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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 18:33:56 GMT 2025
Edited
by admin
on Tue Apr 01 18:33:56 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
28XBT591QG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HISTAMINE H1 RECEPTOR
Common Name English
H1R
Preferred Name English
HRH1
Common Name English
H1
Common Name English
HH1R
Common Name English
Code System Code Type Description
UNIPROT
P35367
Created by admin on Tue Apr 01 18:33:56 GMT 2025 , Edited by admin on Tue Apr 01 18:33:56 GMT 2025
PRIMARY
FDA UNII
28XBT591QG
Created by admin on Tue Apr 01 18:33:56 GMT 2025 , Edited by admin on Tue Apr 01 18:33:56 GMT 2025
PRIMARY
From To
1_100 1_180
1_441 1_444
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_5
N 1_18
Related Record Type Details
Structure of MECLIZINE
INHIBITOR -> TARGET
Structure of Pyrilamine H-3
RADIOLIGAND->TARGET
Kd
Structure of RISPERIDONE
INHIBITOR -> TARGET
INHIBITOR
Ki
Structure of LATREPIRDINE
INHIBITOR -> TARGET
IC50
Structure of DOXYLAMINE
INHIBITOR -> TARGET
Structure of HISTAMINE
AGONIST -> TARGET
CHO-H1 cells, histamine stimulation resulted in a concentration-dependent increase in [Ca2+]i with an EC50 of 170±30 nM.
EC50
Structure of QUETIAPINE
INHIBITOR -> TARGET
Ki
Structure of BAMIRASTINE
INHIBITOR -> TARGET
Structure of NBI-2 (NON-LABELED)
INHIBITOR -> TARGET
Structure of VAPITADINE
INHIBITOR -> TARGET
Structure of NBI-2
INHIBITOR -> TARGET
Structure of TIAPRIDE
INHIBITOR -> TARGET
Structure of FEXOFENADINE
INHIBITOR -> TARGET
Structure of TRIPELENNAMINE
INHIBITOR -> TARGET
Structure of CYCLIZINE
INHIBITOR -> TARGET
Structure of MIZOLASTINE
INHIBITOR -> TARGET
Structure of TECASTEMIZOLE
INHIBITOR -> TARGET
Structure of PF-05150122
INHIBITOR->OFF-TARGET
IC50
Structure of MEQUITAZINE
INHIBITOR -> TARGET
Structure of NBI-1
INHIBITOR -> TARGET
Structure of 6-FLUORO-DMT
AGONIST -> TARGET
Structure of LY-2624803
INHIBITOR -> TARGET
Structure of PHENINDAMINE
INHIBITOR -> TARGET
Structure of RUPATADINE
INHIBITOR -> TARGET
Structure of OLOPATADINE
INHIBITOR -> TARGET
Structure of DEXCHLORPHENIRAMINE
INHIBITOR -> TARGET
Structure of PROMETHAZINE
INHIBITOR -> TARGET
Structure of CIMETIDINE
AGONIST -> TARGET
IC50
Structure of AZATADINE
INHIBITOR -> TARGET
Structure of PROPIOMAZINE
INHIBITOR -> TARGET
Structure of NBI-75043
INHIBITOR -> TARGET
Structure of AZELASTINE
INHIBITOR -> TARGET
Structure of PHENYLTOLOXAMINE
INHIBITOR -> TARGET
Structure of CYPROHEPTADINE
INHIBITOR -> TARGET
Structure of NBI-4
INHIBITOR -> TARGET
Structure of ASTEMIZOLE
INHIBITOR -> TARGET
Structure of CHLORPROMAZINE
INHIBITOR -> TARGET
Structure of EFLETIRIZINE
INHIBITOR -> TARGET
Structure of PALIPERIDONE
INHIBITOR -> TARGET
INHIBITOR
Ki
Structure of HYDROXYZINE
INHIBITOR -> TARGET
Structure of BROMPHENIRAMINE
INHIBITOR -> TARGET
Structure of EMBRAMINE
INHIBITOR -> TARGET
Structure of SUN-1334
INHIBITOR -> TARGET
Structure of NBI-4 (NON-LABELED)
INHIBITOR -> TARGET
Structure of REN-1869
INHIBITOR -> TARGET
Structure of TAGORIZINE
INHIBITOR -> TARGET
Structure of DEXBROMPHENIRAMINE
INHIBITOR -> TARGET
Structure of MIRTAZAPINE
INHIBITOR -> TARGET
Structure of NBI-3
INHIBITOR -> TARGET
Structure of GSK-1004723
INHIBITOR -> TARGET
Long acting slowly dissociates.
BINDING
Ki
Structure of ESMIRTAZAPINE
INHIBITOR -> TARGET
Structure of PHENIRAMINE
INHIBITOR -> TARGET
Structure of ORPHENADRINE
INHIBITOR -> TARGET
Structure of EBASTINE
INHIBITOR -> TARGET
Structure of EPINASTINE
ANTAGONIST->TARGET
Structure of DIMENHYDRINATE
INHIBITOR -> TARGET
Structure of Norquetiapine
INHIBITOR -> TARGET
Ki
Structure of MAPINASTINE
INHIBITOR -> TARGET
Structure of BUCLIZINE
INHIBITOR -> TARGET
Structure of DIPHENHYDRAMINE
INHIBITOR -> TARGET
Structure of CARBINOXAMINE
INHIBITOR -> TARGET
Structure of CETIRIZINE
INHIBITOR -> TARGET
DOXEPIN
INHIBITOR -> TARGET
Structure of Desloratadine
INHIBITOR -> TARGET
Structure of ALCAFTADINE
AGONIST -> TARGET
Alcaftadine is a H1 histamine receptor antagonist and inhibitor of the release of histamine from mast cells.
Structure of LEVOCETIRIZINE
INHIBITOR -> TARGET
Structure of NBI-3 (NON-LABELED)
INHIBITOR -> TARGET
Structure of CHLORPHENIRAMINE
INHIBITOR -> TARGET
Structure of DIMETHINDENE
INHIBITOR -> TARGET
Structure of CLEMASTINE
INHIBITOR -> TARGET
Structure of AZD-3778
INHIBITOR -> TARGET
Structure of TRIPROLIDINE
INHIBITOR -> TARGET
Structure of PYRILAMINE
INHIBITOR -> TARGET
Structure of UR-AK49
AGONIST -> TARGET
Structure of ACRIVASTINE
TARGET -> INHIBITOR
Structure of LEVOMEQUITAZINE
INHIBITOR -> TARGET
Binds stronger than R-isomer
Structure of BEPOTASTINE
INHIBITOR -> TARGET
Structure of BILASTINE
INHIBITOR -> TARGET
Structure of LORATADINE
INHIBITOR -> TARGET
Structure of BROMODIPHENHYDRAMINE
INHIBITOR -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_140] [1_142] [1_279] THREONINE PHOSPHATE 3L4WX7B1EI
AMINO ACID SUBSTITUTION [1_344] [1_347] [1_380] [1_396] [1_398] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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