ELOPIPRAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H22FN3O
Molecular Weight	375.4387
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(C=C1)C2=CC=C(CN3CCN(CC3)C4=C5OC=CC5=CC=C4)N2

InChI

InChIKey=PGNHBJGIQAEIHD-UHFFFAOYSA-N

InChI=1S/C23H22FN3O/c24-19-6-4-17(5-7-19)21-9-8-20(25-21)16-26-11-13-27(14-12-26)22-3-1-2-18-10-15-28-23(18)22/h1-10,15,25H,11-14,16H2

HIDE SMILES / InChI

Molecular Formula	C23H22FN3O
Molecular Weight	375.4387
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800001422 | https://www.ncbi.nlm.nih.gov/pubmed/7756102

Elopiprazole [DU 29894 or 1-(7-benzofuranyl)-4-[[5-(4-fluorophenyl)-1-H-pyrrol-2yl]methyl]piperazine) is an antagonist at dopamine D2 and D3 receptors and an agonist at serotonin1A receptors. Elopiprazole development for the treatment of psychotic disorders has been discontinued.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
A comparison of the neuro-endocrinological and temperature effects of DU 29894, flesinoxan, sulpiride and haloperidol in normal volunteers.	1995 Jan	7756102

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:54:57 GMT 2023` Edited by `admin` on `Sat Dec 16 16:54:57 GMT 2023`
Record UNII	419A0R564U
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ELOPIPRAZOLE

Official Name

English

elopiprazole [INN]

Common Name

English

1-(7-BENZOFURANYL)-4-((5-(P-FLUOROPHENYL)PYRROL-2-YL)METHYL)PIPERAZINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710