U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 11:48:23 GMT 2023
Edited
by admin
on Sat Dec 16 11:48:23 GMT 2023
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
19GBD6T9L7
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
D(2) DOPAMINE RECEPTOR
Common Name English
D2
Common Name English
DRD2
Common Name English
D2R
Common Name English
DRD2L
Common Name English
D2(LONG)
Common Name English
DOPAMINE D2 RECEPTOR
Common Name English
Code System Code Type Description
UNIPROT
P14416
Created by admin on Sat Dec 16 11:48:30 GMT 2023 , Edited by admin on Sat Dec 16 11:48:30 GMT 2023
PRIMARY
PHAROS
P14416
Created by admin on Sat Dec 16 11:48:30 GMT 2023 , Edited by admin on Sat Dec 16 11:48:30 GMT 2023
PRIMARY
FDA UNII
19GBD6T9L7
Created by admin on Sat Dec 16 11:48:30 GMT 2023 , Edited by admin on Sat Dec 16 11:48:30 GMT 2023
PRIMARY
From To
1_107 1_182
1_399 1_401
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_5
N 1_17
N 1_23
Related Record Type Details
RADIOLIGAND->TARGET
AGONIST -> TARGET
ANTAGONIST->TARGET
BINDING
Ki
INHIBITOR -> TARGET
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
Ki
AGONIST -> TARGET
INHIBITOR -> TARGET
Ki
PARTIAL AGONIST->TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR
Ki
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
Ki
INHIBITOR -> TARGET
ANTAGONIST
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
LIGAND->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
INHIBITOR
Ki
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
cell:CHO K1; ligand:3H-spiperone
Ki
AGONIST -> TARGET
INHIBITOR -> TARGET
Ki
PARTIAL AGONIST->TARGET
PARTIAL AGONIST->TARGET
Primary target for antipsychotic activity. The partial agonist actions of aripiprazole vary widely depending upon the cellular milieu. Thus, nearly fullagonism, weak partial agonism and frank antagonism, have all been reported, depending upon the assay system and cellular background.
Ki
AGONIST -> TARGET
INHIBITOR -> TARGET
BINDING
IC50
INHIBITOR -> TARGET
PARTIAL AGONIST->TARGET
AGONIST -> TARGET
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
LIGAND->TARGET
AGONIST -> TARGET
D2R concentration levels were significantly lower in AD patients than in healthy controls (SMD = −1.13, 95%CI: −1.52 to −0.74), with low heterogeneity (I2 = 7.80%), when USA studies were considered.
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
MAJOR
Ki
AGONIST -> TARGET
AGONIST -> TARGET
D2S Primary receptor interaction.. Emax 79%
EC50
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
ANTAGONIST
INHIBITOR -> TARGET
Binding Assay
IC50
RADIOLIGAND->TARGET
Kd
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
AGONIST -> TARGET
PARTIAL AGONIST
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
Co-incubation with a D2L-dopamine receptor sub-saturating concentration of raclopride produced an apparent decrease in the equilibrium dissociation constant of the radioligand (i.e. KD = 6.0 nm vs. 1.9 nm
NON-COMPETITIVE
Kd
INHIBITOR -> TARGET
PARTIAL AGONIST->TARGET
Ki
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
PARTIAL AGONIST->TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
Ki
AGONIST -> TARGET
ANTAGONIST->TARGET
SELECTIVE
INHIBITOR -> TARGET
INVERSE AGONIST->TARGET
Ki
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
AGONIST -> TARGET
BINDING
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
LIGAND->TARGET
LIGAND->OFF TARGET
BINDING
Ki
INHIBITOR -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
PARTIAL AGONIST->TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
BINDING
IC50
AGONIST -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL