U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C8H15N7O2S3
Molecular Weight 337.445
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FAMOTIDINE

SMILES

NC(=N)NC1=NC(CSCCC(=N)NS(N)(=O)=O)=CS1

InChI

InChIKey=XUFQPHANEAPEMJ-UHFFFAOYSA-N
InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

HIDE SMILES / InChI
Molecular Formula C8H15N7O2S3
Molecular Weight 337.445
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/famotidine.html

Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms. Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.

CNS Activity

CNS Penetrant
2554
Curator's Comment: Famotidine is a potent highly selective H2 receptor antagonist which crosses the blood-brain barrier.

Originator

Approval Year

1986
103
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
 0.3 µM [IC50]
Inhibitor
8297
 6.7 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
PEPCID

Approved Use

PEPCID is indicated in: 1. Short-term treatment of active duodenal ulcer. 2. Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of an active ulcer. 3. Short-term treatment of active benign gastric ulcer. 4. Short-term treatment of gastroesophageal reflux disease (GERD). PEPCID is indicated for shortterm treatment of patients with symptoms of GERD PEPCID is also indicated for the short-term treatment of esophagitis due to GERD including erosive or ulcerative disease diagnosed by endoscopy 5. Treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison Syndrome, multiple endocrine adenomas)

Launch Date

1986
Curative
Approved
8429
PEPCID

Approved Use

PEPCID is indicated in: 1. Short-term treatment of active duodenal ulcer. 2. Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of an active ulcer. 3. Short-term treatment of active benign gastric ulcer. 4. Short-term treatment of gastroesophageal reflux disease (GERD). PEPCID is indicated for shortterm treatment of patients with symptoms of GERD PEPCID is also indicated for the short-term treatment of esophagitis due to GERD including erosive or ulcerative disease diagnosed by endoscopy 5. Treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison Syndrome, multiple endocrine adenomas)

Launch Date

1986
Primary
Approved
8429
PEPCID

Approved Use

PEPCID is indicated in: 1. Short-term treatment of active duodenal ulcer. 2. Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of an active ulcer. 3. Short-term treatment of active benign gastric ulcer. 4. Short-term treatment of gastroesophageal reflux disease (GERD). PEPCID is indicated for shortterm treatment of patients with symptoms of GERD PEPCID is also indicated for the short-term treatment of esophagitis due to GERD including erosive or ulcerative disease diagnosed by endoscopy 5. Treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison Syndrome, multiple endocrine adenomas)

Launch Date

1986
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
73 ng/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/019462s039lbl.pdf
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FAMOTIDINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
424 ng × h/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/019462s039lbl.pdf
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FAMOTIDINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
3 h
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/019462s039lbl.pdf
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FAMOTIDINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
82.5%
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/019462s039lbl.pdf
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FAMOTIDINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
0.5 mg/kg 2 times / day steady, oral
Recommended
Dose: 0.5 mg/kg, 2 times / day
Route: oral
Route: steady
Dose: 0.5 mg/kg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7846741/
unhealthy, 11 - 15 years
n = 8
Health Status: unhealthy
Condition: gastric or duodenal ulcers
Age Group: 11 - 15 years
Sex: M
Population Size: 8
Sources:
https://pubmed.ncbi.nlm.nih.gov/7846741/
Sources:
https://pubmed.ncbi.nlm.nih.gov/7846741/
80 mg 3 times / day steady, oral
Highest studied dose
Dose: 80 mg, 3 times / day
Route: oral
Route: steady
Dose: 80 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/32499303/
unhealthy, 20 - 70 years
n = 10
Health Status: unhealthy
Condition: COVID-19
Age Group: 20 - 70 years
Sex: M+F
Population Size: 10
Sources:
https://pubmed.ncbi.nlm.nih.gov/32499303/
Other AEs: Dizziness, Dry skin...
Other AEs:
Dizziness (grade 1, 2 patients)
Dry skin (grade 1, 1 patient)
Insomnia (grade 1, 1 patient)
Gastrointestinal disorder (NOS) (grade 1, 1 patient)
Forgetfulness (grade 1, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/32499303/
1 mg/kg 1 times / day steady, intravenous
Recommended
Dose: 1 mg/kg, 1 times / day
Route: intravenous
Route: steady
Dose: 1 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7846741/
unhealthy, 6 - 15 years
n = 6
Health Status: unhealthy
Condition: gastric or duodenal ulcers
Age Group: 6 - 15 years
Sex: M
Population Size: 6
Sources:
https://pubmed.ncbi.nlm.nih.gov/7846741/
Sources:
https://pubmed.ncbi.nlm.nih.gov/7846741/
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Other AEs: Anemia, Nausea...
Other AEs:
Anemia (2 patients)
Nausea (6 patients)
Dyspepsia (5 patients)
Diarrhea (5 patients)
Constipation (4 patients)
Abdominal pain upper (3 patients)
Gastroesophageal reflux disease (2 patients)
Vomiting (2 patients)
Stomach discomfort (2 patients)
Abdominal pain (2 patients)
Edema peripheral (2 patients)
Arthralgia (1 patient)
Back pain (2 patients)
Headache (3 patients)
Hypertension (3 patients)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
AEs

AEs

AESignificanceDosePopulation
Dry skin grade 1, 1 patient
80 mg 3 times / day steady, oral
Highest studied dose
Dose: 80 mg, 3 times / day
Route: oral
Route: steady
Dose: 80 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/32499303/
unhealthy, 20 - 70 years
n = 10
Health Status: unhealthy
Condition: COVID-19
Age Group: 20 - 70 years
Sex: M+F
Population Size: 10
Sources:
https://pubmed.ncbi.nlm.nih.gov/32499303/
Forgetfulness grade 1, 1 patient
80 mg 3 times / day steady, oral
Highest studied dose
Dose: 80 mg, 3 times / day
Route: oral
Route: steady
Dose: 80 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/32499303/
unhealthy, 20 - 70 years
n = 10
Health Status: unhealthy
Condition: COVID-19
Age Group: 20 - 70 years
Sex: M+F
Population Size: 10
Sources:
https://pubmed.ncbi.nlm.nih.gov/32499303/
Gastrointestinal disorder (NOS) grade 1, 1 patient
80 mg 3 times / day steady, oral
Highest studied dose
Dose: 80 mg, 3 times / day
Route: oral
Route: steady
Dose: 80 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/32499303/
unhealthy, 20 - 70 years
n = 10
Health Status: unhealthy
Condition: COVID-19
Age Group: 20 - 70 years
Sex: M+F
Population Size: 10
Sources:
https://pubmed.ncbi.nlm.nih.gov/32499303/
Insomnia grade 1, 1 patient
80 mg 3 times / day steady, oral
Highest studied dose
Dose: 80 mg, 3 times / day
Route: oral
Route: steady
Dose: 80 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/32499303/
unhealthy, 20 - 70 years
n = 10
Health Status: unhealthy
Condition: COVID-19
Age Group: 20 - 70 years
Sex: M+F
Population Size: 10
Sources:
https://pubmed.ncbi.nlm.nih.gov/32499303/
Dizziness grade 1, 2 patients
80 mg 3 times / day steady, oral
Highest studied dose
Dose: 80 mg, 3 times / day
Route: oral
Route: steady
Dose: 80 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/32499303/
unhealthy, 20 - 70 years
n = 10
Health Status: unhealthy
Condition: COVID-19
Age Group: 20 - 70 years
Sex: M+F
Population Size: 10
Sources:
https://pubmed.ncbi.nlm.nih.gov/32499303/
Arthralgia 1 patient
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Abdominal pain 2 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Anemia 2 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Back pain 2 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Edema peripheral 2 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Gastroesophageal reflux disease 2 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Stomach discomfort 2 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Vomiting 2 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Abdominal pain upper 3 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Headache 3 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Hypertension 3 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Constipation 4 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Diarrhea 5 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Dyspepsia 5 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Nausea 6 patients
26.6 mg 3 times / day steady, oral
Highest studied dose
Dose: 26.6 mg, 3 times / day
Route: oral
Route: steady
Dose: 26.6 mg, 3 times / day
Co-administed with::
ibuprofen(800 mg)
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
unhealthy, adult
n = 1022
Health Status: unhealthy
Condition: chronic pain and inflammation of stomach
Age Group: adult
Sex: M+F
Population Size: 1022
Sources:
https://pubmed.ncbi.nlm.nih.gov/23024710/
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
inhibitor
1587
inhibitor
1612

OverviewOther

Other InhibitorOther SubstrateOther Inducer
CYP1A2
1524

CYP2B6
810

CYP2C19
1478

OCT1
512

OCT2
647

OCT3
150

MATE1
306

MATE2
263
OCT2
355
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
CYP1A2
1692
 weak
likely (co-administration study)
Comment: may lead to substantial increases in blood concentrations of tizanidine, a CYP1A2 substrate; can't find inhibition value
Page: 6.0
OCT2
648
 yes [IC50 114 uM]
OCT1
543
 yes [IC50 28 uM]
OCT3
150
 yes [IC50 6.7 uM]
CYP2B6
1001
 yes [Inhibition 100 uM]
CYP2C19
1553
 yes [Inhibition 100 uM]
CYP3A4
1925
 yes [Inhibition 100 uM]
MATE1
308
 yes [Ki 0.6 uM]
MATE2
263
 yes [Ki 9.7 uM]
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
OCT2
355
 yes
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
hERG
1647
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:4975
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:4975
ChemicalBook
CB5706585
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB5706585
MolPort
MolPort-002-557-620
https://www.molport.com/shop/molecule-link/MolPort-002-557-620
MolPort
MolPort-003-666-342
https://www.molport.com/shop/molecule-link/MolPort-003-666-342
MolPort
MolPort-003-941-395
https://www.molport.com/shop/molecule-link/MolPort-003-941-395
MolPort
MolPort-006-069-255
https://www.molport.com/shop/molecule-link/MolPort-006-069-255
Selleck Chemicals
famotidine-pepcid
http://www.selleckchem.com/products/famotidine-pepcid.html
ZINC
ZINC000001530636
http://zinc15.docking.org/substances/ZINC000001530636
eMolecules
538460
https://www.emolecules.com/cgi-bin/more?vid=538460
eMolecules
6842898
https://www.emolecules.com/cgi-bin/more?vid=6842898
eMolecules
901873
https://www.emolecules.com/cgi-bin/more?vid=901873
PubMed

PubMed

TitleDatePubMed
Differences in the antisecretory actions of the proton pump inhibitor AG-1749 (lansoprazole) and the histamine H2-receptor antagonist famotidine in rats and dogs.
1991 Apr
[Tolerance of famotidine. Study of network of sentinel physicians in pharmaco-vigilance].
1992 May-Jun
[A case of rheumatoid arthritis associated with autoimmune hemolytic anemia due to weekly low-dose methotrexate therapy].
2000 Aug
Acute cholestatic hepatitis in a child treated with famotidine.
2000 Dec
Ultrasonographic evaluation of lansoprazole-induced improvement of submucosal injury in patients with gastroesophageal reflux.
2000 Feb
Developing a dynamic pharmacophore model for HIV-1 integrase.
2000 Jun 1
Amantadine-induced cortical myoclonus.
2001 Jan 23
H(2)-histamine antagonist (famotidine) induced adverse CNS reactions with long-standing secondary mania and epileptic seizures.
2002 Jul
Histamine inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in an intercellular adhesion molecule-1- and B7.1-dependent manner.
2003 Feb
[A successfully treated case of intraoperative latex anaphylaxis during abdominal aorta aneurysm resection].
2003 Jan
Radioprotective properties of histamine H2 receptor antagonists: present and future prospects.
2003 Jun
Effect of exogenous administration of transforming growth factor-beta and famotidine on the healing of duodenal ulcer under the impact of indomethacin.
2003 Jun
On the mechanisms underlying histamine induction of gastric mucosal lesions in rats with partial gastric vascular occlusion.
2003 Jun
Famotidine for infant gastro-oesophageal reflux: a multi-centre, randomized, placebo-controlled, withdrawal trial.
2003 May 1
Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3).
2005 Dec
Synergistic action of famotidine and chlorpheniramine on acetic acid-induced chronic gastric ulcer in rats.
2005 Dec 7
Comparative study of the speed of acid-suppressing effects of oral administration of cimetidine and famotidine.
2005 Jul
Effect of concomitant dosing of famotidine with lansoprazole on gastric acid secretion in relation to CYP2C19 genotype status.
2005 Jul 1
Prediction of genotoxicity of chemical compounds by statistical learning methods.
2005 Jun
A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters.
2005 Oct
Effect of preoperative short course famotidine on TILs and survival in breast cancer.
2005 Oct-Dec
Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes.
2006 Aug
In vitro availability of metformin in presence of h(2) receptor antagonists.
2006 Jan
Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists.
2006 Mar
Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection.
2006 Oct 20
Histamine stimulation of MMP-1(collagenase-1) secretion and gene expression in gastric epithelial cells: role of EGFR transactivation and the MAP kinase pathway.
2007
[Clinical study on effect of Jianwei Yuyang Granule in treating patients with gastric ulcer].
2007 Jul
The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-induced inflammatory liver injury.
2007 Nov
Gastroprotective and antioxidant effects of montelukast on indomethacin-induced gastric ulcer in rats.
2007 Sep
A randomized, double-blind, placebo-controlled clinical study of the histamine H2-receptor antagonist famotidine in Japanese patients with nonerosive reflux disease.
2008
Antinociception induced by central administration of histamine in the formalin test in rats.
2008 Jul-Sep
[Efficacy and safety of famotidine for the treatment of stress ulcers in neonates].
2008 Oct
Risk factors for the development of gastric mucosal lesions in rheumatoid arthritis patients receiving long-term nonsteroidal anti-inflammatory drug therapy and the efficacy of famotidine obtained from the FORCE study.
2009
Comparison of the effects of omeprazole and famotidine in treatment of upper abdominal symptoms in patients with reflux esophagitis.
2009
Effects of pantoprazole on ulcer healing delay associated with NSAID treatment.
2009 Mar
Protective effect of mirtazapine on indomethacin-induced ulcer in rats and its relationship with oxidant and antioxidant parameters.
2009 Sep
Rebamipide may be comparable to H2 receptor antagonist in healing iatrogenic gastric ulcers created by endoscopic mucosal resection: a prospective randomized pilot study.
2010 Apr
Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions.
2010 Jan
Patents

