MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1

Approval Year

Substance Class	Protein Created by `admin` on `Sat Jun 26 18:06:57 UTC 2021` Edited by `admin` on `Sat Jun 26 18:06:57 UTC 2021`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	6NP3XSMIP3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1

Common Name

English

MATE1

Common Name

English

FLJ10847

Common Name

English

SOLUTE CARRIER FAMILY 47 MEMBER 1

Common Name

English

SLC47A1

Common Name

English

MGC64822

Common Name

English

MATE-1

Common Name

English

Classification Tree Code System Code

UCSF-FDA TRANSPORTAL

SLC47A1

Created by admin on Sat Jun 26 18:07:04 UTC 2021 , Edited by admin on Sat Jun 26 18:07:04 UTC 2021

Code System Code Type Description

FDA UNII

6NP3XSMIP3

Created by admin on Sat Jun 26 18:07:04 UTC 2021 , Edited by admin on Sat Jun 26 18:07:04 UTC 2021

PRIMARY

Related Record Type Details


					44RAL3456C

METHAMPHETAMINE

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					X4HES1O11F

ACYCLOVIR

SUBSTRATE -> TRANSPORTER


					DU69T8ZZPA

RIFAMYCIN

INHIBITOR -> TRANSPORTER

Comments:

Rifamycin is an inhibitor of renal transporters organic anion transporter (OAT) 3, multidrug and toxin extrusion (MATE) 1, and MATE2-K transporters in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose, clinically relevant inhibition of these transporters in vivo is unlikely.


					BF4C9Z1J53

AMANTADINE

INHIBITOR -> TRANSPORTER


					N22UPQ09R0

DM-3411

TRANSPORTER -> INHIBITOR


					QTL48N278K

ESTRONE SULFATE

SUBSTRATE -> TRANSPORTER


					5QZO15J2Z8

FAMOTIDINE

INHIBITOR -> TRANSPORTER


					W36ZG6FT64

SIROLIMUS

INHIBITOR -> TRANSPORTER


					EE92BBP03H

DILTIAZEM

INHIBITOR -> TRANSPORTER


					OBN7UDS42Y

CEPHALEXIN

SUBSTRATE -> TRANSPORTER


					UU226QGU97

IMEGLIMIN

INHIBITOR -> TRANSPORTER


					1C39JW444G

CABOZANTINIB

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					F8M63J351A

N-BUTYLPYRIDINIUM CHLORIDE

INHIBITOR -> TRANSPORTER


					7M7YKX2N15

TOPOTECAN

SUBSTRATE -> TRANSPORTER


					L39WTC366D

PROCAINAMIDE

SUBSTRATE -> TRANSPORTER


					5AV7G7EIEE

TETRAETHYLAMMONIUM

SUBSTRATE -> TRANSPORTER


					3QKI37EEHE

REMDESIVIR

INHIBITOR -> TRANSPORTER


					WOH1JD9AR8

OLAPARIB

INHIBITOR -> TRANSPORTER

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:


					884KT10YB7

RANITIDINE

INHIBITOR -> TRANSPORTER


					BSOIY5AKQW

ERVOGASTAT

INHIBITOR -> TRANSPORTER


					8110R61I4U

AMISULPRIDE

SUBSTRATE -> METABOLIC ENZYME


					NI7FZ38DO2

1-(((4-((7-METHOXY-6-(SULFOOXY)-4-QUINOLINYL)OXY)PHENYL)AMINO)CARBONYL)CYCLOPROPANECARBOXYLIC ACID

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					GFO928U8MQ

DISOPYRAMIDE

INHIBITOR -> TRANSPORTER


					7AM2J46Z1Y

TALIPEXOLE

INHIBITOR -> TRANSPORTER


					F1BC02I72W

CEPHRADINE

SUBSTRATE -> TRANSPORTER


					TK8ERE8P56

RIBOCICLIB

INHIBITOR -> METABOLIC ENZYME


					LW2E03M5PG

COBICISTAT

INHIBITOR -> TRANSPORTER


					RIX4E89Y14

LEVOFLOXACIN ANHYDROUS

INHIBITOR -> TRANSPORTER


					CJ0O37KU29

VERAPAMIL

INHIBITOR -> TRANSPORTER


					CK833KGX7E

AMPHETAMINE

SUBSTRATE -> TRANSPORTER


					76RS4S2ET1

RISDIPLAM

INHIBITOR -> TRANSPORTER

Comments:

IN VITRO


					3U6IO1965U

CHLORPHENIRAMINE

INHIBITOR -> TRANSPORTER


					ITX08688JL

QUINIDINE

INHIBITOR -> TRANSPORTER


					1WPE73O1WV

PRALSETINIB

INHIBITOR -> TRANSPORTER


					LYO9XZ250J

PLAZOMICIN

INHIBITOR -> TRANSPORTER


					TG537D343B

DESIPRAMINE

INHIBITOR -> TRANSPORTER


					8237F3U7EH

RUCAPARIB

INHIBITOR -> TRANSPORTER


					9100L32L2N

METFORMIN

INHIBITOR -> TRANSPORTER


					L39WTC366D

PROCAINAMIDE

INHIBITOR -> TRANSPORTER


					64O047KTOA

CETIRIZINE HYDROCHLORIDE

INHIBITOR -> TRANSPORTER


					OGG85SX4E4

IMIPRAMINE

INHIBITOR -> TRANSPORTER


					TY34L4F9OZ

CAPMATINIB

INHIBITOR -> TRANSPORTER

Interaction Type:

REVERSIBLE


					BZ114NVM5P

MITOXANTRONE

INHIBITOR -> TRANSPORTER


					886U3H6UFF

CHLOROQUINE

INHIBITOR -> TRANSPORTER


					P9G3CKZ4P5

GANCICLOVIR

SUBSTRATE -> TRANSPORTER


					8110R61I4U

AMISULPRIDE

INHIBITOR -> TRANSPORTER


					JFENOMOVE6

HUMAN LIVER

TISSUE EXPRESSION->TRANSPORTER


					939U7C91AI

SOLRIAMFETOL

INHIBITOR -> TRANSPORTER

Interaction Type:

WEAK

Qualification:

IC50

Amount:


					7LBRZUYSHU

BRANEBRUTINIB

INHIBITOR -> TRANSPORTER


					R865A5OY8J

CYPERQUAT

SUBSTRATE -> TRANSPORTER


					CEGM9YBNGD

SELPERCATINIB

INHIBITOR -> TRANSPORTER


					H012AL9PN0

DX-619

INHIBITOR -> TRANSPORTER


					80061L1WGD

CIMETIDINE

SUBSTRATE -> TRANSPORTER


					4V9848RS5G

TIRBANIBULIN

INHIBITOR -> TRANSPORTER

Comments:

The results suggest that KLISYRI has no clinically meaningful effect on the PK of drugs mediated by MATE1

Qualification:

IC50

Amount:


					6L1XP550I6

FEDRATINIB

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					80061L1WGD

CIMETIDINE

INHIBITOR -> TRANSPORTER


					4T36H88UA7

APALUTAMIDE

INHIBITOR -> TRANSPORTER


					262P8GS9L9

TAFENOQUINE

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					JU58VJ6Y3B

GUANIDINE

SUBSTRATE -> TRANSPORTER


					UU226QGU97

IMEGLIMIN

SUBSTRATE -> TRANSPORTER


					9100L32L2N

METFORMIN

SUBSTRATE -> TRANSPORTER


					OSP71S83EU

LORLATINIB

INHIBITOR -> TRANSPORTER


					L39WTC366D

PROCAINAMIDE

SUBSTRATE -> TRANSPORTER


					8GB79LOJ07

BICTEGRAVIR

INHIBITOR -> TRANSPORTER

Comments:

Co?administration of BIKTARVY with dofetilide may increase dofetilide plasma concentrations which can lead to serious and/or life threatening events.

Interaction Type:

CLINICALLY SIGNIFICANT

Qualification:

IC50

Amount:


					5E8K9I0O4U

CIPROFLOXACIN

INHIBITOR -> TRANSPORTER


					66D92MGC8M

GILTERITINIB

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					8GTS82S83M

DIPHENHYDRAMINE

INHIBITOR -> TRANSPORTER


					44RAL3456C

METHAMPHETAMINE

SUBSTRATE -> TRANSPORTER


					83619PEU5T

PRAMIPEXOLE

INHIBITOR -> TRANSPORTER


					K673DMO5H9

GLASDEGIB

INHIBITOR -> TRANSPORTER

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL