U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Thu Jul 06 17:47:05 UTC 2023
Edited
by admin
on Thu Jul 06 17:47:05 UTC 2023
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
G9XQ9S7T2F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
D(3) DOPAMINE RECEPTOR
Common Name English
DOPAMINE D3 RECEPTOR
Common Name English
D3R
Common Name English
Code System Code Type Description
FDA UNII
G9XQ9S7T2F
Created by admin on Thu Jul 06 17:47:07 UTC 2023 , Edited by admin on Thu Jul 06 17:47:07 UTC 2023
PRIMARY
From To
1_103 1_181
1_355 1_358
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_12
N 1_19
N 1_97
N 1_173
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
INHIBITOR
Ki
PARTIAL AGONIST->TARGET
Most of the clinically used antipsychotics display fairly high affinity for D3 receptors in vitro, they lack significant D3 receptor binding in vivo. They also do not occupy D3 receptors in schizophrenic patients at clinically-relevant doses, despite having significant and expected D2 receptor occupancy. The lack of in vivo D3 receptor occupancy of currently used antipsychotics may be due to their inability to displace endogenous DA from these sites; especially since DA has approximately 20- fold higher affinity for D3 vs D2 receptors and D3 (but not D2) receptors exist predominantly in a high affinity state for DA”
Ki
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
WEAK INHIBITOR->TARGET
INHIBITOR
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
MAJOR
Ki
INHIBITOR -> TARGET
AGONIST -> TARGET
PARTIAL AGONIST
PARTIAL AGONIST->TARGET
AGONIST -> TARGET
A potent and highly selective agonist for the dopamine D3 receptor.
EC50
AGONIST -> TARGET
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
D3-selective radiotracer.
Ki
RADIOLIGAND->TARGET
AGONIST -> TARGET
PARTIAL AGONIST->TARGET
Ki
ANTAGONIST->TARGET
ANTAGONIST
Ki
AGONIST -> TARGET
Emax 82% Transfected CHO cells
EC50
AGONIST -> TARGET
RADIOLIGAND->TARGET
Did not image D3 receptors.
AGONIST -> TARGET
AGONIST -> TARGET
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
Ki
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
ANTAGONIST
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL