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Details

Stereochemistry ACHIRAL
Molecular Formula C10H16N6S
Molecular Weight 252.339
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of CIMETIDINE

SMILES

CNC(NCCSCC1=C(C)NC=N1)=NC#N

InChI

InChIKey=AQIXAKUUQRKLND-UHFFFAOYSA-N
InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)

HIDE SMILES / InChI
Molecular Formula C10H16N6S
Molecular Weight 252.339
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/cdi/cimetidine.html

Cimetidine is a histamine H2-receptor antagonist. It reduces basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. It is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Cimetidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Cimetidine include an increase in gastric bacterial flora such as nitrate-reducing organisms. Cimetidine binds to an H2-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.

CNS Activity

CNS Penetrant
2432
Curator's Comment: Enhanced cimetidine penetration of the blood brain barrier has been demonstrated in patients with liver disease.

Originator

Approval Year

1977
75
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2737
 70.0 nM [Ki]
Inhibitor
8146
 1.2 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8307
TAGAMET

Approved Use

Treating and preventing ulcers of the stomach and small intestine, and treating gastroesophageal reflux disease (GERD). It may be used for treating esophagitis (inflammation of the esophagus) caused by acid reflux and certain conditions that cause increased acid secretion (eg, Zollinger-Ellison syndrome).

Launch Date

8.0343361E11
Primary
Approved
8307
TAGAMET

Approved Use

Treating and preventing ulcers of the stomach and small intestine, and treating gastroesophageal reflux disease (GERD). It may be used for treating esophagitis (inflammation of the esophagus) caused by acid reflux and certain conditions that cause increased acid secretion (eg, Zollinger-Ellison syndrome).

Launch Date

8.0343361E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
1.056 μg/mL
OTHER GOV
https://www.accessdata.fda.gov/drugsatfda_docs/anda/98/75285_Cimetidine.pdf
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIMETIDINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
4.22 μg × h/mL
OTHER GOV
https://www.accessdata.fda.gov/drugsatfda_docs/anda/98/75285_Cimetidine.pdf
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIMETIDINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2.4 h
OTHER GOV
https://www.accessdata.fda.gov/drugsatfda_docs/anda/98/75285_Cimetidine.pdf
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIMETIDINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
1200 mg 1 times / day multiple, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1200 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
unhealthy, 50 years (range: 22-85 years)
n = 17
Health Status: unhealthy
Age Group: 50 years (range: 22-85 years)
Population Size: 17
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
Other AEs: Headache, Abdominal pain...
Other AEs:
Headache (2 patients)
Abdominal pain (2 patients)
Nausea (2 patients)
Anorexia (2 patients)
Vomiting (2 patients)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
20 g single, oral
Overdose
Dose: 20 g
Route: oral
Route: single
Dose: 20 g
Sources:
https://pubmed.ncbi.nlm.nih.gov/92705
unhealthy, adult
n = 3
Health Status: unhealthy
Age Group: adult
Population Size: 3
Sources:
https://pubmed.ncbi.nlm.nih.gov/92705
Sources:
https://pubmed.ncbi.nlm.nih.gov/92705
3 g 4 times / day multiple, oral
Overdose
Dose: 3 g, 4 times / day
Route: oral
Route: multiple
Dose: 3 g, 4 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/74598
unhealthy, adult
n = 1
Health Status: unhealthy
Condition: duodenal ulcer
Age Group: adult
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/74598
Sources:
https://pubmed.ncbi.nlm.nih.gov/74598
300 mg 4 times / day multiple, respiratory
Recommended
Dose: 300 mg, 4 times / day
Route: respiratory
Route: multiple
Dose: 300 mg, 4 times / day
Sources:
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4aa4ee5b-b5be-4a98-5b8c-6f75e2b59e51
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4aa4ee5b-b5be-4a98-5b8c-6f75e2b59e51
Sources:
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4aa4ee5b-b5be-4a98-5b8c-6f75e2b59e51
AEs

