Jan	11141546
Misdiagnosis of schizophrenia for a patient with epilepsy.	2001 Jan	11141543
Antisocial personality - part II.	2001 Jan	11137962
Changes of biogenic amine levels in haemolymph during diapausing and non-diapausing status in Pieris brassicae L.	2001 Jan	11137444
Chronic endothelial dysfunction after oversized coronary balloon angioplasty in pigs: a 12-week follow-up of coronary vasoreactivity in vivo and in vitro.	2001 Jan	11137083
Levels of serotonin receptor 2A higher in suicide victims?	2001 Jan	11136659
Paroxetine in breast milk.	2001 Jan	11136654
A novel augmentation strategy for treating resistant major depression.	2001 Jan	11136647
The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study.	2001 Jan	11136637
Depression among pregnant adolescents: an integrated treatment approach.	2001 Jan	11136628
Ondansetron hydrochloride for the treatment of delirium after coronary artery surgery.	2001 Jan	11135174
Ischemic preconditioning with opening of mitochondrial adenosine triphosphate-sensitive potassium channels or Na/H exchange inhibition: which is the best protective strategy for heart transplants?	2001 Jan	11135172
Role of dorsal raphe neurons in paradoxical sleep generation in the cat: no evidence for a serotonergic mechanism.	2001 Jan	11135008
Prevention of galanin upregulation following neonatal infraorbital nerve transection or attenuation of axoplasmic transport does not rescue central vibrissae-related patterns in the rat.	2001 Jan	11135001
Selective loss of Sertoli cell and germ cell function leads to a disruption in sertoli cell-germ cell communication during aging in the Brown Norway rat.	2001 Jan	11133664
Ondansetron is no more effective than supplemental intraoperative oxygen for prevention of postoperative nausea and vomiting.	2001 Jan	11133611
Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed.	2001 Jan	11133494
Hypothesized treatment for migraines using low doses of tryptophan, niacin, calcium, caffeine, and acetylsalicylic acid.	2001 Jan	11133261
The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholamines.	2001 Jan	11125028
ANP, BNP, and CNP enhance bradycardic responses to cardiopulmonary chemoreceptor activation in conscious sheep.	2001 Jan	11124162
Effect of inhibition of MAO and COMT on intrarenal dopamine and serotonin and on renal function.	2001 Jan	11124158
A single serotonergic modulatory cell can mediate reinforcement in the withdrawal network of the terrestrial snail.	2001 Jan	11124045
Melatonin potentiates contractile responses to serotonin in isolated porcine coronary arteries.	2001 Jan	11123220
Vasoactive intestinal peptide: cardiovascular effects.	2001 Jan	11121793
Alternating rhythmic activity induced by dorsal root stimulation in the neonatal rat spinal cord in vitro.	2001 Jan 1	11136862
Necessity of thromboxane A2 for initiation of platelet-mediated contact sensitivity: dual activation of platelets and vascular endothelial cells.	2001 Jan 1	11123345
Brain function in a patient with torture related post-traumatic stress disorder before and after fluoxetine treatment: a positron emission tomography provocation study.	2001 Jan 12	11121880
Mapping of 5-HT2A receptors and their mRNA in monkey brain: [3H]MDL100,907 autoradiography and in situ hybridization studies.	2001 Jan 22	11135236
Distribution and chemical coding of orphanin FQ/nociceptin-immunoreactive neurons in the myenteric plexus of guinea pig intestines and sphincter of Oddi.	2001 Jan 29	11135242
Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo.	2001 Jan 5	11146061
M100,907, a selective 5-HT(2A) antagonist, attenuates dopamine release in the rat medial prefrontal cortex.	2001 Jan 5	11146051
Functional effects of corticosterone on 5-HT(1A) and 5-HT(1B) receptor activity in rat brain: in vivo microdialysis studies.	2001 Jan 5	11137865
Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134).	2001 Jan 8	11140733
Alcohol-induced euphoria: exclusion of serotonin.	2001 Jan-Feb	11139411
Pharmacological characterization of the rat paw edema induced by Bothrops lanceolatus (Fer de lance) venom.	2001 Jun	11137542
Functional reconstitution and characterization of recombinant human alpha 1-glycine receptors.	2001 Jun 15	11145968
Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid.	2001 Mar 30	11134050

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:16:50 UTC 2023` Edited by `admin` on `Fri Dec 15 15:16:50 UTC 2023`
Record UNII	333DO1RDJY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SEROTONIN

Common Name

English

THROMBOTONIN

Common Name

English

SEROTONIN [MI]

Common Name

English

3-(2-AMINOETHYL)-1H-INDOL-5-OL

Systematic Name

English

5-HYDROXYTRYPTAMINE

Systematic Name

English

Serotonin [WHO-DD]

Common Name

English

ENTERAMINE

Common Name

English

SEROTONIN [MART.]

Common Name

English

3-(.BETA.-AMINOETHYL)-5-HYDROXYINDOLE

Systematic Name

English

Classification Tree Code System Code

LOINC

14910-4