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Details

Stereochemistry ACHIRAL
Molecular Formula C10H16N6S
Molecular Weight 252.3407
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CIMETIDINE

SMILES

Cc1c(CSCCNC(=NC)NC#N)[nH]cn1

InChI

InChIKey=AQIXAKUUQRKLND-UHFFFAOYSA-N
InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)

HIDE SMILES / InChI
Molecular Formula C10H16N6S
Molecular Weight 252.3407
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: https://www.drugs.com/cdi/cimetidine.html

Cimetidine is a histamine H2-receptor antagonist. It reduces basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. It is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Cimetidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Cimetidine include an increase in gastric bacterial flora such as nitrate-reducing organisms. Cimetidine binds to an H2-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.

CNS Activity

CNS Penetrant
2415
Curator's Comment:: Enhanced cimetidine penetration of the blood brain barrier has been demonstrated in patients with liver disease.

Originator

Approval Year

1977
71
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2577
Stomach Ulcer
Gastroesophageal reflux disease
 70 nM [Ki]
Inhibitor
7701
 1.19999999999999996 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Histamine H2 receptor
Approved
7997
TAGAMET

Approved Use

Treating and preventing ulcers of the stomach and small intestine, and treating gastroesophageal reflux disease (GERD). It may be used for treating esophagitis (inflammation of the esophagus) caused by acid reflux and certain conditions that cause increased acid secretion (eg, Zollinger-Ellison syndrome).

Launch Date

803433600000
Primary
Histamine H2 receptor
Approved
7997
TAGAMET

Approved Use

Treating and preventing ulcers of the stomach and small intestine, and treating gastroesophageal reflux disease (GERD). It may be used for treating esophagitis (inflammation of the esophagus) caused by acid reflux and certain conditions that cause increased acid secretion (eg, Zollinger-Ellison syndrome).

Launch Date

803433600000
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
1.056 μg/mL
OTHER GOV
https://www.accessdata.fda.gov/drugsatfda_docs/anda/98/75285_Cimetidine.pdf
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIMETIDINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
4.22 μg × h/mL
OTHER GOV
https://www.accessdata.fda.gov/drugsatfda_docs/anda/98/75285_Cimetidine.pdf
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIMETIDINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2.4 h
OTHER GOV
https://www.accessdata.fda.gov/drugsatfda_docs/anda/98/75285_Cimetidine.pdf
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIMETIDINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
1200 mg 1 times / day multiple, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1200 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
unhealthy, 50 years (range: 22-85 years)
Health Status: unhealthy
Age Group: 50 years (range: 22-85 years)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
Other AEs: Headache, Abdominal pain...
Other AEs:
Headache (2 patients)
Abdominal pain (2 patients)
Nausea (2 patients)
Anorexia (2 patients)
Vomiting (2 patients)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
20 g single, oral
Overdose
Dose: 20 g
Route: oral
Route: single
Dose: 20 g
Sources:
https://pubmed.ncbi.nlm.nih.gov/92705
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
https://pubmed.ncbi.nlm.nih.gov/92705
Sources:
https://pubmed.ncbi.nlm.nih.gov/92705
3 g 4 times / day multiple, oral
Overdose
Dose: 3 g, 4 times / day
Route: oral
Route: multiple
Dose: 3 g, 4 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/74598
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/74598
Sources:
https://pubmed.ncbi.nlm.nih.gov/74598
300 mg 4 times / day multiple, respiratory
Recommended
Dose: 300 mg, 4 times / day
Route: respiratory
Route: multiple
Dose: 300 mg, 4 times / day
Sources:
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4aa4ee5b-b5be-4a98-5b8c-6f75e2b59e51
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4aa4ee5b-b5be-4a98-5b8c-6f75e2b59e51
Sources:
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4aa4ee5b-b5be-4a98-5b8c-6f75e2b59e51
AEs

