U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C21H21ClN4OS
Molecular Weight 412.9374
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZIPRASIDONE

SMILES

c1ccc2c(c1)c(ns2)N3CCN(CCc4cc5CC(=Nc5cc4Cl)O)CC3

InChI

InChIKey=MVWVFYHBGMAFLY-UHFFFAOYSA-N
InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)

HIDE SMILES / InChI

Molecular Formula C21H21ClN4OS
Molecular Weight 412.9374
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: description was created based on several sources, including https://effectivehealthcare.ahrq.gov/ehc/products/150/786/CER43_Off-LabelAntipsychotics_execsumm_20110928.pdf

Ziprasidone is atypical antipsychotic, approved by the U.S. Food and Drug Administration for the treatment of schizophrenia, and acute mania and mixed states associated with bipolar disorder. Intramuscilar injections of Ziprasidone are indicated for rapid control of the agitation in schizophrenic patients. Ziprasidone is used off-label for treatment of major depressive disorder, anxiety, obsessive compulsive disorder, borderline personality disorder. Ziprasidone functions as an antagonist at the D2, 5HT2A, and 5HT1D receptors, and as an agonist at the 5HT1A receptor.

Originator

Curator's Comment:: # Pfizer

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
GEODON

Approved Use

Ziprasidone hydrochloride capsule is an atypical antipsychotic. In choosing among treatments, prescribers should be aware of the capacity of ziprasidone hydrochloride capsule to prolong the QT interval and may consider the use of other drugs first.

Launch Date

9.8133121E11
Primary
GEODON

Approved Use

Ziprasidone hydrochloride capsule is an atypical antipsychotic. In choosing among treatments, prescribers should be aware of the capacity of ziprasidone hydrochloride capsule to prolong the QT interval and may consider the use of other drugs first. Ziprasidone intramuscular is indicated for the treatment of acute agitation in schizophrenic patients for whom treatment with ziprasidone is appropriate and who need intramuscular antipsychotic medication for rapid control of the agitation. “Psychomotor agitation” is defined in DSM-IV as “excessive motor activity associated with a feeling of inner tension.”

