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Details

Stereochemistry ACHIRAL
Molecular Formula C25H29N3O6S
Molecular Weight 499.579
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of F-17464 FREE BASE

SMILES

CS(=O)(=O)NC1=CC=CC(=C1)N2CCN(CCCCC3=COC4=C(C=C5OCOC5=C4)C3=O)CC2

InChI

InChIKey=KLOYLPZTHLSRRB-UHFFFAOYSA-N
InChI=1S/C25H29N3O6S/c1-35(30,31)26-19-6-4-7-20(13-19)28-11-9-27(10-12-28)8-3-2-5-18-16-32-22-15-24-23(33-17-34-24)14-21(22)25(18)29/h4,6-7,13-16,26H,2-3,5,8-12,17H2,1H3

HIDE SMILES / InChI

Molecular Formula C25H29N3O6S
Molecular Weight 499.579
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Substance Class Chemical
Created
by admin
on Sat Dec 16 05:00:31 GMT 2023
Edited
by admin
on Sat Dec 16 05:00:31 GMT 2023
Record UNII
TDB64DDB5X
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
F-17464 FREE BASE
Common Name English
Code System Code Type Description
FDA UNII
TDB64DDB5X
Created by admin on Sat Dec 16 05:00:31 GMT 2023 , Edited by admin on Sat Dec 16 05:00:31 GMT 2023
PRIMARY
PUBCHEM
51000839
Created by admin on Sat Dec 16 05:00:31 GMT 2023 , Edited by admin on Sat Dec 16 05:00:31 GMT 2023
PRIMARY
CAS
1268334-25-3
Created by admin on Sat Dec 16 05:00:31 GMT 2023 , Edited by admin on Sat Dec 16 05:00:31 GMT 2023
PRIMARY
Related Record Type Details
TARGET->PARTIAL AGONIST
Concentration dependent stimulation of [35S]GTPγS binding by F17464 was observed in 5-HT1a - HeLa cells with a maximal response of 56.9 ± 1 % relative to serotonin 10 μM.
EC50
TARGET->LIGAND
Inhibited 56% of the stimulation by 10 micromolare serotonin.
Ki
TARGET -> INHIBITOR
SALT/SOLVATE -> PARENT
TARGET->PARTIAL ANTAGONIST
F17464 also partially inhibited [35S]GTPγS binding elicited by 1 μM serotonin with a pIC50 of 6.95 ± 0.03 and a residual 59.8 % stimulation at 10 μM.
IC50
TARGET -> INHIBITOR
Ki
TARGET -> INHIBITOR
Ki
Related Record Type Details
ACTIVE MOIETY