AEs

AESignificanceDosePopulation
Abdominal pain 2 patients
1200 mg 1 times / day multiple, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1200 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
unhealthy, 50 years (range: 22-85 years)
Health Status: unhealthy
Age Group: 50 years (range: 22-85 years)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
Anorexia 2 patients
1200 mg 1 times / day multiple, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1200 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
unhealthy, 50 years (range: 22-85 years)
Health Status: unhealthy
Age Group: 50 years (range: 22-85 years)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
Headache 2 patients
1200 mg 1 times / day multiple, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1200 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
unhealthy, 50 years (range: 22-85 years)
Health Status: unhealthy
Age Group: 50 years (range: 22-85 years)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
Nausea 2 patients
1200 mg 1 times / day multiple, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1200 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
unhealthy, 50 years (range: 22-85 years)
Health Status: unhealthy
Age Group: 50 years (range: 22-85 years)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
Vomiting 2 patients
1200 mg 1 times / day multiple, oral
Highest studied dose
Dose: 1200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1200 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
unhealthy, 50 years (range: 22-85 years)
Health Status: unhealthy
Age Group: 50 years (range: 22-85 years)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3520794
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
inhibitor
1318
inhibitor
1421
inhibitor
1360

OverviewOther

Other InhibitorOther SubstrateOther Inducer
CYP1A2
1268

CYP3A4/5
225

CYP2C19
1215

MATE1
290

OCT2
582

OAT3
570

MATE2
258

OCT1
473
OAT3
299

MATE1
123

MATE2
91
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
OCT2
583
 yes [IC50 110 uM]
OCT1
488
 yes [IC50 149 uM]
CYP1A2
1406
 yes [IC50 200 uM]
CYP2D6
1455
 yes [IC50 210 uM]
CYP3A4/5
277
 yes [IC50 480 uM]
yes (co-administration study)
Comment: Coadministration with midazolam: [AUC(0-12)] and AUC(0-∞) values for midazolam were 507.0 ± 265.1 (40%) and 786.1 ± 365.2 (50%) nmol/mL · h, respectively;
Page: 4
OAT3
572
 yes [IC50 79 uM]
CYP2C9
1362
 yes [Inhibition 10 uM]
CYP2C19
1277
 yes [Ki 157.8 uM]
MATE2
258
 yes [Ki 2.1 uM]
MATE1
291
 yes [Ki 3.8 uM]
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
MATE1
123
 yes
MATE2
91
 yes
OAT3
299
 yes
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
hERG
1392
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:3699
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:3699
MolPort
MolPort-001-838-193
https://www.molport.com/shop/molecule-link/MolPort-001-838-193
MolPort
MolPort-002-542-886
https://www.molport.com/shop/molecule-link/MolPort-002-542-886
MolPort
MolPort-003-895-998
https://www.molport.com/shop/molecule-link/MolPort-003-895-998
MolPort
MolPort-006-167-560
https://www.molport.com/shop/molecule-link/MolPort-006-167-560
MolPort
MolPort-016-638-396
https://www.molport.com/shop/molecule-link/MolPort-016-638-396
MolPort
MolPort-020-313-426
https://www.molport.com/shop/molecule-link/MolPort-020-313-426
MolPort
MolPort-042-675-761
https://www.molport.com/shop/molecule-link/MolPort-042-675-761
ZINC
ZINC000018115268
http://zinc15.docking.org/substances/ZINC000018115268
PubMed

PubMed

TitleDatePubMed
[Cimetidine-induced aplastic anemia complicated with nonbacterial thrombotic endocarditis and cerebral infarction].
1990 Dec
Effects of antihistaminics on locomotor activity in mice. Comparison with opiate and amphetamine-induced hyperactivity.
1991
Nifedipine versus cimetidine in prevention of stress-induced gastric ulcers in rats.
1991 Jan 3
Diphenhydramine prevents the haemodynamic changes of cimetidine in ICU patients.
1991 Mar
Cimetidine-dobutamine interaction?
1992 Nov
Cimetidine and a delayed hypersensitivity reaction.
2000 Apr
Nephrotoxicity and hepatotoxicity of histamine H2 receptor antagonists.
2001 Jan
Cimetidine-induced dystonic reaction.
2001 Jul
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
2001 May
Induction of cardiac cytochrome p450 in cocaine-treated mice.
2002 Mar
Experimental anxiety induced by histaminergics in mast cell-deficient and congenitally normal mice.
2002 May
Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells.
2002 Oct
Activity of cathepsin B, D and L in rat cerebrum after cimetidine and famotidine administration.
2003
Bioequivalence and other unresolved issues in generic drug substitution.
2003 Nov
Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A).
2004 Oct 25
Metabolism of territrem B and C in liver microsomes from 14-wk-old Wistar rats is catalyzed by cytochrome P-450 3A.
2005 Feb 27
Comparative study of the speed of acid-suppressing effects of oral administration of cimetidine and famotidine.
2005 Jul
Alteration of intracellular histamine H2 receptor cycling precedes antagonist-induced upregulation.
2005 Nov
Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1.
2005 Oct 1
Effects of histamine 2 receptor antagonists on endothelial-neutrophil adhesion and surface expression of endothelial adhesion molecules induced by high glucose levels.
2007 Jan-Feb
Cimetidine inhibits epidermal growth factor-induced cell signaling.
2007 Mar
Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells.
2009 Apr
Ameliorative effects of histamine on spatial memory deficits induced by scopolamine infusion into bilateral dorsal or ventral hippocampus as evaluated by the radial arm maze task.
2009 Aug
Ocular surface tumors.
2009 Jan
Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selection.
2009 Jun
Antiulcer and anticonvulsant activity of Croton zambesicus.
2009 Oct
Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney.
2010
Novel approaches to inhibition of gastric acid secretion.
2010 Dec
Bioactivation of lamotrigine in vivo in rat and in vitro in human liver microsomes, hepatocytes, and epidermal keratinocytes: characterization of thioether conjugates by liquid chromatography/mass spectrometry and high field nuclear magnetic resonance spectroscopy.
2010 Jan
Drug interaction and pharmacist.
2010 Jul
Cimetidine induces apoptosis in gastric cancer cells in vitro and inhibits tumor growth in vivo.
2010 Mar
Two cases of h(2)-receptor antagonist hypersensitivity and cross-reactivity.
2011 Apr
OCT1 Expression in adipocytes could contribute to increased metformin action in obese subjects.
2011 Jan
Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin E₂.
2011 Jan 15
Involvement of histaminergic receptor mechanisms in the stimulation of NT-3 synthesis in astrocytes.
2011 Jun
Patents

Patents

04093621
3
04140783
6
04255425
2
04267337
3
05075291
2
JP2003530301A
2
JP2007008845A
5
JP3292732B2
14
JP4732696B2
63
JPH01299274A
2
JPH0225468A
2
JPH0245416A
2
JPH0276859A
2
JPH08157354A
2
JPH08512055A
14
JPS56104868A
2
JPS57203071A
2
JPS58174370A
2
JPS58188860A
2
JPS5852213A
2
JPS63190872A
2
JPS63192757A
2

Sample Use Guides

In Vivo Use Guide
Usual Adult Dose for Duodenal Ulcer
Route of Administration: Other
In Vitro Use Guide
Cimetidine (10(-7)M) inhibited IL-10 production and restored IL-12 secretion in LPS-treated murine DCs.
Substance Class Chemical
Created
by admin
on Fri Jun 25 20:52:14 UTC 2021
Edited
by admin
on Fri Jun 25 20:52:14 UTC 2021
Record UNII
80061L1WGD
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CIMETIDINE
EP   HSDB   INN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
USAN   INN  
Official Name English
CIMETIDINE [MI]
Common Name English
2-CYANO-1-METHYL-3-(2-(((5-METHYLIMIDAZOL-4-YL)METHYL)THIO)ETHYL)-GUANIDINE
Systematic Name English
CIMETIDINE [JAN]
Common Name English
CIMETIDINE [USAN]
Common Name English
BRUMETIDINA
Brand Name English
CIMETIDINE [IARC]
Common Name English
TAGAMET
Brand Name English
CIMAL
Brand Name English
CIMETIDINE [MART.]
Common Name English
ACINIL
Brand Name English
STOMEDINE
Brand Name English
CIMETIDINE [WHO-DD]
Common Name English
DYSPAMET
Brand Name English
GASTROMET
Common Name English
CIMETIDINE [INN]
Common Name English
CIMETIDINUM [WHO-IP LATIN]
Common Name English
ULCEDIN
Brand Name English
ULCOMEDINA
Common Name English
CIMETIDINE [WHO-IP]
Common Name English
GUANIDINE, N''-CYANO-N-METHYL-N'-(2-(((5-METHYL-1H-IMIDAZOL-4-YL)METHYL)THIO)ETHYL)-
Systematic Name English
CIMETIDINE [HSDB]
Common Name English
SKF-92334
Code English
CIMETIDINE [USP-RS]
Common Name English
ULCIMET
Brand Name English
CIMETIDINE [USP MONOGRAPH]
Common Name English
ACILOC
Brand Name English
CIMETIDINE [VANDF]
Common Name English
CIMETIDINE [EP MONOGRAPH]
Common Name English
CIMETIDINE [ORANGE BOOK]
Common Name English
NSC-335308
Code English
Classification Tree Code System Code
NCI_THESAURUS C29702
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
WHO-VATC QA02BA01
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
NDF-RT N0000000151
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
WHO-VATC QA02BA51
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
LIVERTOX 209
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
WHO-ATC A02BA01
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
WHO-ATC A02BA51
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
NDF-RT N0000175784
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
Code System Code Type Description
INN
3765
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
CAS
51481-61-9
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
NCI_THESAURUS
C374
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
MESH
D002927
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
MERCK INDEX
M3552
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY Merck Index
EPA CompTox
51481-61-9
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
EVMPD
SUB06279MIG
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
WIKIPEDIA
CIMETIDINE
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
LACTMED
Cimetidine
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
RXCUI
2541
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY RxNorm
HSDB
3917
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
ChEMBL
CHEMBL30
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
FDA UNII
80061L1WGD
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
IUPHAR
1231
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
DRUG BANK
DB00501
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
CIMETIDINE
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY Description: A white to off-white powder; odourless or with a faint odour.Solubility: Sparingly soluble in water; very soluble in methanol R.Category: Antiulcer drug.Storage: Cimetidine should be kept in a well-closed container.
PUBCHEM
2756
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
ECHA (EC/EINECS)
257-232-2
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
USP_CATALOG
1134062
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY USP-RS
DRUG CENTRAL
645
Created by admin on Fri Jun 25 20:52:14 UTC 2021 , Edited by admin on Fri Jun 25 20:52:14 UTC 2021
PRIMARY
Related Record Type Details
OAT-3
TRANSPORTER -> INHIBITOR
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
OCT-1
TRANSPORTER -> SUBSTRATE
CYTOCHROME P450 1A2
METABOLIC ENZYME -> INHIBITOR
POTENT
OCT-3
TRANSPORTER -> SUBSTRATE
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> SUBSTRATE
OAT-3
TRANSPORTER -> SUBSTRATE
CYTOCHROME P450 2D6
METABOLIC ENZYME -> INHIBITOR
POTENT
MATE-2
TRANSPORTER -> INHIBITOR
MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1
TRANSPORTER -> SUBSTRATE
Vmax
MATE-2
TRANSPORTER -> SUBSTRATE
Vmax
MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1
TRANSPORTER -> SUBSTRATE
Km
MATE-2
TRANSPORTER -> SUBSTRATE
Km
OCT-2
TRANSPORTER -> SUBSTRATE
MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1
TRANSPORTER -> INHIBITOR
OCT-1
TRANSPORTER -> INHIBITOR
OCT-2
TRANSPORTER -> INHIBITOR
HISTAMINE H2 RECEPTOR
TARGET -> INHIBITOR
Related Record Type Details
Structure of CIMETIDINE HYDROXYMETHYL
METABOLITE -> PARENT
Structure of CIMETIDINE SULFOXIDE
METABOLITE -> PARENT
MAJOR
URINE
Related Record Type Details
Structure of CIMETIDINE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC
NIH
NCATS
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