U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C10H12N2O
Molecular Weight 176.2155
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SEROTONIN

SMILES

c1cc2c(cc1O)c(CCN)c[nH]2

InChI

InChIKey=QZAYGJVTTNCVMB-UHFFFAOYSA-N
InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2

HIDE SMILES / InChI

Molecular Formula C10H12N2O
Molecular Weight 176.2155
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter produced by serotonergic neurons in the CNS and enterochromaffin cells in the gastrointestinal tract. Pharmacologic action of serotonin is mediated by a large and diverse range of 5-HT receptors. Serotonin plays an important part in the biochemistry of depression, migraine, bipolar disorder, and anxiety. It is also believed to be influential on sexuality and appetite. Creatinine is a product of the metabolic breakdown of creatine phosphate in muscle. Creatinine is filtered by healthy kidneys. Serotonin creatinine sulfate complex was the first isolated salt form of serotonin.

Approval Year

PubMed

PubMed

TitleDatePubMed
New abortive agents for the treatment of migraine.
2001
A clinical trial on a plate? The potential of 384-well format solid phase extraction for high-throughput bioanalysis using liquid chromatography/tandem mass spectrometry.
2001
Peripheral interleukin-6 administration increases extracellular concentrations of serotonin and the evoked release of serotonin in the rat striatum.
2001 Apr
Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1.
2001 Apr 20
Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily.
2001 Apr 6
Identification of the aromatic L-amino acid decarboxylase (AADC) gene and its expression in the attachment and metamorphosis of the barnacle, Balanus amphitrite.
2001 Feb
New avenues in treatment of paediatric migraine: a review of the literature.
2001 Feb
Evidence for a serotonin transporter deficit in experimental acute liver failure.
2001 Feb
Human platelet calcium mobilisation in response to beta-amyloid (25-35): buffer dependency and unchanged response in Alzheimer's disease.
2001 Feb
Endogenous 5-HT tonically inhibits spontaneous firing activity of dorsal hippocampus CA1 pyramidal neurons through stimulation of 5-HT(1A) receptors in quiet awake rats: in vivo electrophysiological evidence.
2001 Feb
Presynaptic neuronal antigens expressed by a small cell lung carcinoma cell line.
2001 Feb 1
Cisapride and dexamethasone in the prevention of delayed emesis after cisplatin administration.
2001 Jan
Atrial arrhythmia in a woman treated with fluoxetine: is there a causal relationship?
2001 Jan
Trimethoprim-sulfamethoxazole and clozapine.
2001 Jan
Misdiagnosis of schizophrenia for a patient with epilepsy.
2001 Jan
Antisocial personality - part II.
2001 Jan
Changes of biogenic amine levels in haemolymph during diapausing and non-diapausing status in Pieris brassicae L.
2001 Jan
Chronic endothelial dysfunction after oversized coronary balloon angioplasty in pigs: a 12-week follow-up of coronary vasoreactivity in vivo and in vitro.
2001 Jan
Levels of serotonin receptor 2A higher in suicide victims?
2001 Jan
Paroxetine in breast milk.
2001 Jan
A novel augmentation strategy for treating resistant major depression.
2001 Jan
The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study.
2001 Jan
Depression among pregnant adolescents: an integrated treatment approach.
2001 Jan
Role of dorsal raphe neurons in paradoxical sleep generation in the cat: no evidence for a serotonergic mechanism.
2001 Jan
Selective loss of Sertoli cell and germ cell function leads to a disruption in sertoli cell-germ cell communication during aging in the Brown Norway rat.
2001 Jan
Ondansetron is no more effective than supplemental intraoperative oxygen for prevention of postoperative nausea and vomiting.
2001 Jan
Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed.
2001 Jan
Hypothesized treatment for migraines using low doses of tryptophan, niacin, calcium, caffeine, and acetylsalicylic acid.
2001 Jan
The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholamines.
2001 Jan
ANP, BNP, and CNP enhance bradycardic responses to cardiopulmonary chemoreceptor activation in conscious sheep.
2001 Jan
Effect of inhibition of MAO and COMT on intrarenal dopamine and serotonin and on renal function.
2001 Jan
Melatonin potentiates contractile responses to serotonin in isolated porcine coronary arteries.
2001 Jan
Chromaffin-adrenocortical cell interactions: effects of chromaffin cell activation in adrenal cell cocultures.
2001 Jan
The extraneuronal monoamine transporter Slc22a3/Orct3 co-localizes with the Maoa metabolizing enzyme in mouse placenta.
2001 Jan
Cell-specific processing of chromogranin A in endocrine cells of the rat stomach.
2001 Jan
Pharmacological agents for the treatment of urinary incontinence due to overactive bladder.
