U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Jun 26 16:51:41 UTC 2021
Edited
by admin
on Sat Jun 26 16:51:41 UTC 2021
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
19GBD6T9L7
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
D(2) DOPAMINE RECEPTOR
Common Name English
DRD2
Common Name English
D2R
Common Name English
DRD2L
Common Name English
D2(LONG)
Common Name English
DOPAMINE D2 RECEPTOR
Common Name English
Code System Code Type Description
UNIPROT
P14416
Created by admin on Sat Jun 26 16:51:49 UTC 2021 , Edited by admin on Sat Jun 26 16:51:49 UTC 2021
PRIMARY
PHAROS
P14416
Created by admin on Sat Jun 26 16:51:49 UTC 2021 , Edited by admin on Sat Jun 26 16:51:49 UTC 2021
PRIMARY
FDA UNII
19GBD6T9L7
Created by admin on Sat Jun 26 16:51:49 UTC 2021 , Edited by admin on Sat Jun 26 16:51:49 UTC 2021
PRIMARY
From To
1_107 1_182
1_399 1_401
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_5
N 1_17
N 1_23
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RADIOLIGAND->TARGET
PARTIAL AGONIST->TARGET
AGONIST -> TARGET
ANTAGONIST->TARGET
BINDING
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PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
INHIBITOR
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INHIBITOR -> TARGET
ANTAGONIST
LIGAND->TARGET
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INHIBITOR -> TARGET
INHIBITOR -> TARGET
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cell:CHO K1; ligand:3H-spiperone
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INHIBITOR -> TARGET
PARTIAL AGONIST->TARGET
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INHIBITOR -> TARGET
PARTIAL AGONIST->TARGET
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PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
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D2R concentration levels were significantly lower in AD patients than in healthy controls (SMD = ?1.13, 95%CI: ?1.52 to ?0.74), with low heterogeneity (I2 = 7.80%), when USA studies were considered.
AGONIST -> TARGET
INHIBITOR -> TARGET
MAJOR
Ki
INHIBITOR -> TARGET
ANTAGONIST
AGONIST -> TARGET
D2S Primary receptor interaction.. Emax 79%
EC50
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
PARTIAL AGONIST
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
ANTAGONIST->TARGET
SELECTIVE
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL