HISTAMINE H2 RECEPTOR

Approval Year

Substance Class	Protein Created by `admin` on `Thu Jul 06 17:19:40 UTC 2023` Edited by `admin` on `Thu Jul 06 17:19:40 UTC 2023`
Protein Type	RECEPTOR
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	XC55JSP2CX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HISTAMINE H2 RECEPTOR

Common Name

English

GASTRIC RECEPTOR I

Common Name

English

HH2R

Common Name

English

H2R

Common Name

English

Code System Code Type Description

PHAROS

P25021

Created by admin on Thu Jul 06 17:19:42 UTC 2023 , Edited by admin on Thu Jul 06 17:19:42 UTC 2023

PRIMARY

UNIPROT

P25021

Created by admin on Thu Jul 06 17:19:42 UTC 2023 , Edited by admin on Thu Jul 06 17:19:42 UTC 2023

PRIMARY

FDA UNII

XC55JSP2CX

Created by admin on Thu Jul 06 17:19:42 UTC 2023 , Edited by admin on Thu Jul 06 17:19:42 UTC 2023

PRIMARY

From	To
1_91	1_174

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_4

Related Record Type Details


					EZU9AIZ69M

TIOTIDINE

INVERSE AGONIST->TARGET


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CIMETIDINE

INHIBITOR -> TARGET


					JJH94R3PWB

NERATINIB

INHIBITOR->OFF-TARGET

Comments:

Radioligand binding assay

Interaction Type:

BINDING

Qualification:

IC50

Amount:


					IV9VHT3YUM

ROXATIDINE

INHIBITOR -> TARGET


					5QZO15J2Z8

FAMOTIDINE

INVERSE AGONIST->TARGET

Amount:


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NIZATIDINE

INHIBITOR -> TARGET

Amount:


					4XRL9PL02Y

PIBUTIDINE

INHIBITOR -> TARGET


					OD9237K1Z6

LATREPIRDINE

WEAK INHIBITOR->TARGET

Qualification:

IC50

Amount:


					JJH94R3PWB

NERATINIB

INHIBITOR -> TRANSPORTER


					L6UH7ZF8HC

RISPERIDONE

WEAK INHIBITOR->TARGET

Interaction Type:

INHIBITOR

Qualification:

Ki

Amount:


					5ASJ6HUZ7D

DOXEPIN

INHIBITOR -> TARGET


					884KT10YB7

RANITIDINE

INHIBITOR -> TARGET


					5QAO860UFG

CP-61146

INHIBITOR -> TARGET


					J4CZH8D9EN

6-FLUORO-DMT

AGONIST -> TARGET

Amount:


					5HML8P3QAT

UR-AK49

AGONIST -> TARGET

Amount:


					49S4O7ADLC

LAFUTIDINE, (+/-)-

INHIBITOR -> TARGET


					838F01T721

PALIPERIDONE

WEAK INHIBITOR->TARGET

Interaction Type:

INHIBITOR

Qualification:

Ki

Amount:


					5QZO15J2Z8

FAMOTIDINE

INVERSE AGONIST->TARGET

Comments:

The mean minimum daily requirement of famotidine to control gastric acid hypersecretion was 0.24 g (range 0.08–0.48 g) compared with 2.1 g (range 0.6–3.6 g) for ranitidine and 7.8 g (range 1.2–13.2 g) for cimetidine. is nine times more potent than ranitidine and 32 times more potent than cimetidine, has a longer duration of action than ranitidine or cimetidine,

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL