U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C8H15N7O2S3
Molecular Weight 337.445
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FAMOTIDINE

SMILES

NC(=N)NC1=NC(CSCCC(=N)NS(N)(=O)=O)=CS1

InChI

InChIKey=XUFQPHANEAPEMJ-UHFFFAOYSA-N
InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

HIDE SMILES / InChI

Molecular Formula C8H15N7O2S3
Molecular Weight 337.445
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/famotidine.html

Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms. Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.

CNS Activity

Curator's Comment: Famotidine is a potent highly selective H2 receptor antagonist which crosses the blood-brain barrier.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
0.3 µM [IC50]
6.7 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
PEPCID

Approved Use

PEPCID is indicated in: 1. Short-term treatment of active duodenal ulcer. 2. Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of an active ulcer. 3. Short-term treatment of active benign gastric ulcer. 4. Short-term treatment of gastroesophageal reflux disease (GERD). PEPCID is indicated for shortterm treatment of patients with symptoms of GERD PEPCID is also indicated for the short-term treatment of esophagitis due to GERD including erosive or ulcerative disease diagnosed by endoscopy 5. Treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison Syndrome, multiple endocrine adenomas)

Launch Date

5.29632002E11
Curative
PEPCID

Approved Use

PEPCID is indicated in: 1. Short-term treatment of active duodenal ulcer. 2. Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of an active ulcer. 3. Short-term treatment of active benign gastric ulcer. 4. Short-term treatment of gastroesophageal reflux disease (GERD). PEPCID is indicated for shortterm treatment of patients with symptoms of GERD PEPCID is also indicated for the short-term treatment of esophagitis due to GERD including erosive or ulcerative disease diagnosed by endoscopy 5. Treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison Syndrome, multiple endocrine adenomas)

Launch Date

5.29632002E11
Primary
PEPCID

Approved Use

PEPCID is indicated in: 1. Short-term treatment of active duodenal ulcer. 2. Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of an active ulcer. 3. Short-term treatment of active benign gastric ulcer. 4. Short-term treatment of gastroesophageal reflux disease (GERD). PEPCID is indicated for shortterm treatment of patients with symptoms of GERD PEPCID is also indicated for the short-term treatment of esophagitis due to GERD including erosive or ulcerative disease diagnosed by endoscopy 5. Treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison Syndrome, multiple endocrine adenomas)

Launch Date

5.29632002E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
73 ng/mL
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FAMOTIDINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
424 ng × h/mL
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FAMOTIDINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
3 h
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FAMOTIDINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
82.5%
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FAMOTIDINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
0.5 mg/kg 2 times / day steady, oral
Recommended
Dose: 0.5 mg/kg, 2 times / day
Route: oral
Route: steady
Dose: 0.5 mg/kg, 2 times / day
Sources:
unhealthy, 11 - 15 years
n = 8
Health Status: unhealthy
Condition: gastric or duodenal ulcers
Age Group: 11 - 15 years
Sex: M
Population Size: 8
Sources:
80 mg 3 times / day steady, oral
Highest studied dose
Dose: 80 mg, 3 times / day
Route: oral
Route: steady
Dose: 80 mg, 3 times / day
Sources:
unhealthy, 20 - 70 years
n = 10
Health Status: unhealthy
Condition: COVID-19
Age Group: 20 - 70 years
Sex: M+F
Population Size: 10
Sources:
Other AEs: Dizziness, Dry skin...
Other AEs:
Dizziness (grade 1, 2 patients)
Dry skin (grade 1, 1 patient)
Insomnia (grade 1, 1 patient)
Gastrointestinal disorder (NOS) (grade 1, 1 patient)
Forgetfulness (grade 1, 1 patient)
Sources:
1 mg/kg 1 times / day steady, intravenous
Recommended
Dose: 1 mg/kg, 1 times / day
Route: intravenous
Route: steady
Dose: 1 mg/kg, 1 times / day
Sources:
unhealthy, 6 - 15 years
n = 6
Health Status: unhealthy
Condition: gastric or duodenal ulcers
Age Group: 6 - 15 years
Sex: M
Population Size: 6
Sources:
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Other AEs: Anemia, Nausea...
Other AEs:
Anemia (2 patients)
Nausea (6 patients)
Dyspepsia (5 patients)
Diarrhea (5 patients)
Constipation (4 patients)
Abdominal pain upper (3 patients)
Gastroesophageal reflux disease (2 patients)
Vomiting (2 patients)
Stomach discomfort (2 patients)
Abdominal pain (2 patients)
Edema peripheral (2 patients)
Arthralgia (1 patient)
Back pain (2 patients)
Headache (3 patients)
Hypertension (3 patients)
Sources:
AEs

AEs

AESignificanceDosePopulation
Dry skin grade 1, 1 patient
80 mg 3 times / day steady, oral
Highest studied dose
Dose: 80 mg, 3 times / day
Route: oral
Route: steady
Dose: 80 mg, 3 times / day
Sources:
unhealthy, 20 - 70 years
n = 10
Health Status: unhealthy
Condition: COVID-19
Age Group: 20 - 70 years
Sex: M+F
Population Size: 10
Sources:
Forgetfulness grade 1, 1 patient
80 mg 3 times / day steady, oral
Highest studied dose
Dose: 80 mg, 3 times / day
Route: oral
Route: steady
Dose: 80 mg, 3 times / day
Sources:
unhealthy, 20 - 70 years
n = 10
Health Status: unhealthy
Condition: COVID-19
Age Group: 20 - 70 years
Sex: M+F
Population Size: 10
Sources:
Gastrointestinal disorder (NOS) grade 1, 1 patient
80 mg 3 times / day steady, oral
Highest studied dose
Dose: 80 mg, 3 times / day
Route: oral
Route: steady
Dose: 80 mg, 3 times / day
Sources:
unhealthy, 20 - 70 years
n = 10
Health Status: unhealthy
Condition: COVID-19
Age Group: 20 - 70 years
Sex: M+F
Population Size: 10
Sources:
Insomnia grade 1, 1 patient
80 mg 3 times / day steady, oral
Highest studied dose
Dose: 80 mg, 3 times / day
Route: oral
Route: steady
Dose: 80 mg, 3 times / day
Sources:
unhealthy, 20 - 70 years
n = 10
Health Status: unhealthy
Condition: COVID-19
Age Group: 20 - 70 years
Sex: M+F
Population Size: 10
Sources:
Dizziness grade 1, 2 patients
80 mg 3 times / day steady, oral
Highest studied dose
Dose: 80 mg, 3 times / day
Route: oral
Route: steady
Dose: 80 mg, 3 times / day
Sources:
unhealthy, 20 - 70 years
n = 10
Health Status: unhealthy
Condition: COVID-19
Age Group: 20 - 70 years
Sex: M+F
Population Size: 10
Sources:
Arthralgia 1 patient
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Abdominal pain 2 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Anemia 2 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Back pain 2 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Edema peripheral 2 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Gastroesophageal reflux disease 2 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Stomach discomfort 2 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Vomiting 2 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Abdominal pain upper 3 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Headache 3 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Hypertension 3 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Constipation 4 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Diarrhea 5 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Dyspepsia 5 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Nausea 6 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG


OverviewOther

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
weak
likely (co-administration study)
Comment: may lead to substantial increases in blood concentrations of tizanidine, a CYP1A2 substrate; can't find inhibition value
Page: 6.0
yes [IC50 114 uM]
yes [IC50 28 uM]
yes [IC50 6.7 uM]
yes [Inhibition 100 uM]
yes [Inhibition 100 uM]
yes [Inhibition 100 uM]
yes [Ki 0.6 uM]
yes [Ki 9.7 uM]
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
yes
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
Differences in the antisecretory actions of the proton pump inhibitor AG-1749 (lansoprazole) and the histamine H2-receptor antagonist famotidine in rats and dogs.
1991 Apr
[Tolerance of famotidine. Study of network of sentinel physicians in pharmaco-vigilance].
1992 May-Jun
Prostacyclin analog prevents stress-induced expression of immediate early genes and gastric mucosal lesions in the rat stomach.
1999
Effect of polyunsaturated fatty acids on dexamethasone-induced gastric mucosal damage.
2000 Feb
Ultrasonographic evaluation of lansoprazole-induced improvement of submucosal injury in patients with gastroesophageal reflux.
2000 Feb
[A case of famotidine-induced aseptic meningitis].
2000 Jan
Developing a dynamic pharmacophore model for HIV-1 integrase.
2000 Jun 1
Effects of H(2)-receptor antagonists on dapsone-induced methaemoglobinaemia in rats.
2002 Apr
Effects of omeprazole and famotidine on fibroblast growth factor-2 during artificial gastric ulcer healing in humans.
2002 Apr
[Use of H2-receptor blocker famotidine (quamatel) in anesthesiology for cardiopulmonary bypass surgery].
2002 Jan-Feb
Ranitidine reduces ischemia/reperfusion-induced liver injury in rats by inhibiting neutrophil activation.
2002 Jun
Randomized comparative study of omeprazole and famotidine in reflux esophagitis.
2002 Sep
[A successfully treated case of intraoperative latex anaphylaxis during abdominal aorta aneurysm resection].
2003 Jan
Radioprotective properties of histamine H2 receptor antagonists: present and future prospects.
2003 Jun
Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3.
2004 May
Effects of cimetidine-like drugs on recombinant GABAA receptors.
2004 Oct 8
Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3.
2004 Sep
Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3).
2005 Dec
Synergistic action of famotidine and chlorpheniramine on acetic acid-induced chronic gastric ulcer in rats.
2005 Dec 7
Effect of concomitant dosing of famotidine with lansoprazole on gastric acid secretion in relation to CYP2C19 genotype status.
2005 Jul 1
Prediction of genotoxicity of chemical compounds by statistical learning methods.
2005 Jun
Preventive therapy for non-steroidal anti-inflammatory drug-induced ulcers in Japanese patients with rheumatoid arthritis: the current situation and a prospective controlled-study of the preventive effects of lansoprazole or famotidine.
2005 Jun
A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters.
2005 Oct
[Complex evaluation of the action of inhibitors of hydrochloric acid secretion on gastric function in ulcer disease].
2006
Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists.
2006 Mar
Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection.
2006 Oct 20
Histamine stimulation of MMP-1(collagenase-1) secretion and gene expression in gastric epithelial cells: role of EGFR transactivation and the MAP kinase pathway.
2007
The efficacy of hydrotalcite compared with OTC famotidine in the on-demand treatment of gastroesophageal reflux disease: a non-inferiority trial.
2007 Jan
Gastroprotective and antioxidant effects of montelukast on indomethacin-induced gastric ulcer in rats.
2007 Sep
A randomized, double-blind, placebo-controlled clinical study of the histamine H2-receptor antagonist famotidine in Japanese patients with nonerosive reflux disease.
2008
Can negative cardiac effect of proton pump inhibitor and high-dose H2-blocker have clinical influence on patients with stable angina?
2008 Aug
Nonsurgical resolution of gallbladder mucocele in two dogs.
2008 Jun 1
Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats.
2009 Jul 15
[Neurological complications of acute intermittent porphyria precipitated by porphyrinogenic drugs and efficiency of heme-arginate treatment].
2009 Sep
Hepatoprotective, antinociceptive and antioxidant activities of cimetidine, ranitidine and famotidine as histamine H2 receptor antagonists.
2011 Feb
Patents

Sample Use Guides

The recommended adult oral dosage for active duodenal ulcer is 40 mg once a day at bedtime. Most patients heal within 4 weeks.
Route of Administration: Oral
Famotidine (10-1,000 µM) inhibited methadone and oxycodone cytochrome P450-dependent metabolism >50%.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:52:37 UTC 2023
Edited
by admin
on Fri Dec 15 15:52:37 UTC 2023
Record UNII
5QZO15J2Z8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FAMOTIDINE
EP   HSDB   INN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
FLUXID
Brand Name English
FAMOTIDINE COMPONENT OF PEPCID COMPLETE
Common Name English
GASTER
Brand Name English
MUCLOX
Brand Name English
AMFAMOX
Brand Name English
FAMOXAL
Brand Name English
PEPDUL
Brand Name English
Famotidine [WHO-DD]
Common Name English
[1-Amino-3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]propylidene]sulfamide
Systematic Name English
FAMOTIDINE [MART.]
Common Name English
PEPCIDINE
Brand Name English
FAMOTIDINE [JAN]
Common Name English
LECEDIL
Brand Name English
MOTIAX
Brand Name English
L 643341
Code English
GANOR
Brand Name English
FAMOTIDINE [MI]
Common Name English
famotidine [INN]
Common Name English
PEPCID COMPLETE COMPONENT FAMOTIDINE
Common Name English
GASTRIDIN
Brand Name English
FAMODIL
Brand Name English
FAMOTIDINE [VANDF]
Common Name English
FAMOTIDINE [USP MONOGRAPH]
Common Name English
YM-11170
Code English
GASTROPEN
Brand Name English
PROPANIMIDAMIDE, N'-(AMINOSULFONYL)-3-(((2-((DIAMINOMETHYLENE)AMINO)-4-THIAZOLYL)METHYL)THIO)-
Systematic Name English
FAMOTIDINE [USP IMPURITY]
Common Name English
FAMOTIDINE [HSDB]
Common Name English
PEPCIDAC
Brand Name English
PEPDINE
Brand Name English
FADUL
Brand Name English
FAMOTIDINE [USP-RS]
Common Name English
FAMOTIDINE [USAN]
Common Name English
FAMOTIDINE [ORANGE BOOK]
Common Name English
FAMOSAN
Brand Name English
PEPCID
Brand Name English
FAMOTIDINE [EP MONOGRAPH]
Common Name English
NSC-757810
Code English
MK-208
Code English
3-((((2-(DIAMINOMETHYLENE)AMINO)-4-THIAZOLYL)METHYL)THIO)-N-SULFAMOYLPROPIONAMIDINE
Common Name English
Classification Tree Code System Code
WHO-ATC A02BA03
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
NDF-RT N0000175784
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
WHO-VATC QA02BA03
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
NCI_THESAURUS C29702
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
WHO-ATC A02BA53
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
LIVERTOX NBK548228
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
WHO-VATC QA02BA53
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
NDF-RT N0000000151
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
Code System Code Type Description
LACTMED
Famotidine
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
EPA CompTox
DTXSID5023039
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
DRUG BANK
DB00927
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
NSC
757810
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
MESH
D015738
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
EVMPD
SUB07503MIG
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
DAILYMED
5QZO15J2Z8
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
INN
5217
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
SMS_ID
100000092363
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
IUPHAR
7074
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
PUBCHEM
3325
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
MERCK INDEX
m5241
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY Merck Index
ChEMBL
CHEMBL902
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
RXCUI
4278
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY RxNorm
WIKIPEDIA
FAMOTIDINE
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
RS_ITEM_NUM
1269200
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
CHEBI
4975
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
DRUG CENTRAL
1129
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
USAN
W-33
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
HSDB
3572
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
NCI_THESAURUS
C29045
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
FDA UNII
5QZO15J2Z8
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
CAS
76824-35-6
Created by admin on Fri Dec 15 15:52:37 UTC 2023 , Edited by admin on Fri Dec 15 15:52:37 UTC 2023
PRIMARY
Related Record Type Details
TRANSPORTER -> INHIBITOR
TRANSPORTER -> INHIBITOR
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
USP
TRANSPORTER -> INHIBITOR
IC50
TRANSPORTER -> INHIBITOR
EXCRETED UNCHANGED
Following IV administration
URINE
TARGET->INVERSE AGONIST
The mean minimum daily requirement of famotidine to control gastric acid hypersecretion was 0.24 g (range 0.08–0.48 g) compared with 2.1 g (range 0.6–3.6 g) for ranitidine and 7.8 g (range 1.2–13.2 g) for cimetidine. is nine times more potent than ranitidine and 32 times more potent than cimetidine, has a longer duration of action than ranitidine or cimetidine,
TRANSPORTER -> INHIBITOR
IC50
TRANSPORTER -> INHIBITOR
TRANSPORTER -> SUBSTRATE
BINDER->LIGAND
BINDING
TARGET->INVERSE AGONIST
TRANSPORTER -> NON-INHIBITOR
IC50
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
Related Record Type Details
METABOLITE -> PARENT
URINE
Related Record Type Details
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.4
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 2.5
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.9
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.7
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 0.19
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC