Details
Stereochemistry | ACHIRAL |
Molecular Formula | C21H23BrFNO2 |
Molecular Weight | 420.315 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C3=CC=C(Br)C=C3
InChI
InChIKey=RKLNONIVDFXQRX-UHFFFAOYSA-N
InChI=1S/C21H23BrFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
Molecular Formula | C21H23BrFNO2 |
Molecular Weight | 420.315 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Bromperidol decanoate is a long-acting antipsychotic medication used in at least Belgium, Germany, Italy, and the Netherlands. In clinical trials, Bromperidol decanoate was effective in the treatment of residual schizophrenia, with significant differences between before and after treatment ratings for symptoms. The preparation seems to be less potent than other depot antipsychotics (such as fluphenazine and haloperidol decanoate) and better than placebo injection. If bromperidol decanoate is available to the clinician it may be a viable choice, especially when there are reasons not to use fluphenazine or haloperidol decanoate.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL339 |
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Target ID: CHEMBL217 Sources: https://www.genome.jp/dbget-bin/www_bget?D02626 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Clinical experiences in an open and a double-blind trial. | 1978 Jan-Feb |
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Effects and side-effects of bromperidol in comparison with other antipsychotic drugs. | 1978 Jan-Feb |
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Double-blind- evaluation of bromperidol versus haloperidol treatment in chronic psychotic patients. | 1978 Jan-Feb |
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The initial US clinical experience in the management of schizophrenic patients with bromperidol. | 1978 Jan-Feb |
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Open study with bromperidol (C-C 2489), a new neuroleptic, for the determination of the neuroleptic threshold and the neuroleptic-therapeutic range. | 1978 Mar |
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Clinical evaluation of bromperidol versus haloperidol in psychotic patients. | 1980 |
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Neuroleptic malignant syndrome after clozapine plus carbamazepine. | 1988 Dec 24-31 |
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Positive and negative symptoms, depression and social disability in chronic schizophrenia: a comparative trial of bromperidol and fluphenazine decanoates. | 1992 Nov |
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Possible interaction between cisapride and bromperidol. | 1997 Jan |
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[Involvement of cytochromeP4503A4 in the metabolism of haloperidol and bromperidol]. | 1998 Feb |
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The characteristics of side-effects of bromperidol in schizophrenic patients. | 2002 Feb |
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Switching to amisulpride due to hepatic complications. | 2002 May |
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Poor reliability of therapeutic drug monitoring data for haloperidol and bromperidol using enzyme immunoassay. | 2003 Dec |
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Depot bromperidol decanoate for schizophrenia. | 2004 |
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[Butyrophenone derivatives]. | 2004 Dec |
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Establishment of new cloned enzyme donor immunoassays (CEDIA) for haloperidol and bromperidol. | 2004 Jun |
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Simultaneous determination of haloperidol and bromperidol and their reduced metabolites by liquid-liquid extraction and automated column-switching high-performance liquid chromatography. | 2004 Jun 5 |
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Atypical properties of several classes of antipsychotic drugs on the basis of differential induction of Fos-like immunoreactivity in the rat brain. | 2004 Nov 26 |
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Treatment with the new antipsychotic sertindole for late-occurring undesirable movement effects. | 2005 Nov |
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The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913). | 2008 Dec 22 |
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Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 Dec |
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Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen. | 2011 Aug |
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Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. | 2015 Jan 5 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: http://www.ndrugs.com/?s=bromperidol
Oral Schizophrenia:
Adult: 1-15 mg daily, up to 50 mg daily.
Intramuscular Schizophrenia:
Adult: Long-term therapy: Up to 300 mg every 4 wk via deep inj.
Intramuscular Psychoses:
Adult: Long-term therapy: Up to 300 mg every 4 wk via deep inj.
Oral Psychoses:
Adult: 1-15 mg daily, up to 50 mg daily.
Route of Administration:
Other
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/417559
Curator's Comment: In in vivo and in vitro experiements the antidopaminergic action of bromperidol, evaluated by PRL release, can be considered intermediate between pimozide and haloperidol.
Bromperidol is able to antagonize as well as haloperidol the DA-induced LH-RH release.
Substance Class |
Chemical
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Record UNII |
LYH6F7I22E
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Record Status |
Validated (UNII)
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C29710
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QN05AD06
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N05AD06
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C006820
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BROMPERIDOL
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10457-90-6
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CHEMBL28218
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