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Details

Stereochemistry ABSOLUTE
Molecular Formula C26H35N3O2
Molecular Weight 420.5757
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of P-943 C-11

SMILES

COC(C)(C)C1=CC=C(C=C1)N2CC[C@@H](CC3=C(C=CC=C3)N4CCN([11CH3])CC4)C2=O

InChI

InChIKey=YGQWVNMSNMDPFQ-SVZFZNDKSA-N
InChI=1S/C26H35N3O2/c1-26(2,31-4)22-9-11-23(12-10-22)29-14-13-21(25(29)30)19-20-7-5-6-8-24(20)28-17-15-27(3)16-18-28/h5-12,21H,13-19H2,1-4H3/t21-/m0/s1/i3-1

HIDE SMILES / InChI

Molecular Formula C26H35N3O2
Molecular Weight 420.5757
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Substance Class Chemical
Created
by admin
on Sat Dec 16 11:36:05 UTC 2023
Edited
by admin
on Sat Dec 16 11:36:05 UTC 2023
Record UNII
N1RS162V1C
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
P-943 C-11
Common Name English
(3R)-1-(4-(1-METHOXY-1-METHYL-ETHYL)PHENYL)-3-((2-(4-METHYLPIPERAZIN-1-YL)PHENYL)METHYL)PYRROLIDIN-2-ONE
Systematic Name English
(11C)P-943
Code English
2-PYRROLIDINONE, 1-(4-(1-METHOXY-1-METHYLETHYL)PHENYL)-3-((2-(4-(METHYL-11C)-1-PIPERAZINYL)PHENYL)METHYL)-, (3R)-
Systematic Name English
Code System Code Type Description
CAS
898807-42-6
Created by admin on Sat Dec 16 11:36:05 UTC 2023 , Edited by admin on Sat Dec 16 11:36:05 UTC 2023
PRIMARY
FDA UNII
N1RS162V1C
Created by admin on Sat Dec 16 11:36:05 UTC 2023 , Edited by admin on Sat Dec 16 11:36:05 UTC 2023
PRIMARY
PUBCHEM
11495467
Created by admin on Sat Dec 16 11:36:05 UTC 2023 , Edited by admin on Sat Dec 16 11:36:05 UTC 2023
PRIMARY
Related Record Type Details
TARGET->RADIOLIGAND
Ki
TARGET->RADIOLIGAND
(11C)P943 is a new radioligand recently developed to image and quantify serotonin 5-Hydroxytryptamine (5-HT1B) receptors with positron emission tomography (PET). The purpose of this study was to evaluate (11C)P943 for this application in humans, and to determine the most suitable quantification method. (11C)P943 is suitable to quantify 5-HT1B receptors in humans in vivo. (11C)P943 binding potentials are significantly correlated with in vitro measurements of the density of 5-HT1B receptors, and in vivo estimates of the (11C)P943 dissociation constant Kd are close to in vitro measurements. Using arterial input functions, MA1 is the method of choice, especially for parametric images computation. Among noninvasive methods, MRTM2* is the preferred method.
Ki
Related Record Type Details
ACTIVE MOIETY