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Approval Year

Unknown
139594
Substance Class Protein
Created
by admin
on Sat Dec 16 08:47:29 UTC 2023
Edited
by admin
on Sat Dec 16 08:47:29 UTC 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
I81U7H57XI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OAT-1
Common Name English
SOLUTE CARRIER FAMILY 22 MEMBER 6
Common Name English
MGC45260
Common Name English
HOAT-1
Common Name English
OAT1
Common Name English
PAH TRANSPORTER
Common Name English
RENAL ORGANIC ANION TRANSPORTER 1
Common Name English
PAHT
Common Name English
FLJ55736
Common Name English
HOAT1
Common Name English
ROAT1
Common Name English
ROAT-1
Common Name English
SLC22A6
Common Name English
Classification Tree Code System Code
UCSF-FDA TRANSPORTAL SLC22A6
Created by admin on Sat Dec 16 08:47:31 UTC 2023 , Edited by admin on Sat Dec 16 08:47:31 UTC 2023
Code System Code Type Description
UNIPROT
Q4U2R8
Created by admin on Sat Dec 16 08:47:31 UTC 2023 , Edited by admin on Sat Dec 16 08:47:31 UTC 2023
PRIMARY
FDA UNII
I81U7H57XI
Created by admin on Sat Dec 16 08:47:31 UTC 2023 , Edited by admin on Sat Dec 16 08:47:31 UTC 2023
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_39
N 1_56
N 1_92
N 1_97
N 1_113
Related Record Type Details
Structure of CILASTATIN
INHIBITOR -> TRANSPORTER
Structure of LORLATINIB
INHIBITOR -> TRANSPORTER
Structure of INDOMETHACIN
INHIBITOR -> TRANSPORTER
Structure of CEPHALORIDINE
INHIBITOR -> TRANSPORTER
Structure of CABOTEGRAVIR
INHIBITOR -> TRANSPORTER
IN VITRO
IC50
Structure of CEFAZOLIN
INHIBITOR -> TRANSPORTER
Structure of INDOXYL SULFATE
INHIBITOR -> TRANSPORTER
Structure of 1-(((4-((7-METHOXY-6-(SULFOOXY)-4-QUINOLINYL)OXY)PHENYL)AMINO)CARBONYL)CYCLOPROPANECARBOXYLIC ACID
INHIBITOR -> TRANSPORTER
IC50
Structure of SULINDAC
INHIBITOR -> TRANSPORTER
Structure of LESINURAD
INHIBITOR -> TRANSPORTER
Based on in vitro studies, lesinurad is a weak inhibitor of OATP1B1, OCT1, OAT1, and OAT3.
WEAK
Structure of PRAVASTATIN
INHIBITOR -> TRANSPORTER
Structure of IBUPROFEN
INHIBITOR -> TRANSPORTER
Structure of ADEFOVIR
INHIBITOR -> TRANSPORTER
Structure of TRICHLORMETHIAZIDE
INHIBITOR -> TRANSPORTER
Structure of FLURBIPROFEN
INHIBITOR -> TRANSPORTER
Structure of ADEFOVIR
SUBSTRATE -> TRANSPORTER
Structure of DOTINURAD
INHIBITOR -> TRANSPORTER
IC50
Structure of Zagociguat
INHIBITOR -> TRANSPORTER
IC50
Structure of ABAMETAPIR CARBOXYL
INHIBITOR -> TRANSPORTER
Structure of ENCORAFENIB
INHIBITOR -> TRANSPORTER
IC50
Structure of BUMETANIDE
INHIBITOR -> TRANSPORTER
Structure of ETHACRYNIC ACID
INHIBITOR -> TRANSPORTER
Structure of LESINURAD
SUBSTRATE -> TRANSPORTER
Based on in vitro studies, lesinurad is a substrate of OAT1 and OAT3.
Structure of MEFENAMIC ACID
INHIBITOR -> TRANSPORTER
Structure of PHENACETIN
INHIBITOR -> TRANSPORTER
Structure of OPICAPONE
INHIBITOR -> TRANSPORTER
IC50
Structure of DICLOFENAC
INHIBITOR -> TRANSPORTER
Structure of CIDOFOVIR
INHIBITOR -> TRANSPORTER
Structure of Salicylic acid
INHIBITOR -> TRANSPORTER
Structure of FLUVASTATIN
INHIBITOR -> TRANSPORTER
Structure of ETODOLAC
INHIBITOR -> TRANSPORTER
Structure of DIFLUNISAL
INHIBITOR -> TRANSPORTER
Structure of CITRININ
INHIBITOR -> TRANSPORTER
Structure of PERAMPANEL
INHIBITOR -> TRANSPORTER
Thus, the unbound Cmax is about 0.09 μM, much lower than 8.5 μM. Therefore, E2007 is unlikely to inhibit OAT1, OAT3, OCT1 and OCT3 in vivo.
Ki
Structure of KETOPROFEN
INHIBITOR -> TRANSPORTER
Structure of NAPROXEN
INHIBITOR -> TRANSPORTER
Structure of PROBENECID
INHIBITOR -> TRANSPORTER
Structure of CEPHALOTHIN
INHIBITOR -> TRANSPORTER
Structure of ACAMPROSATE
SUBSTRATE -> TRANSPORTER
Structure of OLMESARTAN
INHIBITOR -> TRANSPORTER
Structure of IMATINIB
SUBSTRATE -> TRANSPORTER
Structure of EDARAVONE
SUBSTRATE -> TRANSPORTER
WEAK
Structure of TELMISARTAN
INHIBITOR -> TRANSPORTER
Structure of RIFAMPIN
INHIBITOR -> TRANSPORTER
Structure of CYCLOTHIAZIDE
INHIBITOR -> TRANSPORTER
Structure of INDOLEACETIC ACID
INHIBITOR -> TRANSPORTER
Structure of ZIDOVUDINE
SUBSTRATE -> TRANSPORTER
Structure of BMS-986299
SUBSTRATE -> TRANSPORTER
Structure of RESVERATROL
INHIBITOR -> TRANSPORTER
MTX uptake was markedly inhibited by Res in rat kidney slicesand hOAT1/3-HEK293 cell, indicating that OAT1 and OAT3 were involved in the drug interaction in the kidney
Structure of PRALSETINIB
INHIBITOR -> TRANSPORTER
Structure of VALSARTAN
INHIBITOR -> TRANSPORTER
Structure of BETAMIPRON
INHIBITOR -> TRANSPORTER
Structure of ACYCLOVIR
SUBSTRATE -> TRANSPORTER
Structure of TENOFOVIR ANHYDROUS
SUBSTRATE -> TRANSPORTER
May cause renal toxicity
Structure of CEFOTAXIME
INHIBITOR -> TRANSPORTER
Structure of CEFAMANDOLE
INHIBITOR -> TRANSPORTER
CEPHRADINE
INHIBITOR -> TRANSPORTER
Structure of SULFASALAZINE
INHIBITOR -> TRANSPORTER
Structure of HYDROCHLOROTHIAZIDE
INHIBITOR -> TRANSPORTER
Structure of BRANEBRUTINIB
INHIBITOR -> TRANSPORTER
Structure of MEROPENEM
SUBSTRATE -> TRANSPORTER
Structure of HIPPURIC ACID
INHIBITOR -> TRANSPORTER
Structure of CANDESARTAN
INHIBITOR -> TRANSPORTER
Structure of KETOCONAZOLE
INHIBITOR -> TRANSPORTER
Structure of EPAMINURAD
INHIBITOR->OFF-TARGET
Structure of ACETYLCYSTEINE
SUBSTRATE -> TRANSPORTER
Structure of SIMVASTATIN
INHIBITOR -> TRANSPORTER
Structure of PROBENECID
INHIBITOR -> TARGET
Structure of CEFOPERAZONE
INHIBITOR -> TRANSPORTER
Structure of SELEXIPAG
INHIBITOR -> TRANSPORTER
IC50
Structure of METHOTREXATE
SUBSTRATE -> TRANSPORTER
Structure of CHLOROTHIAZIDE
INHIBITOR -> TRANSPORTER
Structure of PIROXICAM
INHIBITOR -> TRANSPORTER
Structure of LOSARTAN
INHIBITOR -> TRANSPORTER
Structure of FAMOTIDINE
INHIBITOR -> TRANSPORTER
Structure of PRATOSARTAN
INHIBITOR -> TRANSPORTER
Structure of CEFADROXIL
INHIBITOR -> TRANSPORTER
Structure of CIDOFOVIR ANHYDROUS
SUBSTRATE -> TRANSPORTER
May cause kidney toxicity. Excretion from kidney proximal tubules unclear
Structure of METHAZOLAMIDE
INHIBITOR -> TRANSPORTER
Structure of CEFTRIAXONE
INHIBITOR -> TRANSPORTER
Structure of Fumaric acid
INHIBITOR -> TRANSPORTER
Structure of NOVOBIOCIN
INHIBITOR -> TRANSPORTER
Structure of ACETAZOLAMIDE
INHIBITOR -> TRANSPORTER
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
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