ZOLMITRIPTAN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H21N3O2
Molecular Weight	287.3568
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CCC1=CNC2=C1C=C(C[C@H]3COC(=O)N3)C=C2

InChI

InChIKey=ULSDMUVEXKOYBU-ZDUSSCGKSA-N

InChI=1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H21N3O2
Molecular Weight	287.3568
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/9154322

Zolmitriptan (Zomig; formerly 311C90) is a novel 5-hydroxytryptamine (5HT)1B/1D receptor agonist with proven efficacy in the acute treatment of migraine with or without preceding aura. The N-desmethyl metabolite also has high affinity for 5-HT1B/1D and moderate affinity for 5-HT1A receptors. Migraines are likely due to local cranial vasodilatation and/or to the release of sensory neuropeptides (vasoactive intestinal peptide, substance P and calcitonin gene-related peptide) through nerve endings in the trigeminal system. The therapeutic activity of Zomig for the treatment of migraine headache is thought to be due to the agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels (including the arterio-venous anastomoses) and sensory nerves of the trigeminal system, which result in cranial vessel constriction, and inhibition of pro-inflammatory neuropeptide release.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin 1d (5-HT1d) receptor 53 Target ID: CHEMBL1983 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9154322	Agonist 2752
Serotonin 1b (5-HT1b) receptor 45 Target ID: CHEMBL1898 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9154322	Agonist 2752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Migraine with aura 11 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf	Palliative		Approved 8583	ZOMIG Approved Use INDICATIONS & USAGE Zolmitriptan is indicated for the acute treatment of migraine with or without aura in adults. Limitations of Use Only use zolmitriptan if a clear diagnosis of migraine has been established. If a patient has no response to zolmitriptan treatment for the first migraine attack, reconsider the diagnosis of migraine before zolmitriptan are administered to treat any subsequent attacks. Zolmitriptan is not indicated for the prevention of migraine attacks. Safety and effectiveness of zolmitriptan have not been established for cluster headache. Zolmitriptan is a serotonin(5-HT)1B/1D receptor agonist (triptan) indicated for the acute treatment of migraine with or without aura in adults (1) Limitations of Use: Use only after a clear diagnosis of migraine has been established (1) Not indicated for the prophylactic therapy of migraine (1) Not indicated for the treatment of cluster headache (1) Launch Date 1997
Migraine without aura 7 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf	Palliative		Approved 8583	ZOMIG Approved Use INDICATIONS & USAGE Zolmitriptan is indicated for the acute treatment of migraine with or without aura in adults. Limitations of Use Only use zolmitriptan if a clear diagnosis of migraine has been established. If a patient has no response to zolmitriptan treatment for the first migraine attack, reconsider the diagnosis of migraine before zolmitriptan are administered to treat any subsequent attacks. Zolmitriptan is not indicated for the prevention of migraine attacks. Safety and effectiveness of zolmitriptan have not been established for cluster headache. Zolmitriptan is a serotonin(5-HT)1B/1D receptor agonist (triptan) indicated for the acute treatment of migraine with or without aura in adults (1) Limitations of Use: Use only after a clear diagnosis of migraine has been established (1) Not indicated for the prophylactic therapy of migraine (1) Not indicated for the treatment of cluster headache (1) Launch Date 1997

C_max

Value	Dose	Analyte	Population
3.3 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	2.5 mg single, oral dose: 2.5 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
3.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	2.5 mg single, oral dose: 2.5 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
5.6 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
9 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
5.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	0.925 mg single, intravenous dose: 0.925 mg route of administration: Intravenous experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
10 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	1.475 mg single, intravenous dose: 1.475 mg route of administration: Intravenous experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
10.6 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	1.85 mg single, intravenous dose: 1.85 mg route of administration: Intravenous experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
22.2 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	2.95 mg single, intravenous dose: 2.95 mg route of administration: Intravenous experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
4.4 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
9.9 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

AUC

Value	Dose	Analyte	Population
17.7 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	2.5 mg single, oral dose: 2.5 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
21.3 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	2.5 mg single, oral dose: 2.5 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
30.9 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
54.8 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
16.8 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	0.925 mg single, intravenous dose: 0.925 mg route of administration: Intravenous experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
32.4 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	1.475 mg single, intravenous dose: 1.475 mg route of administration: Intravenous experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
32.5 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	1.85 mg single, intravenous dose: 1.85 mg route of administration: Intravenous experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
71.2 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	2.95 mg single, intravenous dose: 2.95 mg route of administration: Intravenous experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
23.9 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED
55.7 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

T_1/2

Value	Dose	Analyte	Population
2.29 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	2.5 mg single, oral dose: 2.5 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
2.56 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	2.5 mg single, oral dose: 2.5 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
2.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
2.82 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
2.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	0.925 mg single, intravenous dose: 0.925 mg route of administration: Intravenous experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
2.5 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	1.475 mg single, intravenous dose: 1.475 mg route of administration: Intravenous experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
2.32 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	1.85 mg single, intravenous dose: 1.85 mg route of administration: Intravenous experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
2.66 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9833595	2.95 mg single, intravenous dose: 2.95 mg route of administration: Intravenous experiment type: SINGLE co-administered:	ZOLMITRIPTAN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED

F_unbound

Value	Dose	Co-administered	Analyte	Population
75% DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020768s023,021231s014,021450s010lbl.pdf	unknown, unknown		ZOLMITRIPTAN plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
5 mg single, intranasal Highest studied dose Dose: 5 mg Route: intranasal Route: single Dose: 5 mg Sources: https://pubmed.ncbi.nlm.nih.gov/12921494	unhealthy, 41.7 ± 10.4 Health Status: unhealthy Age Group: 41.7 ± 10.4 Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/12921494	Disc. AE: Taste abnormality, Migraine aggravated... AEs leading to discontinuation/dose reduction: Taste abnormality (0.4%) Migraine aggravated (0.4%) Sources: https://pubmed.ncbi.nlm.nih.gov/12921494
50 mg single, oral Overdose Dose: 50 mg Route: oral Route: single Dose: 50 mg Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf	Other AEs: Sedation... Other AEs: Sedation Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf
5 mg single, oral Recommended Dose: 5 mg Route: oral Route: single Dose: 5 mg Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf	Disc. AE: Arrhythmia, Cerebral hemorrhage... AEs leading to discontinuation/dose reduction: Arrhythmia Cerebral hemorrhage Subarachnoid hemorrhage Stroke Gastrointestinal ischemia Peripheral vasoconstriction Serotonin syndrome Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf

AEs

AE	Significance	Dose	Population
Migraine aggravated	0.4% Disc. AE	5 mg single, intranasal Highest studied dose Dose: 5 mg Route: intranasal Route: single Dose: 5 mg Sources: https://pubmed.ncbi.nlm.nih.gov/12921494	unhealthy, 41.7 ± 10.4 Health Status: unhealthy Age Group: 41.7 ± 10.4 Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/12921494
Taste abnormality	0.4% Disc. AE	5 mg single, intranasal Highest studied dose Dose: 5 mg Route: intranasal Route: single Dose: 5 mg Sources: https://pubmed.ncbi.nlm.nih.gov/12921494	unhealthy, 41.7 ± 10.4 Health Status: unhealthy Age Group: 41.7 ± 10.4 Sex: M+F Sources: https://pubmed.ncbi.nlm.nih.gov/12921494
Sedation		50 mg single, oral Overdose Dose: 50 mg Route: oral Route: single Dose: 50 mg Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf
Arrhythmia	Disc. AE	5 mg single, oral Recommended Dose: 5 mg Route: oral Route: single Dose: 5 mg Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf
Cerebral hemorrhage	Disc. AE	5 mg single, oral Recommended Dose: 5 mg Route: oral Route: single Dose: 5 mg Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf
Gastrointestinal ischemia	Disc. AE	5 mg single, oral Recommended Dose: 5 mg Route: oral Route: single Dose: 5 mg Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf
Peripheral vasoconstriction	Disc. AE	5 mg single, oral Recommended Dose: 5 mg Route: oral Route: single Dose: 5 mg Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf
Serotonin syndrome	Disc. AE	5 mg single, oral Recommended Dose: 5 mg Route: oral Route: single Dose: 5 mg Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf
Stroke	Disc. AE	5 mg single, oral Recommended Dose: 5 mg Route: oral Route: single Dose: 5 mg Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf
Subarachnoid hemorrhage	Disc. AE	5 mg single, oral Recommended Dose: 5 mg Route: oral Route: single Dose: 5 mg Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf	unhealthy Health Status: unhealthy Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020768s019s021,021231s010s011lbl.pdf

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1946	substrate 1193	substrate 1388 inhibitor 2507

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP1A2 2153	CYP2C19 1119 CYP1A2 1197 P-gp 2052 OATP1A2 67

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
CYP2D6 2546	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/97/020768ap_zomig_phrmrp1.pdf#page=26 Page: 26.0	weak
CYP1A2 2333	inhibitor 4027 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/97/020768ap_zomig_phrmrp1.pdf#page=26 Page: 26.0	yes		yes (co-administration study) Comment: The increased exposure to zolmitriptan and 183C91 by cimetidine indicated that a reduction in the total daily recommended dose of zolmitriptan may be necessary when treating migraine patients who are taking nonspecific cytochrome P450 inhibitors or specific cytochrome 1A2 inhibitors. (https://pubmed.ncbi.nlm.nih.gov/18370509/) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/97/020768ap_zomig_phrmrp1.pdf#page=26 Page: 26.0

Drug as victim

Target	Modality	Activity	Metabolite
CYP1A2 1197	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/10553725/ Page: -	no	N-desmethyl-zolmitriptan 1
CYP2C9 1193	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/10553725/ Page: -	no	N-desmethyl-zolmitriptan 1
CYP2D6 1388	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/10553725/ Page: -	no	N-desmethyl-zolmitriptan 1
CYP2C19 1119	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/10553725/ Page: -	weak
CYP2C19 1119	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/10553725/ Page: -	weak	N-desmethyl-zolmitriptan 1
CYP2C9 1193	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/10553725/ Page: -	weak
CYP3A4 1946	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/10553725/ Page: -	weak	N-desmethyl-zolmitriptan 1
CYP2D6 1388	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/97/020768ap_zomig_phrmrp1.pdf#page=25 Page: 25.0	yes
CYP3A4 1946	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/97/020768ap_zomig_phrmrp1.pdf#page=25 Page: 25.0	yes
OATP1A2 67	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/22509823/ Page: -	yes
P-gp 2052	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/17524230/ Page: -	yes

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:10124	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:10124
ChemicalBook	CB3313219	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB3313219
eMolecules	2729142	https://www.emolecules.com/cgi-bin/more?vid=2729142
MolPort	MolPort-003-666-626	https://www.molport.com/shop/molecule-link/MolPort-003-666-626
Selleck Chemicals	Zolmitriptan(Zomig)	http://www.selleckchem.com/products/Zolmitriptan(Zomig).html
ZINC	ZINC000000015515	http://zinc15.docking.org/substances/ZINC000000015515

PubMed

Title	Date	PubMed
Pre-clinical pharmacology of zolmitriptan (Zomig; formerly 311C90), a centrally and peripherally acting 5HT1B/1D agonist for migraine.	1997 Oct	9399012
Pharmacological analysis of the haemodynamic effects of 5-HT1B/D receptor agonists in the normotensive rat.	1998 Jan	9489607
Zolmitriptan (311C90) does not interact with fluoxetine in healthy volunteers.	1998 Jun	9660035
[Mechanism of action of zolmitriptan].	1998 Oct	9859690
Are triptans with enhanced lipophilicity used for the acute treatment of migraine associated with an increased consulting rate for depressive illness?	2000 Oct	11167903
Prediction of genotoxicity of chemical compounds by statistical learning methods.	2005 Jun	15962942
Meta-analysis examining the efficacy and safety of almotriptan in the acute treatment of migraine.	2007 Sep	17883521
In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions.	2008 Aug	18816299
Triptans and troponin: a case report.	2009 Jun 18	19538745
Prinzmetal-variant angina in a patient using zolmitriptan and citalopram.	2010 Feb	20159412
A new stability indicating HPLC method for related substances in zolmitriptan.	2010 Jan	20582203
Takotsubo syndrome (or apical ballooning syndrome) secondary to Zolmitriptan.	2015 Mar-Apr	24100257

Patents

Sample Use Guides

In Vivo Use Guide

The recommended starting dose of ZOMIG (zolmitriptan) is 1.25 mg or 2.5 mg. The 1.25 mg dose can be achieved by manually breaking the functionally-scored 2.5 mg tablet in half. The maximum recommended single dose of ZOMIG is 5 mg.

Route of Administration: Oral

In Vitro Use Guide

Stimulation of a Ca(2+)-dependent K(+) current by zolmitriptan was investigated in C6 glioma cells stably expressing recombinant human 5-HT(1B) receptors. Outward K(+) currents (I(K)) were examined in non-transfected C6 glioma cells and in cells expressing cloned human 5-HT(1B) receptors using the patch-clamp technique in the whole-cell configuration. In C6 glioma cells expressing recombinant human 5-HT 1B) receptor, zolmitriptan increased I(K) in a concentration-dependent manner (maximum increase 16.3+/-7.8%, n=5, p<0.001) with a pD(2) value (geometric mean with 95% confidence intervals) of 7.03 (7.90-6.10). Zolmitriptan failed to elicit increases in I(K) in non-transfected C6 cells.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:12:08 GMT 2025` Edited by `admin` on `Mon Mar 31 18:12:08 GMT 2025`
Record UNII	2FS66TH3YW
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ZOLMITRIPTAN

Official Name

English

ZOMIG

Preferred Name

English

Zolmitriptan [WHO-DD]

Common Name

English

311-C-90

Code

English

ZOLMITRIPTAN [USAN]

Common Name

English

zolmitriptan [INN]

Common Name

English

ZOLMITRIPTAN [MART.]

Common Name

English

ZOLMITRIPTAN [EP MONOGRAPH]

Common Name

English

ZOLMITRIPTAN [MI]

Common Name

English

ZOLMITRIPTAN [ORANGE BOOK]

Common Name

English

311C90

Code

English

ZOLMITRIPTAN [VANDF]

Common Name

English

2-OXAZOLIDINONE, 4-((3-(2-(DIMETHYLAMINO)ETHYL)-1H-INDOL-5-YL)METHYL)-, (S)-

Systematic Name

English

ZOLMITRIPTAN [JAN]

Common Name

English

CVT-427

Common Name

English

(S)-4-[[3-[2-(Dimethylamino)ethyl]indol-5-yl]methyl]-2-oxazolidinone

Systematic Name

English

ZOLMITRIPTAN [USP MONOGRAPH]

Common Name

English

ZOLMITRIPTAN [USP-RS]

Common Name

English

NSC-760383

Code

English

Classification Tree Code System Code

WHO-VATC

QN02CC03