U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
134361
Substance Class Protein
Created
by admin
on Thu Jul 06 17:18:13 UTC 2023
Edited
by admin
on Thu Jul 06 17:18:13 UTC 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
W4BO00H6K6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
5-HYDROXYTRYPTAMINE RECEPTOR 2C
Common Name English
5-HT1C
Common Name English
5-HT2C receptor
Common Name English
HTR1C
Common Name English
5-HYDROXYTRYPTAMINE RECEPTOR 1C
Common Name English
5-HTR2C
Common Name English
SEROTONIN RECEPTOR 2C
Common Name English
5-HT2C
Common Name English
Code System Code Type Description
UNIPROT
P28335
Created by admin on Thu Jul 06 17:18:16 UTC 2023 , Edited by admin on Thu Jul 06 17:18:16 UTC 2023
PRIMARY
PHAROS
P28335
Created by admin on Thu Jul 06 17:18:16 UTC 2023 , Edited by admin on Thu Jul 06 17:18:16 UTC 2023
PRIMARY
FDA UNII
W4BO00H6K6
Created by admin on Thu Jul 06 17:18:16 UTC 2023 , Edited by admin on Thu Jul 06 17:18:16 UTC 2023
PRIMARY
From To
1_95 1_175
1_305 1_309
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_7
Related Record Type Details
Structure of 6-CHLORO-5-ETHOXY-N-(PYRIDIN-2-YL)INDOLINE-1-CARBOXAMIDE
INHIBITOR -> TARGET
Structure of CIMBI-36
AGONIST -> TARGET
Ki
Structure of TEDATIOXETINE
INHIBITOR -> TARGET
Structure of DMBMPP
AGONIST -> TARGET
Structure of BRILAROXAZINE
INHIBITOR -> TARGET
Structure of PALIPERIDONE
INHIBITOR -> TARGET
INHIBITOR
Ki
Structure of RS-102221
INHIBITOR -> TARGET
Binding Assay
IC50
Structure of SB-773812
INHIBITOR -> TARGET
Structure of OLANZAPINE
INHIBITOR -> TRANSPORTER
Structure of LYSERGIDE
AGONIST -> TARGET
Structure of DOTARIZINE
INHIBITOR -> TARGET
Structure of LORCASERIN
AGONIST -> TARGET
EC50
Structure of CPD-1
AGONIST -> TARGET
Structure of 5-MEO-AMT
AGONIST -> TARGET
Ki
Structure of BUFOTENINE
AGONIST -> TARGET
DOXEPIN
INHIBITOR -> TARGET
Structure of PF-04479745
AGONIST -> TARGET
Structure of WAY-163909
AGONIST -> TARGET
Emax, ~90%
EC50
Structure of SERTINDOLE
INHIBITOR -> TARGET
Structure of WAY-161503
AGONIST -> TARGET
Structure of MESCALINE
WEAK AGONIST->TARGET
Structure of 1B-LSD
PARTIAL AGONIST->TARGET
Ki
Structure of PIZOTYLINE
INHIBITOR -> TARGET
Structure of TCB-2
AGONIST -> TARGET
Structure of 2C-B-BUTTERFLY
AGONIST -> TARGET
Structure of DOET
PARTIAL AGONIST->TARGET
Structure of RISPERIDONE
INHIBITOR -> TARGET
INHIBITOR
Ki
Structure of PIMAVANSERIN
INVERSE AGONIST->TARGET
AGONIST
Ki
Structure of MBL C-11
RADIOLIGAND->TARGET
Ki
Structure of ASP-2205
AGONIST -> TARGET
Structure of 1-METHYLPSILOCIN
AGONIST -> TARGET
Selective agonist for the 5-HT2C receptor (IC50 of 12 nM, vs 633 nM at 5-HT2A).
IC50
Structure of 5-MEO-NBPBRT
INHIBITOR -> TARGET
ANTAGONIST
Structure of A-372159
PARTIAL AGONIST->TARGET
Structure of CARIPRAZINE
WEAK INHIBITOR->TARGET
Ki
Structure of SDZ SER-082
INHIBITOR -> TARGET
Acts as a mixed antagonist for the 5-HT2B and 5-HT2C serotonin receptors, with good selectivity over other serotonin receptor subtypes and slight preference for 5-HT2C over 5-HT2B.
ANTAGONIST
Structure of ALD-52
PARTIAL AGONIST->TARGET
Structure of 1-PROPIONYL-LYSERGIC ACID DIETHYLAMIDE
PARTIAL AGONIST->TARGET
Structure of RITANSERIN
INHIBITOR -> TARGET
Ki
Structure of CYPROHEPTADINE
INHIBITOR -> TARGET
Structure of PHA-57378 Free Base
AGONIST -> TARGET
Structure of DERAMCICLANE
ANTAGONIST->TARGET
Structure of ORG-37684 Free Base
AGONIST -> TARGET
Structure of 6-FLUORO-DMT
AGONIST -> TARGET
Structure of PNU-22394
AGONIST -> TARGET
Structure of SB-200646
INHIBITOR -> TARGET
ANTAGONIST
Structure of SEROTONIN
AGONIST -> TARGET
AGONIST
Structure of AL-38022A
AGONIST -> TARGET
Structure of 25CN-NBOH
AGONIST -> TARGET
Structure of 2-BROMOMESCALINE
AGONIST -> TARGET
Structure of RO-60-0175
AGONIST -> TARGET
Structure of 2,5-Dimethoxy-4-trifluoromethylamphetamine
AGONIST -> TARGET
Structure of DEXFENFLURAMINE
ACTIVATOR -> TARGET
STIMULATES THE RELEASE OF SEROTONIN RESULTS IN APPETITE SUPPRESSION; LEAD TO 6-16 FOLD INCREASE IN SEROTONIN IN THE HYPOTHALMUS
Structure of VABICASERIN
AGONIST -> TARGET
EC50
Structure of FENFLURAMINE
AGONIST -> TARGET
STIMULATES THE RELEASE OF SEROTONIN RESULTS IN APPETITE SUPPRESSION; LEAD TO 6-16 FOLD INCREASE IN SEROTONIN IN THE HYPOTHALMUS
Structure of AGOMELATINE
INHIBITOR -> TARGET
Structure of PNU-181731
AGONIST -> TARGET
Structure of AL-37350A
AGONIST -> TARGET
Structure of CIMBI-36_5 C-11
RADIOLIGAND->TARGET
Structure of KETANSERIN
INHIBITOR -> TARGET
Binding Assay
IC50
Structure of 4-HYDROXY-N-METHYL-N-ETHYLTRYPTAMINE
AGONIST -> TARGET
Structure of ORG-12962
AGONIST -> TARGET
Structure of ESMIRTAZAPINE
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966