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Details

Stereochemistry ACHIRAL
Molecular Formula C24H24FN5O2S
Molecular Weight 465.543
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRELANSERIN

SMILES

NC(=O)CN1C(=O)C=C(CCN2CCN(CC2)C3=NC=CC4=C3C=CS4)C5=C1C=C(F)C=C5

InChI

InChIKey=JDLYOFUDIKMYBL-UHFFFAOYSA-N
InChI=1S/C24H24FN5O2S/c25-17-1-2-18-16(13-23(32)30(15-22(26)31)20(18)14-17)4-7-28-8-10-29(11-9-28)24-19-5-12-33-21(19)3-6-27-24/h1-3,5-6,12-14H,4,7-11,15H2,(H2,26,31)

HIDE SMILES / InChI

Molecular Formula C24H24FN5O2S
Molecular Weight 465.543
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Trelanserin, also known as SL-650472, is a serotonin 5-HT2A and 5-HT1B receptors antagonist. It was predicted to be histamine receptor H1 antagonist too. Trelanserin blocked serotonin-induced increases in blood pressure, rate pressure product and circumflex coronary artery flow and reduced serotonin-induced ischemic myocardial segment length shortening. Thus, trelanserin opposes serotonin-induced myocardial dysfunction in a dog model of exercise-induced ischemia. Trelanserin also blocked sumatriptan-induced vasoconstriction in ischemic and normally perfused hindlimbs in dogs.

Approval Year

PubMed

PubMed

TitleDatePubMed
Synthesis and SAR of 3- and 4-substituted quinolin-2-ones: discovery of mixed 5-HT(1B)/5-HT(2A) receptor antagonists.
2001 Aug
Antiplatelet and antithrombotic activity of SL65.0472, a mixed 5-HT1B/5-HT2A receptor antagonist.
2001 Mar
Cardiovascular effects of SL65.0472, a 5-HT receptor antagonist.
2001 Mar 2
Serotonin receptor blockade improves distal perfusion after lower limb ischemia in the fatty Zucker rat.
2002 Nov
SL65.0472 blocks 5-hydroxytryptamine-induced vasoconstriction in a dog hindlimb ischemia model.
2003 Aug 1
Serotonin aggravates exercise-induced cardiac ischemia in the dog: effect of serotonin receptor antagonists.
2004 Aug 16
Overcoming the obstacles in the pharma/biotech industry: 2008 update.
2009 Jan-Feb
Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms.
2014 Jun
Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCastâ„¢ High-Throughput Data.
2016 Aug
Patents

Patents

Substance Class Chemical
Created
by admin
on Fri Dec 15 16:39:26 UTC 2023
Edited
by admin
on Fri Dec 15 16:39:26 UTC 2023
Record UNII
QUD44MBL5S
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TRELANSERIN
INN  
INN  
Official Name English
PYRIDIN-4-YL)PIPERAZIN-1-YL)ETHYL)-1,2-DIHYDROQUINOLIN-1-YL)ACETAMIDE
Common Name English
SL65.0472
Code English
SL-650472
Code English
SL650472
Code English
trelanserin [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C66885
Created by admin on Fri Dec 15 16:39:26 UTC 2023 , Edited by admin on Fri Dec 15 16:39:26 UTC 2023
Code System Code Type Description
PUBCHEM
9869105
Created by admin on Fri Dec 15 16:39:26 UTC 2023 , Edited by admin on Fri Dec 15 16:39:26 UTC 2023
PRIMARY
SMS_ID
300000034398
Created by admin on Fri Dec 15 16:39:26 UTC 2023 , Edited by admin on Fri Dec 15 16:39:26 UTC 2023
PRIMARY
CAS
189003-92-7
Created by admin on Fri Dec 15 16:39:26 UTC 2023 , Edited by admin on Fri Dec 15 16:39:26 UTC 2023
PRIMARY
NCI_THESAURUS
C90946
Created by admin on Fri Dec 15 16:39:26 UTC 2023 , Edited by admin on Fri Dec 15 16:39:26 UTC 2023
PRIMARY
FDA UNII
QUD44MBL5S
Created by admin on Fri Dec 15 16:39:26 UTC 2023 , Edited by admin on Fri Dec 15 16:39:26 UTC 2023
PRIMARY
ChEMBL
CHEMBL3183740
Created by admin on Fri Dec 15 16:39:26 UTC 2023 , Edited by admin on Fri Dec 15 16:39:26 UTC 2023
PRIMARY
EPA CompTox
DTXSID2047355
Created by admin on Fri Dec 15 16:39:26 UTC 2023 , Edited by admin on Fri Dec 15 16:39:26 UTC 2023
PRIMARY
INN
8904
Created by admin on Fri Dec 15 16:39:26 UTC 2023 , Edited by admin on Fri Dec 15 16:39:26 UTC 2023
PRIMARY
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TARGET -> INHIBITOR
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