Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C10H14N2O2.ClH |
| Molecular Weight | 230.691 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.N[C@@H](COC(N)=O)CC1=CC=CC=C1
InChI
InChIKey=KAOVAAHCFNYXNJ-SBSPUUFOSA-N
InChI=1S/C10H14N2O2.ClH/c11-9(7-14-10(12)13)6-8-4-2-1-3-5-8;/h1-5,9H,6-7,11H2,(H2,12,13);1H/t9-;/m1./s1
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C10H14N2O2 |
| Molecular Weight | 194.2304 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
ADX-N05, originally discovered by SK Holdings, is a selective dopamine and norepinephrine reuptake inhibitor (DNRI). ADX-N05 (Solriamfetol, sold under the brand name Sunosi) is approved in the US and is under regulatory review in the EU to improve wakefulness in adult patients with hypersomnia associated with narcolepsy or obstructive sleep apnoea.The US FDA has approved solriamfetol (Sunosi, Jazz Pharmaceuticals) for the treatment of excessive daytime sleepiness in adults with narcolepsy or obstructive sleep apnea.The dual-acting dopamine and norepinephrine reuptake inhibitor is approved for narcolepsy in once-daily 75 mg and 150 mg doses, and in obstructive sleep apnea in once-daily 37.5 mg, 75 mg, and 150 mg doses.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL238 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29891587 |
2.9 µM [IC50] | ||
Target ID: CHEMBL222 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29891587 |
4.4 µM [IC50] |
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
499 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30865315/ |
75 mg single, oral dose: 75 mg route of administration: Oral experiment type: SINGLE co-administered: |
SOLRIAMFETOL plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
5273 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30865315/ |
75 mg single, oral dose: 75 mg route of administration: Oral experiment type: SINGLE co-administered: |
SOLRIAMFETOL plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
7.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/30865315/ |
75 mg single, oral dose: 75 mg route of administration: Oral experiment type: SINGLE co-administered: |
SOLRIAMFETOL plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
Doses
| Dose | Population | Adverse events |
|---|---|---|
112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
Other AEs: Decreased appetite, Insomnia... Other AEs: Decreased appetite (9%) Sources: Insomnia (5%) Anxiety (6%) Headache (16%) Palpitations (2%) Nausea (7%) Dry mouth (4%) Constipation (3%) Agitation (<2%) Bruxism (<2%) Irritability (<2%) Cough (<2%) Hyperhidrosis (<2%) Feeling jittery (<2%) Thirst (<2%) Chest discomfort (<2%) Chest pain (<2%) Weight decreased (<2%) |
150 mg 1 times / day steady, oral Recommended Dose: 150 mg, 1 times / day Route: oral Route: steady Dose: 150 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
Disc. AE: Anxiety, Palpitations... Other AEs: Headache, Nausea... AEs leading to discontinuation/dose reduction: Anxiety (0.5%) Other AEs:Palpitations (0.5%) Restlessness (0.5%) Headache (13%) Sources: Nausea (9%) Decreased appetite (8%) Anxiety (7%) Dry mouth (4%) Diarrhea (5%) |
37.5 mg 1 times / day steady, oral Recommended Dose: 37.5 mg, 1 times / day Route: oral Route: steady Dose: 37.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
Other AEs: Headache, Nausea... Other AEs: Headache (7%) Sources: Nausea (7%) Decreased appetite (2%) Anxiety (2%) Dry mouth (2%) Diarrhea (2%) |
75 mg 1 times / day steady, oral Recommended Dose: 75 mg, 1 times / day Route: oral Route: steady Dose: 75 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
Other AEs: Headache, Nausea... Other AEs: Headache (9%) Sources: Nausea (5%) Decreased appetite (7%) Anxiety (3%) Dry mouth (3%) Diarrhea (4%) |
87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
Other AEs: Decreased appetite, Anxiety... Other AEs: Decreased appetite (6%) Sources: Anxiety (4%) Irritability (3%) Dizziness (2%) Palpitations (3%) Nausea (8%) Diarrhea (4%) Abdominal pain (3%) Dry mouth (3%) Feeling jittery (3%) Chest discomfort (2%) Hyperhidrosis (2%) Bruxism (<2%) Restlessness (<2%) Disturbance in attention (<2%) Tremor (<2%) Cough (<2%) Dyspnea (<2%) Constipation (<2%) Vomiting (<2%) Weight decreased (<2%) |
87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
Other AEs: Blood pressure systolic increased, Blood pressure diastolic increased... Other AEs: Blood pressure systolic increased Sources: Blood pressure diastolic increased Heart rate increased |
300 mg 1 times / day single, oral Studied dose Dose: 300 mg, 1 times / day Route: oral Route: single Dose: 300 mg, 1 times / day Sources: |
healthy, 19 to 54 years Health Status: healthy Age Group: 19 to 54 years Sex: M+F Sources: |
Other AEs: Insomnia, Headache... Other AEs: Insomnia (grade 1, 21.9%) Sources: Headache (grade 1, 15.6%) Hypervigilance (grade 1, 9.4%) Decreased appetite (grade 1, 9.4%) Nausea (grade 1, 9.4%) Insomnia (grade 1, 21.9%) Headache (grade 1, 12.5%) Hypervigilance (grade 1, 12.5%) Decreased appetite (grade 1, 9.4%) Nausea (grade 1, 6.3%) |
1200 mg 1 times / day single, oral Highest studied dose Dose: 1200 mg, 1 times / day Route: oral Route: single Dose: 1200 mg, 1 times / day Sources: |
healthy, mean age 29.3 years Health Status: healthy Age Group: mean age 29.3 years Sex: M Sources: |
Disc. AE: Blood pressure increased, Nervousness... Other AEs: Hypervigilance, Elevated mood... AEs leading to discontinuation/dose reduction: Blood pressure increased (grade 1, 2.4%) Other AEs:Nervousness (grade 1, 2.4%) Hypervigilance (42.9%) Sources: Elevated mood (23.8%) Dry mouth (21.4%) Nausea (21.4%) Feeling of relaxation (19%) Decreased appetite (19%) Hyperhidrosis (19%) Insomnia (16.7%) Headache (14.3%) Restlessness (14.3%) Palpitations (11.9%) Paresthesia (7.1%) |
150 mg 1 times / day multiple, oral Studied dose Dose: 150 mg, 1 times / day Route: oral Route: multiple Dose: 150 mg, 1 times / day Sources: |
unhealthy Health Status: unhealthy Sex: M+F Sources: |
Disc. AE: Blood pressure increased, Hypertension... AEs leading to discontinuation/dose reduction: Blood pressure increased (0.48%) Sources: Hypertension (0.24%) |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Headache | 16% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Palpitations | 2% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Constipation | 3% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Dry mouth | 4% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Insomnia | 5% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Anxiety | 6% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Nausea | 7% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Decreased appetite | 9% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Agitation | <2% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Bruxism | <2% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Chest discomfort | <2% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Chest pain | <2% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Cough | <2% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Feeling jittery | <2% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Hyperhidrosis | <2% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Irritability | <2% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Thirst | <2% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Weight decreased | <2% | 112.5 mg 1 times / day steady, oral Recommended Dose: 112.5 mg, 1 times / day Route: oral Route: steady Dose: 112.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Anxiety | 0.5% Disc. AE |
150 mg 1 times / day steady, oral Recommended Dose: 150 mg, 1 times / day Route: oral Route: steady Dose: 150 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Palpitations | 0.5% Disc. AE |
150 mg 1 times / day steady, oral Recommended Dose: 150 mg, 1 times / day Route: oral Route: steady Dose: 150 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Restlessness | 0.5% Disc. AE |
150 mg 1 times / day steady, oral Recommended Dose: 150 mg, 1 times / day Route: oral Route: steady Dose: 150 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Headache | 13% | 150 mg 1 times / day steady, oral Recommended Dose: 150 mg, 1 times / day Route: oral Route: steady Dose: 150 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Dry mouth | 4% | 150 mg 1 times / day steady, oral Recommended Dose: 150 mg, 1 times / day Route: oral Route: steady Dose: 150 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Diarrhea | 5% | 150 mg 1 times / day steady, oral Recommended Dose: 150 mg, 1 times / day Route: oral Route: steady Dose: 150 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Anxiety | 7% | 150 mg 1 times / day steady, oral Recommended Dose: 150 mg, 1 times / day Route: oral Route: steady Dose: 150 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Decreased appetite | 8% | 150 mg 1 times / day steady, oral Recommended Dose: 150 mg, 1 times / day Route: oral Route: steady Dose: 150 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Nausea | 9% | 150 mg 1 times / day steady, oral Recommended Dose: 150 mg, 1 times / day Route: oral Route: steady Dose: 150 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Anxiety | 2% | 37.5 mg 1 times / day steady, oral Recommended Dose: 37.5 mg, 1 times / day Route: oral Route: steady Dose: 37.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Decreased appetite | 2% | 37.5 mg 1 times / day steady, oral Recommended Dose: 37.5 mg, 1 times / day Route: oral Route: steady Dose: 37.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Diarrhea | 2% | 37.5 mg 1 times / day steady, oral Recommended Dose: 37.5 mg, 1 times / day Route: oral Route: steady Dose: 37.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Dry mouth | 2% | 37.5 mg 1 times / day steady, oral Recommended Dose: 37.5 mg, 1 times / day Route: oral Route: steady Dose: 37.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Headache | 7% | 37.5 mg 1 times / day steady, oral Recommended Dose: 37.5 mg, 1 times / day Route: oral Route: steady Dose: 37.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Nausea | 7% | 37.5 mg 1 times / day steady, oral Recommended Dose: 37.5 mg, 1 times / day Route: oral Route: steady Dose: 37.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Anxiety | 3% | 75 mg 1 times / day steady, oral Recommended Dose: 75 mg, 1 times / day Route: oral Route: steady Dose: 75 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Dry mouth | 3% | 75 mg 1 times / day steady, oral Recommended Dose: 75 mg, 1 times / day Route: oral Route: steady Dose: 75 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Diarrhea | 4% | 75 mg 1 times / day steady, oral Recommended Dose: 75 mg, 1 times / day Route: oral Route: steady Dose: 75 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Nausea | 5% | 75 mg 1 times / day steady, oral Recommended Dose: 75 mg, 1 times / day Route: oral Route: steady Dose: 75 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Decreased appetite | 7% | 75 mg 1 times / day steady, oral Recommended Dose: 75 mg, 1 times / day Route: oral Route: steady Dose: 75 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Headache | 9% | 75 mg 1 times / day steady, oral Recommended Dose: 75 mg, 1 times / day Route: oral Route: steady Dose: 75 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Chest discomfort | 2% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Dizziness | 2% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Hyperhidrosis | 2% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Abdominal pain | 3% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Dry mouth | 3% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Feeling jittery | 3% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Irritability | 3% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Palpitations | 3% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Anxiety | 4% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Diarrhea | 4% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Decreased appetite | 6% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Nausea | 8% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Bruxism | <2% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Constipation | <2% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Cough | <2% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Disturbance in attention | <2% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Dyspnea | <2% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Restlessness | <2% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Tremor | <2% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Vomiting | <2% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Weight decreased | <2% | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
| Blood pressure diastolic increased | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
|
| Blood pressure systolic increased | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
|
| Heart rate increased | 87.5 mg 1 times / day steady, oral Recommended Dose: 87.5 mg, 1 times / day Route: oral Route: steady Dose: 87.5 mg, 1 times / day Sources: |
unhealthy, 18 to 75 years Health Status: unhealthy Age Group: 18 to 75 years Sex: M+F Sources: |
|
| Headache | grade 1, 12.5% | 300 mg 1 times / day single, oral Studied dose Dose: 300 mg, 1 times / day Route: oral Route: single Dose: 300 mg, 1 times / day Sources: |
healthy, 19 to 54 years Health Status: healthy Age Group: 19 to 54 years Sex: M+F Sources: |
| Hypervigilance | grade 1, 12.5% | 300 mg 1 times / day single, oral Studied dose Dose: 300 mg, 1 times / day Route: oral Route: single Dose: 300 mg, 1 times / day Sources: |
healthy, 19 to 54 years Health Status: healthy Age Group: 19 to 54 years Sex: M+F Sources: |
| Headache | grade 1, 15.6% | 300 mg 1 times / day single, oral Studied dose Dose: 300 mg, 1 times / day Route: oral Route: single Dose: 300 mg, 1 times / day Sources: |
healthy, 19 to 54 years Health Status: healthy Age Group: 19 to 54 years Sex: M+F Sources: |
| Insomnia | grade 1, 21.9% | 300 mg 1 times / day single, oral Studied dose Dose: 300 mg, 1 times / day Route: oral Route: single Dose: 300 mg, 1 times / day Sources: |
healthy, 19 to 54 years Health Status: healthy Age Group: 19 to 54 years Sex: M+F Sources: |
| Insomnia | grade 1, 21.9% | 300 mg 1 times / day single, oral Studied dose Dose: 300 mg, 1 times / day Route: oral Route: single Dose: 300 mg, 1 times / day Sources: |
healthy, 19 to 54 years Health Status: healthy Age Group: 19 to 54 years Sex: M+F Sources: |
| Nausea | grade 1, 6.3% | 300 mg 1 times / day single, oral Studied dose Dose: 300 mg, 1 times / day Route: oral Route: single Dose: 300 mg, 1 times / day Sources: |
healthy, 19 to 54 years Health Status: healthy Age Group: 19 to 54 years Sex: M+F Sources: |
| Decreased appetite | grade 1, 9.4% | 300 mg 1 times / day single, oral Studied dose Dose: 300 mg, 1 times / day Route: oral Route: single Dose: 300 mg, 1 times / day Sources: |
healthy, 19 to 54 years Health Status: healthy Age Group: 19 to 54 years Sex: M+F Sources: |
| Decreased appetite | grade 1, 9.4% | 300 mg 1 times / day single, oral Studied dose Dose: 300 mg, 1 times / day Route: oral Route: single Dose: 300 mg, 1 times / day Sources: |
healthy, 19 to 54 years Health Status: healthy Age Group: 19 to 54 years Sex: M+F Sources: |
| Hypervigilance | grade 1, 9.4% | 300 mg 1 times / day single, oral Studied dose Dose: 300 mg, 1 times / day Route: oral Route: single Dose: 300 mg, 1 times / day Sources: |
healthy, 19 to 54 years Health Status: healthy Age Group: 19 to 54 years Sex: M+F Sources: |
| Nausea | grade 1, 9.4% | 300 mg 1 times / day single, oral Studied dose Dose: 300 mg, 1 times / day Route: oral Route: single Dose: 300 mg, 1 times / day Sources: |
healthy, 19 to 54 years Health Status: healthy Age Group: 19 to 54 years Sex: M+F Sources: |
| Palpitations | 11.9% | 1200 mg 1 times / day single, oral Highest studied dose Dose: 1200 mg, 1 times / day Route: oral Route: single Dose: 1200 mg, 1 times / day Sources: |
healthy, mean age 29.3 years Health Status: healthy Age Group: mean age 29.3 years Sex: M Sources: |
| Headache | 14.3% | 1200 mg 1 times / day single, oral Highest studied dose Dose: 1200 mg, 1 times / day Route: oral Route: single Dose: 1200 mg, 1 times / day Sources: |
healthy, mean age 29.3 years Health Status: healthy Age Group: mean age 29.3 years Sex: M Sources: |
| Restlessness | 14.3% | 1200 mg 1 times / day single, oral Highest studied dose Dose: 1200 mg, 1 times / day Route: oral Route: single Dose: 1200 mg, 1 times / day Sources: |
healthy, mean age 29.3 years Health Status: healthy Age Group: mean age 29.3 years Sex: M Sources: |
| Insomnia | 16.7% | 1200 mg 1 times / day single, oral Highest studied dose Dose: 1200 mg, 1 times / day Route: oral Route: single Dose: 1200 mg, 1 times / day Sources: |
healthy, mean age 29.3 years Health Status: healthy Age Group: mean age 29.3 years Sex: M Sources: |
| Decreased appetite | 19% | 1200 mg 1 times / day single, oral Highest studied dose Dose: 1200 mg, 1 times / day Route: oral Route: single Dose: 1200 mg, 1 times / day Sources: |
healthy, mean age 29.3 years Health Status: healthy Age Group: mean age 29.3 years Sex: M Sources: |
| Feeling of relaxation | 19% | 1200 mg 1 times / day single, oral Highest studied dose Dose: 1200 mg, 1 times / day Route: oral Route: single Dose: 1200 mg, 1 times / day Sources: |
healthy, mean age 29.3 years Health Status: healthy Age Group: mean age 29.3 years Sex: M Sources: |
| Hyperhidrosis | 19% | 1200 mg 1 times / day single, oral Highest studied dose Dose: 1200 mg, 1 times / day Route: oral Route: single Dose: 1200 mg, 1 times / day Sources: |
healthy, mean age 29.3 years Health Status: healthy Age Group: mean age 29.3 years Sex: M Sources: |
| Dry mouth | 21.4% | 1200 mg 1 times / day single, oral Highest studied dose Dose: 1200 mg, 1 times / day Route: oral Route: single Dose: 1200 mg, 1 times / day Sources: |
healthy, mean age 29.3 years Health Status: healthy Age Group: mean age 29.3 years Sex: M Sources: |
| Nausea | 21.4% | 1200 mg 1 times / day single, oral Highest studied dose Dose: 1200 mg, 1 times / day Route: oral Route: single Dose: 1200 mg, 1 times / day Sources: |
healthy, mean age 29.3 years Health Status: healthy Age Group: mean age 29.3 years Sex: M Sources: |
| Elevated mood | 23.8% | 1200 mg 1 times / day single, oral Highest studied dose Dose: 1200 mg, 1 times / day Route: oral Route: single Dose: 1200 mg, 1 times / day Sources: |
healthy, mean age 29.3 years Health Status: healthy Age Group: mean age 29.3 years Sex: M Sources: |
| Hypervigilance | 42.9% | 1200 mg 1 times / day single, oral Highest studied dose Dose: 1200 mg, 1 times / day Route: oral Route: single Dose: 1200 mg, 1 times / day Sources: |
healthy, mean age 29.3 years Health Status: healthy Age Group: mean age 29.3 years Sex: M Sources: |
| Paresthesia | 7.1% | 1200 mg 1 times / day single, oral Highest studied dose Dose: 1200 mg, 1 times / day Route: oral Route: single Dose: 1200 mg, 1 times / day Sources: |
healthy, mean age 29.3 years Health Status: healthy Age Group: mean age 29.3 years Sex: M Sources: |
| Blood pressure increased | grade 1, 2.4% Disc. AE |
1200 mg 1 times / day single, oral Highest studied dose Dose: 1200 mg, 1 times / day Route: oral Route: single Dose: 1200 mg, 1 times / day Sources: |
healthy, mean age 29.3 years Health Status: healthy Age Group: mean age 29.3 years Sex: M Sources: |
| Nervousness | grade 1, 2.4% Disc. AE |
1200 mg 1 times / day single, oral Highest studied dose Dose: 1200 mg, 1 times / day Route: oral Route: single Dose: 1200 mg, 1 times / day Sources: |
healthy, mean age 29.3 years Health Status: healthy Age Group: mean age 29.3 years Sex: M Sources: |
| Hypertension | 0.24% Disc. AE |
150 mg 1 times / day multiple, oral Studied dose Dose: 150 mg, 1 times / day Route: oral Route: multiple Dose: 150 mg, 1 times / day Sources: |