Launch Date

9.8133121E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
51 ng/mL
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ZIPRASIDONE serum
Homo sapiens
population: UNHEALTHY
age: ADOLESCENT
sex: FEMALE / MALE
food status: FED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
457 ng × h/mL
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ZIPRASIDONE serum
Homo sapiens
population: UNHEALTHY
age: ADOLESCENT
sex: FEMALE / MALE
food status: FED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
4.1 h
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ZIPRASIDONE serum
Homo sapiens
population: UNHEALTHY
age: ADOLESCENT
sex: FEMALE / MALE
food status: FED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
1%
ZIPRASIDONE plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
4480 mg single, oral
Overdose
Dose: 4480 mg
Route: oral
Route: single
Dose: 4480 mg
Co-administed with::
Clomethiazole(192 mg)
Sources:
unhealthy, 22 years
n = 1
Health Status: unhealthy
Condition: Paranoid Schizophrenia
Age Group: 22 years
Sex: M
Population Size: 1
Sources:
Disc. AE: Sedation, Hypotension...
AEs leading to
discontinuation/dose reduction:
Sedation (1 patient)
Hypotension (1 patient)
Sources:
20 mg single, oral
Overdose
Dose: 20 mg
Route: oral
Route: single
Dose: 20 mg
Sources:
healthy, 30 month
n = 1
Health Status: healthy
Age Group: 30 month
Sex: F
Population Size: 1
Sources:
Disc. AE: Respiratory depression...
AEs leading to
discontinuation/dose reduction:
Respiratory depression (1 patient)
Sources:
780 mg single, oral
Overdose
Dose: 780 mg
Route: oral
Route: single
Dose: 780 mg
Sources:
unhealthy, 31 years
n = 1
Health Status: unhealthy
Condition: Mixed personality disorder
Age Group: 31 years
Sex: M
Population Size: 1
Sources:
Disc. AE: Drowsiness...
AEs leading to
discontinuation/dose reduction:
Drowsiness (1 patient)
Sources:
1120 mg single, oral
Overdose
Dose: 1120 mg
Route: oral
Route: single
Dose: 1120 mg
Sources:
unhealthy, 35 years
n = 1
Health Status: unhealthy
Condition: Schizophrenia
Age Group: 35 years
Sex: M
Population Size: 1
Sources:
4400 mg single, oral
Overdose
Dose: 4400 mg
Route: oral
Route: single
Dose: 4400 mg
Co-administed with::
Clomethiazole(768 mg)
flunitrazepam(4 mg)
Sources:
unhealthy, 57 years
n = 1
Health Status: unhealthy
Condition: Manic-depressive disorder
Age Group: 57 years
Sex: F
Population Size: 1
Sources:
Disc. AE: Drowsiness, Tremor...
AEs leading to
discontinuation/dose reduction:
Drowsiness (1 patient)
Tremor (1 patient)
Anxiety (1 patient)
Sources:
20 mg 2 times / day steady, intramuscular
Studied dose
Dose: 20 mg, 2 times / day
Route: intramuscular
Route: steady
Dose: 20 mg, 2 times / day
Sources:
unhealthy, 60 – 81 years
n = 21
Health Status: unhealthy
Condition: Schizophrenia
Age Group: 60 – 81 years
Sex: M+F
Population Size: 21
Sources:
Other AEs: Blurred vision, Sedation...
Other AEs:
Blurred vision (1 patient)
Sedation (1 patient)
Sources:
40 mg 1 times / day steady, oral
Studied dose
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
unhealthy, 7 – 17 years
n = 28
Health Status: unhealthy
Condition: Tourette's syndrome
Age Group: 7 – 17 years
Sex: M+F
Population Size: 28
Sources:
Other AEs: Somnolence, Akathisia...
Other AEs:
Somnolence (1 patient)
Akathisia (1 patient)
Sources:
20 mg single, oral
Dose: 20 mg
Route: oral
Route: single
Dose: 20 mg
Sources:
unhealthy, 7-16 years
n = 24
Health Status: unhealthy
Condition: Tourette's disorder or chronic tic disorder
Age Group: 7-16 years
Sex: M+F
Population Size: 24
Sources:
Other AEs: Somnolence, Syncope hypotensive...
Other AEs:
Somnolence (16 patients)
Syncope hypotensive (2 patients)
Sources:
AEs

AEs

AESignificanceDosePopulation
Hypotension 1 patient
Disc. AE
4480 mg single, oral
Overdose
Dose: 4480 mg
Route: oral
Route: single
Dose: 4480 mg
Co-administed with::
Clomethiazole(192 mg)
Sources:
unhealthy, 22 years
n = 1
Health Status: unhealthy
Condition: Paranoid Schizophrenia
Age Group: 22 years
Sex: M
Population Size: 1
Sources:
Sedation 1 patient
Disc. AE
4480 mg single, oral
Overdose
Dose: 4480 mg
Route: oral
Route: single
Dose: 4480 mg
Co-administed with::
Clomethiazole(192 mg)
Sources:
unhealthy, 22 years
n = 1
Health Status: unhealthy
Condition: Paranoid Schizophrenia
Age Group: 22 years
Sex: M
Population Size: 1
Sources:
Respiratory depression 1 patient
Disc. AE
20 mg single, oral
Overdose
Dose: 20 mg
Route: oral
Route: single
Dose: 20 mg
Sources:
healthy, 30 month
n = 1
Health Status: healthy
Age Group: 30 month
Sex: F
Population Size: 1
Sources:
Drowsiness 1 patient
Disc. AE
780 mg single, oral
Overdose
Dose: 780 mg
Route: oral
Route: single
Dose: 780 mg
Sources:
unhealthy, 31 years
n = 1
Health Status: unhealthy
Condition: Mixed personality disorder
Age Group: 31 years
Sex: M
Population Size: 1
Sources:
Anxiety 1 patient
Disc. AE
4400 mg single, oral
Overdose
Dose: 4400 mg
Route: oral
Route: single
Dose: 4400 mg
Co-administed with::
Clomethiazole(768 mg)
flunitrazepam(4 mg)
Sources:
unhealthy, 57 years
n = 1
Health Status: unhealthy
Condition: Manic-depressive disorder
Age Group: 57 years
Sex: F
Population Size: 1
Sources:
Drowsiness 1 patient
Disc. AE
4400 mg single, oral
Overdose
Dose: 4400 mg
Route: oral
Route: single
Dose: 4400 mg
Co-administed with::
Clomethiazole(768 mg)
flunitrazepam(4 mg)
Sources:
unhealthy, 57 years
n = 1
Health Status: unhealthy
Condition: Manic-depressive disorder
Age Group: 57 years
Sex: F
Population Size: 1
Sources:
Tremor 1 patient
Disc. AE
4400 mg single, oral
Overdose
Dose: 4400 mg
Route: oral
Route: single
Dose: 4400 mg
Co-administed with::
Clomethiazole(768 mg)
flunitrazepam(4 mg)
Sources:
unhealthy, 57 years
n = 1
Health Status: unhealthy
Condition: Manic-depressive disorder
Age Group: 57 years
Sex: F
Population Size: 1
Sources:
Blurred vision 1 patient
20 mg 2 times / day steady, intramuscular
Studied dose
Dose: 20 mg, 2 times / day
Route: intramuscular
Route: steady
Dose: 20 mg, 2 times / day
Sources:
unhealthy, 60 – 81 years
n = 21
Health Status: unhealthy
Condition: Schizophrenia
Age Group: 60 – 81 years
Sex: M+F
Population Size: 21
Sources:
Sedation 1 patient
20 mg 2 times / day steady, intramuscular
Studied dose
Dose: 20 mg, 2 times / day
Route: intramuscular
Route: steady
Dose: 20 mg, 2 times / day
Sources:
unhealthy, 60 – 81 years
n = 21
Health Status: unhealthy
Condition: Schizophrenia
Age Group: 60 – 81 years
Sex: M+F
Population Size: 21
Sources:
Akathisia 1 patient
40 mg 1 times / day steady, oral
Studied dose
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
unhealthy, 7 – 17 years
n = 28
Health Status: unhealthy
Condition: Tourette's syndrome
Age Group: 7 – 17 years
Sex: M+F
Population Size: 28
Sources:
Somnolence 1 patient
40 mg 1 times / day steady, oral
Studied dose
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
unhealthy, 7 – 17 years
n = 28
Health Status: unhealthy
Condition: Tourette's syndrome
Age Group: 7 – 17 years
Sex: M+F
Population Size: 28
Sources:
Somnolence 16 patients
20 mg single, oral
Dose: 20 mg
Route: oral
Route: single
Dose: 20 mg
Sources:
unhealthy, 7-16 years
n = 24
Health Status: unhealthy
Condition: Tourette's disorder or chronic tic disorder
Age Group: 7-16 years
Sex: M+F
Population Size: 24
Sources:
Syncope hypotensive 2 patients
20 mg single, oral
Dose: 20 mg
Route: oral
Route: single
Dose: 20 mg
Sources:
unhealthy, 7-16 years
n = 24
Health Status: unhealthy
Condition: Tourette's disorder or chronic tic disorder
Age Group: 7-16 years
Sex: M+F
Population Size: 24
Sources:
OverviewDrug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
no [IC50 >100 uM]
no [IC50 >100 uM]
no [IC50 >100 uM]
no [IC50 >133 uM]
no [IC50 >133 uM]
no [IC50 >133 uM]
no [IC50 >133 uM]
no
yes [IC50 5.8 uM]
no (co-administration study)