AEs

AESignificanceDosePopulation
Abdominal pain 2 patients
1200 mg 1 times / day multiple, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1200 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
unhealthy, 50 years (range: 22-85 years)
n = 17
Health Status: unhealthy
Age Group: 50 years (range: 22-85 years)
Population Size: 17
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
Anorexia 2 patients
1200 mg 1 times / day multiple, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1200 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
unhealthy, 50 years (range: 22-85 years)
n = 17
Health Status: unhealthy
Age Group: 50 years (range: 22-85 years)
Population Size: 17
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
Headache 2 patients
1200 mg 1 times / day multiple, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1200 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
unhealthy, 50 years (range: 22-85 years)
n = 17
Health Status: unhealthy
Age Group: 50 years (range: 22-85 years)
Population Size: 17
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
Nausea 2 patients
1200 mg 1 times / day multiple, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1200 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
unhealthy, 50 years (range: 22-85 years)
n = 17
Health Status: unhealthy
Age Group: 50 years (range: 22-85 years)
Population Size: 17
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
Vomiting 2 patients
1200 mg 1 times / day multiple, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1200 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
unhealthy, 50 years (range: 22-85 years)
n = 17
Health Status: unhealthy
Age Group: 50 years (range: 22-85 years)
Population Size: 17
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
inhibitor
1695
inhibitor
1789
inhibitor
1570

OverviewOther

Other InhibitorOther SubstrateOther Inducer
CYP1A2
1463

CYP3A4/5
261

CYP2C19
1410

MATE1
302

OCT2
630

OAT3
625

MATE2
259

OCT1
498
OAT3
328

MATE1
131

MATE2
93
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
OCT2
631
 yes [IC50 110 uM]
OCT1
513
 yes [IC50 149 uM]
CYP1A2
1620
 yes [IC50 200 uM]
CYP2D6
1826
 yes [IC50 210 uM]
CYP3A4/5
314
 yes [IC50 480 uM]
yes (co-administration study)
Comment: Coadministration with midazolam: [AUC(0-12)] and AUC(0-∞) values for midazolam were 507.0 ± 265.1 (40%) and 786.1 ± 365.2 (50%) nmol/mL · h, respectively;
Page: 4.0
OAT3
627
 yes [IC50 79 uM]
CYP2C9
1747
 yes [Inhibition 10 uM]
CYP2C19
1484
 yes [Ki 157.8 uM]
MATE2
259
 yes [Ki 2.1 uM]
MATE1
304
 yes [Ki 3.8 uM]
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
MATE1
131
 yes
MATE2
93
 yes
OAT3
328
 yes
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
hERG
1603
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:3699
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:3699
ChemicalBook
CB31086794
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB31086794
ChemicalBook
CB4229414
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB4229414
MolPort
MolPort-001-838-193
https://www.molport.com/shop/molecule-link/MolPort-001-838-193
MolPort
MolPort-003-895-998
https://www.molport.com/shop/molecule-link/MolPort-003-895-998
MolPort
MolPort-016-638-396
https://www.molport.com/shop/molecule-link/MolPort-016-638-396
MolPort
MolPort-020-313-426
https://www.molport.com/shop/molecule-link/MolPort-020-313-426
MolPort
MolPort-042-675-761
https://www.molport.com/shop/molecule-link/MolPort-042-675-761
Selleck Chemicals
Cimetidine(Tagamet)
http://www.selleckchem.com/products/Cimetidine(Tagamet).html
ZINC
ZINC000018115268
http://zinc15.docking.org/substances/ZINC000018115268
eMolecules
1107425
https://www.emolecules.com/cgi-bin/more?vid=1107425
eMolecules
19230646
https://www.emolecules.com/cgi-bin/more?vid=19230646
eMolecules
26714830
https://www.emolecules.com/cgi-bin/more?vid=26714830
eMolecules
6208997
https://www.emolecules.com/cgi-bin/more?vid=6208997
eMolecules
901649
https://www.emolecules.com/cgi-bin/more?vid=901649
PubMed

PubMed

TitleDatePubMed
[Cimetidine-induced aplastic anemia complicated with nonbacterial thrombotic endocarditis and cerebral infarction].
1990 Dec
[Confusion induced by the combination cimetidine-benzodiazepine; apropos of a case report].
1990 Jan
Polyuria and weight-loss associated with cimetidine.
1992 Sep
A case of cimetidine-induced acute tubulointerstitial nephritis associated with antineutrophil cytoplasmic antibody.
1999 Feb
Effects of H(2)-receptor antagonists on dapsone-induced methaemoglobinaemia in rats.
2002 Apr
Na+/H+ exchanger blockade inhibits enterocyte inflammatory response and protects against colitis.
2002 Jul
Induction of cardiac cytochrome p450 in cocaine-treated mice.
2002 Mar
Experimental anxiety induced by histaminergics in mast cell-deficient and congenitally normal mice.
2002 May
Histamine inhibits atrial myocytic ANP release via H2 receptor-cAMP-protein kinase signaling.
2003 Aug
Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3.
2004 May
Metabolism of territrem B and C in liver microsomes from 14-wk-old Wistar rats is catalyzed by cytochrome P-450 3A.
2005 Feb 27
Enhanced antinociception by intracerebroventricularly administered orexin A in histamine H1 or H2 receptor gene knockout mice.
2005 Nov
Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
2005 Nov
Feasibility of biowaiver extension to biopharmaceutics classification system class III drug products: cimetidine.
2006
In vitro availability of metformin in presence of h(2) receptor antagonists.
2006 Jan
[Usefulness of equations based on serum cystatin C concentration in the study of renal function].
2007
Visions of drug discovery. Cimetidine (Tagamet).
2009 Feb
Gastroprotective activity of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora Krause (Rutaceae).
2009 Jul 15
Pharmacokinetics of cimetidine in dogs after oral administration of cimetidine tablets.
2009 Jun
Enhanced ERbeta immunoexpression and apoptosis in the germ cells of cimetidine-treated rats.
2009 Nov 18
Novel approaches to inhibition of gastric acid secretion.
2010 Dec
Bioactivation of lamotrigine in vivo in rat and in vitro in human liver microsomes, hepatocytes, and epidermal keratinocytes: characterization of thioether conjugates by liquid chromatography/mass spectrometry and high field nuclear magnetic resonance spectroscopy.
2010 Jan
Two cases of h(2)-receptor antagonist hypersensitivity and cross-reactivity.
2011 Apr
Involvement of histaminergic receptor mechanisms in the stimulation of NT-3 synthesis in astrocytes.
2011 Jun
Patents

Patents

04093621
3
04140783
6
04255425
2
04267337
3
05075291
2
JP2003530301A
2
JP2007008845A
5
JP3292732B2
20
JP4732696B2
66
JPH01299274A
2
JPH0225468A
2
JPH0245416A
2
JPH0276859A
2
JPH08157354A
2
JPH08512055A
14
JPS56104868A
2
JPS57203071A
2
JPS58174370A
2
JPS58188860A
2
JPS5852213A
2
JPS63190872A
2
JPS63192757A
2

Sample Use Guides

In Vivo Use Guide
Usual Adult Dose for Duodenal Ulcer Parenteral: 300 mg IV or IM every 6 to 8 hours. Alternatively, a continuous IV infusion may be administered at a rate of 37.5 to 50 mg/hour, or up to a maximum rate of 100 mg/hour (2.4 g/day). Oral: 800 mg to 1600 mg once a day at bedtime. Alternatively, dosage regimens of 300 mg four times per day, with meals and at bedtime, or 400 mg twice daily, in the morning and at bedtime, have shown to be effective.
Route of Administration: Other
In Vitro Use Guide
Cimetidine (10(-7)M) inhibited IL-10 production and restored IL-12 secretion in LPS-treated murine DCs.
Substance Class Chemical
Created
by admin
on Fri Dec 16 18:23:13 UTC 2022
Edited
by admin
on Fri Dec 16 18:23:13 UTC 2022
Record UNII
80061L1WGD
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CIMETIDINE
EP   HSDB   INN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
USAN   INN  
Official Name English
CIMETIDINE [MI]
Common Name English
2-CYANO-1-METHYL-3-(2-(((5-METHYLIMIDAZOL-4-YL)METHYL)THIO)ETHYL)-GUANIDINE
Systematic Name English
CIMETIDINE [JAN]
Common Name English
CIMETIDINE [USAN]
Common Name English
BRUMETIDINA
Brand Name English
CIMETIDINE [IARC]
Common Name English
TAGAMET
Brand Name English
CIMAL
Brand Name English
CIMETIDINE [MART.]
Common Name English
ACINIL
Brand Name English
STOMEDINE
Brand Name English
DYSPAMET
Brand Name English
GASTROMET
Common Name English
Cimetidine [WHO-DD]
Common Name English
cimetidine [INN]
Common Name English
CIMETIDINUM [WHO-IP LATIN]
Common Name English
ULCEDIN
Brand Name English
ULCOMEDINA
Common Name English
CIMETIDINE [WHO-IP]
Common Name English
GUANIDINE, N''-CYANO-N-METHYL-N'-(2-(((5-METHYL-1H-IMIDAZOL-4-YL)METHYL)THIO)ETHYL)-
Systematic Name English
CIMETIDINE [HSDB]
Common Name English
SKF-92334
Code English
CIMETIDINE [USP-RS]
Common Name English
ULCIMET
Brand Name English
CIMETIDINE [USP MONOGRAPH]
Common Name English
ACILOC
Brand Name English
CIMETIDINE [VANDF]
Common Name English
CIMETIDINE [EP MONOGRAPH]
Common Name English
CIMETIDINE [ORANGE BOOK]
Common Name English
NSC-335308
Code English
Classification Tree Code System Code
NCI_THESAURUS C29702
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
WHO-VATC QA02BA01
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
NDF-RT N0000000151
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
WHO-VATC QA02BA51
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
LIVERTOX NBK548130
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
WHO-ATC A02BA01
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
WHO-ATC A02BA51
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
NDF-RT N0000175784
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
Code System Code Type Description
NSC
335308
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
INN
3765
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
CAS
51481-61-9
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
CHEBI
50362
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
RS_ITEM_NUM
1134062
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
NCI_THESAURUS
C374
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
CHEBI
3699
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
MESH
D002927
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
MERCK INDEX
M3552
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY Merck Index
EPA CompTox
DTXSID4020329
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
EVMPD
SUB06279MIG
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
WIKIPEDIA
CIMETIDINE
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
LACTMED
Cimetidine
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
RXCUI
2541
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY RxNorm
HSDB
3917
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
ChEMBL
CHEMBL30
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
FDA UNII
80061L1WGD
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
IUPHAR
1231
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
DRUG BANK
DB00501
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
CIMETIDINE
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY Description: A white to off-white powder; odourless or with a faint odour.Solubility: Sparingly soluble in water; very soluble in methanol R.Category: Antiulcer drug.Storage: Cimetidine should be kept in a well-closed container.
PUBCHEM
2756
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
ECHA (EC/EINECS)
257-232-2
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
DAILYMED
80061L1WGD
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
DRUG CENTRAL
645
Created by admin on Fri Dec 16 18:23:13 UTC 2022 , Edited by admin on Fri Dec 16 18:23:13 UTC 2022
PRIMARY
Related Record Type Details
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
OCT-1
TRANSPORTER -> SUBSTRATE
OAT-3
TRANSPORTER -> SUBSTRATE
OCT-2
TRANSPORTER -> SUBSTRATE
MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1
TRANSPORTER -> SUBSTRATE
Vmax
MATE-2
TRANSPORTER -> SUBSTRATE
Vmax
CYTOCHROME P450 1A2
METABOLIC ENZYME -> INHIBITOR
POTENT
MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1
TRANSPORTER -> INHIBITOR
CYTOCHROME P450 2D6
METABOLIC ENZYME -> INHIBITOR
POTENT
MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1
TRANSPORTER -> SUBSTRATE
Km
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> SUBSTRATE
MATE-2
TRANSPORTER -> SUBSTRATE
Km
MATE-2
TRANSPORTER -> INHIBITOR
OCT-3
TRANSPORTER -> SUBSTRATE
OCT-1
TRANSPORTER -> INHIBITOR
OAT-3
TRANSPORTER -> INHIBITOR
HISTAMINE H2 RECEPTOR
TARGET -> INHIBITOR
OCT-2
TRANSPORTER -> INHIBITOR
Related Record Type Details
Structure of CIMETIDINE HYDROXYMETHYL
METABOLITE -> PARENT
Structure of CIMETIDINE SULFOXIDE
METABOLITE -> PARENT
MAJOR
URINE
Related Record Type Details
Structure of CIMETIDINE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC
NIH
NCATS
PRIVACY ACT
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