U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C10H13NO2
Molecular Weight 179.2157
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHENACETIN

SMILES

CCOC1=CC=C(NC(C)=O)C=C1

InChI

InChIKey=CPJSUEIXXCENMM-UHFFFAOYSA-N
InChI=1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)

HIDE SMILES / InChI

Molecular Formula C10H13NO2
Molecular Weight 179.2157
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/18140117 | https://www.ncbi.nlm.nih.gov/pubmed/3552585 | https://www.ncbi.nlm.nih.gov/pubmed/12242329 | https://www.ncbi.nlm.nih.gov/pubmed/14592552

Phenacetin was used as an analgesic and fever-reducing drug in both human and veterinary medicine for many years. Since a major portion of a dose of phenacetin is rapidly metabolised to paracetamol, it seems possible that phenacetin owes some of its therapeutic activity to its main metabolite, paracetamol, whereas its most troublesome side effect (methaemoglobinaemia) is due to another metabolite, p-phenetidine. Phenacetin was shown to inhibit cyclooxygenase (COX)-3, a cyclooxygenase-1 variant while p-phenetidine potently inhibits both COX-1 and COX-2. There is sufficient evidence in humans for the carcinogenicity of analgesic mixtures containing phenacetin. Analgesic mixtures containing phenacetin cause cancer of the renal pelvis, and of the ureter. Phenacetin was withdrawn from many analgesic mixtures long before the legal ban in several countries.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Q8HZR1
Gene ID: 403544.0
Gene Symbol: PTGS1
Target Organism: Canis lupus familiaris (Dog) (Canis familiaris)
102.0 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Phenacetin

Approved Use

Phenacetin was used as an analgesic and fever-reducing drug in both human and veterinary medicine for many years.

Launch Date

1886
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
6.9 μg/mL
900 mg single, oral
dose: 900 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ACETAMINOPHEN plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
13.5 μg/mL
1.5 g single, oral
dose: 1.5 g
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENACETIN plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
1.48 μg/mL
900 mg single, oral
dose: 900 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENACETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
1.84 μg/mL
900 mg single, oral
dose: 900 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENACETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
2.5 μg/mL
900 mg single, oral
dose: 900 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENACETIN plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
40.4 μg × h/mL
900 mg single, oral
dose: 900 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ACETAMINOPHEN plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
20.72 μg × h/mL
1.5 g single, oral
dose: 1.5 g
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENACETIN plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
1.58 μg × h/mL
900 mg single, oral
dose: 900 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENACETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
1.84 μg × h/mL
900 mg single, oral
dose: 900 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENACETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
5.3 μg × h/mL
900 mg single, oral
dose: 900 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENACETIN plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2.6 h
900 mg single, oral
dose: 900 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ACETAMINOPHEN plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
0.6 h
1.5 g single, oral
dose: 1.5 g
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENACETIN plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
0.98 h
900 mg single, oral
dose: 900 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENACETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
1.1 h
900 mg single, oral
dose: 900 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENACETIN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
0.9 h
900 mg single, oral
dose: 900 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENACETIN plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
70%
PHENACETIN plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
1.5 g 1 times / day multiple, oral
Studied dose
Dose: 1.5 g, 1 times / day
Route: oral
Route: multiple
Dose: 1.5 g, 1 times / day
Sources:
unhealthy, 34 years
n = 1
Health Status: unhealthy
Condition: migraine
Age Group: 34 years
Sex: F
Population Size: 1
Sources:
Other AEs: Nephropathy...
Other AEs:
Nephropathy
Sources:
250 mg multiple, oral
Studied dose
Dose: 250 mg
Route: oral
Route: multiple
Dose: 250 mg
Co-administed with::
acetylsalicylic acid(250 mg; 40 years)
codeine phosphate(10 mg; 40 years)
Sources:
unhealthy, 54 years
n = 1
Health Status: unhealthy
Condition: migraine
Age Group: 54 years
Sex: F
Population Size: 1
Sources:
Other AEs: Nephropathy...
Other AEs:
Nephropathy
Sources:
1 g 1 times / day multiple, oral
Studied dose
Dose: 1 g, 1 times / day
Route: oral
Route: multiple
Dose: 1 g, 1 times / day
Sources:
unhealthy, 56 years
n = 1
Health Status: unhealthy
Condition: knee pain
Age Group: 56 years
Sex: M
Population Size: 1
Sources:
Other AEs: Transitional cell carcinoma...
Other AEs:
Transitional cell carcinoma
Sources:
625 mg 1 times / day multiple, oral (mean)
Studied dose
Dose: 625 mg, 1 times / day
Route: oral
Route: multiple
Dose: 625 mg, 1 times / day
Sources:
unhealthy, 85 years
n = 1
Health Status: unhealthy
Condition: migraine
Age Group: 85 years
Sex: M
Population Size: 1
Sources:
Other AEs: Urothelial carcinoma...
Other AEs:
Urothelial carcinoma
Sources:
0.9 g 4 times / day multiple, oral
Studied dose
Dose: 0.9 g, 4 times / day
Route: oral
Route: multiple
Dose: 0.9 g, 4 times / day
Sources:
healthy, age 18 to 44 years
n = 10
Health Status: healthy
Age Group: age 18 to 44 years
Sex: M+F
Population Size: 10
Sources:
Other AEs: Nephritis NEC...
Other AEs:
Nephritis NEC (20%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Nephropathy
1.5 g 1 times / day multiple, oral
Studied dose
Dose: 1.5 g, 1 times / day
Route: oral
Route: multiple
Dose: 1.5 g, 1 times / day
Sources:
unhealthy, 34 years
n = 1
Health Status: unhealthy
Condition: migraine
Age Group: 34 years
Sex: F
Population Size: 1
Sources:
Nephropathy
250 mg multiple, oral
Studied dose
Dose: 250 mg
Route: oral
Route: multiple
Dose: 250 mg
Co-administed with::
acetylsalicylic acid(250 mg; 40 years)
codeine phosphate(10 mg; 40 years)
Sources:
unhealthy, 54 years
n = 1
Health Status: unhealthy
Condition: migraine
Age Group: 54 years
Sex: F
Population Size: 1
Sources:
Transitional cell carcinoma
1 g 1 times / day multiple, oral
Studied dose
Dose: 1 g, 1 times / day
Route: oral
Route: multiple
Dose: 1 g, 1 times / day
Sources:
unhealthy, 56 years
n = 1
Health Status: unhealthy
Condition: knee pain
Age Group: 56 years
Sex: M
Population Size: 1
Sources:
Urothelial carcinoma
625 mg 1 times / day multiple, oral (mean)
Studied dose
Dose: 625 mg, 1 times / day
Route: oral
Route: multiple
Dose: 625 mg, 1 times / day
Sources:
unhealthy, 85 years
n = 1
Health Status: unhealthy
Condition: migraine
Age Group: 85 years
Sex: M
Population Size: 1
Sources:
Nephritis NEC 20%
0.9 g 4 times / day multiple, oral
Studied dose
Dose: 0.9 g, 4 times / day
Route: oral
Route: multiple
Dose: 0.9 g, 4 times / day
Sources:
healthy, age 18 to 44 years
n = 10
Health Status: healthy
Age Group: age 18 to 44 years
Sex: M+F
Population Size: 10
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG



OverviewOther

Other InhibitorOther SubstrateOther Inducer




Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
inconclusive
inconclusive
inconclusive
inconclusive
major
yes (co-administration study)
Comment: cigarette smoking induced CYP1A2 and increased O-deethylase activity
Page: 1.0
minor
minor
PubMed