Comment: Estimated Cfree,plasma = 0.29-0.73 nM (80mg BID); Coadministration of Ziprasidone had no effect on the urinary Dextromethorphan/Dextrophan ratio.
Page: 16, (ClinPharm) 16, (ClinPharm4) 58-60
yes [Ki 64 uM]
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
likely
major
yes (co-administration study)
Comment: Ketoconazole inhibited formation of Ziprasidone sulfoxide by 77% in vitro.; Coadministration of Ketoconazoke (strong CYP3A4 inhibitor) increased Ziprasidone AUC and Cmax by about 30%. Coadministration of Carbamazepine (strong CYP3A4 inducer) decreased Ziprasidone AUC by 36% and Cmax by 27%.
Page: 15-16, (ClinPhar) 15-16, (ClinPharm3) 65-66, (ClinPharm4) 35-38, 64-66
minor
yes
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
Pharmacological options for the treatment of Tourette's disorder.
2001
Emerging options in the treatment of bipolar disorders.
2001
The pharmacology of weight gain with antipsychotics.
2001
Ziprasidone and the QTc interval: pharmacokinetic and pharmacodynamic considerations.
2001 Autumn
Ziprasidone in the short-term treatment of patients with schizoaffective disorder: results from two double- blind, placebo-controlled, multicenter studies.
2001 Feb
Barriers to progress--the impact of tolerability problems.
2001 Jan
Bodyweight gain with atypical antipsychotics. A comparative review.
2001 Jan
Use of atypical antipsychotics in mood disorders.
2001 Jul
Ziprasidone: a new atypical antipsychotic.
2001 Jun
Ziprasidone, a new atypical antipsychotic drug.
2001 Jun
Antipsychotic medication: effects on regulation of glucose and lipids.
2001 Oct
Inverse agonist properties of antipsychotic agents at cloned, human (h) serotonin (5-HT)(1B) and h5-HT(1D) receptors.
2001 Sep
Psychopharmacology news.
2001 Summer
Ziprasidone: a review of its use in schizophrenia and schizoaffective disorder.
2002
Advances in atypical antipsychotics for the treatment of schizophrenia: new formulations and new agents.
2002
Effects of newer antipsychotics on extrapyramidal function.
2002
A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs.
2002 Aug 16
Recent developments in pharmacotherapy for the acutely psychotic patient.
2002 Dec
Aripiprazole: profile on efficacy and safety.
2002 Dec
Neuroleptic Malignant Syndrome with ziprasidone.
2002 Dec
Cholinergic modulation of basal and amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens.
2002 Dec 20
Atypical antipsychotics: mechanism of action.
2002 Feb
New antipsychotic agents for schizophrenia: pharmacokinetics and metabolism update.
2002 Jul
The value of atypical antipsychotics in the treatment of schizophrenia.
2002 Jul
Stimulation by antipsychotic agents of mitogen-activated protein kinase (MAPK) coupled to cloned, human (h)serotonin (5-HT)(1A) receptors.
2002 Jul
The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia.
2002 Jul 3
Overdose of ziprasidone.
2002 Jun
5-HT(1A) and 5-HT(2A) receptors minimally contribute to clozapine-induced acetylcholine release in rat medial prefrontal cortex.
2002 Jun 7
Schizophrenia: genesis, receptorology and current therapeutics.
2002 Mar
Experience with ziprasidone.
2002 May
Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat.
2002 May
[Psychopharmacological treatment of bipolar disease].
2002 May 6
Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism.
2002 Nov 29
Antipsychotics: impact on prolactin levels.
2002 Oct
Comprehensive understanding of schizophrenia and its treatment.
2002 Sep 1
Continuum of care: stabilizing the acutely agitated patient.
2002 Sep 1
Cataract occurrence with antipsychotic drugs.
2002 Sep-Oct
Clinical significance of drug binding, protein binding, and binding displacement drug interactions.
2002 Summer
Safety and tolerability: how do newer generation "atypical" antipsychotics compare?
2002 Winter
Antipsychotic-induced hyperprolactinemia and sexual dysfunction.
2002 Winter
Ziprasidone-associated galactorrhea in a female teenager.
2003 Jan
Constitutive coupling of a chimeric dopamine D2/alpha 1B receptor to the phospholipase C pathway: inverse agonism to silent antagonism by neuroleptic drugs.
2003 Jan
Patents