Patents

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2
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2
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2
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3
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2
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5
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2
JP2011229496A
2
JP2011525178A
25
JP2011528275A
455
JP4664289B2
2
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104
JP4732696B2
67
JP4739217B2
51
JP4756823B2
22
JP4763957B2
87
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101
JPH01100162A
2
JPH01197439A
2

Sample Use Guides

In Vivo Use Guide
The recommended adult oral dosage for active duodenal ulcer is 40 mg once a day at bedtime. Most patients heal within 4 weeks.
Route of Administration: Oral
In Vitro Use Guide
Famotidine (10-1,000 µM) inhibited methadone and oxycodone cytochrome P450-dependent metabolism >50%.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:52:37 GMT 2023
Edited
by admin
on Fri Dec 15 15:52:37 GMT 2023
Record UNII
5QZO15J2Z8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FAMOTIDINE
EP   HSDB   INN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
FLUXID
Brand Name English
FAMOTIDINE COMPONENT OF PEPCID COMPLETE
Common Name English
GASTER
Brand Name English
MUCLOX
Brand Name English
AMFAMOX
Brand Name English
FAMOXAL
Brand Name English
PEPDUL
Brand Name English
Famotidine [WHO-DD]
Common Name English
[1-Amino-3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]propylidene]sulfamide
Systematic Name English
FAMOTIDINE [MART.]
Common Name English
PEPCIDINE
Brand Name English
FAMOTIDINE [JAN]
Common Name English
LECEDIL
Brand Name English
MOTIAX
Brand Name English
L 643341
Code English
GANOR
Brand Name English
FAMOTIDINE [MI]
Common Name English
famotidine [INN]
Common Name English
PEPCID COMPLETE COMPONENT FAMOTIDINE
Common Name English
GASTRIDIN
Brand Name English
FAMODIL
Brand Name English
FAMOTIDINE [VANDF]
Common Name English
FAMOTIDINE [USP MONOGRAPH]
Common Name English
YM-11170
Code English
GASTROPEN
Brand Name English
PROPANIMIDAMIDE, N'-(AMINOSULFONYL)-3-(((2-((DIAMINOMETHYLENE)AMINO)-4-THIAZOLYL)METHYL)THIO)-
Systematic Name English
FAMOTIDINE [USP IMPURITY]
Common Name English
FAMOTIDINE [HSDB]
Common Name English
PEPCIDAC
Brand Name English
PEPDINE
Brand Name English
FADUL
Brand Name English
FAMOTIDINE [USP-RS]
Common Name English
FAMOTIDINE [USAN]
Common Name English
FAMOTIDINE [ORANGE BOOK]
Common Name English
FAMOSAN
Brand Name English
PEPCID
Brand Name English
FAMOTIDINE [EP MONOGRAPH]
Common Name English
NSC-757810
Code English
MK-208
Code English
3-((((2-(DIAMINOMETHYLENE)AMINO)-4-THIAZOLYL)METHYL)THIO)-N-SULFAMOYLPROPIONAMIDINE
Common Name English
Classification Tree Code System Code
WHO-ATC A02BA03
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
NDF-RT N0000175784
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
WHO-VATC QA02BA03
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
NCI_THESAURUS C29702
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
WHO-ATC A02BA53
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
LIVERTOX NBK548228
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
WHO-VATC QA02BA53
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
NDF-RT N0000000151
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
Code System Code Type Description
LACTMED
Famotidine
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
EPA CompTox
DTXSID5023039
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
DRUG BANK
DB00927
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
NSC
757810
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
MESH
D015738
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
EVMPD
SUB07503MIG
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
DAILYMED
5QZO15J2Z8
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
