Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H21N3O2 |
| Molecular Weight | 287.3568 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCC1=CNC2=C1C=C(C[C@@H]3COC(=O)N3)C=C2
InChI
InChIKey=ULSDMUVEXKOYBU-CYBMUJFWSA-N
InChI=1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m1/s1
| Molecular Formula | C16H21N3O2 |
| Molecular Weight | 287.3568 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Sumatriptan: pharmacological basis and clinical results. | 2001 |
|
| New abortive agents for the treatment of migraine. | 2001 |
|
| Sumatriptan, 5-HT(1D) receptors and obsessive-compulsive disorder. | 2001 Apr |
|
| [Current topics: expectation for new triptans]. | 2001 Apr 10 |
|
| Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain. | 2001 Aug 17 |
|
| A systematic review of the use of triptans in acute migraine. | 2001 Feb |
|
| What is the optimal strategy for managing acute migraine headaches? | 2001 Feb |
|
| NMR studies on three optical active drug molecules. | 2001 Jan-Feb |
|
| An open preference study with sumatriptan 50 mg and zolmitriptan 2.5 mg in 100 migraine patients. | 2001 Jul |
|
| Safety and rational use of the triptans. | 2001 Jul |
|
| Molecular cloning, pharmacological properties and tissue distribution of the porcine 5-HT(1B) receptor. | 2001 Jul |
|
| Establishing a standard of speed for assessing the efficacy of the serotonin(1B/1D) agonists (triptans). | 2001 Jul |
|
| Migraine treatment outcomes with rizatriptan in triptan-naive patients: a naturalistic study. | 2001 Jun |
|
| Current options for the prevention and treatment of migraine. | 2001 Jun |
|
| Recent development in paediatric headache. | 2001 Jun |
|
| Donitriptan (Pierre Fabre). | 2001 Mar |
|
| Zolmitriptan versus sumatriptan comparison trial. | 2001 Mar |
|
| 4991W93 inhibits release of calcitonin gene-related peptide in the cat but only at doses with 5HT(1B/1D) receptor agonist activity? | 2001 Mar |
|
| Effect of MAO-A inhibition on the pharmacokinetics of almotriptan, an antimigraine agent in humans. | 2001 May |
|
| Decreased sensitivity of 5-HT(1D) receptors in melancholic depression. | 2001 May |
|
| Zolmitriptan versus sumatriptan for the acute oral treatment of migraine: a randomized, double-blind, international study. | 2001 May |
|
| Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials. | 2001 Nov 17 |
|
| Zolmitriptan--a 5-HT1B/D agonist, alcohol, and aggression in mice. | 2001 Sep |
|
| Dexamethasone decreases migraine recurrence observed after treatment with a triptan combined with a nonsteroidal anti-inflammatory drug. | 2001 Sep |
|
| Effect of rizatriptan and other triptans on the nausea symptom of migraine: a post hoc analysis. | 2001 Sep |
|
| What matters is not the differences between triptans, but the differences between patients. | 2001 Sep |
|
| Triptans are all different. | 2001 Sep |
|
| Have the triptans fulfilled their promise? | 2001 Sep |
|
| Rizatriptan: an update of its use in the management of migraine. | 2002 |
|
| Selegiline: a second look. Six years later: too risky in Parkinson's disease. | 2002 Aug |
|
| Comparison of triptan tablet consumption per attack: a prospective study of migraineurs in Spain. | 2002 Feb |
|
| [Treatment of migraine in patients with hypertension and ischemic heart disease]. | 2002 Jan 20 |
|
| The pharmacokinetics of the antimigraine compound zolmitriptan in Japanese and Caucasian subjects. | 2002 Jul |
|
| Mechanisms of action of the 5-HT1B/1D receptor agonists. | 2002 Jul |
|
| Gateways to Clinical Trials. June 2002. | 2002 Jun |
|
| Zolmitriptan is effective and well tolerated in Japanese patients with migraine: a dose-response study. | 2002 Jun |
|
| Efficacy of oral ketoprofen in acute migraine: a double-blind randomized clinical trial. | 2002 Jun 11 |
|
| Newer formulations of the triptans: advances in migraine management. | 2003 |
|
| Tolerability and consistency of effect of zolmitriptan nasal spray in a long-term migraine treatment trial. | 2003 |
|
| Management of trigeminal autonomic cephalgias and hemicrania continua. | 2003 |
|
| Transcranial Doppler in migraine attacks before and after treatment with oral zolmitriptan or sumatriptan. | 2003 Jan |
|
| Coprescription of triptans with potentially interacting medications: a cohort study involving 240,268 patients. | 2003 Jan |
|
| Migraine prevalence and treatment patterns: the global Migraine and Zolmitriptan Evaluation survey. | 2003 Jan |
|
| Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein. | 2003 Jul |
|
| The evolving management of migraine. | 2003 Jun |
|
| Safety profile of the triptans. | 2003 Mar |
|
| [Highly selective beginning. Associated symptoms and side effects in retrospect]. | 2003 May 26 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:48:02 GMT 2023
by
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on
Sat Dec 16 10:48:02 GMT 2023
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| Record UNII |
F3YOE57701
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| Record Status |
Validated (UNII)
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| Record Version |
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1727018
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139264-24-7
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441240
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
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