Sample Use Guides

For treatment of schizophrenia, GEODON capsules should be administered at an initial daily dose of 20 mg BID with food. Daily dosage may subsequently be adjusted on the basis of individual clinical status up to 80 mg BID. Systematic evaluation of ziprasidone has shown that its efficacy in schizophrenia is maintained for periods of up to 52 weeks at a dose of 20 to 80 mg BID. For treatment of bipolar mania, oral ziprasidone should be administered at an initial daily dose of 40 mg BID with food. The dose should then be increased to 60 mg or 80 mg BID on the second day of treatment and subsequently adjusted on the basis of toleration and efficacy within the range 40-80 mg BID. The recommended dose for intramuscular administration is 10 to 20 mg administered as required up to a maximum dose of 40 mg per day. Doses of 10 mg may be administered every two hours; doses of 20 mg may be administered every four hours up to a maximum of 40 mg/day.
Route of Administration: Other
In Vitro Use Guide
Standard receptor-binding methods were used to label dopamine D2 receptors using [3H]spiperone. Briefly, rats were sacrificed by decapitation and the brains rapidly removed. The corpus striatum was dissected and homogenized in 20 vol at 50 mM Tris HCl (pH 7.2) buffer using a Brinkman Polytron homogenizer (setting 7 for 15 s). The homogenate was centrifuged for 10 min at 40000g. The pellet was resuspended in fresh ice-cold 50 mM Tris (pH 7.2) buffer with the Polytron homogenizer and recentrifuged. The final pellet was resuspended in 50 mM Tris HCl buffer (pH 7.2) containing 1 mM MgCl2 and 100 mM NaCl. Assays were initiated by the addition of tissue to tubes containing [3H]spiperone (0.2 nM) and drug or buffer in a final volume of 1 mL. Blocking agents (500 nM cinanserin and 1 mM prazosin) were present to prevent [3H]spiperone from labeling 5-HT2 and R1 noradrenergic receptors. Nonspecific binding was defined as the radioligand bound in the presence of 10 uM (+)-butaclamol. After a 15 min incubation at 37 °C, tissue samples were filtered onto Whatman GF/B glass fiber filters using a Brandel harvester and rinsed two times with 5 mL of ice-cold 50 mM Tris HCl (pH 7.4) buffer. Filters were soaked in 10 mL of Ready-Safe (Beckman Instruments), and the radioactivity was quantified using liquid scintillation counting. Ziprasidone binds to D2 receptors with pKi of 8.32 nM.
Substance Class Chemical
Created
by admin
on Sat Jun 26 07:47:49 UTC 2021
Edited
by admin
on Sat Jun 26 07:47:49 UTC 2021
Record UNII
6UKA5VEJ6X
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZIPRASIDONE
HSDB   INN   MART.   MI   VANDF   WHO-DD  
INN  
Official Name English
ZIPRASIDONE [HSDB]
Common Name English
ZIPRASIDONE [INN]
Common Name English
ZIPRASIDONE [WHO-DD]
Common Name English
ZIPRASIDONE [MI]
Common Name English
ZIPRADON
Brand Name English
ZIPRASIDONE [MART.]
Common Name English
ZIPRASIDONE [VANDF]
Common Name English
Classification Tree Code System Code
LIVERTOX 1050
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
WHO-VATC QN05AE04
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
NDF-RT N0000175430
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
NCI_THESAURUS C29710
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
WHO-ATC N05AE04
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
Code System Code Type Description
PUBCHEM
60854
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY
IUPHAR
59
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY
RXCUI
115698
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY RxNorm
ChEMBL
CHEMBL708
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY
DRUG BANK
DB00246
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY
WIKIPEDIA
ZIPRASIDONE
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY
MESH
C092292
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY
EVMPD
SUB00168MIG
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY
LACTMED
Ziprasidone
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY
HSDB
7745
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY
INN
7155
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY
DRUG CENTRAL
2865
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY
FDA UNII
6UKA5VEJ6X
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY
EPA CompTox
146939-27-7
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY
NCI_THESAURUS
C47788
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY
MERCK INDEX
M11641
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY Merck Index
CAS
146939-27-7
Created by admin on Sat Jun 26 07:47:50 UTC 2021 , Edited by admin on Sat Jun 26 07:47:50 UTC 2021
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
TARGET -> INHIBITOR
SALT/SOLVATE -> PARENT
BINDER->LIGAND
BINDING
TARGET -> AGONIST
SHORT-ACTING
DEGRADENT -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
TARGET -> INHIBITOR
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
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METABOLITE -> PARENT
METABOLITE -> PARENT
METABOLITE -> PARENT
MAJOR
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ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC