Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H18N4O2 |
Molecular Weight | 298.3397 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C(N1CCN(CC1)C2=NC=CC=N2)C3=CC=C4OCOC4=C3
InChI
InChIKey=OQDPVLVUJFGPGQ-UHFFFAOYSA-N
InChI=1S/C16H18N4O2/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14/h1-5,10H,6-9,11-12H2
Molecular Formula | C16H18N4O2 |
Molecular Weight | 298.3397 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
CNS Activity
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P35462 Gene ID: 1814.0 Gene Symbol: DRD3 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/11222455 |
|||
Target ID: P14416 Gene ID: 1813.0 Gene Symbol: DRD2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8588823 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | TRIVASTAL Approved UseAdjunctive treatment of intermittent claudication in chronic obliterating arteriopathies of the lower limbs (in stage 2). |
|||
Palliative | TRIVASTAL Approved UseAdjunctive symptomatic treatment of chronic pathological cognitive and neurosensorial deficit in elderly subjects (excluding Alzheimer's disease and other dementia). |
|||
Primary | TRIVASTAL Approved UseTreatment of Parkinson's disease: either as monotherapy (treatment of forms with predominant tremor), or in association with dopatherapy from the outset, or secondarily, particularly in forms with tremor. |
PubMed
Title | Date | PubMed |
---|---|---|
Clinical and pharmacological evaluation of the effects of piribedil in patients with parkinsonism. | 1975 Jan |
|
Piribedil: its synergistic effect in multidrug regimens for parkinsonism. | 1976 May |
|
Parkinsonism by haloperidol and piribedil. | 1978 Oct 31 |
|
Sleep attacks and Parkinson's disease treatment. | 2000 Apr 15 |
|
Discriminative stimulus properties of the dopamine D3 receptor agonists, PD128,907 and 7-OH-DPAT: a comparative characterization with novel ligands at D3 versus D2 receptors. | 2000 Feb 14 |
|
Pharmacological treatment for aphasia following stroke. | 2001 |
|
Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alterations of pallidal neurones in the MPTP-treated monkey. | 2001 Mar |
|
Randomized study of the dopamine receptor agonist piribedil in the treatment of mild cognitive impairment. | 2001 Sep |
|
DA agonists -- non-ergot derivatives: piribedil: management of Parkinson's disease. | 2002 |
|
Gateways to clinical trials. | 2002 Jul-Aug |
|
Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. | 2002 Nov |
|
[The use of pronoran (piribedil) in Parkinson's disease]. | 2003 |
|
Efficacy of piribedil as early combination to levodopa in patients with stable Parkinson's disease: a 6-month, randomized, placebo-controlled study. | 2003 Apr |
|
Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha 2A-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors. | 2003 Apr |
|
Quantitative determination of some pharmaceutical piperazine derivatives through complexation with iron(III) chloride. | 2003 Aug |
|
Piribedil as an adjunct to levodopa in advanced Parkinson's disease: the Asian experience. | 2003 Dec |
|
Electroanalytical characteristics of piribedil and its differential pulse and square wave voltammetric determination in pharmaceuticals and human serum. | 2003 Mar 10 |
|
[Clinical and stabilometric analysis of postural instability in Parkinson's disease]. | 2004 |
|
Adsorptive stripping voltammetric behaviour of azomethine group in pyrimidine-containing drugs. | 2004 Feb 18 |
|
Drugs in development for Parkinson's disease. | 2004 Jul |
|
End-of-dose akinesia after a single intravenous infusion of the dopaminergic agonist piribedil in Parkinson's disease patients: a pharmacokinetic/pharmacodynamic, randomized, double-blind study. | 2005 Jul |
|
Chemically modified carbon paste electrode for the potentiometric flow injection analysis of piribedil in pharmaceutical preparation and urine. | 2005 Jul 15 |
|
Evidence-based medical review update: pharmacological and surgical treatments of Parkinson's disease: 2001 to 2004. | 2005 May |
|
[The role of pronoran in the therapy of late stage of Parkinson's disease]. | 2006 |
|
Early piribedil monotherapy of Parkinson's disease: A planned seven-month report of the REGAIN study. | 2006 Dec |
|
Restless legs syndrome: diagnosis and review of management options. | 2006 Jun |
|
Activation of D2-like receptors induces sympathetic climactic-like responses in male and female anaesthetised rats. | 2006 Jun |
|
Prevalence and costs of parkinsonian syndromes associated with orthostatic hypotension. | 2006 Mar-Apr |
|
The dopamine agonist piribedil with L-DOPA improves attentional dysfunction: relevance for Parkinson's disease. | 2006 Nov |
|
Effects of the dopamine agonist piribedil on prefrontal temporal cortical network function in normal aging as assessed by verbal fluency. | 2007 Jan 30 |
|
About the anti-Parkinson equivalency of levodopa and dopamine agonists. | 2007 Jan-Feb |
|
Peripheral edema and dopamine agonists in Parkinson disease. | 2007 Oct |
|
Current management of the cognitive dysfunction in Parkinson's disease: how far have we come? | 2008 Aug |
|
Parkinson's disease sleep scale, sleep logs, and actigraphy in the evaluation of sleep in parkinsonian patients. | 2009 Sep |
|
Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome. | 2010 Dec 29 |
|
Impulse control disorder and piribedil: report of 5 cases. | 2010 Jan-Feb |
|
From the cell to the clinic: a comparative review of the partial D₂/D₃receptor agonist and α2-adrenoceptor antagonist, piribedil, in the treatment of Parkinson's disease. | 2010 Nov |
|
Pre-treatment with dopamine agonists influence L-dopa mediated rotations without affecting abnormal involuntary movements in the 6-OHDA lesioned rat. | 2010 Nov 12 |
Patents
Sample Use Guides
For the treatment of Parkinson's disease as a monotherapy, piribedil should be administered orally at 150 to 250 mg.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11222455
Binding of piribedil to D2, D3 and D4 receptors was measured using [3H]spiperone as a radiolabel. Coronal sections from rat brains were cut at the level of the anterior caudate-putame. The sections were thaw-mounted on gelatin-coated glass slides. Sections were incubated for 5 min in a 50mM Tris-HCl buffer, then were incubated for 30 min at room temperature in the incubation buffer. Piribedil was tested in vitro at 5 different concentrations, from 10 uM to 1 nM.
Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Jul 05 22:35:53 UTC 2023
by
admin
on
Wed Jul 05 22:35:53 UTC 2023
|
Record UNII |
DO22K1PRDJ
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Brand Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
WHO-ATC |
N04BC08
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
||
|
WHO-VATC |
QN04BC08
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
||
|
NCI_THESAURUS |
C66884
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
DB12478
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY | |||
|
D010891
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY | |||
|
8353
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY | RxNorm | ||
|
DO22K1PRDJ
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY | |||
|
C81082
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY | |||
|
M8877
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY | Merck Index | ||
|
222-764-6
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY | |||
|
PIRIBEDIL
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY | |||
|
CHEMBL1371770
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY | |||
|
3605-01-4
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY | |||
|
2569
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY | |||
|
DTXSID9045188
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY | |||
|
4850
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY | |||
|
100000081665
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY | |||
|
2202
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY | |||
|
SUB09908MIG
Created by
admin on Wed Jul 05 22:35:53 UTC 2023 , Edited by admin on Wed Jul 05 22:35:53 UTC 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
SALT/SOLVATE -> PARENT | |||
|
TARGET -> AGONIST |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |