Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C25H29N3O6S |
| Molecular Weight | 499.579 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CS(=O)(=O)NC1=CC=CC(=C1)N2CCN(CCCCC3=COC4=C(C=C5OCOC5=C4)C3=O)CC2
InChI
InChIKey=KLOYLPZTHLSRRB-UHFFFAOYSA-N
InChI=1S/C25H29N3O6S/c1-35(30,31)26-19-6-4-7-20(13-19)28-11-9-27(10-12-28)8-3-2-5-18-16-32-22-15-24-23(33-17-34-24)14-21(22)25(18)29/h4,6-7,13-16,26H,2-3,5,8-12,17H2,1H3
| Molecular Formula | C25H29N3O6S |
| Molecular Weight | 499.579 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:00:31 UTC 2023
by
admin
on
Sat Dec 16 05:00:31 UTC 2023
|
| Record UNII |
TDB64DDB5X
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
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Common Name | English |
| Code System | Code | Type | Description | ||
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TDB64DDB5X
Created by
admin on Sat Dec 16 05:00:31 UTC 2023 , Edited by admin on Sat Dec 16 05:00:31 UTC 2023
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PRIMARY | |||
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51000839
Created by
admin on Sat Dec 16 05:00:31 UTC 2023 , Edited by admin on Sat Dec 16 05:00:31 UTC 2023
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PRIMARY | |||
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1268334-25-3
Created by
admin on Sat Dec 16 05:00:31 UTC 2023 , Edited by admin on Sat Dec 16 05:00:31 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET->PARTIAL AGONIST |
Concentration dependent stimulation of [35S]GTPγS binding by F17464 was observed in 5-HT1a - HeLa cells with a maximal response of 56.9 ± 1 % relative to serotonin 10 μM.
EC50
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TARGET->LIGAND |
Inhibited 56% of the stimulation by 10 micromolare serotonin.
Ki
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TARGET -> INHIBITOR |
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SALT/SOLVATE -> PARENT |
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TARGET->PARTIAL ANTAGONIST |
F17464 also partially inhibited [35S]GTPγS binding elicited by 1 μM serotonin with a pIC50 of 6.95 ± 0.03 and a residual 59.8 % stimulation at 10 μM.
IC50
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TARGET -> INHIBITOR |
Ki
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TARGET -> INHIBITOR |
Ki
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
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