U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C19H24N2
Molecular Weight 280.4073
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IMIPRAMINE

SMILES

CN(C)CCCN1C2=C(CCC3=C1C=CC=C3)C=CC=C2

InChI

InChIKey=BCGWQEUPMDMJNV-UHFFFAOYSA-N
InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C19H24N2
Molecular Weight 280.4073
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/087846s028,087844s027,087845s027lbl.pdf

Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin. A tertiary amine, imipramine inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally. With chronic use, imipramine also down-regulates cerebral cortical β-adrenergic receptors and sensitizes post-synaptic sertonergic receptors, which also contributes to increased serotonergic transmission. It takes approximately 2 - 4 weeks for antidepressants effects to occur. The onset of action may be longer, up to 8 weeks, in some individuals. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack. Imipramine works by inhibiting the neuronal reuptake of the neurotransmitters norepinephrine and serotonin. It binds the sodium-dependent serotonin transporter and sodium-dependent norepinephrine transporter preventing or reducing the reuptake of norepinephrine and serotonin by nerve cells. Depression has been linked to a lack of stimulation of the post-synaptic neuron by norepinephrine and serotonin. Slowing the reuptake of these neurotransmitters increases their concentration in the synaptic cleft, which is thought to contribute to relieving symptoms of depression. In addition to acutely inhibiting neurotransmitter re-uptake, imipramine causes down-regulation of cerebral cortical beta-adrenergic receptors and sensitization of post-synaptic serotonergic receptors with chronic use. This leads to enhanced serotonergic transmission. Used for relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older. May also be used to manage panic disorders, with or without agoraphobia, as a second line agent in ADHD, management of eating disorders, for short-term management of acute depressive episodes in bipolar disorder and schizophrenia, and for symptomatic treatment of postherpetic neuralgia.

CNS Activity

Curator's Comment: CNS active and penetrant http://onlinelibrary.wiley.com/doi/10.1016/S0009-9236(03)90534-0/abstract;jsessionid=0501D49064CCA6E885143C367F1535B3.f02t02

Originator

Curator's Comment: Roland Kuhn, Swiss psychiatrist, discovered the therapeutic affect of imipramine in depression in 1957 http://www.cinp.org/wp-content/uploads/2015/06/history1.pdf

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P27169
Gene ID: 5444.0
Gene Symbol: PON1
Target Organism: Homo sapiens (Human)
12.0 nM [Ki]
3.2 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Tofranil

Approved Use

Tofranil is used for: Treating depression. It is also used in some children to help reduce bedwetting. It may also be used for other conditions as determined by your doctor.

Launch Date

4.5394559E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
107 μg/L
130 mg 1 times / day steady-state, oral
dose: 130 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered: Desipramine
IMIPRAMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
24.5 ng/mL
50 mg single, oral
dose: 50 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
IMIPRAMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
427 ng × h/mL
50 mg single, oral
dose: 50 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
IMIPRAMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
12 h
130 mg 1 times / day steady-state, oral
dose: 130 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered: Desipramine
IMIPRAMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
21.1 h
50 mg single, oral
dose: 50 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
IMIPRAMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
22%
130 mg 1 times / day steady-state, oral
dose: 130 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered: Desipramine
IMIPRAMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
200 mg/day 1 times / day steady, oral
Dose: 200 mg/day, 1 times / day
Route: oral
Route: steady
Dose: 200 mg/day, 1 times / day
Sources:
unhealthy, 18-70 years
n = 82
Health Status: unhealthy
Condition: major depression | melancholia
Age Group: 18-70 years
Population Size: 82
Sources:
Disc. AE: Nausea...
AEs leading to
discontinuation/dose reduction:
Nausea (1 patient)
Sources:
25 mg/day 1 times / day steady, oral
Dose: 25 mg/day, 1 times / day
Route: oral
Route: steady
Dose: 25 mg/day, 1 times / day
Sources:
unhealthy, 42.6 ± 12.4 years
n = 59
Health Status: unhealthy
Condition: irritable bowel syndrome
Age Group: 42.6 ± 12.4 years
Sex: M+F
Population Size: 59
Sources:
Disc. AE: Sleep disturbance, Urinary tract signs and symptoms NEC...
AEs leading to
discontinuation/dose reduction:
Sleep disturbance (3 patients)
Urinary tract signs and symptoms NEC (2 patients)
Palpitations (2 patients)
Anxiety (1 patient)
Dry mouth (1 patient)
Dizziness (3 patients)
Flushing (1 patient)
Constipation (1 patient)
Sources:
75 mg/day 1 times / day steady, oral (starting)
Recommended
Dose: 75 mg/day, 1 times / day
Route: oral
Route: steady
Dose: 75 mg/day, 1 times / day
Sources:
unhealthy, < 24 years
Health Status: unhealthy
Condition: depression
Age Group: < 24 years
Sources:
Disc. AE: Suicidal ideation...
AEs leading to
discontinuation/dose reduction:
Suicidal ideation (grade 5)
Sources:
AEs

AEs

AESignificanceDosePopulation
Nausea 1 patient
Disc. AE
200 mg/day 1 times / day steady, oral
Dose: 200 mg/day, 1 times / day
Route: oral
Route: steady
Dose: 200 mg/day, 1 times / day
Sources:
unhealthy, 18-70 years
n = 82
Health Status: unhealthy
Condition: major depression | melancholia
Age Group: 18-70 years
Population Size: 82
Sources:
Anxiety 1 patient
Disc. AE
25 mg/day 1 times / day steady, oral
Dose: 25 mg/day, 1 times / day
Route: oral
Route: steady
Dose: 25 mg/day, 1 times / day
Sources:
unhealthy, 42.6 ± 12.4 years
n = 59
Health Status: unhealthy
Condition: irritable bowel syndrome
Age Group: 42.6 ± 12.4 years
Sex: M+F
Population Size: 59
Sources:
Constipation 1 patient
Disc. AE
25 mg/day 1 times / day steady, oral
Dose: 25 mg/day, 1 times / day
Route: oral
Route: steady
Dose: 25 mg/day, 1 times / day
Sources:
unhealthy, 42.6 ± 12.4 years
n = 59
Health Status: unhealthy
Condition: irritable bowel syndrome
Age Group: 42.6 ± 12.4 years
Sex: M+F
Population Size: 59
Sources:
Dry mouth 1 patient
Disc. AE
25 mg/day 1 times / day steady, oral
Dose: 25 mg/day, 1 times / day
Route: oral
Route: steady
Dose: 25 mg/day, 1 times / day
Sources:
unhealthy, 42.6 ± 12.4 years
n = 59
Health Status: unhealthy
Condition: irritable bowel syndrome
Age Group: 42.6 ± 12.4 years
Sex: M+F
Population Size: 59
Sources:
Flushing 1 patient
Disc. AE
25 mg/day 1 times / day steady, oral
Dose: 25 mg/day, 1 times / day
Route: oral
Route: steady
Dose: 25 mg/day, 1 times / day
Sources:
unhealthy, 42.6 ± 12.4 years
n = 59
Health Status: unhealthy
Condition: irritable bowel syndrome
Age Group: 42.6 ± 12.4 years
Sex: M+F
Population Size: 59
Sources:
Palpitations 2 patients
Disc. AE
25 mg/day 1 times / day steady, oral
Dose: 25 mg/day, 1 times / day
Route: oral
Route: steady
Dose: 25 mg/day, 1 times / day
Sources:
unhealthy, 42.6 ± 12.4 years
n = 59
Health Status: unhealthy
Condition: irritable bowel syndrome
Age Group: 42.6 ± 12.4 years
Sex: M+F
Population Size: 59
Sources:
Urinary tract signs and symptoms NEC 2 patients
Disc. AE
25 mg/day 1 times / day steady, oral
Dose: 25 mg/day, 1 times / day
Route: oral
Route: steady
Dose: 25 mg/day, 1 times / day
Sources:
unhealthy, 42.6 ± 12.4 years
n = 59
Health Status: unhealthy
Condition: irritable bowel syndrome
Age Group: 42.6 ± 12.4 years
Sex: M+F
Population Size: 59
Sources:
Dizziness 3 patients
Disc. AE
25 mg/day 1 times / day steady, oral
Dose: 25 mg/day, 1 times / day
Route: oral
Route: steady
Dose: 25 mg/day, 1 times / day
Sources:
unhealthy, 42.6 ± 12.4 years
n = 59
Health Status: unhealthy
Condition: irritable bowel syndrome
Age Group: 42.6 ± 12.4 years
Sex: M+F
Population Size: 59
Sources:
Sleep disturbance 3 patients
Disc. AE
25 mg/day 1 times / day steady, oral
Dose: 25 mg/day, 1 times / day
Route: oral
Route: steady
Dose: 25 mg/day, 1 times / day
Sources:
unhealthy, 42.6 ± 12.4 years
n = 59
Health Status: unhealthy
Condition: irritable bowel syndrome
Age Group: 42.6 ± 12.4 years
Sex: M+F
Population Size: 59
Sources:
Suicidal ideation grade 5
Disc. AE
75 mg/day 1 times / day steady, oral (starting)
Recommended
Dose: 75 mg/day, 1 times / day
Route: oral
Route: steady
Dose: 75 mg/day, 1 times / day
Sources:
unhealthy, < 24 years
Health Status: unhealthy
Condition: depression
Age Group: < 24 years
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG



OverviewOther

Drug as perpetrator​

Drug as perpetrator​

Drug as victimTox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
Imipramine toxicity.
1975 Sep
Pediatric cardiovascular effects of imipramine and desipramine.
1991 Jan
Rabbit syndrome, antidepressant use, and cerebral perfusion SPECT scan findings.
1991 Nov
[Clinical-pharmacological case report: drug-induced inappropriate ADH secretion].
1992 Nov 17
The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation.
1999
The effect of therapeutic drugs and other pharmacologic agents on activity of porphobilinogen deaminase, the enzyme that is deficient in intermittent acute porphyria.
1999
Identification of a novel splice variant of heat shock cognate protein 70 after chronic antidepressant treatment in rat frontal cortex.
1999 Aug 2
Gabapentin therapy for cocaine cravings.
2000 Dec
Antidepressant drugs appear to enhance cocaine-induced toxicity.
2000 Feb
Induction of cysteine string protein after chronic antidepressant treatment in rat frontal cortex.
2001 Apr 6
[Depression in the elderly. Medical treatment].
2001 Feb 24
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
2003 Aug
Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients.
2003 Feb 1
Serotonergic platelet markers of suicidal behavior--do they really exist?
2004 Apr
Effect of anxiolytic, antidepressant, and antipsychotic drugs on cocaine-induced seizures and mortality.
2004 Dec
[Hypnotherapy in the treatment of refractory nocturnal enuresis].
2004 Feb 19
Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus.
2004 Jun 18
[Effect of acute melipramine administration on motor activity and defensive conditioned reflexes of passive and active avoidance in rats].
2004 Nov-Dec
[Influence of chronic melipramine administration abolition on locomotion and defensive conditioned reflexes in passive and active avoidance in rats].
2005 Jan-Feb
Prediction of genotoxicity of chemical compounds by statistical learning methods.
2005 Jun
Serotonin (5HT), fluoxetine, imipramine and dopamine target distinct 5HT receptor signaling to modulate Caenorhabditis elegans egg-laying behavior.
2005 Mar
UDP-glucuronosyltransferase 1A4 polymorphisms in a Japanese population and kinetics of clozapine glucuronidation.
2005 May
[Lack of antidepresant-like activity of some ligands of polyamine binding sites of NMDA receptors in models of depression].
2006 Jan-Feb
Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells.
2006 Mar 13
Mechanism of imipramine-induced seizures in amygdala-kindled rats.
2006 Nov
Polypharmacy and EPS in a child; a case report.
2007
Influence of antidepressants on hemostasis.
2007
[Chemico-toxicological analysis of haloperidol in blood with high-performance liquid chromatography in combined poisoning].
2007 May-Jun
Sub-chronic administration of rimonabant causes loss of antidepressive activity and decreases doublecortin immunoreactivity in the mouse hippocampus.
2009 Dec 25
Suppressive effect of imipramine on vincristine-induced mechanical allodynia in mice.
2009 Jul
Possible role of trazodone and imipramine in sleep deprivation-induced anxiety-like behavior and oxidative damage in mice.
2009 Jul-Aug
Behavioral changes in rats induced by a dipeptidyl peptidase IV inhibitor methionyl-2(S)-cyanopyrrolidine: experimental model of anxiety-depression disorder.
2009 Mar
Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression.
2009 May 28
A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel.
2009 Nov 1
Medicine and psychiatry in Western culture: Ancient Greek myths and modern prejudices.
2009 Oct 7
Imipramine enhances cell proliferation and decreases neurodegeneration in the hippocampus after transient global cerebral ischemia in rats.
2010 Feb 5
Prediction of phospholipidosis-inducing potential of drugs by in vitro biochemical and physicochemical assays followed by multivariate analysis.
2010 Mar
Hormonal responses to the 5-HT1A agonist buspirone in remitted endogenous depressive patients after long-term imipramine treatment.
2010 May
Patents

