U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Thu Jul 06 17:32:02 UTC 2023
Edited
by admin
on Thu Jul 06 17:32:02 UTC 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
UE9PX4FTL0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
5-HYDROXYTRYPTAMINE RECEPTOR 1B
Common Name English
5-HT1B
Common Name English
SEROTONIN RECEPTOR 1B
Common Name English
S12
Common Name English
HTR1DB
Common Name English
SEROTONIN 1D BETA RECEPTOR
Common Name English
Code System Code Type Description
FDA UNII
UE9PX4FTL0
Created by admin on Thu Jul 06 17:32:03 UTC 2023 , Edited by admin on Thu Jul 06 17:32:03 UTC 2023
PRIMARY
PHAROS
P28222
Created by admin on Thu Jul 06 17:32:03 UTC 2023 , Edited by admin on Thu Jul 06 17:32:03 UTC 2023
PRIMARY
UNIPROT
P28222
Created by admin on Thu Jul 06 17:32:03 UTC 2023 , Edited by admin on Thu Jul 06 17:32:03 UTC 2023
PRIMARY
From To
1_122 1_199
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_24
N 1_32
Related Record Type Details
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR
Ki
LIGAND->TARGET
Kd
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR
Ki
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
Kd
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
(11C)P943 is a new radioligand recently developed to image and quantify serotonin 5-Hydroxytryptamine (5-HT1B) receptors with positron emission tomography (PET). The purpose of this study was to evaluate (11C)P943 for this application in humans, and to determine the most suitable quantification method. (11C)P943 is suitable to quantify 5-HT1B receptors in humans in vivo. (11C)P943 binding potentials are significantly correlated with in vitro measurements of the density of 5-HT1B receptors, and in vivo estimates of the (11C)P943 dissociation constant Kd are close to in vitro measurements. Using arterial input functions, MA1 is the method of choice, especially for parametric images computation. Among noninvasive methods, MRTM2* is the preferred method.
Ki
AGONIST -> TARGET
ANTAGONIST->TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL