5-HYDROXYTRYPTAMINE RECEPTOR 1B

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 11:55:12 GMT 2023` Edited by `admin` on `Sat Dec 16 11:55:12 GMT 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	UE9PX4FTL0
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

5-HYDROXYTRYPTAMINE RECEPTOR 1B

Common Name

English

5-HT1B

Common Name

English

SEROTONIN RECEPTOR 1B

Common Name

English

S12

Common Name

English

HTR1DB

Common Name

English

SEROTONIN 1D BETA RECEPTOR

Common Name

English

Code System Code Type Description

FDA UNII

UE9PX4FTL0

Created by admin on Sat Dec 16 11:55:13 GMT 2023 , Edited by admin on Sat Dec 16 11:55:13 GMT 2023

PRIMARY

PHAROS

P28222

Created by admin on Sat Dec 16 11:55:13 GMT 2023 , Edited by admin on Sat Dec 16 11:55:13 GMT 2023

PRIMARY

UNIPROT

P28222

Created by admin on Sat Dec 16 11:55:13 GMT 2023 , Edited by admin on Sat Dec 16 11:55:13 GMT 2023

PRIMARY

From	To
1_122	1_199

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_24
N	1_32

Related Record Type Details


					1O4XL5SN61

ALMOTRIPTAN

AGONIST -> TARGET

Amount:


					333DO1RDJY

SEROTONIN

AGONIST -> TARGET

Qualification:

IC50

Amount:


					FYC6YY5RYL

CP-94253

AGONIST -> TARGET

Amount:


					6RS056L04P

AVITRIPTAN

AGONIST -> TARGET

Amount:


					R51CRO65DC

BMS-181885

AGONIST -> TARGET


					838F01T721

PALIPERIDONE

INHIBITOR -> TARGET

Interaction Type:

INHIBITOR

Qualification:

Ki

Amount:


					SU46MTA7D5

AZ-10419369

LIGAND->TARGET

Qualification:

Kd

Amount:


					2FS66TH3YW

ZOLMITRIPTAN

AGONIST -> TARGET


					PR834Q503T

ERGOTAMINE

AGONIST -> TARGET

Amount:


					L6UH7ZF8HC

RISPERIDONE

INHIBITOR -> TARGET

Interaction Type:

INHIBITOR

Qualification:

Ki

Amount:


					5TB4SXQ7HG

CGS 12066B-PARENT

AGONIST -> TARGET

Interaction Type:

BINDING

Qualification:

IC50

Amount:


					7ADR2UWC8X

GR125743 H-3

RADIOLIGAND->TARGET

Qualification:

Kd

Amount:


					25X80EK95O

P-943

INHIBITOR -> TARGET

Amount:


					AA33A3F5PC

AZ-10419369 C-11

RADIOLIGAND->TARGET

Qualification:

Kd

Amount:


					B57Z82EOGE

ALNIDITAN

AGONIST -> TARGET

Qualification:

IC50

Amount:


					3NC9ASE900

AZD-3783

INHIBITOR -> TARGET


					8R78F6L9VO

SUMATRIPTAN

AGONIST -> TARGET


					51086HBW8G

RIZATRIPTAN

AGONIST -> TARGET


					IWS1724PX6

8-OH-DPAT

AGONIST -> TARGET

Interaction Type:

BINDING

Qualification:

IC50

Amount:


					QUD44MBL5S

TRELANSERIN

INHIBITOR -> TARGET

Amount:


					97F9DE4CT4

KETANSERIN

INHIBITOR -> TARGET

Interaction Type:

BINDING

Qualification:

IC50

Amount:


					N1RS162V1C

P-943 C-11

RADIOLIGAND->TARGET

Comments:

(11C)P943 is a new radioligand recently developed to image and quantify serotonin 5-Hydroxytryptamine (5-HT1B) receptors with positron emission tomography (PET). The purpose of this study was to evaluate (11C)P943 for this application in humans, and to determine the most suitable quantification method. (11C)P943 is suitable to quantify 5-HT1B receptors in humans in vivo. (11C)P943 binding potentials are significantly correlated with in vitro measurements of the density of 5-HT1B receptors, and in vivo estimates of the (11C)P943 dissociation constant Kd are close to in vitro measurements. Using arterial input functions, MA1 is the method of choice, especially for parametric images computation. Among noninvasive methods, MRTM2* is the preferred method.

Qualification:

Ki

Amount:


					70968BVH2J

DONITRIPTAN

AGONIST -> TARGET

Amount:


					933PJL964R

ELZASONAN

ANTAGONIST->TARGET

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL