U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
139594
Substance Class Protein
Created
by admin
on Sat Dec 16 11:36:57 GMT 2023
Edited
by admin
on Sat Dec 16 11:36:57 GMT 2023
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
UKK18ES9TF
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
5-HYDROXYTRYPTAMINE RECEPTOR 1A
Common Name English
ADRB2RL1
Common Name English
5-HT1A
Common Name English
ADRBRL1
Common Name English
G-21
Common Name English
SEROTONIN RECEPTOR 1A
Common Name English
Code System Code Type Description
UNIPROT
P08908
Created by admin on Sat Dec 16 11:37:03 GMT 2023 , Edited by admin on Sat Dec 16 11:37:03 GMT 2023
PRIMARY
PHAROS
P08908
Created by admin on Sat Dec 16 11:37:03 GMT 2023 , Edited by admin on Sat Dec 16 11:37:03 GMT 2023
PRIMARY
FDA UNII
UKK18ES9TF
Created by admin on Sat Dec 16 11:37:03 GMT 2023 , Edited by admin on Sat Dec 16 11:37:03 GMT 2023
PRIMARY
From To
1_109 1_187
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_10
N 1_11
N 1_24
Related Record Type Details
Structure of BEFIRADOL
AGONIST -> TARGET
Structure of REPINOTAN
AGONIST -> TARGET
Structure of MEPHEDRONE
INHIBITOR -> TARGET
Structure of CARIPRAZINE
PARTIAL AGONIST->TARGET
Ki
Structure of RISPERIDONE
WEAK INHIBITOR->TARGET
INHIBITOR
Ki
Structure of 8-OH-DPAT
AGONIST -> TARGET
BINDING
IC50
Structure of F-17464 FREE BASE
LIGAND->TARGET
Inhibited 56% of the stimulation by 10 micromolare serotonin.
Ki
Structure of CUMI-101 C-11
RADIOLIGAND->TARGET
Kd
Structure of EBALZOTAN
AGONIST -> TARGET
Structure of NORQUETIAPINE
PARTIAL AGONIST->TARGET
Ki
Structure of PIRENPERONE
INHIBITOR -> TARGET
Structure of LYSERGIDE
AGONIST -> TARGET
Ki
Structure of PINDOLOL
PARTIAL AGONIST->TARGET
Structure of U-92016A
AGONIST -> TARGET
Structure of F-17464 FREE BASE
PARTIAL AGONIST->TARGET
Concentration dependent stimulation of [35S]GTPγS binding by F17464 was observed in 5-HT1a - HeLa cells with a maximal response of 56.9 ± 1 % relative to serotonin 10 μM.
EC50
Structure of ARIPIPRAZOLE
PARTIAL AGONIST->TARGET
Emax = 68.1% of effect of 1 micromolar of 5-HT.
EC50
Structure of ACEPROMAZINE
INHIBITOR -> TARGET
IC50
Structure of 2-BROMOMESCALINE
AGONIST -> TARGET
Structure of BMS-181101
AGONIST -> TARGET
Structure of 8-OH-DPAT H-3
RADIOLIGAND->TARGET
Kd
Structure of MESCALINE
AGONIST -> TARGET
Structure of 8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN, (+)-
AGONIST -> TARGET
Structure of DIMETHYLTRYPTAMINE
AGONIST -> TARGET
AGONIST
Ki
Structure of F-17464 FREE BASE
PARTIAL ANTAGONIST->TARGET
F17464 also partially inhibited [35S]GTPγS binding elicited by 1 μM serotonin with a pIC50 of 6.95 ± 0.03 and a residual 59.8 % stimulation at 10 μM.
IC50
Structure of ZOLMITRIPTAN
AGONIST -> TARGET
Structure of 5-MEO-AMT
AGONIST -> TARGET
Structure of BEFIRADOL F-18
RADIOLIGAND->TARGET
Structure of CANNABIDIOL
ACTIVATOR -> TARGET
Structure of FLIBANSERIN
AGONIST -> TARGET
Ki
Structure of PARDOPRUNOX
AGONIST -> TARGET
Structure of WAY-100635
INHIBITOR -> TARGET
Exhibited antagonism activity at both presynaptic and postsynaptic 5-HT1A receptor sites.