PubMed

TitleDatePubMed
Letter: The clinical course of patients with analgesic nephropathy.
1975 Aug 9
The induction of renal papillary necrosis in Gunn rats by analgesics and analgesic mixtures.
1975 Feb
The radiological diagnosis of analgesic nephropathy.
1975 Jul
Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice.
1999 Jul
Epidemiology and etiology of premalignant and malignant urothelial changes.
2000
Neonatal mouse model: review of methods and results.
2001
Xpa and Xpa/p53+/- knockout mice: overview of available data.
2001
[Determination of three components in compound chlorophenamine tablet by iterative target transformation factor analysis].
2001 Apr
Relationship between nonphenacetin-combined analgesics and nephropathy.
2001 Jun
Relationship between nonphenacetin-combined analgesics and nephropathy.
2001 Jun
Relationship between nonphenacetin-combined analgesics and nephropathy.
2001 Jun
Suppression of agglomeration in fluidized bed coating. IV. Effects of sodium citrate concentration on the suppression of particle agglomeration and the physical properties of HPMC film.
2001 Mar 14
Optimization of an exogenous metabolic activation system for FETAX. II. Preliminary evaluation.
2001 May
Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.
2001 Nov
Review of potential risk factors for kidney (renal cell) cancer.
2001 Nov
Relationship between nonphenacetin combined analgesics and nephropathy.
2001 Nov
Fondaparinux sodium is not metabolised in mammalian liver fractions and does not inhibit cytochrome P450-mediated metabolism of concomitant drugs.
2002
Decreased hepatic drug metabolising enzyme activity in rats with nitrosamine-induced tumours.
2002
In vivo effect of diallyl sulfide and cimetidine on phenacetin metabolism and bioavailability in rat.
2002
Comparison of vasoconstrictor responses to selected NSAIDs in rabbit renal and femoral arteries.
2002
The onset of action and the analgesic efficacy of Saridon (a propyphenazone/paracetamol/ caffeine combination) in comparison with paracetamol, ibuprofen, aspirin and placebo (pooled statistical analysis).
2002
Phenacetin O-deethylation in extrahepatic tissues of rats.
2002 Apr-Jun
Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method.
2002 Aug
Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions.
2002 Dec
[Simultaneous determination of four components in the compound child phenobarbital tablet using ultraviolet spectrophotometry].
2002 Feb 28
Evaluation of the surfactant properties of ascorbyl palmitate sodium salt.
2002 Jul
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.
2002 Mar 1
Use of analgesics in self-medication.
2002 Mar-Apr
[A case of renal pelvic tumor due to phenacetin abuse].
2002 May
Hydrogen bonding with adsorbent during storage governs drug dissolution from solid-dispersion granules.
2002 Nov
Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs.
2002 Nov
Phenotype of CYP2C19 and CYP3A4 by determination of omeprazole and its two main metabolites in plasma using liquid chromatography with liquid-liquid extraction.
2002 Nov 25
Monolithic silica rod liquid chromatography with ultraviolet or fluorescence detection for metabolite analysis of cytochrome P450 marker reactions.
2002 Nov 25
Hospitalized poisonings after renal transplantation in the United States.
2002 Nov 26
COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression.
2002 Oct 15
Polymer particle erosion controlling drug release. II. Swelling investigations to clarify the release mechanism.
2002 Oct 24
Correlation between induction of DNA fragmentation in urinary bladder cells from rats and humans and tissue-specific carcinogenic activity.
2002 Sep 30
Analgesics and renal disease in the postphenacetin era.
2003 Aug
Identification of cytochrome P450 1A2 as enzyme involved in the microsomal metabolism of Huperzine A.
2003 Feb 14
High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry.
2003 Jan 1
Simultaneous liquid chromatography-tandem mass spectrometric determination of albendazole sulfoxide and albendazole sulfone in plasma.
2003 Jan 5
Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation.
2003 Jul
Effects of phenacetin and its metabolite p-phenetidine on COX-1 and COX-2 activities and expression in vitro.
2003 Jun 15
Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.
2003 Nov
Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis.
2003 Oct 31
HPLC analyses and pharmacokinetic studies of baicalin and oxymatrine in rabbits.
2003 Sep
Assessment of tableting properties using infinitesimal quantities of powdered medicine.
2003 Sep 16
Atomoxetine hydrochloride: clinical drug-drug interaction prediction and outcome.
2004 Feb
In vitro metabolism and inductive or inhibitive effect of DL111 on rat cytochrome P4501A enzyme.
2004 Mar 15
Patents

