Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H24FN5O2S |
| Molecular Weight | 465.543 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC(=O)CN1C(=O)C=C(CCN2CCN(CC2)C3=NC=CC4=C3C=CS4)C5=C1C=C(F)C=C5
InChI
InChIKey=JDLYOFUDIKMYBL-UHFFFAOYSA-N
InChI=1S/C24H24FN5O2S/c25-17-1-2-18-16(13-23(32)30(15-22(26)31)20(18)14-17)4-7-28-8-10-29(11-9-28)24-19-5-12-33-21(19)3-6-27-24/h1-3,5-6,12-14H,4,7-11,15H2,(H2,26,31)
| Molecular Formula | C24H24FN5O2S |
| Molecular Weight | 465.543 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Trelanserin, also known as SL-650472, is a serotonin 5-HT2A and 5-HT1B receptors antagonist. It was predicted to be histamine receptor H1 antagonist too. Trelanserin blocked serotonin-induced increases in blood pressure, rate pressure product and circumflex coronary artery flow and reduced serotonin-induced ischemic myocardial segment length shortening. Thus, trelanserin opposes serotonin-induced myocardial dysfunction in a dog model of exercise-induced ischemia. Trelanserin also blocked sumatriptan-induced vasoconstriction in ischemic and normally perfused hindlimbs in dogs.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:39:26 GMT 2023
by
admin
on
Fri Dec 15 16:39:26 GMT 2023
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| Record UNII |
QUD44MBL5S
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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Official Name | English | ||
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Code | English | ||
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Common Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C66885
Created by
admin on Fri Dec 15 16:39:26 GMT 2023 , Edited by admin on Fri Dec 15 16:39:26 GMT 2023
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| Code System | Code | Type | Description | ||
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9869105
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300000034398
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189003-92-7
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C90946
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QUD44MBL5S
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CHEMBL3183740
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DTXSID2047355
Created by
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8904
Created by
admin on Fri Dec 15 16:39:26 GMT 2023 , Edited by admin on Fri Dec 15 16:39:26 GMT 2023
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PRIMARY |
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