Kd
Structure of CUMI-101
PARTIAL AGONIST->TARGET
Kd
Structure of 4-FLUORO-5-METHOXY-DMT
AGONIST -> TARGET
Structure of 8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN, (-)-
AGONIST -> TARGET
Structure of OCAPERIDONE
AGONIST -> TARGET
Structure of CPC-222
LIGAND->TARGET
Structure of EPTAPIRONE
AGONIST -> TARGET
Structure of LECOZOTAN
INHIBITOR -> TARGET
Structure of BREXPIPRAZOLE
PARTIAL AGONIST->TARGET
Structure of OXITRIPTAN
AGONIST -> TARGET
Structure of SSR-181507
AGONIST -> TARGET
Structure of CHLORPROMAZINE
INHIBITOR -> TARGET
Structure of Alnespirone
AGONIST -> TARGET
ED50
Structure of 5-METHOXY-N,N-DIISOPROPYLTRYPTAMINE
AGONIST -> TARGET
The strongest receptor binding affinity for 5-MeO-DiPT is at the 5-HT1A receptor.
Structure of SUNEPITRON
AGONIST -> TARGET
SELECTIVE
Structure of VILAZODONE
PARTIAL AGONIST->TARGET
Structure of EPM-301
ACTIVATOR -> TARGET
Enhances activation after agonist binding
Structure of 1B-LSD
PARTIAL AGONIST->TARGET
Ki
Structure of OSEMOZOTAN
AGONIST -> TARGET
Structure of Ulotaront
AGONIST -> TARGET
Structure of NALUZOTAN
AGONIST -> TARGET
Structure of ADOPRAZINE
AGONIST -> TARGET
Structure of E-2110 FREE BASE
INHIBITOR -> TARGET
Structure of SARIZOTAN
AGONIST -> TARGET
Structure of ELETRIPTAN
AGONIST -> TARGET
Eletriptan binds with high affinity to 5-HT1B, 5-HT1D and 5-HT1F receptors, has modest affinity for 5-HT1A, 5-HT1E, 5-HT2B and 5-HT7 receptors
BINDING
Structure of BUSPIRONE
PARTIAL AGONIST->TARGET
Structure of CPC-222 C-11
RADIOLIGAND->TARGET
Structure of 4-HYDROXY-N-METHYL-N-ETHYLTRYPTAMINE
AGONIST -> TARGET
Structure of SUMATRIPTAN
AGONIST -> TARGET
Structure of PICLOZOTAN
PARTIAL AGONIST->TARGET
Structure of VORTIOXETINE
AGONIST -> TARGET
Structure of WAY-100635 C-11
RADIOLIGAND->TARGET
Kd
Structure of (11C)(R)-(-)-RWAY
RADIOLIGAND->TARGET
Structure of BIFEPRUNOX
AGONIST -> TARGET
Structure of BRILAROXAZINE
PARTIAL AGONIST->TARGET
Structure of PALIPERIDONE
INHIBITOR -> TARGET
INHIBITOR
Ki
Structure of CP-94253
AGONIST -> TARGET
Structure of CORYDALMINE, (-)-
AGONIST -> TARGET
Structure of MPPF F-18
RADIOLIGAND->TARGET
Kd
Structure of WAY-100635 CARBONYL-C-11
RADIOLIGAND->TARGET
Kd
Structure of ROBALZOTAN
INHIBITOR -> TARGET
Structure of FCWAY F-18
RADIOLIGAND->TARGET
Structure of Mebufotenin
AGONIST -> TARGET
Ki
Structure of LERIMAZOLINE
LIGAND->TARGET
Structure of 6-FLUORO-DMT
AGONIST -> TARGET
Structure of XALIPRODEN
AGONIST -> TARGET
Structure of PIROMELATINE
AGONIST -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966