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Details

Stereochemistry ACHIRAL
Molecular Formula C13H18N2
Molecular Weight 202.2954
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LERIMAZOLINE

SMILES

CC1=CC(C)=C(CC2=NCCN2)C(C)=C1

InChI

InChIKey=DUHARNKZLBMPBS-UHFFFAOYSA-N
InChI=1S/C13H18N2/c1-9-6-10(2)12(11(3)7-9)8-13-14-4-5-15-13/h6-7H,4-5,8H2,1-3H3,(H,14,15)

HIDE SMILES / InChI

Molecular Formula C13H18N2
Molecular Weight 202.2954
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Lerimazoline is a sympathomimetic drug that belongs to the imidazoline class of compounds, and is used as a nasal decongestant. Lerimazoline displayed high affinity for the 5-HT1A receptor and for the 5-HT1D receptor. Binding affinity estimates for α1-adrenoceptor, 5-HT2A, and D2 receptors were more than ten times lower. The mechanism of vasoconstrictor action of lerimazoline encompasses both, the activation of 5-HT2A, and to a lesser degree α1 -adrenergic receptors. These results also suggest that lerimazoline is an “atypical” decongestant. It inhibits secretion of nasal mucus. Lerimazoline causes hypertension.

Approval Year

PubMed

PubMed

TitleDatePubMed
Elucidation of the profound antagonism of contractile action of phenylephrine in rat aorta effected by an atypical sympathomimetic decongestant.
2017 Jul
Patents

Patents

Substance Class Chemical
Created
by admin
on Sat Dec 16 09:04:16 UTC 2023
Edited
by admin
on Sat Dec 16 09:04:16 UTC 2023
Record UNII
1YZY0ACA91
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LERIMAZOLINE
INN   WHO-DD  
INN  
Official Name English
Lerimazoline [WHO-DD]
Common Name English
ST-71
Code English
lerimazoline [INN]
Common Name English
1H-IMIDAZOLE, 4,5-DIHYDRO-2-((2,4,6-TRIMETHYLPHENYL)METHYL)-
Systematic Name English
Code System Code Type Description
INN
9846
Created by admin on Sat Dec 16 09:04:16 UTC 2023 , Edited by admin on Sat Dec 16 09:04:16 UTC 2023
PRIMARY
CAS
54765-26-3
Created by admin on Sat Dec 16 09:04:16 UTC 2023 , Edited by admin on Sat Dec 16 09:04:16 UTC 2023
PRIMARY
NCI_THESAURUS
C166525
Created by admin on Sat Dec 16 09:04:16 UTC 2023 , Edited by admin on Sat Dec 16 09:04:16 UTC 2023
PRIMARY
PUBCHEM
3016908
Created by admin on Sat Dec 16 09:04:16 UTC 2023 , Edited by admin on Sat Dec 16 09:04:16 UTC 2023
PRIMARY
FDA UNII
1YZY0ACA91
Created by admin on Sat Dec 16 09:04:16 UTC 2023 , Edited by admin on Sat Dec 16 09:04:16 UTC 2023
PRIMARY
SMS_ID
100000183711
Created by admin on Sat Dec 16 09:04:16 UTC 2023 , Edited by admin on Sat Dec 16 09:04:16 UTC 2023
PRIMARY
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