Sample Use Guides

In Vivo Use Guide
Usual Adult Dose for Depression Tablets: Initial dose: 100 mg orally per day Maintenance dose: 100 to 200 mg orally per day (If no response after 2 weeks, increase to 250 to 300 mg per day) Maximum dose: 300 mg orally per day
Route of Administration: Oral
The inhibition percentage of human PON1 for imipramine was 15.6% at 100 ug/L after incubation for 1 h). At 350 ug/L, the inhibition percentage for imipramine 19.2% after 1 h and 20.2% after 2 h.
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:46:31 UTC 2023
Edited
by admin
on Wed Jul 05 22:46:31 UTC 2023
Record UNII
OGG85SX4E4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IMIPRAMINE
HSDB   INN   MART.   MI   VANDF   WHO-DD  
INN  
Official Name English
MELIPRAMINE
Common Name English
IMIPRAMINE [HSDB]
Common Name English
CLOMIPRAMINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]
Common Name English
SERMONIL
Common Name English
IMIPRAMINE [MI]
Common Name English
imipramine [INN]
Common Name English
IMIPRAMINE [VANDF]
Common Name English
CRISTALIA
Common Name English
TRIMIPRAMINE MALEATE IMPURITY D [EP IMPURITY]
Common Name English
5-(3-(DIMETHYLAMINO)PROPYL)-10,11-DIHYDRO-5H-DIBENZ(B,F)AZEPINE
Systematic Name English
N-(.GAMMA.-DIMETHYLAMINOPROPYL)IMINODIBENZYL
Common Name English
BERKOMINE
Common Name English
ORG-2463
Code English
IMIPRAMINE [MART.]
Common Name English
ANTIDEPRIN
Common Name English
5H-DIBENZ(B,F)AZEPINE-5-PROPANAMINE, 10,11-DIHYDRO-N,N-DIMETHYL-
Systematic Name English
NSC-169866
Code English
TRIMIPRAMINE MALEATE IMPURITY, IMIPRAMINE- [USP IMPURITY]
Common Name English
Imipramine [WHO-DD]
Common Name English
Classification Tree Code System Code
WHO-VATC QN06AA02
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
LIVERTOX NBK547884
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
WHO-ATC N06AA02
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
NCI_THESAURUS C94727
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
NDF-RT N0000175752
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
Code System Code Type Description
DRUG CENTRAL
1427
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
NCI_THESAURUS
C62039
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
INN
793
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
FDA UNII
OGG85SX4E4
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
MESH
D007099
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
EVMPD
SUB08152MIG
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-042-1
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
LACTMED
Imipramine
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
NSC
169866
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
EPA CompTox
DTXSID1043881
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
PUBCHEM
3696
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
ChEMBL
CHEMBL11
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
IUPHAR
357
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
DAILYMED
OGG85SX4E4
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
MERCK INDEX
M6232
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY Merck Index
RXCUI
5691
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY RxNorm
WIKIPEDIA
IMIPRAMINE
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
DRUG BANK
DB00458
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
CAS
50-49-7
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
SMS_ID
100000083920
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
CHEBI
47499
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
HSDB
3100
Created by admin on Wed Jul 05 22:46:32 UTC 2023 , Edited by admin on Wed Jul 05 22:46:32 UTC 2023
PRIMARY
Related Record Type Details
METABOLIC ENZYME -> SUBSTRATE
SALT/SOLVATE -> PARENT
TRANSPORTER -> INHIBITOR
SALT/SOLVATE -> PARENT
METABOLIC ENZYME -> SUBSTRATE
Metabolizing reaction by CYP2D6: 2-Hydroxylation
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
10%-20% OF TOTAL METABOLISM
BINDING PROTEIN->LIGAND
TRANSPORTER -> INHIBITOR
TARGET -> INHIBITOR
TRANSPORTER -> INHIBITOR
TRANSPORTER -> INHIBITOR
TARGET -> INHIBITOR
BINDER->LIGAND
Related Record Type Details
METABOLITE ACTIVE -> PARENT
Imipramine has activities at both the serotonin and norepeinephrine transporters with greater affinity for the serotonin transporter while desipramine and 2-hydroxydesipramine have greater affinities for the norepinephrine transporter (Owens et al., 1997).
METABOLITE ACTIVE -> PARENT
Related Record Type Details
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
PARENT -> IMPURITY
Related Record Type Details
ACTIVE MOIETY