Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H21N3O2 |
| Molecular Weight | 287.3568 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCC1=CNC2=C1C=C(C[C@@H]3COC(=O)N3)C=C2
InChI
InChIKey=ULSDMUVEXKOYBU-CYBMUJFWSA-N
InChI=1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m1/s1
| Molecular Formula | C16H21N3O2 |
| Molecular Weight | 287.3568 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Comparative aspects of triptans in treating migraine. | 2001 |
|
| Zolmitriptan: differences from sumatriptan. | 2001 |
|
| Sumatriptan: pharmacological basis and clinical results. | 2001 |
|
| [The problems of migraine headache treatment]. | 2002 |
|
| An introduction to migraine: from ancient treatment to functional pharmacology and antimigraine therapy. | 2002 |
|
| Restoring migraine sufferers' ability to function normally: a comparison of rizatriptan and other triptans in randomized trials. | 2002 |
|
| Spotlight on rizatriptan in migraine. | 2002 |
|
| Patient perceptions and treatment preferences in migraine management. | 2002 |
|
| Selegiline: a second look. Six years later: too risky in Parkinson's disease. | 2002 Aug |
|
| Triptans reduce the inflammatory response in bacterial meningitis. | 2002 Aug |
|
| Ergot and triptan overuse in Austria--an evaluation of clinical data and cost. | 2002 Dec |
|
| The antimigraine 5-HT 1B/1D receptor agonists, sumatriptan, zolmitriptan and dihydroergotamine, attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain. | 2002 Dec |
|
| [Treatment of migraine in patients with hypertension and ischemic heart disease]. | 2002 Jan 20 |
|
| The pharmacokinetics of the antimigraine compound zolmitriptan in Japanese and Caucasian subjects. | 2002 Jul |
|
| Gateways to Clinical Trials. June 2002. | 2002 Jun |
|
| Pharmacokinetics, dose proportionality, and tolerability of single and repeat doses of a nasal spray formulation of zolmitriptan in healthy volunteers. | 2002 Nov |
|
| Preliminary studies of the pharmacokinetics and tolerability of zolmitriptan nasal spray in healthy volunteers. | 2002 Nov |
|
| Triptans (serotonin, 5-HT1B/1D agonists) in migraine: detailed results and methods of a meta-analysis of 53 trials. | 2002 Oct |
|
| Social and neural determinants of aggressive behavior: pharmacotherapeutic targets at serotonin, dopamine and gamma-aminobutyric acid systems. | 2002 Oct |
|
| A comparison of familial and sporadic migraine in a headache clinic population. | 2002 Oct-Dec |
|
| Newer formulations of the triptans: advances in migraine management. | 2003 |
|
| Tolerability and consistency of effect of zolmitriptan nasal spray in a long-term migraine treatment trial. | 2003 |
|
| Management of trigeminal autonomic cephalgias and hemicrania continua. | 2003 |
|
| Pharmacological approaches to migraine. | 2003 |
|
| Speed of onset and efficacy of zolmitriptan nasal spray in the acute treatment of migraine: a randomised, double-blind, placebo-controlled, dose-ranging study versus zolmitriptan tablet. | 2003 |
|
| Topical agents in the treatment of cluster headache. | 2003 Apr |
|
| [Zolmitriptan-induced hepatotoxicity]. | 2003 Dec |
|
| In vitro metabolism of zolmitriptan in rat cytochromes induced with beta-naphthoflavone and the interaction between six drugs and zolmitriptan. | 2003 Dec 15 |
|
| Reassessing the contraindication of zolmitriptan and serotonin reuptake inhibitors: an evidence-based pharmacotherapeutic case report. | 2003 Feb |
|
| [Zolmitriptan as fast-melt tablet in the acute treatment of patients with migraine attacks: the ZORO study]. | 2003 Feb 26 |
|
| Transcranial Doppler in migraine attacks before and after treatment with oral zolmitriptan or sumatriptan. | 2003 Jan |
|
| Coprescription of triptans with potentially interacting medications: a cohort study involving 240,268 patients. | 2003 Jan |
|
| Migraine prevalence and treatment patterns: the global Migraine and Zolmitriptan Evaluation survey. | 2003 Jan |
|
| [Triptane. Zolmitriptan--fast and effective in migraine]. | 2003 Jan |
|
| Meta-analysis of oral triptan therapy for migraine: number needed to treat and relative cost to achieve relief within 2 hours. | 2003 Jan-Feb |
|
| Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein. | 2003 Jul |
|
| The evolving management of migraine. | 2003 Jun |
|
| Safety profile of the triptans. | 2003 Mar |
|
| Zolmitriptan for treatment of migrainous vertigo: a pilot randomized placebo-controlled trial. | 2003 Mar 11 |
|
| [Highly selective beginning. Associated symptoms and side effects in retrospect]. | 2003 May 26 |
|
| [Improved pharmacokinetics. Fast tryptan with sustained response]. | 2003 May 26 |
|
| Impact of antimigraine compounds on cognitive processing: a placebo-controlled crossover study. | 2003 Nov-Dec |
|
| Abnormal habituation of 'nociceptive' blink reflex in migraine--evidence for increased excitability of trigeminal nociception. | 2003 Oct |
|
| Clinical applications of new therapeutic deliveries in migraine. | 2003 Oct 28 |
|
| Zolmitriptan nasal spray: advances in migraine treatment. | 2003 Oct 28 |
|
| Patients with migraine prefer zolmitriptan orally disintegrating tablet to sumatriptan conventional oral tablet. | 2003 Sep |
|
| Migraine: diagnosis and management. | 2003 Sep-Oct |
|
| Defeating migraine pain with triptans: a race against the development of cutaneous allodynia. | 2004 Jan |
|
| Effects of acute or chronic administration of anti-migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain. | 2004 Jan |
|
| Zolmitriptan (Zomig) nasal spray for migraine. | 2004 Jan 19 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:48:02 GMT 2023
by
admin
on
Sat Dec 16 10:48:02 GMT 2023
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| Record UNII |
F3YOE57701
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| Record Status |
Validated (UNII)
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| Record Version |
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1727018
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139264-24-7
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441240
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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