2001 Jan
Alternating rhythmic activity induced by dorsal root stimulation in the neonatal rat spinal cord in vitro.
2001 Jan 1
Necessity of thromboxane A2 for initiation of platelet-mediated contact sensitivity: dual activation of platelets and vascular endothelial cells.
2001 Jan 1
Brain function in a patient with torture related post-traumatic stress disorder before and after fluoxetine treatment: a positron emission tomography provocation study.
2001 Jan 12
Mapping of 5-HT2A receptors and their mRNA in monkey brain: [3H]MDL100,907 autoradiography and in situ hybridization studies.
2001 Jan 22
Distribution and chemical coding of orphanin FQ/nociceptin-immunoreactive neurons in the myenteric plexus of guinea pig intestines and sphincter of Oddi.
2001 Jan 29
Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo.
2001 Jan 5
M100,907, a selective 5-HT(2A) antagonist, attenuates dopamine release in the rat medial prefrontal cortex.
2001 Jan 5
Functional effects of corticosterone on 5-HT(1A) and 5-HT(1B) receptor activity in rat brain: in vivo microdialysis studies.
2001 Jan 5
Differential sensitivities to the lethal, but not the neurotoxic, effects of p-chloroamphetamine in inbred rat strains.
2001 Jan 5
Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134).
2001 Jan 8
Alcohol-induced euphoria: exclusion of serotonin.
2001 Jan-Feb
Pharmacological characterization of the rat paw edema induced by Bothrops lanceolatus (Fer de lance) venom.
2001 Jun
Functional reconstitution and characterization of recombinant human alpha 1-glycine receptors.
2001 Jun 15
Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid.
2001 Mar 30
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 04:30:39 UTC 2021
Edited
by admin
on Sat Jun 26 04:30:39 UTC 2021
Record UNII
333DO1RDJY
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SEROTONIN
MART.   MI   WHO-DD  
Common Name English
THROMBOTONIN
Common Name English
SEROTONIN [MI]
Common Name English
3-(2-AMINOETHYL)-1H-INDOL-5-OL
Systematic Name English
5-HYDROXYTRYPTAMINE
Systematic Name English
SEROTONIN [WHO-DD]
Common Name English
ENTERAMINE
Common Name English
SEROTONIN [MART.]
Common Name English
3-(.BETA.-AMINOETHYL)-5-HYDROXYINDOLE
Systematic Name English
Classification Tree Code System Code
LOINC 14910-4
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
NCI_THESAURUS C687
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 2939-7
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
DSLD 4216 (Number of products:1)
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 42671-8
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 32339-4
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 25524-0
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 34373-1
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 34374-9
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 25981-2
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 17003-5
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 2940-5
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 18375-6
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 2941-3
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 71804-9
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 18253-5
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 56978-0
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 26035-6
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
LOINC 27057-9
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
Code System Code Type Description
PUBCHEM
5202
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
PRIMARY
WIKIPEDIA
SEROTONIN
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
PRIMARY
NCI_THESAURUS
C828
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
PRIMARY
MERCK INDEX
M9871
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
PRIMARY Merck Index
ECHA (EC/EINECS)
200-058-9
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
PRIMARY
MESH
D012701
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
PRIMARY
CAS
50-67-9
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
PRIMARY
RXCUI
1311214
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
PRIMARY RxNorm
EPA CompTox
50-67-9
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
PRIMARY
DRUG BANK
DB08839
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
PRIMARY
FDA UNII
333DO1RDJY
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
PRIMARY
EVMPD
SUB15230MIG
Created by admin on Sat Jun 26 04:30:39 UTC 2021 , Edited by admin on Sat Jun 26 04:30:39 UTC 2021
PRIMARY
Related Record Type Details
TRANSPORTER -> SUBSTRATE
SALT/SOLVATE -> PARENT
TARGET -> AGONIST
AGONIST
SALT/SOLVATE -> PARENT
Related Record Type Details
METABOLITE -> PARENT
METABOLITE -> PARENT
PARENT -> METABOLITE ACTIVE
Related Record Type Details
ACTIVE MOIETY