U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 11:40:49 GMT 2023
Edited
by admin
on Sat Dec 16 11:40:49 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
W4BO00H6K6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
5-HYDROXYTRYPTAMINE RECEPTOR 2C
Common Name English
5-HT1C
Common Name English
5-HT2C receptor
Common Name English
HTR1C
Common Name English
5-HYDROXYTRYPTAMINE RECEPTOR 1C
Common Name English
5-HTR2C
Common Name English
SEROTONIN RECEPTOR 2C
Common Name English
5-HT2C
Common Name English
Code System Code Type Description
UNIPROT
P28335
Created by admin on Sat Dec 16 11:40:52 GMT 2023 , Edited by admin on Sat Dec 16 11:40:52 GMT 2023
PRIMARY
PHAROS
P28335
Created by admin on Sat Dec 16 11:40:52 GMT 2023 , Edited by admin on Sat Dec 16 11:40:52 GMT 2023
PRIMARY
FDA UNII
W4BO00H6K6
Created by admin on Sat Dec 16 11:40:52 GMT 2023 , Edited by admin on Sat Dec 16 11:40:52 GMT 2023
PRIMARY
From To
1_95 1_175
1_305 1_309
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_7
Related Record Type Details
INHIBITOR -> TARGET
AGONIST -> TARGET
Ki
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR
Ki
INHIBITOR -> TARGET
Binding Assay
IC50
INHIBITOR -> TARGET
INHIBITOR -> TRANSPORTER
AGONIST -> TARGET
Ki
INHIBITOR -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
AGONIST -> TARGET
Ki
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Emax, ~90%
EC50
INHIBITOR -> TARGET
AGONIST -> TARGET
WEAK AGONIST->TARGET
PARTIAL AGONIST->TARGET
Ki
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
INHIBITOR
Ki
INVERSE AGONIST->TARGET
AGONIST
Ki
RADIOLIGAND->TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
Selective agonist for the 5-HT2C receptor (IC50 of 12 nM, vs 633 nM at 5-HT2A).
IC50
INHIBITOR -> TARGET
ANTAGONIST
PARTIAL AGONIST->TARGET
WEAK INHIBITOR->TARGET
Ki
INHIBITOR -> TARGET
Acts as a mixed antagonist for the 5-HT2B and 5-HT2C serotonin receptors, with good selectivity over other serotonin receptor subtypes and slight preference for 5-HT2C over 5-HT2B.
ANTAGONIST
PARTIAL AGONIST->TARGET
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
AGONIST -> TARGET
ANTAGONIST->TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
ANTAGONIST
AGONIST -> TARGET
AGONIST
AGONIST -> TARGET
AGONIST -> TARGET
Assumed agonist
Ki
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
ACTIVATOR -> TARGET
STIMULATES THE RELEASE OF SEROTONIN RESULTS IN APPETITE SUPPRESSION; LEAD TO 6-16 FOLD INCREASE IN SEROTONIN IN THE HYPOTHALMUS
AGONIST -> TARGET
EC50
AGONIST -> TARGET
STIMULATES THE RELEASE OF SEROTONIN RESULTS IN APPETITE SUPPRESSION; LEAD TO 6-16 FOLD INCREASE IN SEROTONIN IN THE HYPOTHALMUS
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
RADIOLIGAND->TARGET
INHIBITOR -> TARGET
Binding Assay
IC50
WEAK AGONIST->TARGET
Ki
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL