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Details

Stereochemistry ABSOLUTE
Molecular Formula C10H14N2O2
Molecular Weight 194.2304
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SOLRIAMFETOL

SMILES

N[C@@H](COC(N)=O)CC1=CC=CC=C1

InChI

InChIKey=UCTRAOBQFUDCSR-SECBINFHSA-N
InChI=1S/C10H14N2O2/c11-9(7-14-10(12)13)6-8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H2,12,13)/t9-/m1/s1

HIDE SMILES / InChI

Molecular Formula C10H14N2O2
Molecular Weight 194.2304
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
4.4 µM [IC50]
2.9 µM [IC50]
Substance Class Chemical
Created
by admin
on Mon Oct 21 22:40:18 UTC 2019
Edited
by admin
on Mon Oct 21 22:40:18 UTC 2019
Record UNII
939U7C91AI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SOLRIAMFETOL
USAN   INN  
Official Name English
(2R)-2-AMINO-3-PHENYLPROPYL CARBAMATE
Systematic Name English
YKP-10A
Code English
R-228060
Code English
SOLRIAMFETOL [WHO-DD]
Common Name English
SUNOSI
Brand Name English
BENZENEPROPANOL, .BETA.-AMINO-, CARBAMATE (ESTER), (R)-
Systematic Name English
BENZENEPROPANOL, .BETA.-AMINO-, 1-CARBAMATE, (.BETA.R)-
Systematic Name English
JZP-110
Code English
SOLRIAMFETOL [INN]
Common Name English
ADX-N-05
Code English
SKL-N-05
Code English
SOLRIAMFETOL [USAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C78272
Created by admin on Mon Oct 21 22:40:18 UTC 2019 , Edited by admin on Mon Oct 21 22:40:18 UTC 2019
Code System Code Type Description
INN
10117
Created by admin on Mon Oct 21 22:40:18 UTC 2019 , Edited by admin on Mon Oct 21 22:40:18 UTC 2019
PRIMARY
CAS
178429-62-4
Created by admin on Mon Oct 21 22:40:18 UTC 2019 , Edited by admin on Mon Oct 21 22:40:18 UTC 2019
PRIMARY
PUBCHEM
10130337
Created by admin on Mon Oct 21 22:40:18 UTC 2019 , Edited by admin on Mon Oct 21 22:40:18 UTC 2019
PRIMARY
NCI_THESAURUS
C152389
Created by admin on Mon Oct 21 22:40:18 UTC 2019 , Edited by admin on Mon Oct 21 22:40:18 UTC 2019
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
TRANSPORTER -> INHIBITOR
WEAK
IC50
TRANSPORTER -> INHIBITOR
WEAK
IC50
BINDER->LIGAND
BINDING
EXCRETED UNCHANGED
Approximately 95% of the dose was recovered in urine as unchanged solriamfetol, 1% or less of the administered dose was recovered in urine as the minor inactive metabolite N-acetyl solriamfetol.
URINE
Related Record Type Details
METABOLITE INACTIVE -> PARENT
METABOLITE -> PARENT
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC
ORAL BIOAVAILABILITY PHARMACOKINETIC
Tmax PHARMACOKINETIC