Approval Year
Substance Class |
Protein
Created
by
admin
on
Edited
Sat Jun 26 16:52:05 UTC 2021
by
admin
on
Sat Jun 26 16:52:05 UTC 2021
|
Protein Type | RECEPTOR |
Protein Sub Type | |
Sequence Origin | HUMAN |
Sequence Type | COMPLETE |
Record UNII |
G9XQ9S7T2F
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
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Common Name | English |
Code System | Code | Type | Description | ||
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G9XQ9S7T2F
Created by
admin on Sat Jun 26 16:52:07 UTC 2021 , Edited by admin on Sat Jun 26 16:52:07 UTC 2021
|
PRIMARY |
From | To |
---|---|
1_103 | 1_181 |
1_355 | 1_358 |
Glycosylation Type | HUMAN |
Glycosylation Link Type | Site |
---|---|
N | 1_12 |
N | 1_19 |
N | 1_97 |
N | 1_173 |
Related Record | Type | Details | ||
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AGONIST -> TARGET | |||
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INHIBITOR -> TARGET |
INHIBITOR
Ki
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PARTIAL AGONIST->TARGET |
Most of the clinically used antipsychotics display fairly high affinity for D3 receptors in vitro, they lack significant D3 receptor binding in vivo. They also do not occupy D3 receptors in schizophrenic patients at clinically-relevant doses, despite having significant and expected D2 receptor occupancy. The lack of in vivo D3 receptor occupancy of currently used antipsychotics may be due to their inability to displace endogenous DA from these sites; especially since DA has approximately 20- fold higher affinity for D3 vs D2 receptors and D3 (but not D2) receptors exist predominantly in a high affinity state for DA”
Ki
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INHIBITOR -> TARGET |
Ki
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INHIBITOR -> TARGET |
INHIBITOR
Ki
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
MAJOR
Ki
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AGONIST -> TARGET |
PARTIAL AGONIST
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PARTIAL AGONIST->TARGET | |||
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AGONIST -> TARGET | |||
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RADIOLIGAND->TARGET | |||
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AGONIST -> TARGET | |||
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ANTAGONIST->TARGET |
ANTAGONIST
Ki
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|
AGONIST -> TARGET |
Emax 82% Transfected CHO cells
EC50
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AGONIST -> TARGET | |||
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AGONIST -> TARGET | |||
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PARTIAL AGONIST->TARGET | |||
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AGONIST -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
ANTAGONIST
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|
AGONIST -> TARGET | |||
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INHIBITOR -> TARGET |
Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
---|---|---|---|---|---|---|
Molecular Formula | CHEMICAL |
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MOL_WEIGHT | CHEMICAL |
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