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Approval Year

Unknown
127998
Substance Class Protein
Created
by admin
on Sun Dec 18 09:21:24 UTC 2022
Edited
by admin
on Sun Dec 18 09:21:24 UTC 2022
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
G9XQ9S7T2F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
D(3) DOPAMINE RECEPTOR
Common Name English
DOPAMINE D3 RECEPTOR
Common Name English
D3R
Common Name English
Code System Code Type Description
FDA UNII
G9XQ9S7T2F
Created by admin on Sun Dec 18 09:21:26 UTC 2022 , Edited by admin on Sun Dec 18 09:21:26 UTC 2022
PRIMARY
From To
1_103 1_181
1_355 1_358
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_12
N 1_19
N 1_97
N 1_173
Related Record Type Details
Structure of TRAZPIROBEN
INHIBITOR -> TARGET
Structure of ROTIGOTINE
AGONIST -> TARGET
Structure of PALIPERIDONE
INHIBITOR -> TARGET
INHIBITOR
Ki
Structure of CARIPRAZINE
PARTIAL AGONIST->TARGET
Most of the clinically used antipsychotics display fairly high affinity for D3 receptors in vitro, they lack significant D3 receptor binding in vivo. They also do not occupy D3 receptors in schizophrenic patients at clinically-relevant doses, despite having significant and expected D2 receptor occupancy. The lack of in vivo D3 receptor occupancy of currently used antipsychotics may be due to their inability to displace endogenous DA from these sites; especially since DA has approximately 20- fold higher affinity for D3 vs D2 receptors and D3 (but not D2) receptors exist predominantly in a high affinity state for DA”
Ki
Structure of MESDOPETAM
INHIBITOR -> TARGET
Ki
Structure of 3-(2-oxo-3-{2-[4-(trifluoromethyl)piperidin-1-yl]ethyl}imidazolidin-1-yl)benzonitrile
INHIBITOR -> TARGET
Structure of RISPERIDONE
WEAK INHIBITOR->TARGET
INHIBITOR
Ki
Structure of GSK-598809
INHIBITOR -> TARGET
Structure of CORYDALMINE, (-)-
INHIBITOR -> TARGET
Structure of ILOPERIDONE
INHIBITOR -> TARGET
MAJOR
Ki
Structure of PIMOZIDE
INHIBITOR -> TARGET
Structure of CI-1007
AGONIST -> TARGET
PARTIAL AGONIST
Structure of BRILAROXAZINE
PARTIAL AGONIST->TARGET
Structure of PF-219061
AGONIST -> TARGET
A potent and highly selective agonist for the dopamine D3 receptor.
EC50
Structure of DINOXYLINE
AGONIST -> TARGET
Structure of FLUORTRIOPRIDE F-18
RADIOLIGAND->TARGET
D3-selective radiotracer.
Ki
Structure of NAXAGOLIDE C-11
RADIOLIGAND->TARGET
Structure of BROMOCRIPTINE
AGONIST -> TARGET
Structure of AMISULPRIDE
ANTAGONIST->TARGET
ANTAGONIST
Ki
Structure of APOMORPHINE
AGONIST -> TARGET
Emax 82% Transfected CHO cells
EC50
Structure of ROPINIROLE
AGONIST -> TARGET
Structure of 3-[2-Oxo-3-[2-[4-(trifluoromethyl)-1-piperidinyl]ethyl]-1-imidazolidinyl]benzonitrile-cyano-11C
RADIOLIGAND->TARGET
Did not image D3 receptors.
Structure of 8-OH-PBZI
AGONIST -> TARGET
Structure of PERGOLIDE
AGONIST -> TARGET
Structure of BP-14979
PARTIAL AGONIST->TARGET
Structure of RACLOPRIDE
INHIBITOR -> TARGET
Ki
Structure of PRAMIPEXOLE
AGONIST -> TARGET
Structure of SB-773812
INHIBITOR -> TARGET
Structure of DESMETHOXYFALLYPRIDE
INHIBITOR -> TARGET
ANTAGONIST
Structure of PF-592379
AGONIST -> TARGET
Structure of METOPIMAZINE
INHIBITOR -> TARGET
Structure of 6-FLUORO-DMT
AGONIST -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL
NIH
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