unhealthy Health Status: unhealthy Sex: M+F Sources: |
| Blood pressure increased | 0.48% Disc. AE |
150 mg 1 times / day multiple, oral Studied dose Dose: 150 mg, 1 times / day Route: oral Route: multiple Dose: 150 mg, 1 times / day Sources: |
unhealthy Health Status: unhealthy Sex: M+F Sources: |
Overview
| CYP3A4 | CYP2C9 | CYP2D6 | hERG |
|---|---|---|---|
OverviewOther
| Other Inhibitor | Other Substrate | Other Inducer |
|---|---|---|
Drug as perpetrator
| Target | Modality | Activity | Metabolite | Clinical evidence |
|---|---|---|---|---|
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/211230Orig1Orig2s000PharmR.pdf#page=30 Page: 30.0 |
no | |||
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/211230Orig1Orig2s000PharmR.pdf#page=30 Page: 30.0 |
no | |||
| weak [IC50 146 uM] | ||||
| weak [IC50 211 uM] | ||||
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/211230Orig1Orig2s000PharmR.pdf#page=30 Page: 30.0 |
weak [IC50 360 uM] |
Drug as victim
| Target | Modality | Activity | Metabolite | Clinical evidence |
|---|---|---|---|---|
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no |
Tox targets
| Target | Modality | Activity | Metabolite | Clinical evidence |
|---|---|---|---|---|
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/211230Orig1Orig2s000PharmR.pdf#page=20 Page: 20.0 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| New developments in the management of narcolepsy. | 2017 |
|
| Effect of Oral JZP-110 (ADX-N05) on Wakefulness and Sleepiness in Adults with Narcolepsy: A Phase 2b Study. | 2016-07-01 |
|
| Effect of oral JZP-110 (ADX-N05) treatment on wakefulness and sleepiness in adults with narcolepsy. | 2015-09 |
Sample Use Guides
The dual-acting dopamine and norepinephrine reuptake inhibitor is approved for narcolepsy in once-daily 75 mg and 150 mg doses, and in obstructive sleep apnea in once-daily 37.5 mg, 75 mg, and 150 mg doses.
Route of Administration:
Oral
Solriamfetol binds to the dopamine transporter and norepinephrine transporter with low affinity (Ki=14.2 uM and 3.7 uM, respectively), and inhibits the reuptake of dopamine and norepinephrine with low potency (IC50 =2.9 uM and 4.4 uM, respectively). Solriamfetol has no appreciable binding affinity for the serotonin transporter (Ki=81.5 uM) and does not inhibit serotonin reuptake (IC50 > 100 uM).
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:58:34 GMT 2025
by
admin
on
Mon Mar 31 17:58:34 GMT 2025
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| Record UNII |
K7RO88SP7A
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| Record Status |
Validated (UNII)
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| Record Version |
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FDA ORPHAN DRUG |
375112
Created by
admin on Mon Mar 31 17:58:34 GMT 2025 , Edited by admin on Mon Mar 31 17:58:34 GMT 2025
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| Code System | Code | Type | Description | ||
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2121750
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C170379
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DTXSID101027927
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m12132
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C470510
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K7RO88SP7A
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EF-114
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DBSALT002865
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67583702
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178429-65-7
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100000180154
Created by
admin on Mon Mar 31 17:58:34 GMT 2025 , Edited by admin on Mon Mar 31 17:58:34 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE |
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RACEMATE -> ENANTIOMER |
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
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