INN
5217
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
SMS_ID
100000092363
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
IUPHAR
7074
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
PUBCHEM
3325
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
MERCK INDEX
m5241
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY Merck Index
ChEMBL
CHEMBL902
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
RXCUI
4278
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY RxNorm
WIKIPEDIA
FAMOTIDINE
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
RS_ITEM_NUM
1269200
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
CHEBI
4975
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
DRUG CENTRAL
1129
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
USAN
W-33
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
HSDB
3572
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
NCI_THESAURUS
C29045
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
FDA UNII
5QZO15J2Z8
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
CAS
76824-35-6
Created by admin on Fri Dec 15 15:52:37 GMT 2023 , Edited by admin on Fri Dec 15 15:52:37 GMT 2023
PRIMARY
Related Record Type Details
MATE-2
TRANSPORTER -> INHIBITOR
MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1
TRANSPORTER -> INHIBITOR
Structure of FAMOTIDINE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
USP
OAT-1
TRANSPORTER -> INHIBITOR
IC50
OCT-1
TRANSPORTER -> INHIBITOR
Structure of FAMOTIDINE
EXCRETED UNCHANGED
Following IV administration
URINE
HISTAMINE H2 RECEPTOR
TARGET->INVERSE AGONIST
The mean minimum daily requirement of famotidine to control gastric acid hypersecretion was 0.24 g (range 0.08–0.48 g) compared with 2.1 g (range 0.6–3.6 g) for ranitidine and 7.8 g (range 1.2–13.2 g) for cimetidine. is nine times more potent than ranitidine and 32 times more potent than cimetidine, has a longer duration of action than ranitidine or cimetidine,
OCT-2
TRANSPORTER -> INHIBITOR
IC50
OCT-3
TRANSPORTER -> INHIBITOR
OCT-1
TRANSPORTER -> SUBSTRATE
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
HISTAMINE H2 RECEPTOR
TARGET->INVERSE AGONIST
OAT-3
TRANSPORTER -> NON-INHIBITOR
IC50
Structure of FAMOTIDINE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
Related Record Type Details
Structure of FAMOTIDINE SULFOXIDE
METABOLITE -> PARENT
URINE
Related Record Type Details
Structure of FAMOTIDINE CYANOAMIDINE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.4
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 3-((2-(DIAMINOMETHYLENEAMINO)THIAZOL-4-YL)METHYLTHIO)PROPANIMIDAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of FAMOTIDINE PROPANAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of FAMOTIDINE PROPIONIC ACID
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of FAMOTIDINE PROPANAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of FAMOTIDINE DIMER
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 2.5
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of FAMOTIDINE SULFAMOYL PROPANAMIDE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.9
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of FAMOTIDINE DIMER
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of FAMOTIDINE DISULFIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of FAMOTIDINE SULFAMOYL PROPANAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of FAMOTIDINE CYANOAMIDINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of FAMOTIDINE PROPIONIC ACID
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.7
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 3-((2-(DIAMINOMETHYLENEAMINO)THIAZOL-4-YL)METHYLTHIO)PROPANIMIDAMIDE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 0.19
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of FAMOTIDINE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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