Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C26H35N3O2 |
| Molecular Weight | 420.5757 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC(C)(C)C1=CC=C(C=C1)N2CC[C@@H](CC3=CC=CC=C3N4CCN([11CH3])CC4)C2=O
InChI
InChIKey=YGQWVNMSNMDPFQ-SVZFZNDKSA-N
InChI=1S/C26H35N3O2/c1-26(2,31-4)22-9-11-23(12-10-22)29-14-13-21(25(29)30)19-20-7-5-6-8-24(20)28-17-15-27(3)16-18-28/h5-12,21H,13-19H2,1-4H3/t21-/m0/s1/i3-1
| Molecular Formula | C26H35N3O2 |
| Molecular Weight | 420.5757 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Apr 01 16:39:12 GMT 2025
by
admin
on
Tue Apr 01 16:39:12 GMT 2025
|
| Record UNII |
N1RS162V1C
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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Common Name | English | ||
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Preferred Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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898807-42-6
Created by
admin on Tue Apr 01 16:39:12 GMT 2025 , Edited by admin on Tue Apr 01 16:39:12 GMT 2025
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PRIMARY | |||
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N1RS162V1C
Created by
admin on Tue Apr 01 16:39:12 GMT 2025 , Edited by admin on Tue Apr 01 16:39:12 GMT 2025
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PRIMARY | |||
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11495467
Created by
admin on Tue Apr 01 16:39:12 GMT 2025 , Edited by admin on Tue Apr 01 16:39:12 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
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TARGET->RADIOLIGAND |
Ki
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TARGET->RADIOLIGAND |
(11C)P943 is a new radioligand recently developed to image and quantify serotonin 5-Hydroxytryptamine (5-HT1B) receptors with positron emission tomography (PET). The purpose of this study was to evaluate (11C)P943 for this application in humans, and to determine the most suitable quantification method. (11C)P943 is suitable to quantify 5-HT1B receptors in humans in vivo. (11C)P943 binding potentials are significantly correlated with in vitro measurements of the density of 5-HT1B receptors, and in vivo estimates of the (11C)P943 dissociation constant Kd are close to in vitro measurements. Using arterial input functions, MA1 is the method of choice, especially for parametric images computation. Among noninvasive methods, MRTM2* is the preferred method.
Ki
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ACTIVE MOIETY |
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