Sample Use Guides

Analgesic mixtures containing phenacetin were previously marketed as tablets or capsules containing between 150 and 300 mg phenacetin. Common combinations were: 150 mg phenacetin, 230 mg aspirin, and 15 or 30 mg caffeine; or 150 mg phenacetin, 230 mg aspirin, 30 mg caffeine, and 8, 15, 30, or 60 mg codeine phosphate. Phenacetin alone was also available in 250 and 300 mg doses as tablets, and up to 500 mg doses as powder. The usual dose was 300 mg 4–6 times per day, and the daily dose was not to exceed 2 g
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:05:26 GMT 2023
Edited
by admin
on Fri Dec 15 15:05:26 GMT 2023
Record UNII
ER0CTH01H9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PHENACETIN
HSDB   INCI   INN   JAN   MART.   MI   VANDF   WHO-DD  
INN   INCI  
Official Name English
PHENACETIN [VANDF]
Common Name English
4-ETHOXY-1-ACETYLAMINOBENZENE
Systematic Name English
FENIDINA
Common Name English
NSC-7651
Code English
PHENACETIN [MART.]
Common Name English
ACETAMIDE, N-(4-ETHOXYPHENOL)-
Common Name English
PHENACETIN [JAN]
Common Name English
ACETPHENETIDIN
Common Name English
KALMIN
Common Name English
PHENACETIN [INCI]
Common Name English
PHENACETIN MELTING POINT STANDARD
USP-RS  
Common Name English
PHENACETIN [MI]
Common Name English
PHENACETINUM
HPUS  
Common Name English
PHENACETINUM [HPUS]
Common Name English
PHENACETIN [USP-RS]
Common Name English
PHENACETIN [IARC]
Common Name English
PHENAZETIN
Common Name English
phenacetin [INN]
Common Name English
P-ACETOPHENETIDIDE
Common Name English
Phenacetin [WHO-DD]
Common Name English
PHENACETIN [HSDB]
Common Name English
ACETOPHENETIDIN
Common Name English
Classification Tree Code System Code
WHO-ATC N02BE53
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
WHO-VATC QN02BE53
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
WHO-ATC N02BE03
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
WHO-VATC QN02BE73
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
IARC Phenacetin
WHO-ATC N02BE73
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
NCI_THESAURUS C45176
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
WHO-VATC QN02BE03
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
Code System Code Type Description
EVMPD
SUB09745MIG
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
IUPHAR
7402
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
CAS
62-44-2
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
CHEBI
8050
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
FDA UNII
ER0CTH01H9
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
RS_ITEM_NUM
1514008
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
ALTERNATIVE
NSC
7651
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
INN
412
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
NCI_THESAURUS
C44432
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
DAILYMED
ER0CTH01H9
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
DRUG CENTRAL
2115
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
WIKIPEDIA
PHENACETIN
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
HSDB
3152
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
RS_ITEM_NUM
1513005
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
RXCUI
8113
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY RxNorm
ChEMBL
CHEMBL16073
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
MESH
D010615
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
EPA CompTox
DTXSID1021116
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
DRUG BANK
DB03783
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
MERCK INDEX
m8589
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY Merck Index
SMS_ID
100000088566
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-533-0
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
PUBCHEM
4754
Created by admin on Fri Dec 15 15:05:26 GMT 2023 , Edited by admin on Fri Dec 15 15:05:26 GMT 2023
PRIMARY
Related Record Type Details
METABOLIC ENZYME -> SUBSTRATE
TRANSPORTER -> INHIBITOR
TRANSPORTER -> INHIBITOR
TRANSPORTER -> INHIBITOR
METABOLIC ENZYME -> SUBSTRATE
Related Record Type Details
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METABOLITE ACTIVE -> PARENT
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AMOUNT ADMINISTERED
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METABOLITE ACTIVE -> PARENT
Metabolite to parent drug ratio in non-uraemic human plasma.
METABOLITE TO PARENT DRUG RATIO
PLASMA; URINE
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ACTIVE MOIETY